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Cytomolecular Organisation of the Nuclear Genome
This special issue belongs to the section “Molecular Biology“.
Special Issue Information
Dear Colleagues,
Modern molecular cytogenetics enables a variety of observations of nuclear genome organisation at the level of the chromosome or in the interphase nucleus. This progress is driven by powerful, high resolution methodology; DNA:DNA fluorescence in situ hybridisation combined using the latest microscopes with image acquisition and processing systems enables simultaneous two- or three-dimensional, multicolour visualisation of highly repetitive, low-repeat, and single-copy sequences in the genome. Fluorescent antibodies to specific targets can also be used to selectively localise epigenetically modified components of chromatin, such as methylated DNA and histones. They also have utility in highlighting proteins comprising important biological structures, such as the synaptonemal complex and the enzymatic machinery responsible for genetic recombination events.
This Special Issue encompasses a wide range of topics connected with various aspects of the organisation of the nuclear genome at the cytomolecular level in eukaryotes, including plants, animals, humans, fungi, and protists. The topics may cover, inter alia, analyses of the structure and evolution of karyotypes, the cell cycle and cell division, chromatin arrangement at interphase and nuclear genome instability after mutagenic treatment. Original research on these and other related topics is welcome.
Prof. Dr. Robert Hasterok
Dr. Natalia Borowska-Zuchowska
Dr. Ewa Robaszkiewicz
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- cell cycle
- cell division
- chromosome aberrations
- chromosome painting
- chromosome territories
- chromosomes
- cytogenetics
- epigenetics
- evolution of repetitive DNA
- fluorescence in situ hybridisation
- immunolocalisation
- karyotype structure and evolution
- interphase nucleus
- meiosis
- mitosis
- molecular cytogenetics
- nucleolar dominance
- nucleolus
- polyploidy
- Rabl configuration
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