Special Issue "Frontiers of Microfluidics in Biology"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (20 November 2018)

Special Issue Editor

Guest Editor
Dr. Jack Merrin

Nanofabrication Facility, Institute of Science and Technology Austria, Klosterneuburg, Austria
E-Mail
Interests: microfluidics for biological applications and physics

Special Issue Information

Dear Colleagues,

Microfluidics is a useful tool in the study of biology and medicine, from the single molecule level, such as single cell DNA sequencing or single cell RNA profiling, to the properties of gene expression and genetic noise, and all the way up to the systems biology level.

Increasingly more microfluidic assays are being developed for the isolation of rare cells, separation of cell types, single cell analysis of rare cells, and pharmacological investigations. Assays and culture of cells are now routinely miniaturized with microfluidics through droplets, chemical reaction chambers, and mother machines.

Meanwhile, microfluidics can also facilitate biochemical and DNA computation. Organisms built into arcade systems now perform as hardware components in biotic games. Microfluidic inkjet printing facilitates the synthesis of DNA with error correction allowing new cellular processes and organisms to be designed from the ground up.

This Special Issue provides a platform and advanced academic forum for the experts in the area of microfluidics to share their knowledge. We look forward to your contributions.

Dr. Jack Merrin

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle Viscous Fingering of Miscible Liquids in Porous and Swellable Media for Rapid Diagnostic Tests
Bioengineering 2018, 5(4), 94; https://doi.org/10.3390/bioengineering5040094
Received: 15 September 2018 / Revised: 22 October 2018 / Accepted: 23 October 2018 / Published: 29 October 2018
PDF Full-text (7138 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
In lateral flow and colorimetric test strip diagnostics, the effects of capillary action and diffusion on speed and sensitivity have been well studied. However, another form of fluid motion can be generated due to stresses and instabilities generated in pores when two miscible
[...] Read more.
In lateral flow and colorimetric test strip diagnostics, the effects of capillary action and diffusion on speed and sensitivity have been well studied. However, another form of fluid motion can be generated due to stresses and instabilities generated in pores when two miscible liquids with different densities and viscosities come into contact. This study explored how a swellable test pad can be deployed for measuring urea in saliva by partially prefilling the pad with a miscible solution of greater viscosity and density. The resultant Korteweg stresses and viscous fingering patterns were analyzed using solutions with added food color through video analysis and image processing. Image analysis was simplified using the saturation channel after converting RGB image sequences to HSB. The kinetics of liquid mixing agreed with capillary displacement results for miscible liquids undergoing movement from Korteweg stresses. After capillary filling, there was significant movement of liquid due to these fluidic effects, which led to mixing of the saliva sample with an enzyme test solution. Owing to the simplicity and speed of this test method, urea can be analyzed with an electronic nose over a useful range for detecting salivary urea concentration for rapid and early detection of dehydration. Full article
(This article belongs to the Special Issue Frontiers of Microfluidics in Biology)
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