Understanding the function and control of channel transport is of paramount importance for cell physiology and nanotechnology. In particular, if several species are involved, the mechanisms of selectivity, competition, cooperation, pumping, and its m...
The calcium-release-activated calcium (CRAC) channel, activated by the release of Ca2+ from the endoplasmic reticulum (ER), is critical for Ca2+ homeostasis and active signal transduction in a plethora of cell types. Spurred by the long-sought decryp...
This paper proposes an approach to identify interacting objects (IOs) and determine their interaction losses (ILs) using point cloud data from wide-band double-directional channel sounding data. The scattering points (SPs) were identified using the m...
BmP02, a short-chain peptide with 28 residues from the venom of Chinese scorpion Buthus martensi Karsch, has been reported to inhibit the transient outward potassium currents (Ito) in rat ventricular muscle cells. However, it remains unclear whether...
We designed an end-to-end dual-branch residual network architecture that inputs a low-resolution (LR) depth map and a corresponding high-resolution (HR) color image separately into the two branches, and outputs an HR depth map through a multi-scale,...
Voltage-gated Na+ (Nav) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Nav channel α subunit that have been described (Nav1.1-Nav1.9), Nav1.1, Nav1.2, and Nav1.6 are the primary isoforms e...
Sea ice segmentation based on Synthetic Aperture Radar (SAR) images has become an important technical means for polar climate change monitoring and navigation safety guarantee. However, the existing methods have limitations in the utilization of SAR...
Multivariate time series forecasting (TSF) is a fundamental task in intelligent systems, yet accurate and efficient modeling remains challenging under high dimensionality, non-stationarity, and complex cross-variate dependencies. The Mamba architectu...
Under the influence of circular economy theory, waste clothing recycling has been widely studied in the resource sector, and the waste clothing recycling channel (WCRC) is the vital link that affects the recycling efficiency of waste clothing. How to...
Contemporary techniques of molecular modeling allow for rational design of several specific classes of artificial proteins. Transmembrane channels are among these classes. A recent successful synthesis of self-assembling, highly symmetrical 12- or 16...
Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulati...
The lipid matrix of cellular membranes is an elastic liquid crystalline medium. Its deformations regulate the functionality and interactions of membrane proteins,f membrane-bound peptides, lipid and protein-lipid domains. Gramicidin A (gA) is a pepti...
Constitutive or regulated membrane protein trafficking is a key cell biology process. Transient receptor potential channels are somatosensory proteins in charge of detecting several physical and chemical stimuli, thus requiring fine vesicular traffic...
Fixed-wing aircraft with vertical takeoff and landing capabilities need a lower speed and a higher lift during transition. To meet these needs, a tandem-channel wing layout has been developed, including a FLR (front wing lower than rear wing) configu...
The swimming mode of two interacting squirmers under gravity in a narrow vertical channel is simulated numerically using the lattice Boltzmann method (LBM) in the range of self-propelling strength 0.1 ≤ α ≤ 1.1 and swimming type −5...
KV channel-interacting proteins (KChIP1-4) belong to a family of Ca2+-binding EF-hand proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. KChIPs are predominantly expressed in the brain and heart, where they contribu...
Few-shot object detection suffers from limited annotations, redundant background interference, insufficient feature interaction, and severe sample imbalance. Existing meta-learning-based methods extract class prototypes from support images but often...
Based on expert system theory and fluid–structure interaction (FSI), this paper suggests an intelligent design optimization system to derive the optimal shape of both the fluid and solid domain of flow channels. A parametric modeling scheme of flow c...
To address the current challenges of low single-sensor recognition accuracy for coal and rock cutting states, redundant channel feature responses, and poor performance in traditional neural network models, this paper proposes a new multi-sensor coal...
The rise of three-dimensional bioprinting technology provides a new way to fabricate in tissue engineering in vitro, but how to provide sufficient nutrition for the internal region of the engineered printed tissue has become the main obstacle. In vit...
In cochlear implants (CI), spread of neural excitation may produce channel interaction. Channel interaction disturbs the spectral resolution and, among other factors, seems to impair speech recognition, especially in noise. In this study, two tests w...
Ion and water transport at the Angstrom/Nano scale has always been one of the focuses of experimental and theoretical research. In particular, the surface properties of the angstrom channel and the solid-liquid interface interaction will play a decis...
We study the ground state of a one-dimensional channel with strong attractive electron–electron interactions at low temperatures. In spite of the fact that, at low temperatures, the ground state of one-dimensional attracting electrons is a stat...
Bedrock channel evolution is shaped by the combined effects of mechanical incision and weathering processes that operate under seasonal variability. This study employs numerical simulations to examine how bedload-impact abrasion and freeze–thaw...
Based on FLAC3D finite element analysis and field measurements, this paper studies the synchronous excavation of the deep foundation pit and the adjacent underground channel in the 17th section of the Beijing Metro Line 10 Phase II project. Due to th...
