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124 Results Found

  • Article
  • Open Access
3 Citations
5,401 Views
18 Pages

4 June 2015

Since Advanced Encryption Standard (AES) in stream modes, such as counter (CTR), output feedback (OFB) and cipher feedback (CFB), can meet most industrial requirements, the range of applications for dedicated stream ciphers is decreasing. There are m...

  • Communication
  • Open Access
4 Citations
4,602 Views
9 Pages

16 February 2021

This paper presents a digitally controlled oscillator (DCO) with a low-complexity circuit structure that combines multiple delay circuits to achieve a high timing resolution and wide output frequency range simultaneously while also significantly redu...

  • Article
  • Open Access
2,455 Views
10 Pages

30 October 2021

This paper presents a regulated pulse current driver with a spread spectrum clock generator (SSCG) to lower the electromagnetic interference (EMI) effect. An SSCG is used and implemented by applying a triangular wave to modulate a voltage-controlled...

  • Article
  • Open Access
9 Citations
2,761 Views
15 Pages

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock

  • Luise Fuhr,
  • Alireza Basti,
  • Teresa Silva Brás,
  • Maria F. Duarte and
  • Angela Relógio

15 August 2022

The circadian clock generates 24 h rhythms in behavioural, cellular and molecular processes. Malfunctions of the clock are associated with enhanced susceptibility to cancer, worse treatment response and poor prognosis. Clock-controlled genes are invo...

  • Article
  • Open Access
3 Citations
3,157 Views
16 Pages

A Cryo-CMOS, Low-Power, Low-Noise, Phase-Locked Loop Design for Quantum Computers

  • Kewei Xin,
  • Mingche Lai,
  • Fangxu Lv,
  • Kaile Guo,
  • Zhengbin Pang,
  • Chaolong Xu,
  • Geng Zhang,
  • Wenchen Wang and
  • Meng Li

This paper analyzes the performance requirements that need to be met by a clock generator applied to a low-temperature quantum computer and analyzes the negative effects on the clock generator circuit under low-temperature conditions. In order to mee...

  • Article
  • Open Access
2 Citations
1,809 Views
11 Pages

A Mixed Approach for Clock Synchronization in Distributed Data Acquisition Systems

  • Gabriele Manduchi,
  • Andrea Rigoni,
  • Luca Trevisan and
  • Tommaso Patton

23 September 2024

Proper timing synchronization is important when data from sensors are acquired by different devices. This paper proposes a simple but effective solution for System on Chip (SoC) architectures that integrates a general-purpose Field Programmable Gate...

  • Article
  • Open Access
1 Citations
1,820 Views
18 Pages

7 December 2024

This paper describes an all-digital clock and data recovery (CDR) circuit for implementing edge processing with a wireless body area network (WBAN). The CDR circuit performs delay-locked loop (DLL)-based and phase-locked loop (PLL)-based operations d...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,609 Views
12 Pages

Clocks are widely used in multimedia and electronic devices, and they usually have different frequency demands. This paper presents the design of a multi-output clock generator using an analog integer-N phase-locked loop (PLL) and open-loop fractiona...

  • Article
  • Open Access
21 Citations
3,528 Views
17 Pages

The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity

  • Christopher DeVera,
  • Jendayi Dixon,
  • Micah A. Chrenek,
  • Kenkichi Baba,
  • Yun Z. Le,
  • P. Michael Iuvone and
  • Gianluca Tosini

The diurnal peak of phagocytosis by the retinal pigment epithelium (RPE) of photoreceptor outer segments (POS) is under circadian control and believed that this process involves interactions from the retina and RPE. Previous studies have demonstrated...

  • Article
  • Open Access
15 Citations
7,040 Views
21 Pages

An Autonomous Satellite Time Synchronization System Using Remotely Disciplined VC-OCXOs

  • Xiaobo Gu,
  • Qing Chang,
  • Eamonn P. Glennon,
  • Baoda Xu,
  • Andrew G. Dempster,
  • Dun Wang and
  • Jiapeng Wu

23 July 2015

An autonomous remote clock control system is proposed to provide time synchronization and frequency syntonization for satellite to satellite or ground to satellite time transfer, with the system comprising on-board voltage controlled oven controlled...

