Skip to Content

101 Results Found

  • Article
  • Open Access
1 Citations
2,343 Views
12 Pages

8 February 2024

This study aimed to investigate the morphological characteristics of fruits and seeds from Diptychocarpus strictus, a plant species inhabiting the cold desert pastoral area of China. Furthermore, this study sought to evaluate the germination potentia...

(This article belongs to the Section Plant Science)
  • Article
  • Open Access
909 Views
16 Pages

9 July 2025

The distinctive leaf and twig heteromorphism in Euphrates poplar (Populus euphratica Oliv.) reflects its adaptive strategies to cope with arid environments across ontogenetic stages. In the key distribution area of P. euphratica forests in China, we...

(This article belongs to the Section Forest Ecophysiology and Biology)
  • Article
  • Open Access
275 Views
18 Pages

Germination Strategies of Heteromorphic Seeds and Their Implications for Coastal Wetland Restoration in Suaeda heteroptera

  • Haixia Sun,
  • Shupan Lv,
  • Jiawei Lv,
  • Xinzhu Zhang,
  • Wenbo Qi,
  • Rui Yan,
  • Ming Liu,
  • Quan Liu and
  • Yan Zhang

12 August 2026

Coastal wetlands are increasingly threatened by salinization and habitat degradation, which limit the natural regeneration of native halophytes. Suaeda heteroptera, an important halophytic species in temperate coastal wetlands, plays a critical role...

  • Article
  • Open Access
41 Citations
3,682 Views
22 Pages

A Novel Heteromorphous Convolutional Neural Network for Automated Assessment of Tumors in Colon and Lung Histopathology Images

  • Saeed Iqbal,
  • Adnan N. Qureshi,
  • Musaed Alhussein,
  • Khursheed Aurangzeb and
  • Seifedine Kadry

The automated assessment of tumors in medical image analysis encounters challenges due to the resemblance of colon and lung tumors to non-mitotic nuclei and their heteromorphic characteristics. An accurate assessment of tumor nuclei presence is cruci...

(This article belongs to the Special Issue Bionic Artificial Neural Networks and Artificial Intelligence)
  • Article
  • Open Access
12 Citations
3,291 Views
16 Pages

12 September 2022

Populus euphratica Oliv., a pioneer species of desert riparian forest, is characterized heterophylly. To understand the adaptation strategies of the heteromorphic leaves of P. euphratica to soil drought, we assessed the structural and functional char...

(This article belongs to the Section Phytochemistry)
  • Article
  • Open Access
5 Citations
1,716 Views
18 Pages

The Identification and Characterization of the PeGRF Gene Family in Populus euphratica Oliv. Heteromorphic Leaves Provide a Theoretical Basis for the Functional Study of PeGRF9

  • Ying Wang,
  • Zhihua Wu,
  • Mingyu Jia,
  • Jing Li,
  • Tongrui Song,
  • Hongyan Jin,
  • Jianhao Sun,
  • Chen Qiu,
  • Xiaona Lu and
  • Zhijun Li
  • + 3 authors

Populus euphratica Oliv. typically has four kinds of heteromorphic leaves: linear (Li), lanceolate (La), ovate (Ov) and broad ovate (Bo). Heteromorphic leaves help P. euphratica adapt to extreme desert environments and further contribute to protectio...

(This article belongs to the Special Issue The Role and Mechanism of Hydrogen Sulfide and ROS in Plants)
  • Review
  • Open Access
9 Citations
3,744 Views
12 Pages

15 October 2022

Chromosomal heteromorphisms (CHs) are a part of genetic variation in man. The past literature largely posited whether CHs could be correlated with the development of malignancies. While this possibility seemed closed by end of the 1990s, recent data...

(This article belongs to the Section Cell Nuclei: Function, Transport and Receptors)
  • Article
  • Open Access
4 Citations
2,078 Views
46 Pages

23 March 2025

The MAT1-1-1 and MAT1-2-1 proteins are essential for the sexual reproduction of Ophiocordyceps sinensis. Although Hirsutella sinensis has been postulated to be the sole anamorph of O. sinensis and to undergo self-fertilization under homothallism or p...

