1,963 Results Found

Urban heritage materials face accelerated decay due to the synergistic effects of air pollution and climate change. Dose–response functions (DRFs) have emerged as a key tool to quantify and predict these risks. This review synthesizes the scien...

Nickel is a well-known skin allergen; however, few studies to date have investigated the association between nickel exposure and lung function impairment. The present study, therefore, evaluated the relationship between blood nickel concentrations an...

This study aimed to determine the dose-response relationship between exercise duration and task switching in older adults. Acute moderate intensity aerobic exercise for 20 min resulted in shorter response times than control and 10-min sessions in the...

Previous studies indicated that Tai Chi might be an effective way to improve or prevent cognitive impairments in older populations. However, existing research does not provide clear recommendations about the optimal dose of Tai Chi practice, which is...

Most stained-glass windows installed during the Middle Ages have deteriorated over time due to climate and pollution. To reconstruct their alteration history over the centuries, evaluate the current environmental risk, and predict their alteration in...

Air pollution is among the major causes of death and disease all around the globe. The prime impact of ambient air pollution is on the lungs through the respiratory system. This study aims to estimate the health cost due to air pollution from a Sugar...

Folate may have beneficial effects on physical function through its antioxidant effect. Thus, we investigated the associations between serum folate and functional disability in older adults. Data from the National Health and Nutrition Examination Sur...

When construction materials are exposed to the atmospheric environment, they are subject to deterioration, which varies according to the time period of exposure and the location. A tool named Dose–Response Functions (DRFs) has been developed to...

The deterioration of stone materials due to atmospheric factors is a growing global concern, affecting the integrity and preservation of numerous UNESCO World Heritage Sites around the world. This study provides an estimate of the long-term impact of...

The brachial artery flow-mediated dilation test (FMD) is the noninvasive gold standard used to test endothelial function. Reduced FMD is an early event in the development of atherosclerosis and provides a marker for predicting future cardiovascular d...

Fc-mediated effector functions of antibodies, including antibody-dependent cytotoxicity (ADCC), have been shown to contribute to vaccine-induced protection from HIV-1 infection, especially those directed against non-neutralizing, CD4 inducible (CD4i)...

The potential outcomes framework serves as a fundamental tool for quantifying causal effects. The average dose–response function $\mu \left(t\right)$ (also called the effect curve) is typically of interest when dealing with a continuous treatment variable (...

Messenger RNA is rapidly gaining significance as a therapeutic modality. Here, we address the dependence of dose–response functions on the type of delivery vehicle, cell line, and incubation time. Knowledge of these characteristics is crucial for the...

Metabolic activities within the gut microbiome are intimately linked to human health and disease, especially within the context of environmental exposure and its potential ramifications. Perturbations within this microbiome, termed “gut microbi...

The present study aimed to analyze the impact of overground walking interval training (WIT) in a group of sedentary older adults, comparing two different dose-distributions. In this quasi-experimental and longitudinal study, we recruited twenty-three...

In recent years, Ghanaian agriculture has witnessed a surge in the use of agrochemicals, with the likely consequence that nonoptimal levels of application could cause environmental damage and economic losses. We identify the factors that affect the a...

A micro segmented-flow approach was utilized for the isolation soil bacteria that can degrade synthetic polymers as polyethylene glycols (PEG) and polyacrylamide (PAM). We had been able to obtain many strains; among them, five Achromobacter spanius s...

The WHO has developed a tool to assess the risk of newly emerging influenza viruses with pandemic potential (TIPRA). According to TIPRA, the main parameters for assessing the risk of human-to-human transmission of a novel influenza virus are its abil...

Background: Detraining refers to the decline in physical fitness that occurs after the cessation of exercise, compromising the adaptations resulting from regular exercise training. To understand how long the benefits acquired from an exercise program...

Impacts of air pollution are not limited to human health and ecosystems, but are also important for building materials. The main objective of this study is the quantification and mapping of air pollution effects on the materials, namely the soiling e...

This paper reports estimated maintenance-cleaning costs, cost savings and cleaning interval increases for structural surfaces and windows in Europe obtainable by reducing the air pollution. Methodology and data from the ICP-materials project were use...

Objective: The purpose of this study was to explore the dose–response relationships of different dimensions of physical activity (intensity, time, frequency, capacity, and metabolic equivalent) with daily physical function (DPF) and cognitive f...

Paraxanthine (PXN) is a metabolite of caffeine that has recently been reported to enhance cognition at a dose of 200 mg. Objective: To determine the acute and short-term (7-day) effects of varying doses of PXN on cognitive function and side effects....

Background: Rhodiola rosea (RR) is marketed as an adaptogen; however, evidence for acute/short-term effects—and especially dose–response effects—in trained adults across performance and cognition is limited. Objective: Test whether...

To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly ra...

Aflatoxin B₁ (AFB₁), a mycotoxin found in food and feed, exerts harmful effects on humans and animals. The liver is the earliest target of AFB₁, and its effects have been evaluated in animal models exposed to acute or chronic doses. Considering the p...