  • Review
  • Open Access
17 Citations
8,275 Views
37 Pages

7 July 2015

Blue light, a key abiotic signal, regulates a wide variety of physiological processes in many organisms. One of these phenomena is the circadian rhythm presents in organisms sensitive to the phase-setting effects of blue light and under control of t...

  • Article
  • Open Access
1 Citations
1,494 Views
10 Pages

Design a Robust Control System for Rubidium Fountain Clock

  • Dandan Liu,
  • Hui Zhang,
  • Yang Bai,
  • Sichen Fan,
  • Jun Ruan and
  • Shougang Zhang

Rubidium fountain clocks are operated by a control system. In this study, first, the control requirements of a rubidium fountain clock are analyzed; then, a control system is designed and divided into a timing sequence control system, a data acquisit...

  • Article
  • Open Access
20 Citations
17,521 Views
48 Pages

A Self-Operating Time Crystal Model of the Human Brain: Can We Replace Entire Brain Hardware with a 3D Fractal Architecture of Clocks Alone?

  • Pushpendra Singh,
  • Komal Saxena,
  • Anup Singhania,
  • Pathik Sahoo,
  • Subrata Ghosh,
  • Rutuja Chhajed,
  • Kanad Ray,
  • Daisuke Fujita and
  • Anirban Bandyopadhyay

27 April 2020

Time crystal was conceived in the 1970s as an autonomous engine made of only clocks to explain the life-like features of a virus. Later, time crystal was extended to living cells like neurons. The brain controls most biological clocks that regenerate...

  • Article
  • Open Access
1 Citations
2,956 Views
19 Pages

5 March 2024

Optical lattice clocks combine the accuracy and stability required for next-generation frequency standards. At the heart of these clocks are carefully engineered optical lattices tuned to a wavelength where the differential AC Stark shift between gro...

  • Article
  • Open Access
5 Citations
2,738 Views
17 Pages

Circadian Activity and Clock Genes in Pachycrepoideus vindemmiae: Implications for Field Applications and Circadian Clock Mechanisms of Parasitoid Wasps

  • Ziwen Teng,
  • Mengran Huo,
  • Yanan Zhou,
  • Yuqi Zhou,
  • Yunjie Liu,
  • Yan Lin,
  • Qi Zhang,
  • Zhiqi Zhang,
  • Fanghao Wan and
  • Hongxu Zhou

22 May 2023

Despite the importance of circadian rhythms in insect behavior, our understanding of circadian activity and the molecular oscillatory mechanism in parasitoid wasp circadian clocks is limited. In this study, behavioral activities expected to be under...

  • Review
  • Open Access
28 Citations
10,330 Views
21 Pages

31 March 2023

Like other biological functions, food intake and energy metabolism display daily rhythms controlled by the circadian timing system that comprises a main circadian clock and numerous secondary clocks in the brain and peripheral tissues. Each secondary...

  • Review
  • Open Access
32 Citations
8,997 Views
16 Pages

23 November 2018

The rotation of the Earth entails changes in environmental conditions that pervasively influence an organism’s physiology and metabolism. An internal cellular mechanism known as the circadian clock acts as an internal timekeeper that is able to...

  • Review
  • Open Access
6 Citations
5,024 Views
30 Pages

22 February 2024

Circadian clocks drive a large array of physiological and behavioral activities. At the molecular level, circadian clocks are composed of positive and negative elements that form core oscillators generating the basic circadian rhythms. Over the cours...

  • Article
  • Open Access
1,836 Views
26 Pages

8 April 2024

Clock synchronization is one of the popular research topics in Distributed Measurement and Control Systems (DMCSs). In most industrial fields, such as Smart Grid and Flight Test, the highest requirement for synchronization accuracy is 1 μs. IEEE 1...

  • Article
  • Open Access
6 Citations
3,307 Views
14 Pages

Changes in Loneliness, BDNF, and Biological Aging Predict Trajectories in a Blood-Based Epigenetic Measure of Cortical Aging: A Study of Older Black Americans

  • Ronald L. Simons,
  • Mei Ling Ong,
  • Man-Kit Lei,
  • Steven R. H. Beach,
  • Yue Zhang,
  • Robert Philibert and
  • Michelle M. Mielke

31 March 2023

A recent epigenetic measure of aging has developed based on human cortex tissue. This cortical clock (CC) dramatically outperformed extant blood-based epigenetic clocks in predicting brain age and neurological degeneration. Unfortunately, measures th...

