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  • Article
  • Open Access
36 Citations
5,892 Views
14 Pages

The Manufacturing Process of Kiwifruit Fruit Powder with High Dietary Fiber and Its Laxative Effect

  • Ziqi Zhuang,
  • Min Chen,
  • Jihan Niu,
  • Na Qu,
  • Bing Ji,
  • Xiang Duan,
  • Zhande Liu,
  • Xuebo Liu,
  • Yutang Wang and
  • Beita Zhao

23 October 2019

Kiwifruit is rich in vitamins, minerals, dietary fiber and other functional components, and it has long been used as a functional food to treat intestinal ailments such as constipation. The current research made full use of the kiwifruit, the juice w...

  • Article
  • Open Access
9 Citations
3,908 Views
19 Pages

22 October 2021

Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract of Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials and Methods: Animal studies were conducted with...

  • Article
  • Open Access
8 Citations
5,351 Views
27 Pages

Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (Pinus densiflora) in Sprague-Dawley Rats with Loperamide-Induced Constipation

  • Hee-Jin Song,
  • Ayun Seol,
  • Jumin Park,
  • Ji-Eun Kim,
  • Tae-Ryeol Kim,
  • Ki-Ho Park,
  • Eun-Seo Park,
  • Su-Jeong Lim,
  • Su-Ha Wang and
  • Dae-Youn Hwang
  • + 3 authors

31 December 2024

Oxidative stress is the key cause of the etiopathogenesis of several diseases associated with constipation. This study examined whether the green pine cone can improve the symptoms of constipation based on the antioxidant activities. The changes in t...

  • Article
  • Open Access
19 Citations
5,098 Views
10 Pages

Laxative Effects of Total Diterpenoids Extracted from the Roots of Euphorbia pekinensis Are Attributable to Alterations of Aquaporins in the Colon

  • Kuilong Wang,
  • Lian Liu,
  • Jianyu Huang,
  • Hongli Yu,
  • Hao Wu,
  • Yu Duan,
  • Xiaobing Cui,
  • Xingde Zhang,
  • Liping Liu and
  • Wei Wang

This study was designed to evaluate the toxic effects of total diterpenoids extracted from the roots of Euphorbia pekinensis (TDEP) on the mouse colon and to clarify the mechanism. Dried powdered roots of E. pekinensis were extracted with chloroform,...

  • Article
  • Open Access
17 Citations
3,901 Views
19 Pages

Laxative Effects of Phlorotannins Derived from Ecklonia cava on Loperamide-Induced Constipation in SD Rats

  • Ji-Eun Kim,
  • Yun-Ju Choi,
  • Su-Jin Lee,
  • Jeong-Eun Gong,
  • You-Jung Jin,
  • So-Hae Park,
  • Hee-Seob Lee,
  • Young-Whan Choi,
  • Jin-Tae Hong and
  • Dae-Youn Hwang

28 November 2021

This study investigated the laxative effects of phlorotannins (Pt) derived from Ecklonia cava (E. cave) on chronic constipation by evaluating alterations in stool parameters, gastrointestinal motility, histopathological structure, mucin secretion, ga...

  • Article
  • Open Access
32 Citations
5,742 Views
18 Pages

Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model

  • Ji Eun Kim,
  • Ji Won Park,
  • Mi Ju Kang,
  • Hyeon Jun Choi,
  • Su Ji Bae,
  • Yusang Choi,
  • Young Ju Lee,
  • Sungbaek Seo,
  • Jin Tae Hong and
  • Dae Youn Hwang

Researches on spicatoside A (SpiA)-containing natural products suggest the possibility of SpiA as a potential laxative to alleviate chronic constipation. However, no studies have been conducted with single compound administration of SpiA. To verify t...

