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Int. J. Mol. Sci. 2016, 17(7), 1172;

Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation

Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 25 May 2016 / Revised: 12 July 2016 / Accepted: 14 July 2016 / Published: 20 July 2016
(This article belongs to the Special Issue Aquaporin)
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Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3. View Full-Text
Keywords: aquaporin; colon; diarrhea; laxative; constipation; morphine aquaporin; colon; diarrhea; laxative; constipation; morphine

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Ikarashi, N.; Kon, R.; Sugiyama, K. Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation. Int. J. Mol. Sci. 2016, 17, 1172.

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