The Ca2+-permeable Transient Receptor Potential channel vanilloid subfamily member 4 (TRPV4) is involved in a broad range of physiological processes, including the regulation of systemic osmotic pressure, bone resorption, vascular tone, and bladder f...
This study investigated the effects of downstream channel obstacles and the lateral transition distance to the dam on dam-break wave evolution as a wave–structure interaction problem. Numerical simulations were conducted using three-dimensional...
One of the most dangerous geological disaster risks in mountainous areas is granular flow. Slit dams, which might partially block the granular flow and let downstream flow at a slower speed, have been crucial in reducing the geohazards associated wit...
The thermal vacuum test (TVT) is an important verification process in the development of spacecraft and load. There are often multiple temperature points on the device under test (DUT) that require control. The interaction among multiple channels pos...
Ca2+ binding to the ubiquitous Ca2+ sensing protein calmodulin (CaM) activates the intermediate conductance Ca2+-activated SK4 channel. Potential hydrophilic pockets for CaM binding have been identified at the intracellular HA and HB helices in the C...
Pannexin 1 (Panx1) is a ubiquitously expressed hexameric integral membrane protein known to function as an adenosine triphosphate (ATP) release channel. Panx1 proteins exist in unglycosylated core form (Gly0). They undergo critical post-translational...
This work’s goal is to numerically investigate the interactions between two gas bubbles in a fluid flow in a circular cross-section channel, both in the presence and in the absence of gravitational forces, with several Reynolds and Weber number...
A Ca2+-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified in the distal N-terminus of the human TRPM4 channel (Glu5 to Lys5; E7K) was found to be arrhythmo...
Caveolae constitute membrane microdomains where receptors and ion channels functionally interact. Caveolin-3 (cav-3) is the key structural component of muscular caveolae. Mutations in CAV3 lead to caveolinopathies, which result in both muscular dystr...
It is very important to rapidly test the key indicators of water in the field to fully evaluate the quality of the regional water environment. However, a high-resolution measuring device that can generate small currents for low-concentration analytes...
The voltage-dependent anion channel (VDAC), a highly conserved major mitochondrial outer membrane protein, plays crucial roles in energy metabolism and metabolite transport. However, knowledge about the roles of the VDAC family in plants is limited....
This study investigates the interfacial interactions between two organic semiconductors (tetrathiafulvalene (TTF) and hexaazatriphenylene-hexacarbonitrile (HAT-CN)) and graphene-based materials (nanocrystalline graphite and vertically aligned graphen...
In the field of 3D technology, depth-image-based rendering (DIBR) has been widely adopted due to its inherent advantages including low data volume and strong compatibility. However, during network transmission of DIBR 3D images, both center and virtu...
The Kv1.2 channel plays an important role in the maintenance of resting membrane potential and the regulation of the cellular excitability of neurons, whose silencing or mutations can elicit neuropathic pain or neurological diseases (e.g., epilepsy a...
Multimodal entity linking (MEL) grounds entity mentions in text-image contexts to entries in a structured knowledge base; however, most existing systems still decompose a multimodal document into independent mention-level decisions. This formulation...
Nowadays, a lot of efforts are being made to increase turbine inlet temperatures (TIT), with the aim of increasing efficiency in aircraft and power generation turbines. Due to the higher temperature level, advanced cooling solutions to preserve mater...
Aβ (1-40) can transfer from the aqueous phase to the bilayer and thus form stable ion-channel-like pores where the protein has alpha-helical conformation. The stability of the pores is due to the presence of the GXXXG motif. It has been reported...
The characterization of calcium channel interactome in the last decades opened a new way of perceiving ion channel function and regulation. Partner proteins of ion channels can now be considered as major components of the calcium homeostatic mechanis...
The purpose of this study is to examine the interaction between Industry 4.0 technologies, inter-organizational trust, sustainable distributor channel development, and marketing channel operational performance. The research employed a quantitative ap...
Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies, which represent an extraordinary challenge for study an...
Monocular depth estimation provides low-cost environmental information for intelligent systems such as autonomous vehicles and robots, supporting sustainable development by reducing reliance on expensive, energy-intensive sensors and making technolog...
TASK-3 potassium (K+) channels are highly expressed in the central nervous system, regulating the membrane potential of excitable cells. TASK-3 is involved in neurotransmitter action and has been identified as an oncogenic K+ channel. For this reason...
Water flow in channels with a compound cross-section involves an exchange of water mass and momentum between the slower flowing water in the floodplains and the faster water in the main channel. This process is called the streams interaction. As a re...
Background/Objectives: Electroencephalography (EEG), with its high temporal resolution, non-invasiveness, and cost-effectiveness, provides a suitable modality for investigating task-related signal patterns associated with Visual Sustained Attention (...
A strong nonlinear ice load has a significant impact on the resistance and power demand of polar transport ships under different drafts in brash ice channels. In this study, the CFD-DEM coupling method is used to investigate the self-propulsion perfo...
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