  • Article
  • Open Access
1 Citations
1,656 Views
15 Pages

1 August 2025

DNA methylation, mediated by DNA methyltransferases (DMTs) and demethylases (DMLs), is an important epigenetic modification that maintains genomic stability and regulates gene expression in plant growth, development, and stress responses. However, a...

(This article belongs to the Special Issue Advancement in Gene Expression Regulation in Plants: Coordinating Growth, Development, and Stress Resilience)
  • Article
  • Open Access
2,858 Views
22 Pages

Category theory has foundational importance because it provides conceptual lenses to characterize what is important and universal in mathematics—with adjunction seeming to be the primary lens. Our topic is a theory showing “where adjoints...

(This article belongs to the Section Mathematical Sciences)
  • Article
  • Open Access
1 Citations
2,618 Views
15 Pages

18 January 2024

Mallios and Zafiris emphasize that adjoint functors, or adjunctions, are not only “ubiquitous” in category theory but also characterize the naturality of their approach to physical geometry. Hence, in this paper, the history and theory of...

(This article belongs to the Section E4: Mathematical Physics)
  • Communication
  • Open Access
9 Citations
5,293 Views
11 Pages

Recent findings on the molecular basis of heteromorphic self-incompatibility in Primula have shown that the controlling self-incompatibility (S)-locus is not allelic, but is instead a small hemizygous region of only a few genes in the thrum genotype....

  • Article
  • Open Access
2 Citations
5,205 Views
14 Pages

Karyological Diversification in the Genus Lyciasalamandra (Urodela: Salamandridae)

  • Marcello Mezzasalma,
  • Gaetano Odierna,
  • Agnese Petraccioli,
  • Michael Veith and
  • Fabio Maria Guarino

8 June 2021

We performed the first cytogenetic analysis on five out of the seven species of the genus Lyciasalamandra, including seven subspecies, and representatives of its sister genus Salamandra. All the studied species have a similar karyotype of 2n = 24, mo...

(This article belongs to the Section Animal Genetics and Genomics)
  • Article
  • Open Access
7 Citations
9,691 Views
20 Pages

Origin and Evolution of the Neo-Sex Chromosomes in Pamphagidae Grasshoppers through Chromosome Fusion and Following Heteromorphization

  • Ilyas Yerkinovich Jetybayev,
  • Alexander Gennadievich Bugrov,
  • Olesya Georgievna Buleu,
  • Anton Gennadievich Bogomolov and
  • Nikolay Borisovich Rubtsov

13 November 2017

In most phylogenetic lineages, the evolution of sex chromosomes is accompanied by their heteromorphization and degradation of one of them. The neo-sex chromosomes are useful model for studying early stages of these processes. Recently two lineages of...

(This article belongs to the Special Issue Chromosomal Evolution)
  • Review
  • Open Access
43 Citations
6,197 Views
10 Pages

19 February 2021

Repetitive DNA in humans is still widely considered to be meaningless, and variations within this part of the genome are generally considered to be harmless to the carrier. In contrast, for euchromatic variation, one becomes more careful in classifyi...

(This article belongs to the Special Issue Repetitive DNA Sequences in Eukaryotic Genomes)
  • Article
  • Open Access
1 Citations
2,756 Views
14 Pages

18 February 2024

The size of leaves is a vital factor in the development and overall biomass of a plant, serving as a key indicator of how a plant adapts to its environment. Rhamnus heterophylla, a species known for its heteromorphic leaves of varying sizes, presents...

(This article belongs to the Section Horticultural and Floricultural Crops)
  • Article
  • Open Access
23 Citations
3,847 Views
24 Pages

17 October 2019

Heterophylly is the phenomenon of leaf forms varying along the longitudinal axis within a single plant. Populus euphratica, a heterophyllous woody plant, develops lanceolate leaves and dentate broad-ovate leaves on the bottom and top of the canopy, r...

(This article belongs to the Section Molecular Plant Sciences)
  • Article
  • Open Access
430 Views
33 Pages

11 August 2026

The MAT1-1-1 and MAT1-2-1 proteins perform essential DNA-binding activities and regulation of the transcription of genes governing sexual reproduction in Ophiocordyceps sinensis. Previous studies have documented differential occurrence, alternative s...

