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12,442 Results Found

  • Article
  • Open Access
3 Citations
2,909 Views
15 Pages

Cell-Set Modelling for a Microtab Implementation on a DU91W(2)250 Airfoil

  • Alejandro Ballesteros-Coll,
  • Unai Fernandez-Gamiz,
  • Iñigo Aramendia,
  • Ekaitz Zulueta and
  • José Antonio Ramos-Hernanz

20 December 2020

Microtabs (MTs) are a regularly used flow control device in terms of wind turbine optimization. The present study introduces the application of the novel cell-set model for an MT implementation on a DU91W(2)250 airfoil. The cell-set model is based on...

(This article belongs to the Special Issue Selected Papers from Eight European Conference on Renewable Energy Systems (ECRES2020))
  • Article
  • Open Access
9 Citations
3,044 Views
18 Pages

Testing the Accuracy of the Cell-Set Model Applied on Vane-Type Sub-Boundary Layer Vortex Generators

  • Koldo Portal-Porras,
  • Unai Fernandez-Gamiz,
  • Iñigo Aramendia,
  • Daniel Teso-Fz-Betoño and
  • Ekaitz Zulueta

11 March 2021

Vortex Generators (VGs) are applied before the expected region of separation of the boundary layer in order to delay or remove the flow separation. Although their height is usually similar to that of the boundary layer, in some applications, lower VG...

(This article belongs to the Special Issue CFD Based Researches and Applications for Fluid Machinery and Fluid Device)
  • Article
  • Open Access
6 Citations
2,895 Views
17 Pages

Accuracy of the Cell-Set Model on a Single Vane-Type Vortex Generator in Negligible Streamwise Pressure Gradient Flow with RANS and LES

  • Iosu Ibarra-Udaeta,
  • Koldo Portal-Porras,
  • Alejandro Ballesteros-Coll,
  • Unai Fernandez-Gamiz and
  • Javier Sancho

2 December 2020

Passive flow control devices are included in the design of wind turbine blades in order to obtain better performance and reduce loads without consuming any external energy. Vortex Generators are one of the most popular flow control devices, whose mai...

(This article belongs to the Section Physical Oceanography)
  • Article
  • Open Access
5 Citations
3,114 Views
14 Pages

Rotating Microtab Implementation on a DU91W250 Airfoil Based on the Cell-Set Model

  • Alejandro Ballesteros-Coll,
  • Koldo Portal-Porras,
  • Unai Fernandez-Gamiz,
  • Ekaitz Zulueta and
  • Jose Manuel Lopez-Guede

14 August 2021

Flow control device modeling is an engaging research field for wind turbine optimization, since in recent years wind turbines have grown in proportions and weight. The purpose of the present work was to study the performance and effects generated by...

(This article belongs to the Section Energy Sustainability)
  • Article
  • Open Access
20 Citations
4,191 Views
10 Pages

23 August 2018

This paper presents a comparative study on the performance of different sizes of sensor sets on polymer electrolyte membrane (PEM) fuel cell fault diagnosis. The effectiveness of three sizes of sensor sets, including fuel cell voltage only, all the a...

(This article belongs to the Special Issue Sensors for Prognostics and Health Management)
  • Communication
  • Open Access
3 Citations
6,627 Views
8 Pages

Current perspectives in Set7 mediated stem cell differentiation

  • Nazanin Karimnia,
  • Haloom Rafehi,
  • Natasha K Tuano,
  • Mark Ziemann,
  • Harikrishnan K.N,
  • Jun Okabe and
  • Assam El-Osta

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell f...

(This article belongs to the Section Detection and Biomarkers of Non-Coding RNA)
  • Article
  • Open Access
5 Citations
3,382 Views
23 Pages

A Novel Evolution Strategy of Level Set Method for the Segmentation of Overlapping Cervical Cells

  • Guangqi Liu,
  • Qinghai Ding,
  • Haibo Luo,
  • Moran Ju,
  • Tianming Jin,
  • Miao He and
  • Gang Dong

5 January 2021

Development of an accurate and automated algorithm to completely segment cervical cells in Pap images is still one of the most challenging tasks. The main reasons are the presence of overlapping cells and the lack of guiding mechanism for the converg...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
3 Citations
3,653 Views
17 Pages

19 January 2022

As 5G small cells gradually become the main force of 5G indoor deployment, it is necessary to study channel estimators for 5G small base stations, but there has been limited research on high-performance channel estimators in recent years. This study...

