Transistor-Based Biosensors and Their Applications

Dear Colleagues,

Transistor-based biosensors have emerged as a transformative platform in modern bioanalytical technology, thanks to their remarkable sensitivity, label-free detection, real-time response, and compatibility with portable and wearable electronics. By harnessing the intrinsic amplification capabilities of field-effect transistors (FETs), these biosensors effectively translate molecular binding events into measurable electrical signals with high precision.

Recent advancements in device architecture—including extended-gate FETs, electrolyte-gated FETs, and electric double-layer transistors—have greatly enhanced the detection capabilities of these systems, enabling the identification of ions, proteins, nucleic acids, exosomes, and small molecules. Additionally, innovations in nanomaterials, 2D materials, and hybrid structures, combined with advanced biofunctionalization strategies, have improved selectivity, stability, and scalability. Their integration with microfluidics, wireless communication modules, and AI-driven analytics further facilitates their application in next-generation point-of-care diagnostics.

This Special Issue aims to showcase the latest advancements in the design, fabrication, characterization, and application of transistor-based biosensors across various fields, including medical diagnostics, environmental monitoring, food safety, wearable health systems, and precision agriculture. We invite original research articles and comprehensive reviews that focus on innovative device configurations, novel materials, biomolecular sensing mechanisms, and the real-world deployment of these systems.

Topics of interest include, but are not limited to, the following:

1. The application of novel transistor architectures in biosensing.
2. The design and utilization of electric double-layer transistors (EDLTs) and electrolyte-gated field-effect transistors (EGFETs).
3. The use of advanced nanomaterials and two-dimensional materials to enhance signal detection in transistor biosensors.
4. Label-free detection strategies for biomolecular sensing utilizing transistor-based platforms.
5. The development and implementation of portable and point-of-care diagnostic systems based on transistor technology.
6. The integration of transistor biosensors with flexible electronics and wearable devices.
7. The application of field-effect transistor (FET) biosensors for detecting disease markers and monitoring drug levels.
8. FET-based sensors for the detection of environmental toxins and pollutants.
9. The role of transistor biosensors in ensuring food safety and quality control.
10. Applications of transistor biosensors in precision agriculture, such as assessing soil nutrients, monitoring pesticides, and evaluating crop health.
11. System-level integration of transistor biosensing systems, incorporating microfluidics, wireless readout capabilities, and artificial intelligence analytics.

We look forward to your contributions to this Special Issue and to collectively advancing the field of biosensing.

Dr. Sheng-Chun Hung
Guest Editor

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