(This article belongs to the Special Issue Protein Structure, Dynamics and Interactions)
  • Review
  • Open Access
2 Citations
1,692 Views
22 Pages

Seed Germination as an Adaptive Response in Halophytes

  • Keriman Şekerci,
  • Nahoko Higashitani,
  • Atsushi Higashitani and
  • Ismail Turkan

2 June 2026

Halophytes thrive in saline habitats through highly specialized adaptive responses, including seed-based strategies to regulate germination timing and ensure reproductive success under fluctuating environmental conditions. Salt-induced quiescence, st...

(This article belongs to the Section Plant Response to Abiotic Stress and Climate Change)
  • Article
  • Open Access
11 Citations
6,288 Views
20 Pages

Transcriptomics Investigation into the Mechanisms of Self-Incompatibility between Pin and Thrum Morphs of Primula maximowiczii

  • Wanpei Lu,
  • Xiaomeng Bian,
  • Weiru Yang,
  • Tangren Cheng,
  • Jia Wang,
  • Qixiang Zhang and
  • Huitang Pan

Heteromorphic self-incompatibility (SI) is an important system for preventing inbreeding in the genus Primula. However, investigations into the molecular mechanisms of Primula SI are lacking. To explore the mechanisms of SI in Primula maximowiczii, t...

(This article belongs to the Special Issue Pollen Tube and Plant Reproduction)
  • Perspective
  • Open Access
24 Citations
10,171 Views
15 Pages

15 February 2023

The powerful utilities of current DNA sequencing technology question the value of developing clinical cytogenetics any further. By briefly reviewing the historical and current challenges of cytogenetics, the new conceptual and technological platform...

(This article belongs to the Special Issue Advances in Clinical Cytogenetics)
  • Article
  • Open Access
460 Views
23 Pages

26 July 2026

Successful germination is a critical stage for the establishment and persistence of annual halophytes in Mediterranean saltmarshes, where highly variable salinity creates narrow recruitment windows. Seed heteromorphism is a common feature of annual h...

(This article belongs to the Special Issue Mediterranean Plant Diversity: Ecology, Adaptation and Sustainable Futures)
  • Article
  • Open Access
105 Views
36 Pages

This study re-evaluates the evolutionary relationships of Horstia and allied bee-associated astigmatid mites using an integrative framework combining morphological reassessment and previously generated molecular phylogenetic evidence. Our results fun...

  • Article
  • Open Access
3 Citations
1,454 Views
17 Pages

14 April 2025

There are obvious individual differences in the growth and development of Cynoglossus semilaevis, mainly due to female bias. We selected 500 female Cynoglossus semilaevis of different sizes for GWAS and transcriptome analysis to screen for differenti...

(This article belongs to the Special Issue Advances in Research on Functional Genes and Economic Traits in Fish)
  • Article
  • Open Access
7 Citations
2,730 Views
16 Pages

A Novel Heteromorphic Ensemble Algorithm for Hand Pose Recognition

  • Shiruo Liu,
  • Xiaoguang Yuan,
  • Wei Feng,
  • Aifeng Ren,
  • Zhenyong Hu,
  • Zuheng Ming,
  • Adnan Zahid,
  • Qammer H. Abbasi and
  • Shuo Wang

21 March 2023

Imagining recognition of behaviors from video sequences for a machine is full of challenges but meaningful. This work aims to predict students’ behavior in an experimental class, which relies on the symmetry idea from reality to annotated reality cen...

(This article belongs to the Section A: Computer Science)
  • Article
  • Open Access
19 Citations
5,527 Views
18 Pages

Evidence for Dosage Compensation in Coccinia grandis, a Plant with a Highly Heteromorphic XY System

  • Cécile Fruchard,
  • Hélène Badouin,
  • David Latrasse,
  • Ravi S. Devani,
  • Aline Muyle,
  • Bénédicte Rhoné,
  • Susanne S. Renner,
  • Anjan K. Banerjee,
  • Abdelhafid Bendahmane and
  • Gabriel A. B. Marais

13 July 2020

About 15,000 angiosperms are dioecious, but the mechanisms of sex determination in plants remain poorly understood. In particular, how Y chromosomes evolve and degenerate, and whether dosage compensation evolves as a response, are matters of debate....