(This article belongs to the Section Communications)
  • Article
  • Open Access
528 Views
20 Pages

Estradiol Reshapes Cell-Type-Dependent Basal Redox Set-Points in Colorectal Carcinoma Cells

  • Natasa Z. Djordjevic,
  • Nemanja Vučićević and
  • Milica Pešić

Background/Objectives: Since redox balance is critical to colorectal cancer cell survival, and estradiol, a potent antioxidant, correlates with reduced disease incidence, understanding the redox basis of cellular responsiveness to estradiol is essent...

(This article belongs to the Section Cancer Biology and Oncology)
  • Article
  • Open Access
2 Citations
3,793 Views
16 Pages

Unraveling the Complexity of Vaso-Occlusive Crises in Sickle Cell Disease: Insights from a Resource-Limited Setting

  • Ali Kaponda,
  • Kalunga Muya,
  • Jules Panda,
  • Kodondi Kule Koto and
  • Bruno Bonnechère

25 April 2024

Background/Objectives: This study investigated vaso-occlusive crises (VOCs) in sickle cell disease in Lubumbashi, Democratic Republic of Congo, aiming to understand the disease complexities amidst limited resources. With sickle cell hemoglobinopathie...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
23 Citations
5,441 Views
23 Pages

30 March 2018

An optimal load-tracking operation strategy for a grid-connected tubular solid oxide fuel cell (SOFC) is studied based on the steady-state analysis of the system thermodynamics and electrochemistry. Control of the SOFC is achieved by a two-level hier...

(This article belongs to the Special Issue Distributed Renewable Generation 2018)
  • Article
  • Open Access
10 Citations
3,741 Views
15 Pages

Computational Methods for Modelling and Optimization of Flow Control Devices

  • Alejandro Ballesteros-Coll,
  • Unai Fernandez-Gamiz,
  • Iñigo Aramendia,
  • Ekaitz Zulueta and
  • Jose Manuel Lopez-Guede

19 July 2020

Over the last few years, the advances in size and weight for wind turbines have led to the development of flow control devices. The current work presents an innovative method to model flow control devices based on a cell-set model, such as Gurney fla...

  • Review
  • Open Access
22 Citations
5,609 Views
13 Pages

The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response

  • Alexandra Daks,
  • Elena Vasileva,
  • Olga Fedorova,
  • Oleg Shuvalov and
  • Nickolai A. Barlev

2 March 2022

Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substr...

(This article belongs to the Special Issue Structure, Activity, and Function of Protein Methyltransferases)
  • Article
  • Open Access
19 Citations
8,923 Views
20 Pages

A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors

  • Barbara Costa,
  • Michael N. C. Fletcher,
  • Pavle Boskovic,
  • Ekaterina L. Ivanova,
  • Tanja Eisemann,
  • Sabrina Lohr,
  • Lukas Bunse,
  • Martin Löwer,
  • Stefanie Burchard and
  • Heike Peterziel
  • + 8 authors

10 January 2021

Glioblastomas (GBM) are the most aggressive tumors affecting the central nervous system in adults, causing death within, on average, 15 months after diagnosis. Immunocompetent in-vivo models that closely mirror human GBM are urgently needed for decip...

(This article belongs to the Special Issue Glioblastomas)
  • Article
  • Open Access
9 Citations
3,541 Views
26 Pages

Identifying Genetic Signatures from Single-Cell RNA Sequencing Data by Matrix Imputation and Reduced Set Gene Clustering

  • Soumita Seth,
  • Saurav Mallik,
  • Atikul Islam,
  • Tapas Bhadra,
  • Arup Roy,
  • Pawan Kumar Singh,
  • Aimin Li and
  • Zhongming Zhao

17 October 2023

In this current era, the identification of both known and novel cell types, the representation of cells, predicting cell fates, classifying various tumor types, and studying heterogeneity in various cells are the key areas of interest in the analysis...

  • Article
  • Open Access
16 Citations
5,760 Views
23 Pages

6 December 2018

One of the still open questions in Ewing sarcoma, a rare bone tumor with weak therapeutic options, is to identify the tumor-driving cell (sub) population and to understand the specifics in the biological network of these cells. This basic scientific...