  • Article
  • Open Access
42 Citations
7,969 Views
24 Pages

Anti-Inflammatory Response and Muscarinic Cholinergic Regulation during the Laxative Effect of Asparagus cochinchinensis in Loperamide-Induced Constipation of SD Rats

  • Ji Eun Kim,
  • Ji Won Park,
  • Mi Ju Kang,
  • Hyeon Jun Choi,
  • Su Ji Bae,
  • You Sang Choi,
  • Young Ju Lee,
  • Hee Seob Lee,
  • Jin Tae Hong and
  • Dae Youn Hwang

21 February 2019

Several types of saponins and herbal plants containing saponins have been reported to have anti-inflammatory or laxative activities. To verify the therapeutic effects of saponin-enriched extracts of Asparagus cochinchinensis (SPA) on the anti-inflamm...

  • Article
  • Open Access
1 Citations
2,892 Views
13 Pages

The Effects of Prophylactic Laxative Use on Critically Ill Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study

  • Heqing Tao,
  • Ligang Liu,
  • Weipeng Lu,
  • Ziyan Ni,
  • Xueqing Chen,
  • Milap C. Nahata and
  • Liang Peng

1 November 2024

Objective: To investigate the effects of prophylactic use of stimulant laxatives and/or docusate on the clinical outcomes in critically ill patients who required mechanical ventilation (MV). Methods: A single-center, retrospective, cohort study was c...

  • Article
  • Open Access
12 Citations
4,282 Views
15 Pages

Prokinetic and Laxative Effects of Chrozophora tinctoria Whole Plant Extract

  • Ayaz Ali Sher,
  • Arshad Iqbal,
  • Naveed Muhammad,
  • Syed Lal Badshah,
  • Abdul-Hamid Emwas and
  • Mariusz Jaremko

26 March 2022

Chrozophora tinctoria (Euphorbiaceae) has been used as an emetic, anthelminthic, and cathartic agent in traditional medicine. We used gas chromatography-mass spectrometry (GC-MS) to characterize the composition of ethyl acetate (EAC) and dichlorometh...

  • Correction
  • Open Access
86 Views
2 Pages

27 February 2026

In the original publication [...]

  • Article
  • Open Access
16 Citations
3,696 Views
14 Pages

Exogenous Carbon Compounds Modulate Tomato Root Development

  • Ana Isabel González-Hernández,
  • Loredana Scalschi,
  • Pilar García-Agustín and
  • Gemma Camañes

3 July 2020

NO3 is not only a nutrient, but also a signaling compound that plays an important role in several plant processes, like root development. The present study aimed to investigate the effect of three different exogenous C compounds (sucrose, gluc...

  • Article
  • Open Access
13 Citations
5,982 Views
13 Pages

Neurogenic Bowel in Acute Rehabilitation Following Spinal Cord Injury: Impact of Laxatives and Opioids

  • Andrew M. Round,
  • Min Cheol Joo,
  • Carolyn M. Barakso,
  • Nader Fallah,
  • Vanessa K. Noonan and
  • Andrei V. Krassioukov

14 April 2021

Objective: To explore the association between bowel dysfunction and use of laxatives and opioids in an acute rehabilitation setting following spinal cord injury (SCI). Methods: Data was collected regarding individuals with acute traumatic/non-traumat...

  • Article
  • Open Access
11 Citations
2,960 Views
15 Pages

Lanthanum Exchanged Keggin Structured Heteropoly Compounds for Biodiesel Production

  • Badriah Al-Shammari,
  • Qana A. Alsulami and
  • Katabathini Narasimharao

21 November 2019

La-exchanged 12-tungstophosphoric acid (LaxTPA) and 12-molybdophosphoric acid (LaxMPA) salts (x = 0.25, 0.50, 0.75 and 1.00) were prepared via an ion exchange method. The physico-chemical characteristics of the materials were analyzed by using elemen...

  • Article
  • Open Access
36 Citations
3,803 Views
19 Pages

Manipulating the Structure and Characterization of Sr1−xLaxTiO3 Nanocubes toward the Photodegradation of 2-Naphthol under Artificial Solar Light

  • Minh-Vien Le,
  • Ngoc-Quoc-Duy Vo,
  • Quoc-Cuong Le,
  • Vy Anh Tran,
  • Thi-Que-Phuong Phan,
  • Chao-Wei Huang and
  • Van-Huy Nguyen

28 April 2021

Effective La-doped SrTiO3 (Sr1−xLaxTiO3, x = 0–0.1 mol.% La-doped) nanocubes were successfully synthesized by a hydrothermal method. The influence of different La dopant concentrations on the physicochemical properties of the host structure of SrTiO3...

