Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics
Abstract
:1. Introduction
2. Nrf2 and Neuroprotection
3. Heat Shock Response and Neuroprotection
4. Polyphenols
4.1. Flavonoids
4.2. Stilbene
4.3. Hydroxytyrosol
4.4. Curcumin
4.5. Tannins
4.6. Phenolic Acid
5. Attempt to Increase the Bioavailability of Polyphenols
6. Development of Model Systems to Elucidate the Hearing Loss Prevention Mechanism of Polyphenols
6.1. C. elegans Models
6.2. Organoid Models
7. Polyphenol and the Hormesis Paradigm: Conclusions and Future Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Osakabe, N.; Modafferi, S.; Ontario, M.L.; Rampulla, F.; Zimbone, V.; Migliore, M.R.; Fritsch, T.; Abdelhameed, A.S.; Maiolino, L.; Lupo, G.; et al. Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics. Medicina 2023, 59, 2045. https://doi.org/10.3390/medicina59112045
Osakabe N, Modafferi S, Ontario ML, Rampulla F, Zimbone V, Migliore MR, Fritsch T, Abdelhameed AS, Maiolino L, Lupo G, et al. Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics. Medicina. 2023; 59(11):2045. https://doi.org/10.3390/medicina59112045
Chicago/Turabian StyleOsakabe, Naomi, Sergio Modafferi, Maria Laura Ontario, Francesco Rampulla, Vincenzo Zimbone, Maria Rita Migliore, Tilman Fritsch, Ali S. Abdelhameed, Luigi Maiolino, Gabriella Lupo, and et al. 2023. "Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics" Medicina 59, no. 11: 2045. https://doi.org/10.3390/medicina59112045