(This article belongs to the Special Issue Current Advances in Soft Tissue and Bone Sarcoma)
  • Article
  • Open Access
1 Citations
2,452 Views
15 Pages

Finite Control Set—Model Predictive Control with Non-Spread Spectrum and Reduced Switching Frequency Applied to Multi-Cell Rectifiers

  • Eduardo Espinosa,
  • José Espinoza,
  • Pedro Melín,
  • Jaime Rohten,
  • Carlos Baier and
  • Marcelo Reyes

23 September 2021

Multi-cell converters are widely used in medium-voltage AC drives. This equipment is based on power cells that operate with low-voltage-rating semiconductors and require an input multipulse transformer. This transformer cancels the low-frequency curr...

(This article belongs to the Special Issue Electrical Power Engineering: Efficiency and Control Strategies)
  • Article
  • Open Access
3 Citations
8,782 Views
13 Pages

Abnormal accumulation of alpha synuclein (α-Syn) in sporadic and familial Parkinson’s disease (PD) may be a key step in its pathogenesis. In this study, the expression matrix of the GSE95427 dataset after α-Syn overexpression in hum...

(This article belongs to the Section Neurobiology and Clinical Neuroscience)
  • Article
  • Open Access
14 Citations
3,341 Views
11 Pages

20 August 2022

A flexible and versatile method for manufacturing open-cell metal foams, called lost-PLA, is presented in this work. With a double extruder 3D printer (FDM, Ultimaker S3, Utrecht, The Netherlands), it is possible to make polymer-based samples of the...

(This article belongs to the Special Issue Modeling, Testing and Applications of Metallic Foams and Cellular Materials)
  • Brief Report
  • Open Access
12 Citations
4,471 Views
14 Pages

Proportion of the CD19-Positive and CD19-Negative Lymphocytes and Monocytes within the Peripheral Blood Mononuclear Cell Set Is Characteristic for Rheumatoid Arthritis

  • Irina Kholodnyuk,
  • Anda Kadisa,
  • Simons Svirskis,
  • Sabine Gravelsina,
  • Peteris Studers,
  • Irina Spaka,
  • Alina Sultanova,
  • Sandra Lejniece,
  • Aivars Lejnieks and
  • Modra Murovska

24 September 2019

Background and objectives: Composition of the peripheral blood (PB) cell populations and their activation state reflect the immune status of a patient. Rheumatoid arthritis (RA) is characterized by abnormal B- and T-cell functions. The objective of t...

  • Article
  • Open Access
29 Citations
4,236 Views
15 Pages

Detecting and Reducing Biases in Cellular-Based Mobility Data Sets

  • Alicia Rodriguez-Carrion,
  • Carlos Garcia-Rubio and
  • Celeste Campo

25 September 2018

Correctly estimating the features characterizing human mobility from mobile phone traces is a key factor to improve the performance of mobile networks, as well as for mobility model design and urban planning. Most related works found their conclusion...

(This article belongs to the Special Issue Information Theory and 5G Technologies)
  • Article
  • Open Access
7 Citations
5,460 Views
18 Pages

Evaluation of Reliable Digital Elevation Model Resolution for TOPMODEL in Two Mountainous Watersheds, South Korea

  • Daeryong Park,
  • Huan-Jung Fan,
  • Jun-Jie Zhu,
  • Sang-Eun Oh,
  • Myoung-Jin Um and
  • Kichul Jung

5 September 2019

This study analyzed the result of parameter optimization using the digital elevation model (DEM) resolution in the TOPography-based hydrological MODEL (TOPMODEL). Also, this study investigated the sensitivity of the TOPMODEL efficiency by applying th...

(This article belongs to the Special Issue Recent Advances in Geographic Information System for Earth Sciences)
  • Article
  • Open Access
63 Citations
5,731 Views
17 Pages

High G2M Pathway Score Pancreatic Cancer is Associated with Worse Survival, Particularly after Margin-Positive (R1 or R2) Resection

  • Masanori Oshi,
  • Stephanie Newman,
  • Yoshihisa Tokumaru,
  • Li Yan,
  • Ryusei Matsuyama,
  • Itaru Endo,
  • Matthew H. G. Katz and
  • Kazuaki Takabe

6 October 2020

Pancreatic cancer is highly mortal due to uncontrolled cell proliferation. The G2M checkpoint pathway is an essential part of the cell cycle. We hypothesized that a high G2M pathway score is associated with cell proliferation and worse survival in pa...