  • Article
  • Open Access
976 Views
7 Pages

Synthesis, Structure and Magnetic Properties of Sm6−xLaxMn23 (0.5 ≤ x ≤ 4) Alloys

  • Ying-Hua Liang,
  • Zhong Zhang,
  • Jihoon Park,
  • Jia-Cheng Lyu,
  • Hong-Liang Ge,
  • Ping-Zhan Si and
  • Chul-Jin Choi

The structure and magnetic properties of Sm6−xLaxMn23 (x = 0.5, 1, 2, 3 and 4) alloys have been studied systematically. We found that the Th6Mn23-type Sm6−xLaxMn23 alloys become less stable with increasing La content, and α-Mn becom...

  • Article
  • Open Access
24 Citations
5,811 Views
13 Pages

2 August 2018

In this work, plasma-catalytic removal of H2S over LaxMnO3 (x = 0.90, 0.95, 1, 1.05 and 1.10) has been studied in a coaxial dielectric barrier discharge (DBD) reactor. The non-stoichiometric effect of the LaxMnO3 catalysts on the removal of H2S and s...

  • Article
  • Open Access
2 Citations
1,893 Views
9 Pages

30 April 2022

Discrete integrable nonlinear differential difference equations (NDDEs) have various mathematical structures and properties, such as Lax pair, infinitely many conservation laws, Hamiltonian structure, and different kinds of symmetries, including Lie...

  • Article
  • Open Access
1,428 Views
20 Pages

Ba1−xCexMnO3 (BM-Cex) and Ba1−xLaxMn0.7Cu0.3O3 (BMC-Lax) perovskite-type mixed oxides were synthesized using the sol–gel method adapted for aqueous media with different values of x (0, 0.1, 0.3, 0.6) to estimate the effect of the de...

  • Article
  • Open Access
2 Citations
5,539 Views
14 Pages

The Effects of Laxogenin and 5-Alpha-hydroxy-laxogenin on Myotube Formation and Maturation During Cultured Meat Production

  • Jeong Ho Lim,
  • Syed Sayeed Ahmad,
  • Ye Chan Hwang,
  • Ananda Baral,
  • Sun Jin Hur,
  • Eun Ju Lee and
  • Inho Choi

Cultured meat (CM) is derived from the in vitro myogenesis of muscle satellite (stem) cells (MSCs) and offers a promising alternative protein source. However, the development of a cost-effective media formulation that promotes cell growth has yet to...

  • Systematic Review
  • Open Access
3 Citations
14,559 Views
16 Pages

30 June 2025

Chronic constipation is common among older adults, significantly reducing quality of life and increasing healthcare burden. While dietary fiber is a traditional intervention for constipation, its efficacy in elderly populations remains inconclusive....

  • Review
  • Open Access
64 Citations
41,408 Views
12 Pages

Magnesium Oxide in Constipation

  • Hideki Mori,
  • Jan Tack and
  • Hidekazu Suzuki

28 January 2021

Magnesium oxide has been widely used as a laxative for many years in East Asia, yet its prescription has largely been based on empirical knowledge. In recent years, several new laxatives have been developed, which has led to a resurgence in interest...

  • Article
  • Open Access
4 Citations
2,973 Views
13 Pages

16 March 2025

As an endogenous hormone, auxin plays a crucial role in regulating plants’ growth and development, and also in the responses to abiotic stresses. However, the effects and mechanism of auxin and its inhibitors on plant growth and mineral nutrien...

  • Review
  • Open Access
140 Citations
12,468 Views
10 Pages

Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tra...