  • Article
  • Open Access
1,414 Views
32 Pages

9 March 2025

Terrestrial and satellite communications, tactical data links, positioning, navigation, and timing (PNT), as well as distributed sensing will continue to require precise timing and the ability to synchronize and disseminate time effectively. However,...

  • Article
  • Open Access
39 Citations
9,040 Views
13 Pages

Quantum-dot cellular automata (QCA) is a low-power, non-von-Neumann, general-purpose paradigm for classical computing using transistor-free logic. Here, classical bits are encoded on the charge configuration of individual computing primitives known a...

  • Article
  • Open Access
1 Citations
1,326 Views
19 Pages

Deterministic Ethernet (DetEth) is widely used in real-time distributed systems, such as avionics and in-vehicle control. Clock synchronization protocols (CSPs) establish global time, which is a critical foundation for deterministic communication in...

  • Article
  • Open Access
3 Citations
1,797 Views
12 Pages

The high precision and low power consumption of the clock generator are critical in passive RFID transponders and passive IoT chips, but fluctuations in PVT can cause considerable degradation in the precision of the chip’s internal clocks. This...

  • Article
  • Open Access
10 Citations
13,892 Views
16 Pages

A 100 Gb/s quad-lane SerDes receiver with a phase-interpolator (PI)-based quarter-rate all-digital clock and data recovery (CDR) is presented. The proposed CDR utilizes a multi-phase multiplying delay-locked loop (MDLL) to generate the eight-phase re...

  • Article
  • Open Access
6 Citations
3,202 Views
15 Pages

The CRISPR/Cas9 site-directed gene-editing system offers great advantages for identifying gene function and crop improvement. The circadian clock measures and conveys day length information to control rhythmic hypocotyl growth in photoperiodic condit...

  • Article
  • Open Access
8 Citations
3,700 Views
16 Pages

25 February 2021

An image processing pipeline and multi-output shift register of a foveation-based driving scheme are proposed for the realization of immersive head-mounted displays in 2019. In addition, this paper describes a variable clock generation circuit to man...

  • Communication
  • Open Access
1,557 Views
14 Pages

Design of a Board-Level Integrated Multi-Channel Radio Frequency Source for the Transportable 40Ca+ Ion Optical Clock

  • Bin Wang,
  • Yuanhang Yang,
  • Huaqing Zhang,
  • Ruming Hu,
  • Haicen Mao,
  • Yao Huang,
  • Kelin Gao and
  • Hua Guan

10 February 2025

As one of the most precise timekeeping instruments ever developed, the optical clock will be used as the measuring equipment for the next generation of second definition. The demand for the miniaturization of optical clocks is progressively urgent. I...

  • Communication
  • Open Access
62 Citations
4,970 Views
7 Pages

Relationship between HIF-1 and Circadian Clock Proteins in Obstructive Sleep Apnea Patients—Preliminary Study

  • Agata Gabryelska,
  • Marcin Sochal,
  • Szymon Turkiewicz and
  • Piotr Białasiewicz

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and associated with the disruption of circadian rhythm. The study aimed to assess the relationship between hypoxia-inducible factor (HIF) subunits, circadian clock proteins, and p...

  • Letter
  • Open Access
10 Citations
5,081 Views
13 Pages

Design of an Ultrasound Transceiver ASIC with a Switching-Artifact Reduction Technique for 3D Carotid Artery Imaging

  • Taehoon Kim,
  • Fabian Fool,
  • Djalma Simoes dos Santos,
  • Zu-Yao Chang,
  • Emile Noothout,
  • Hendrik J. Vos,
  • Johan G. Bosch,
  • Martin D. Verweij,
  • Nico de Jong and
  • Michiel A. P. Pertijs

29 December 2020

This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imagin...

  • Review
  • Open Access
97 Citations
10,514 Views
16 Pages

Circadian Clocks in Fish—What Have We Learned so far?

  • Inga A. Frøland Steindal and
  • David Whitmore

19 March 2019

Zebrafish represent the one alternative vertebrate, genetic model system to mice that can be easily manipulated in a laboratory setting. With the teleost Medaka (Oryzias latipes), which now has a significant following, and over 30,000 other fish spec...