(This article belongs to the Special Issue Molecular Biomarkers and Precision Medicine for Pancreatic, Liver and Biliary Tract Cancers)
  • Article
  • Open Access
2 Citations
1,358 Views
15 Pages

In Vitro Biocompatibility of Calcium Silicate-Based Materials for Retrograde Endodontic Treatment Under Different Setting Conditions

  • Kremena Markova,
  • Neshka Manchorova-Veleva,
  • Veselina Todorova,
  • Lyubomir Vangelov and
  • Desislava Petkova

Background: Calcium silicate-based materials are widely used in retrograde endodontic treatment due to their bioactivity and favorable biological properties. The environmental conditions during setting and the time-dependent release of soluble compon...

(This article belongs to the Section Dental Biomaterials)
  • Article
  • Open Access
4 Citations
2,808 Views
14 Pages

30 June 2020

This paper presents the design of an autonomous dynamic adaptability system (ADAS) for maintaining the irradiance levels of a steady-state xenon arc lamp solar simulator (SS). The solar simulator is used to carry out indoor testing and accelerated ag...

(This article belongs to the Section Electrical, Electronics and Communications Engineering)
  • Article
  • Open Access
2 Citations
3,172 Views
8 Pages

8 July 2020

A dynamic model of a Direct Methanol Fuel Cell is developed in the MATLAB platform. A newly proposed Coefficient Diagram based Proportional Integral Controller (CD-PIC) is designed and its parameters are calculated. The newly designed CD-PIC is imple...

(This article belongs to the Special Issue Applications of Process Control in Energy Systems)
  • Article
  • Open Access
5 Citations
1,497 Views
15 Pages

Valemetostat–SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells

  • Michele Di Crosta,
  • Francesca Chiara Ragone,
  • Rossella Benedetti,
  • Gabriella D’Orazi,
  • Roberta Santarelli,
  • Maria Saveria Gilardini Montani and
  • Mara Cirone

17 September 2025

Background/Objective: Aberrant acetylation and methylation of histone and non-histone proteins contribute to carcinogenesis. Among non-histone proteins, wild-type (wt) p53 is particularly notable for the critical role that acetylation and methylation...

(This article belongs to the Section Cell Biology and Pathology)
  • Article
  • Open Access
8 Citations
3,874 Views
12 Pages

Huntingtin-interacting protein 1-related protein (HIP1R) plays an important role in the regulation of programmed death-ligand 1 (PD-L1). The aim of this study was to investigate the expression of HIP1R and confirm its predictive or prognostic roles i...

(This article belongs to the Special Issue Non-small Cell Lung Cancer: Current Therapies and New Targeted Treatments)
  • Article
  • Open Access
1 Citations
3,257 Views
20 Pages

Dynamic Set Planning for Coordinated Multi-Point in B4G/5G Networks

  • Jia-Ming Liang,
  • Ching-Kuo Hsu,
  • Jen-Jee Chen,
  • Po-Han Lin,
  • Po-Min Hsu and
  • Tzung-Shi Chen

3 March 2021

Coordinated Multi-Point (CoMP) is an important technique in B4G/5G networks. With CoMP, multiple base stations can be clustered to compose a cooperating set to improve system throughput, especially for the users in cell edges. Existed studies have di...

(This article belongs to the Special Issue Energy-Efficient Resource Allocation for beyond 5G and IoT Systems)
  • Article
  • Open Access
1,212 Views
15 Pages

Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues

  • Hyunsoo Kim,
  • Erich Kummerfeld,
  • Laura J. Niedernhofer,
  • Constantin Aliferis,
  • Paul D. Robbins and
  • Jinhua Wang

The senescence-associated secretory phenotype (SASP) is a hallmark of senescent cells and plays a critical role in the development and progression of various age-related diseases, including cancer, cardiovascular disorders, and neurodegenerative dise...

(This article belongs to the Special Issue Advances in Next-Generation Sequencing for Aging and Cancer Research)
  • Review
  • Open Access
3 Citations
4,406 Views
50 Pages

Advances in Citrus Fruit Set and Development: A Review

  • Manuel Agustí,
  • Carmina Reig,
  • Amparo Martínez-Fuentes and
  • Carlos Mesejo

Citrus species develop fruits through both sexual reproduction and parthenocarpy, following a growth pattern with an initial exponential phase dominated by cell division in the ovary wall, followed by a linear phase driven by cell expansion in juice...