  • Article
  • Open Access
3,779 Views
12 Pages

Computational Prediction of New Series of Topological Ternary Compounds LaXS (X = Si, Ge, Sn) from First-Principles

  • Jack Howard,
  • Joshua Steier,
  • Neel Haldolaarachchige and
  • Kalani Hettiarachchilage

30 September 2021

Dirac materials and their advanced physical properties are one of the most active fields of topological matter. In this paper, we present an ab initio study of electronics properties of newly designed LaXS (X = Si, Ge, Sn) tetragonal structured terna...

  • Article
  • Open Access
9 Citations
2,550 Views
66 Pages

18 October 2023

The standard approach to integrable nonlinear evolution equations (NLEE) usually uses the following steps: (1) Lax representation [L,M]=0; (2) construction of fundamental analytic solutions (FAS); (3) reducing the inverse scattering problem (ISP) to...

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,811 Views
20 Pages

5 December 2017

The classical Lagrange-d’Alembert principle had a decisive influence on formation of modern analytical mechanics which culminated in modern Hamilton and Poisson mechanics. Being mainly interested in the geometric interpretation of this principle, we...

  • Article
  • Open Access
6 Citations
9,123 Views
8 Pages

Clinical Trial: Marine Lipid Suppositories as Laxatives

  • Orri Thor Ormarsson,
  • Thormodur Geirsson,
  • Einar Stefan Bjornsson,
  • Tomas Jonsson,
  • Pall Hegli Moller,
  • Thorsteinn Loftsson and
  • Einar Stefansson

20 September 2012

Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositorie...

  • Article
  • Open Access
758 Views
13 Pages

16 May 2025

The effects of the La element and heat treatment on the phase composition and magnetic properties of SmFe10V2 melt-spun ribbons are studied by X-ray diffraction (XRD) and vibrating sample magnetometry (VSM). The XRD results show that the Sm1−xL...

  • Article
  • Open Access
2 Citations
1,163 Views
24 Pages

30 October 2024

We successively reanalyzed modern Lie-algebraic approaches lying in the background of effective constructions of integrable super-Hamiltonian systems on functional N=1,2,3- supermanifolds, possessing rich supersymmetries and endowed with suitably rel...

  • Article
  • Open Access
5 Citations
2,274 Views
9 Pages

The Effectiveness of a Very Low-Volume Compared to High-Volume Laxative in Colon Capsule Endoscopy

  • Benedicte Schelde-Olesen,
  • Artur Nemeth,
  • Gabriele Wurm Johansson,
  • Ulrik Deding,
  • Thomas Bjørsum-Meyer,
  • Henrik Thorlacius,
  • Gunnar Baatrup,
  • Anastasios Koulaouzidis and
  • Ervin Toth

Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with pa...

  • Article
  • Open Access
1 Citations
3,069 Views
9 Pages

22 February 2024

Opioids are highly effective drugs but need close monitoring to avoid harm to patients. The aim of this study was to analyze how guideline recommendations are met for (i) the avoidance of the concomitant use of anxiolytics, hypnotics, or sedatives; (...

  • Article
  • Open Access
2,021 Views
14 Pages

Constipation is a prevalent gastrointestinal disorder that significantly impairs quality of life. While pharmacological agents such as loperamide are widely used to induce constipation in experimental models, there is increasing interest in natural a...

  • Review
  • Open Access
33 Citations
22,201 Views
14 Pages

10 July 2020

Functional constipation (FC) is a chronic constipation for which no physiological, anatomical or iatrogenic origin can be evidenced. This condition has a high impact on a patient’s quality of life and healthcare costs. Since FC is frequently as...

  • Article
  • Open Access
7 Citations
3,881 Views
16 Pages

28 June 2024

An increase in carbon emissions (CO2) may increase inward foreign direct investment (FDI) in developing countries since they are seen as pollution havens because of lax environmental regulations (pollution haven hypothesis). Developed countries may a...