(This article belongs to the Special Issue Unraveling the Genetic Control of Sexual Reproduction in Wild Plants and Their Domesticated Cousins)
  • Article
  • Open Access
3 Citations
3,022 Views
10 Pages

22 February 2022

Young sex chromosomes possess unique and ongoing dynamics that allow us to understand processes that have an impact on their evolution and divergence. The genus Silene includes species with evolutionarily young sex chromosomes, and two species of sec...

(This article belongs to the Special Issue Cytomolecular Organisation of the Nuclear Genome)
  • Article
  • Open Access
4 Citations
3,147 Views
11 Pages

4 January 2023

Yams (Dioscorea spp.) are a pantropical genus located worldwide that constitute an important source of nutrients and pharmaceutical substances. Some Dioscorea crop species are widely grown in West Africa. One species that is mainly cultivated in Came...

(This article belongs to the Special Issue Beyond Mendel's Laws)
  • Article
  • Open Access
1 Citations
2,543 Views
28 Pages

Typification of the Economically Important Species Thyreophagus entomophagus (Acari: Astigmata: Acaridae) Used for the Industrial Production of Predatory Mites: The Designation of a Neotype with Detailed Morphological and DNA Sequence Data

  • Pavel B. Klimov,
  • Vasiliy B. Kolesnikov,
  • Alexander A. Khaustov,
  • Vladimir A. Khaustov,
  • Jonas Merckx,
  • Marcus V. A. Duarte,
  • Dominiek Vangansbeke,
  • Ilse Geudens and
  • Almir Pepato

26 January 2025

The mite Thyreophagus entomophagus is a cosmopolitan species of significant economic importance in biocontrol applications, serving as a factitious prey for the mass rearing of predatory mites. This species has been reported from a variety of habitat...

  • Article
  • Open Access
4 Citations
5,866 Views
14 Pages

23 April 2018

Hemispherical Janus particles that were coated with silver or nickel on the equatorial plane of hemispherical polymer microparticles were prepared and dispersed in water and the responses to AC electric and stationary magnetic fields applied were inv...

(This article belongs to the Section Optics and Lasers)
  • Article
  • Open Access
6 Citations
3,437 Views
21 Pages

6 December 2022

Agaricus bisporus var. bisporus, the button mushroom, has a predominantly pseudohomothallic life cycle. Most of its spores are heterokaryotic and give rise to fertile heterokaryons. However, previous studies have suggested that outcrossing shoul...

(This article belongs to the Section Fungal Evolution, Biodiversity and Systematics)
  • Article
  • Open Access
8 Citations
3,411 Views
27 Pages

29 July 2022

Plant communities can undergo drastic changes in their composition if the ecosystem is severely altered by human actions or climate change. These changes endanger any vulnerable species, mainly if it lives in a small area, as is the case of Picris wi...

(This article belongs to the Special Issue Seed Dormancy and Germination)
  • Article
  • Open Access
1 Citations
799 Views
52 Pages

19 January 2026

The MATα_HMGbox and HMG-box_ROX1-like domains of the MAT1-1-1 and MAT1-2-1 proteins, respectively, play essential roles in DNA binding and the subsequent regulation of gene transcription, controlling Ophiocordyceps sinensis sexual reproduction....

(This article belongs to the Section Biochemistry and Molecular Biology)
  • Article
  • Open Access
7 Citations
4,518 Views
15 Pages

17 January 2021

Ex situ plant collections established from seeds of natural populations are key tools for understanding mating systems of intricate taxonomic complexes, as in the Limonium Mill. genus (sea lavenders, Plumbaginaceae). Plants show a polymorphic sexual...

  • Review
  • Open Access
54 Citations
13,124 Views
18 Pages

25 January 2024

Bidens pilosa L. is native to tropical America and has widely naturized from tropical to warm temperate regions in Europe, Africa, Asia, Australia, and North and South America. The species has infested a wide range of habitats such as grasslands, for...

(This article belongs to the Special Issue Plant Invasion 2023)
  • Review
  • Open Access
61 Citations
10,852 Views
17 Pages

26 March 2021

Frogs are ideal organisms for studying sex chromosome evolution because of their diversity in sex chromosome differentiation and sex-determination systems. We review 222 anuran frogs, spanning ~220 Myr of divergence, with characterized sex chromosome...