(This article belongs to the Special Issue Integrated Cultivation Strategies for Citrus Orchards: Enhancing Yield and Quality)
  • Article
  • Open Access
1 Citations
3,045 Views
17 Pages

9 July 2023

We present a mathematical model of an individual cell to expand the simulation of invadopodia formation to a three-dimensional (3D) domain for a more realistic complexity. Simulating invadopodia replication in order for it to be biologically relevant...

(This article belongs to the Special Issue Mathematical Modeling and Data Science for Biology and Medicine)
  • Article
  • Open Access
1 Citations
2,295 Views
17 Pages

The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate

  • Radoslava Stulajterova,
  • Maria Giretova,
  • Lubomir Medvecky,
  • Tibor Sopcak,
  • Lenka Luptakova and
  • Vladimir Girman

18 November 2022

The effect of nanosilica on the microstructure setting process of tetracalcium phosphate/nanomonetite calcium phosphate cement mixture (CPC) with the addition of 5 wt% of magnesium pyrophosphate (assigned as CT5MP) and osteogenic differentiation of m...

(This article belongs to the Section Advanced Composites)
  • Article
  • Open Access
8 Citations
4,616 Views
18 Pages

16 February 2021

Heat demand of buildings and related CO2 emissions caused by energy supply contribute to global climate change. Spatial data-based heat planning enables municipalities to reorganize local heating sectors towards efficient use of regional renewable en...

  • Article
  • Open Access
26 Citations
6,349 Views
11 Pages

Red Blood Cell Deformability Is Expressed by a Set of Interrelated Membrane Proteins

  • Gregory Barshtein,
  • Alexander Gural,
  • Dan Arbell,
  • Refael Barkan,
  • Leonid Livshits,
  • Ivana Pajic-Lijakovic and
  • Saul Yedgar

13 August 2023

Red blood cell (RBC) deformability, expressing their ability to change their shape, allows them to minimize their resistance to flow and optimize oxygen delivery to the tissues. RBC with reduced deformability may lead to increased vascular resistance...

(This article belongs to the Special Issue Molecular Research of Regulation of Red Blood Cells in Health, Hereditary or Acquired Diseases)
  • Article
  • Open Access
3 Citations
3,172 Views
21 Pages

Characterization of Tetracalcium Phosphate/Monetite Biocement Modified by Magnesium Pyrophosphate

  • Radoslava Stulajterova,
  • Lubomir Medvecky,
  • Maria Giretova,
  • Tibor Sopcak,
  • Lenka Luptakova,
  • Radovan Bures and
  • Eva Szekiova

31 March 2022

Magnesium pyrophosphate modified tetracalcium phosphate/monetite cement mixtures (MgTTCPM) were prepared by simple mechanical homogenization of compounds in a ball mill. The MgP2O7 was chosen due to the suitable setting properties of the final cement...

(This article belongs to the Section Biomaterials)
  • Review
  • Open Access
8 Citations
7,205 Views
20 Pages

18 March 2025

Blinatumomab, a bispecific T-cell engager (BiTE), has shown substantial efficacy in treating both relapsed/refractory (R/R) Philadelphia chromosome (Ph)-positive and Ph-negative acute lymphoblastic leukemia (ALL). With its targeted mechanism of actio...

(This article belongs to the Section Hematology)
  • Review
  • Open Access
14 Citations
10,070 Views
21 Pages

Improving the Sensitivity and Functionality of Mobile Webcam-Based Fluorescence Detectors for Point-of-Care Diagnostics in Global Health

  • Reuven Rasooly,
  • Hugh Alan Bruck,
  • Joshua Balsam,
  • Ben Prickril,
  • Miguel Ossandon and
  • Avraham Rasooly

Resource-poor countries and regions require effective, low-cost diagnostic devices for accurate identification and diagnosis of health conditions. Optical detection technologies used for many types of biological and clinical analysis can play a signi...

  • Article
  • Open Access
4 Citations
3,669 Views
12 Pages

Sources of Thermal Power Generation and Their Influence on the Operating Temperature of Organic Solar Cells

  • Hooman Mehdizadeh-Rad,
  • Kiran Sreedhar Ram,
  • Farhad Mehdizadeh-Rad,
  • David Ompong,
  • Daniel Dodzi Yao Setsoafia,
  • Naveen Kumar Elumalai,
  • Furong Zhu and
  • Jai Singh

27 January 2022

Thermal stability, closely associated with the operating temperature, is one of the desired properties for practical applications of organic solar cells (OSCs). In this paper, an OSC of the structure of ITO/PEDOT:PSS/P3HT:PCBM/ZnO/Ag was fabricated,...