  • Article
  • Open Access
12 Citations
4,026 Views
12 Pages

Consuming Genistein Improves Survival Rates in the Absence of Laxative in ΔF508-CF Female Mice

  • Ryan Lord,
  • Nathan Fairbourn,
  • Charisma Mylavarapu,
  • Ammer Dbeis,
  • Taylor Bowman,
  • Archana Chandrashekar,
  • Tatum Banayat,
  • Craig A. Hodges and
  • Layla Al-Nakkash

3 October 2018

Genistein is a naturally occurring isoflavone found in soy. Genistein has been shown to increase the open probability of the most common cystic fibrosis (CF) disease-associated mutation, ∆F508-CFTR. Mice homozygous for the ∆F508 mutation are characte...

  • Article
  • Open Access
4 Citations
2,022 Views
21 Pages

28 November 2024

Vidarabine (VID) is an antiviral medication that is commonly utilized to treat conditions such as hand, foot, and mouth disease and herpes. Constipation is a prevalent complication of these diseases. Could VID treat these diseases by influencing defe...

  • Article
  • Open Access
40 Citations
5,962 Views
16 Pages

Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats

  • Yixin Cao,
  • Ying He,
  • Cong Wei,
  • Jing Li,
  • Lejing Qu,
  • Huiqin Zhang,
  • Ying Cheng and
  • Boling Qiao

17 October 2018

Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific j...

  • Communication
  • Open Access
15 Citations
10,592 Views
15 Pages

The Formation of Rice Tillers and Factors Influencing It

  • Rong Yuan,
  • Yuxin Mao,
  • Dehai Zhang,
  • Shun Wang,
  • Huina Zhang,
  • Meng Wu,
  • Miao Ye and
  • Zujian Zhang

5 December 2024

The number of effective rice tillers determines the number of effective panicles and then affects the final yield. Rice tillering ability shows great differences among cultivars and under different environmental conditions, but the underlying mechani...

  • Article
  • Open Access
2 Citations
6,814 Views
21 Pages

8 December 2015

This paper investigates the impact of what the extant literature has come to view as some of the major causes of the 2007 US housing market crisis. In particular we investigate the hypothesized effect of, lax financial regulations, the “savings glut”...

  • Article
  • Open Access
3 Citations
3,832 Views
17 Pages

Early Childhood Temperamental Trajectories following Very Preterm Birth and Their Association with Parenting Style

  • Irene Lovato,
  • Lucy D. Vanes,
  • Chiara Sacchi,
  • Alessandra Simonelli,
  • Laila Hadaya,
  • Dana Kanel,
  • Shona Falconer,
  • Serena Counsell,
  • Maggie Redshaw and
  • Chiara Nosarti
  • + 2 authors

Childhood temperament is an early characteristic shaping later life adjustment. However, little is currently known about the stability of early temperament and its susceptibility to the environment in children born very preterm (VPT; <33 weeks&rsq...

  • Article
  • Open Access
1,088 Views
7 Pages

21 July 2025

This research investigates the effects of the addition of the rare-earth element La on the microstructure, phase transformation, and mechanical properties of Ni50Ti30Hf20−xLax (x = 0, 0.5, 1, 2) alloys. The results show that a primary matrix co...

  • Article
  • Open Access
3 Citations
1,247 Views
15 Pages

Enhanced Energy Storage Performance in La-Doped CaBi4Ti4O15 Films Through the Formation of a Weakly Coupled Relaxor

  • Quanlong Liu,
  • Lei Zhang,
  • Jun Ouyang,
  • Yan Liu,
  • Zhehong Tang,
  • Jieyu Chen,
  • Fei Guo and
  • Yunpeng Zhou

13 December 2024

Relaxor ferroelectric film capacitors exhibit high power density with ultra-fast charge and discharge rates, making them highly advantageous for consumer electronics and advanced pulse power supplies. The Aurivillius-phase bismuth layered ferroelectr...

  • Case Report
  • Open Access
3 Citations
8,054 Views
6 Pages

Constipation is a gastrointestinal motility disorder that represents a major health problem in Japan. Approximately 26% of young Japanese adult women are reported to have this complaint. We report on the health effects of daily intake of Sujiaonori a...