(This article belongs to the Special Issue Vertebrate Karyotype Evolution: How Far Have We Come, and Where Are We Going?)
  • Article
  • Open Access
5 Citations
5,266 Views
12 Pages

Genome-Wide SNP Analysis of Male and Female Rice Field Frogs, Hoplobatrachus rugulosus, Supports a Non-Genetic Sex Determination System

  • Thitipong Panthum,
  • Worapong Singchat,
  • Nararat Laopichienpong,
  • Syed Farhan Ahmad,
  • Ekaphan Kraichak,
  • Prateep Duengkae,
  • Narongrit Muangmai,
  • Noppadon Kitana and
  • Kornsorn Srikulnath

16 October 2021

Sex determination systems (SDSs) in anurans are diverse and have undergone independent evolutionary transitions among species. The mode of sexual reproduction of the rice field frog (Hoplobatrachus rugulosus)—an economically viable, edible amphibian...

(This article belongs to the Section Animal Diversity)
  • Article
  • Open Access
2 Citations
2,342 Views
11 Pages

The First Identification of Homomorphic XY Sex Chromosomes by Integrating Cytogenetic and Transcriptomic Approaches in Plestiodon elegans (Scincidae)

  • Wannan Xu,
  • Taiyue Li,
  • Jiahui Li,
  • Siqi Liu,
  • Xing Yu,
  • Min Tang,
  • Jingxiu Dong,
  • Jianjun Liu,
  • Xingjiang Bu and
  • Liuwang Nie
  • + 2 authors

23 May 2024

The sex chromosomes of skinks are usually poorly differentiated and hardly distinguished by cytogenetic methods. Therefore, identifying sex chromosomes in species lacking easily recognizable heteromorphic sex chromosomes is necessary to fully underst...

(This article belongs to the Section Cytogenomics)
  • Article
  • Open Access
6 Citations
4,114 Views
57 Pages

Going Asexual: A Survey of Mites of the Genus Thyreophagus (Acari: Acaridae) Revealing a Large Number of New Parthenogenetic Species in the Holarctic Region

  • Pavel B. Klimov,
  • Vasiliy B. Kolesnikov,
  • Emilie P. Demard,
  • Clive S. A. Stinson,
  • Jonas Merckx,
  • Marcus V. A. Duarte,
  • Luiz Gustavo A. Pedroso,
  • Alexander A. Khaustov,
  • James Leslie Myers-Hansen and
  • Dominiek Vangansbeke
  • + 1 author

5 November 2023

Mites of the genus Thyreophagus (Acari: Acaridae) are distributed worldwide; they inhabit concealed habitats and include several beneficial and economically important species. However, species identification is difficult because many species are poor...

(This article belongs to the Topic Arthropod Biodiversity: Ecological and Functional Aspects)
  • Article
  • Open Access
6 Citations
5,287 Views
13 Pages

W Chromosome Evolution by Repeated Recycling in the Frog Glandirana rugosa

  • Mitsuaki Ogata,
  • Foyez Shams,
  • Yuri Yoshimura,
  • Tariq Ezaz and
  • Ikuo Miura

1 August 2022

The Y or W sex chromosome of a heteromorphic pair is usually heterochromatinised and degenerated. However, whether chromosome degeneration constantly proceeds toward an extreme end is not fully understood. Here, we present a case of intermittent evol...

(This article belongs to the Special Issue Selected Papers from the Joint Meeting of the 23rd International Chromosome Conference (ICC) and the 24th International Colloquium in Animal Cytogenetics and Genomics (ICACG))
  • Article
  • Open Access
3 Citations
2,141 Views
26 Pages

16 November 2023

As part of a survey of the subcortical astigmatic mites of Crimea, we discovered a new sexual acarid species, Thyreophagus tauricus sp. n. This species was cultured in the laboratory to correlate the adult and deutonymphal stages. Using specimens obt...

(This article belongs to the Section Animal Genetics and Genomics)
  • Article
  • Open Access
12 Citations
3,247 Views
12 Pages

12 August 2022

We provide here the first karyotype description of eight Uroplatus species and a characterization of their chromosomal diversity. We performed a molecular taxonomic assessment of several Uroplatus samples using the mitochondrial 12S marker and a comp...