Epidemiological evidence on the relationship between copper (Cu) and kidney function is rare, and few studies examine the sex differences in this association. We aimed to explore the overall and sex-based relationship between exposure to Cu and bioma...

The water extract of Gracilaria tenuistipitata have been found to be protective against oxidative stress-induced cellular DNA damage, but the biological function of the ethanolic extracts of G. tenuistipitata (EEGT) is still unknown. In this study, t...

Background: Functional Hypothalamic Amenorrhea (FHA) is a stress-induced blockade of the reproductive axis. Such impairment is mainly due to altered control of GnRH-induced gonadotropin secretion as well as alterations of other endocrine functions. M...

The effect of copper on the mitochondrial carnitine/acylcarnitine carrier (CAC) was studied. Transport function was assayed as [³H]carnitine/carnitine antiport in proteoliposomes reconstituted with the native protein extracted from rat liver mitochon...

A sensitization procedure is used to enhance the thermoluminescence (TL) sensitivity of phyllite to emit radiation. Phyllite is a type of foliated metamorphic rock made from slate. This study examines naturally grown phyllite rock, which had not been...

Alcohol use has been causally linked to more than 200 disease and injury conditions, as defined by three-digit ICD-10 codes. The understanding of how alcohol use is related to these conditions is essential to public health and policy research. Accord...

Background: Large positive responses to placebo are common in clinical trials and pose a major challenge when evaluating different treatments, including new foods. Standard between-group comparisons may fail to detect true effects when placebo improv...

Background: Diabetes is associated with sub-optimal vascular function. Current evidence suggested purified anthocyanins (ACNs) could improve cardio-metabolic health, but the dose–response effects on arterial stiffness have not been verified. Ob...

There has been a great deal of interest in bovine colostrum within sports nutrition over the last 25 years. Studies have investigated the effects on body composition, physical performance, recovery, gut damage and permeability, immune function, and i...

Chemical biology and the application of small molecules has proven to be a potent perturbation strategy, especially for the functional elucidation of proteins, their networks, and regulators. In recent years, the cellular thermal shift assay (CETSA)...

Temozolomide (TMZ) is an alkylating agent used in the treatment of high-grade malignant glioma, notably glioblastoma multiforme, the most aggressive form of brain cancer. The drug induces a dozen DNA methylation adducts, including O⁶-methylguanine (O...

Many red algae-derived natural products are known to have anticancer effects. The biological functions of the red alga Solieria robusta from the Karachi coast (Pakistan) remain unclear. Here, we prepared a methanolic extracts of S. robusta (MESR) to...

A comparative investigation of the induction of double-strand DNA breaks (DSBs) in the Chinese hamster V79 cells by γ-radiation at dose rates of 1, 10 and 400 mGy/min (doses ranged from 0.36 to 4.32 Gy) was performed. The acute radiation exposure at...

We explored the dose-response relations of sodium, potassium, magnesium and calcium with cardiovascular disease (CVD) risk in the Framingham Offspring Study, as well as the combined effects of these minerals. Analyses included 2362 30–64 year-o...

Patients with known vascular disease are at increased risk for cognitive impairments. Exercise has been shown to improve cognition in healthy elderly populations and those with mild cognitive impairments. We explored the literature to understand exer...

In this study, we explore how the in vitro conditions chosen to cultivate and observe the long-term (up to 72 h) toxic effect of Cu(II) on the freshwater microalga Coccomyxa cimbrica sp.nov. can affect the dose response in time. We test three differe...

Aquaculture currently supplies over half of the world’s fish and relies heavily on feed additives to enhance growth, improve feed efficiency, and increase disease resistance. This review consolidates peer-reviewed studies identified through tar...

Background: Burning Mouth Syndrome (BMS) is a nociplastic pain condition characterized by altered central nervous system pain processing, significantly impacting patient quality of life. Pharmacological management often involves amitriptyline (monoth...

There is substantial experimental and clinical interest in providing effective ways to both prevent and slow the onset of hearing loss. Auditory hair cells, which occur along the basilar membrane of the cochlea, often lose functionality due to age-re...

A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact...

In this article a dose–response model was developed to describe the effect of soil temperature, soil moisture content, and soil water-holding capacity, on the decay of European beech (Fagus sylvatica) wood specimens exposed to soil contact. The devel...

Hydroelectric power stations generate turbulent flow conditions, which represent a potentially significant hydraulic stressor to fish passing through the turbine system. A test facility has been developed using two randomly actuated synthetic jet arr...

We extend techniques and learnings about the stochastic properties of nonlinear responses from finance to medicine, particularly oncology, where it can inform dosing and intervention. We define antifragility. We propose uses of risk analysis for medi...

Background/Objectives: Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder with significant clinical and reproductive implications. Identifying dose–response relationships between clinical, physical, and reproductive factors...