  • Article
  • Open Access
5 Citations
3,784 Views
16 Pages

The First Result of Relative Positioning and Velocity Estimation Based on CAPS

  • Jiaojiao Zhao,
  • Zishen Li,
  • Jian Ge,
  • Liang Wang,
  • Ningbo Wang,
  • Kai Zhou and
  • Hong Yuan

12 May 2018

The Chinese Area Positioning System (CAPS) is a new positioning system developed by the Chinese Academy of Sciences based on the communication satellites in geosynchronous orbit. The CAPS has been regarded as a pilot system to test the new technology...

  • Article
  • Open Access
5 Citations
4,239 Views
17 Pages

A 48 GHz Fundamental Frequency PLL with Quadrature Clock Generation for 60 GHz Transceiver

  • Xiaokang Niu,
  • Xu Wu,
  • Lianming Li,
  • Long He,
  • Depeng Cheng and
  • Dongming Wang

This paper presents a design of a 48 GHz CMOS phase-locked loop (PLL) for 60 GHz millimeter-wave (mmWave) communication systems. For the sliding intermediate frequency (sliding-IF) transceiver applications, a fundamental frequency PLL with quadrature...

  • Article
  • Open Access
6 Citations
2,583 Views
14 Pages

3 May 2022

This paper presents a switched inductor (SI) DC–DC boost regulator designed for thermoelectric generator (TEG) applications. To boost and regulate the output voltage, two feedback loops are implemented which control the duty cycle of the SI clo...

  • Communication
  • Open Access
4 Citations
3,291 Views
12 Pages

11 January 2022

This paper presents a nine-bit integrator-based time-to-digital converter (I-TDC) realized in a 180 nm CMOS technology for the applications of indoor home-monitoring light detection and ranging (LiDAR) sensors. The proposed I-TDC exploits a clock-fre...

  • Article
  • Open Access
1 Citations
2,034 Views
16 Pages

Circadian rhythms, characterized by approximately 24 h cycles, play a pivotal role in enabling various organisms to synchronize their biological activities with daily variations. While ubiquitous in Eukaryotes, circadian clocks remain exclusively cha...

  • Article
  • Open Access
4 Citations
2,074 Views
17 Pages

Research on Distributed Autonomous Timekeeping Algorithm for Low-Earth-Orbit Constellation

  • Shui Yu,
  • Jing Peng,
  • Ming Ma,
  • Hang Gong,
  • Zongnan Li and
  • Shaojie Ni

2 November 2024

The time of a satellite navigation system is primarily generated by the main control station of the ground system. Consequently, when ground stations fail, there is a risk to the continuous provision of time services to the equipment and users. Furth...

  • Article
  • Open Access
1 Citations
7,390 Views
12 Pages

Modern automotive control applications require a holistic time-sensitive development. Nowadays, this is achieved by technologies specifically designed for the automotive domain, like FlexRay, which offer a fault-tolerant time synchronization mechanis...

  • Article
  • Open Access
25 Citations
4,419 Views
17 Pages

7 January 2019

Controlling the microstructure homogeneity is crucial in achieving high quality tantalum (Ta) sputtering targets used in integrated circuit fabrication. Unluckily, traditional rolling easily generates a microstructure gradient along the thickness dir...

  • Review
  • Open Access
1 Citations
2,240 Views
20 Pages

28 August 2025

The relationship between sleep and epilepsy involves complex interactions between thalamocortical circuits, circadian mechanisms, and sleep architecture that fundamentally influence seizure susceptibility and cognitive outcomes. Epileptic activity di...

  • Article
  • Open Access
6 Citations
2,881 Views
18 Pages

A Low-Noise Interface ASIC for MEMS Disk Resonator Gyroscope

  • Wenbo Zhang,
  • Liang Yin,
  • Yihang Wang,
  • Risheng Lv,
  • Haifeng Zhang,
  • Weiping Chen,
  • Xiaowei Liu and
  • Qiang Fu

15 June 2023

This paper proposes a low-noise interface application-specific integrated circuit (ASIC) for a microelectromechanical systems (MEMS) disk resonator gyroscope (DRG) which operates in force-to-rebalance (FTR) mode. The ASIC employs an analog closed-loo...