(This article belongs to the Special Issue Reptile Evolution and Genetics - Special Issue Dedicated to the Memory of Prof. Teresa Capriglione)
  • Feature Paper
  • Article
  • Open Access
1 Citations
2,181 Views
11 Pages

6 June 2024

We present a comparative chromosome study of several taxa of the Malagasy ground geckos of the Paroedura bastardi and P. picta species groups. We employed a preliminary molecular analysis using a trait of the mitochondrial 16S rRNA gene (of about 570...

(This article belongs to the Section Animal Genetics and Genomics)
  • Review
  • Open Access
18 Citations
21,407 Views
26 Pages

Snake W Sex Chromosome: The Shadow of Ancestral Amniote Super-Sex Chromosome

  • Worapong Singchat,
  • Syed Farhan Ahmad,
  • Nararat Laopichienpong,
  • Aorarat Suntronpong,
  • Thitipong Panthum,
  • Darren K. Griffin and
  • Kornsorn Srikulnath

31 October 2020

Heteromorphic sex chromosomes, particularly the ZZ/ZW sex chromosome system of birds and some reptiles, undergo evolutionary dynamics distinct from those of autosomes. The W sex chromosome is a unique karyological member of this heteromorphic pair, w...

(This article belongs to the Collection Non-human Chromosome Analysis)
  • Article
  • Open Access
9 Citations
2,321 Views
17 Pages

9 June 2023

Populus pruinosa Schrenk has the biological characteristics of heteromorphic leaves and is a pioneer species for wind prevention and sand fixation. The functions of heteromorphic leaves at different developmental stages and canopy heights of P. pruin...

(This article belongs to the Section Plant Development and Morphogenesis)
  • Review
  • Open Access
17 Citations
6,901 Views
35 Pages

Dosage Compensation in Females with X-Linked Metabolic Disorders

  • Patrycja Juchniewicz,
  • Ewa Piotrowska,
  • Anna Kloska,
  • Magdalena Podlacha,
  • Jagoda Mantej,
  • Grzegorz Węgrzyn,
  • Stefan Tukaj and
  • Joanna Jakóbkiewicz-Banecka

Through the use of new genomic and metabolomic technologies, our comprehension of the molecular and biochemical etiologies of genetic disorders is rapidly expanding, and so are insights into their varying phenotypes. Dosage compensation (lyonization)...

(This article belongs to the Special Issue Epigenetic Mechanisms and Human Pathology 2.0)
  • Article
  • Open Access
9 Citations
3,629 Views
15 Pages

18 August 2022

Taxonomy in Bufonidae witnessed notable transformations. Bufotes viridis and Epidalea calamita, previously included in genus Bufo, were relocated in other genera, while the genus Bufo was restricted to members of the earlier Bufo bufo group. On the o...

(This article belongs to the Special Issue Chromosome Evolution and Karyotype Analysis)
  • Article
  • Open Access
147 Citations
8,739 Views
22 Pages

A New Deep Hybrid Boosted and Ensemble Learning-Based Brain Tumor Analysis Using MRI

  • Mirza Mumtaz Zahoor,
  • Shahzad Ahmad Qureshi,
  • Sameena Bibi,
  • Saddam Hussain Khan,
  • Asifullah Khan,
  • Usman Ghafoor and
  • Muhammad Raheel Bhutta

1 April 2022

Brain tumor analysis is essential to the timely diagnosis and effective treatment of patients. Tumor analysis is challenging because of tumor morphology factors like size, location, texture, and heteromorphic appearance in medical images. In this reg...

(This article belongs to the Section Intelligent Sensors)
  • Feature Paper
  • Article
  • Open Access
14 Citations
6,339 Views
13 Pages

4 May 2018

During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chr...

(This article belongs to the Special Issue The Evolutionary Life Cycle of Sex Chromosomes)
  • Article
  • Open Access
5 Citations
4,391 Views
13 Pages

Blocking Nonspecific Interactions Using Y-Shape Poly(ethylene glycol)

  • Zhengyu Xu,
  • Qingtai Li,
  • Yaying Huang,
  • Kaiqiang Guo,
  • Bin Xue,
  • Yi Cao and
  • Yiran Li

4 August 2023

Nonspecific interactions play a significant role in physiological activities, surface chemical modification, and artificial adhesives. However, nonspecificity sometimes causes sticky problems, including surface fouling, decreased target specificity,...

(This article belongs to the Collection Feature Papers in Materials Science)

of 3