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High-Throughput 2018, 7(2), 18; https://doi.org/10.3390/ht7020018

Microfluidic Devices for Drug Assays

1
Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
2
Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow G12 8LT, UK
Current address: Manchester Institute of Biotechnology (MIB), School of Chemistry, University of Manchester, Manchester M1 7DN, UK.
*
Author to whom correspondence should be addressed.
Received: 2 May 2018 / Revised: 7 June 2018 / Accepted: 13 June 2018 / Published: 20 June 2018
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Abstract

In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuous flow, diffusion and concentration gradients-based microfluidic drug assays. Therefore, we reviewed over 100 recent publications in the field and sorted them according to their microfluidic approach. As a result, we are showcasing, comparing and discussing broadly applied approaches as well as singular promising ones that might contribute to shaping the future of this field. View Full-Text
Keywords: microfluidics; drug assays; high-throughput; review; well plates; droplet-microfluidics; drug discovery; continuous flow microfluidics microfluidics; drug assays; high-throughput; review; well plates; droplet-microfluidics; drug discovery; continuous flow microfluidics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Regnault, C.; Dheeman, D.S.; Hochstetter, A. Microfluidic Devices for Drug Assays. High-Throughput 2018, 7, 18.

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