  • Article
  • Open Access
13 Citations
3,614 Views
13 Pages

Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines

  • Akihiko Sakamoto,
  • Yusuke Terui,
  • Takeshi Uemura,
  • Kazuei Igarashi and
  • Keiko Kashiwagi

28 January 2021

Polyamines stimulate the synthesis of specific proteins at the level of translation, and the genes encoding these proteins are termed as the “polyamine modulon”. The circadian clock generates daily rhythms in mammalian physiology and behavior. We inv...

  • Article
  • Open Access
2 Citations
2,932 Views
18 Pages

29 September 2023

A double-edge-triggered digital low dropout regulator (DLDO) is proposed with a built-in adaptive voltage-controlled oscillator (VCO) clock (AVC) for a system-on-chip (SoC) application. To achieve a fast transient response, the main comparator genera...

  • Article
  • Open Access
22 Citations
7,504 Views
12 Pages

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

  • Shin-ichiro Fujita,
  • Lindsay Rutter,
  • Quang Ong and
  • Masafumi Muratani

11 September 2020

Rodent models have been widely used as analogs for estimating spaceflight-relevant molecular mechanisms in human tissues. NASA GeneLab provides access to numerous spaceflight omics datasets that can potentially generate novel insights and hypotheses...

  • Article
  • Open Access
6 Citations
4,118 Views
15 Pages

Access Control Model Based on Time Synchronization Trust in Wireless Sensor Networks

  • Zhaobin Liu,
  • Qiang Ma,
  • Wenzhi Liu,
  • Victor S. Sheng,
  • Liang Zhang and
  • Gang Liu

30 June 2018

Internal reliability and external safety of Wireless Sensor Networks (WSN) data transmission have become increasingly outstanding issues with the wide applications of WSN. This paper proposes a new method for access control and mitigation of interfer...

  • Article
  • Open Access
2 Citations
489 Views
13 Pages

18 April 2025

A new method of macroevolutionary analysis—high-resolution phylogenetics, integrating both morphological and molecular traits—has revealed well-supported evidence of complexity-based processes generating and controlling biodiversity. A no...

  • Article
  • Open Access
17 Citations
6,191 Views
12 Pages

The Role of Electron Trajectories in XUV-Initiated High-Harmonic Generation

  • Michael Krüger,
  • Doron Azoury,
  • Barry D. Bruner and
  • Nirit Dudovich

22 January 2019

High-harmonic generation spectroscopy is a powerful tool for ultrafast spectroscopy with intrinsic attosecond time resolution. Its major limitation—the fact that a strong infrared driving pulse is governing the entire generation process—i...

  • Article
  • Open Access
12 Citations
4,311 Views
18 Pages

Throughput/Area Optimized Architecture for Elliptic-Curve Diffie-Hellman Protocol

  • Muhammad Rashid,
  • Harish Kumar,
  • Sikandar Zulqarnain Khan,
  • Ismail Bahkali,
  • Ahmed Alhomoud and
  • Zahid Mehmood

18 April 2022

This paper presents a high-speed and low-area accelerator architecture for shared key generation using an elliptic-curve Diffie-Hellman protocol over GF(2233). Concerning the high speed, the proposed architecture employs a two-stage pipelining and a...

  • Article
  • Open Access
1,491 Views
27 Pages

Precision Time Interval Generator Based on CMOS Counters and Integration with IoT Timing Systems

  • Nebojša Andrijević,
  • Zoran Lovreković,
  • Vladan Radivojević,
  • Svetlana Živković Radeta and
  • Hadžib Salkić

12 August 2025

Precise time interval generation is a cornerstone of modern measurement, automation, and distributed control systems, particularly within Internet of Things (IoT) architectures. This paper presents the design, implementation, and evaluation of a low-...

  • Article
  • Open Access
4 Citations
2,106 Views
20 Pages

Study of Fast and Reliable Time Transfer Methods Using Low Earth Orbit Enhancement

  • Mingyue Liu,
  • Rui Tu,
  • Qiushi Chen,
  • Qi Li,
  • Junmei Chen,
  • Pengfei Zhang and
  • Xiaochun Lu

6 June 2024

The Global Navigation Satellite System (GNSS) can be utilized for long-distance and high-precision time transmission. With the ongoing development of low Earth orbit (LEO) satellites and the rapidly changing geometric relationships between them, the...

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