  • Article
  • Open Access
5 Citations
3,654 Views
17 Pages

Extraction and Fractionation of Prokinetic Phytochemicals from Chrozophora tinctoria and Their Bioactivities

  • Arshad Iqbal,
  • Ayaz Ali Sher,
  • Naveed Muhammad,
  • Syed Lal Badshah,
  • Abdul-Hamid Emwas and
  • Mariusz Jaremko

Chrozophora tinctoria is an annual plant of the family Euphorbiaceae, traditionally used as a laxative, a cathartic and an emetic. A methanolic extract of Chrozophora tinctoria (MEC) whole plant and an n-butanol fraction of Chrozophora tinctoria (NBF...

  • Case Report
  • Open Access
1 Citations
2,452 Views
12 Pages

Alveolar Ridge Preservation Using Three-Dimensional Root Replicas of Polycaprolactone: A Radiological and Histological Evaluation of a Case Report

  • Pedro Christian Aravena,
  • Mario E Flores,
  • Larissa Córdova Turones,
  • Francisca Pavicic and
  • Pamela Ehrenfeld

Background and Clinical Significance: To describe the effectiveness of alveolar ridge preservation under the radiological and histological analysis of a customized resorbable scaffold three-dimensionally printed with polycaprolactone (PCL) reinforced...

  • Article
  • Open Access
6 Citations
2,458 Views
13 Pages

The coupled cubic-quintic nonlinear Schrödinger (CQNLS) equation is a universal mathematical model describing many physical situations, such as nonlinear optics and Bose–Einstein condensate. In this paper, in order to simplify the process...

  • Article
  • Open Access
7 Citations
3,729 Views
15 Pages

Exploring the High-Temperature Electrical Performance of Ca3−xLaxCo4O9 Thermoelectric Ceramics for Moderate and Low Substitution Levels

  • Gabriel Constantinescu,
  • Shahed Rasekh,
  • Parisa Amirkhizi,
  • Daniela V. Lopes,
  • Miguel A. Vieira,
  • Andrei V. Kovalevsky,
  • Juan C. Diez,
  • Andres Sotelo,
  • Maria A. Madre and
  • Miguel A. Torres

1 May 2021

Aliovalent substitutions in Ca3Co4O9 often result in complex effects on the electrical properties and the solubility, and impact of the substituting cation also depends largely on the preparation and processing method. It is also well-known that the...

  • Article
  • Open Access
2 Citations
3,340 Views
6 Pages

Surgical Treatment for Rectocele by Posterior Colporrhaphy Compared to Stapled Transanal Rectal Resection

  • Ohad Gluck,
  • Doraid Matani,
  • Ada Rosen,
  • Elad Barber,
  • Eran Weiner and
  • Shimon Ginath

15 January 2023

Background: Rectocele is defined as a defect in the rectovaginal septum, causing symptoms like obstructed defecation syndrome (ODS), vaginal bulging, etc. Once the rectocele is larger than 3 cm and/or symptomatic, surgery should be considered. The su...

  • Opinion
  • Open Access
6 Citations
7,240 Views
11 Pages

Improving Diagnosis and Management of Opioid-Induced Constipation (OIC) in Clinical Practice: An Italian Expert Opinion

  • Giustino Varrassi,
  • Giuseppe Casale,
  • Maria Grazia De Marinis,
  • Francesco Dentali,
  • Paolo Evangelista,
  • Gino Gobber,
  • Gaetano Lanzetta,
  • Pierangelo Lora Aprile,
  • Maria Caterina Pace and
  • Andrea Ungar
  • + 2 authors

7 November 2024

Opioid-induced constipation (OIC) is a very common and troublesome gastrointestinal side effect following the use of opioids. Despite existing international guidelines, OIC is largely underdiagnosed and undertreated. ECHO OIC is a European project de...

  • Review
  • Open Access
8 Citations
2,453 Views
25 Pages

19 November 2022

The current EU energy policy aims to diversify energy sources to ensure energy security while decarbonising the economy and promoting low carbon and clean energy technologies. These tasks are carried out under the European Green Deal Program. Therefo...

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