Special Issue "Membrane Channels and Transporters"

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membranes in Life Sciences".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editors

Assoc. Prof. Dr. Andreas Horner
Guest Editor
Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria
Interests: protein engineering; protein oligomerization; protein-protein interactions; protein-lipid interactions; small molecule transport; aquaporins; urea channels
Dr. Denis Knyazev
Guest Editor
Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria
Interests: protein translocation; translocon; single channel electrophysiology; surface proton; protein-lipid interactions
Dr. Kristyna Pluhackova
Guest Editor
Department of Biosystems Science and Engineering, Eidgenössiche Technische Hochschule (ETH) Zürich, Mattenstr. 26, 4058, Basel, Switzerland
Interests: multiscaling molecular dynamics simulations; protein-lipid interactions; aggregation of transmembrane proteins; peptide adsorption to membranes; biological membrane channels; water transport; realistic membrane models

Special Issue Information

Dear Colleagues,

Membrane channels facilitate passive solute and solvent transport across biomembranes and are of utmost physiological importance. Their selectivity, transport rate, and substrate size vary widely ranging from highly efficient and selective aquaporins or ion channels, which can accommodate only water molecules or ions in single-file fashion respectively, to large non-specific transmembrane pores such as porins and gasdermins. Transporters such as uniporters, symporters and antiporters, are responsible for active transport.

The rapid development of experimental and in silico methods such as cryoEM, MS, high speed AFM, super-resolution microscopy, electrophysiology and molecular dynamics simulations, to name a few, have recently brought new insight on diverse regulation mechanisms of membrane channel and transporter function. Growing attention is brought to the influence of the lipid bilayer on protein structure and function, including specific protein-lipid interactions and the mechanical parameters of the lipid matrix housing the respective membrane proteins. Thereby, new physical models appear which account for the membrane effect on the complex channel behaviour and suggest how conformational changes can be transferred between domains over large scales.

In this Special Issue, we want to focus on the recent achievements in the field and invite you to submit reviews and original research papers further advancing our knowledge on the structure, function, and regulation of membrane channels and transporters by in-vivo, in-vitro, or in-silico investigations. In this context, we will also consider methodological developments and advancements used to study membrane channels and transporters.

Assoc. Prof. Dr. Andreas Horner
Dr. Denis Knyazev
Dr. Kristyna Pluhackova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Membrane permeability
  • Aqua(glycero)porins
  • Ion channels
  • Transporters
  • Membrane channel regulation and gating
  • Protein-lipid interactions
  • Protein oligomerization
  • Protein translocation
  • Transmembrane transport of large cargo molecules
  • Holins
  • Pore-forming toxis
  • Gasdermins
  • Artificial lipid bilayers
  • Protein reconstitution

Published Papers

This special issue is now open for submission.
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