  • Article
  • Open Access
359 Views
20 Pages

Multi-Model Finite Control Set Model-Based Predictive Voltage Control of a Floating Interleaved Boost DC–DC Converter in Fuel Cell Applications

  • Juan José Galeano-Dinatale,
  • Jorge Rodas,
  • Fabian Palacios-Pereira,
  • Larizza Delorme and
  • Alfredo Renault

10 September 2026

Fuel cell systems require high-efficiency DC–DC interfaces capable of regulating rapid voltage variations while respecting the operational constraints of proton-exchange membrane fuel cells (PEMFCs). The floating interleaved boost converter (FI...

(This article belongs to the Special Issue Advanced Nonlinear Control and Optimization for Renewable Energy Systems, Smart Grids and Electric Vehicles)
  • Article
  • Open Access
51 Citations
5,167 Views
17 Pages

Intratumoral Adipocyte-High Breast Cancer Enrich for Metastatic and Inflammation-Related Pathways but Associated with Less Cancer Cell Proliferation

  • Yoshihisa Tokumaru,
  • Masanori Oshi,
  • Eriko Katsuta,
  • Li Yan,
  • Jing Li Huang,
  • Masayuki Nagahashi,
  • Nobuhisa Matsuhashi,
  • Manabu Futamura,
  • Kazuhiro Yoshida and
  • Kazuaki Takabe

11 August 2020

Cancer-associated adipocytes are known to cause inflammation, leading to cancer progression and metastasis. The clinicopathological and transcriptomic data from 2256 patients with breast cancer were obtained based on three cohorts: The Cancer Genome...

(This article belongs to the Special Issue Unraveling the Involvement of the Adipose Tissue in Breast Cancer Progression)
  • Article
  • Open Access
143 Citations
8,626 Views
17 Pages

G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer

  • Masanori Oshi,
  • Hideo Takahashi,
  • Yoshihisa Tokumaru,
  • Li Yan,
  • Omar M. Rashid,
  • Ryusei Matsuyama,
  • Itaru Endo and
  • Kazuaki Takabe

The vast majority of breast cancer death is a result of metastasis. Thus, accurate identification of patients who are likely to have metastasis is expected to improve survival. The G2M checkpoint plays a critical role in cell cycle. We hypothesized t...

(This article belongs to the Special Issue Metastasis Inhibition)
  • Article
  • Open Access
4 Citations
4,681 Views
11 Pages

Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals

  • Csaba Fehér,
  • Roque Pastor-lbáñez,
  • Lorna Leal,
  • Montserrat Plana,
  • Mireia Arnedo,
  • Henk-Jan van den Ham,
  • Arno C. Andeweg,
  • Rob A. Gruters,
  • Francisco Díez-Fuertes and
  • Felipe García
  • + 2 authors

Systems vaccinology has seldomly been used in therapeutic HIV-1 vaccine research. Our aim was to identify early gene ‘signatures’ that predicted virus load control after analytical therapy interruption (ATI) in participants of a dendritic cell-based...

(This article belongs to the Section HIV Vaccines)
  • Article
  • Open Access
12 Citations
5,185 Views
19 Pages

Transcriptomic, Hormonomic and Metabolomic Analyses Highlighted the Common Modules Related to Photosynthesis, Sugar Metabolism and Cell Division in Parthenocarpic Tomato Fruits during Early Fruit Set

  • Miyako Kusano,
  • Kanjana Worarad,
  • Atsushi Fukushima,
  • Ken Kamiya,
  • Yuka Mitani,
  • Yozo Okazaki,
  • Yasuhiro Higashi,
  • Ryo Nakabayashi,
  • Makoto Kobayashi and
  • Hiroshi Ezura
  • + 11 authors

22 April 2022

Parthenocarpy, the pollination-independent fruit set, can raise the productivity of the fruit set even under adverse factors during the reproductive phase. The application of plant hormones stimulates parthenocarpy, but artificial hormones incur extr...

(This article belongs to the Special Issue Metabolomics as a Tool for Functional Genomics)
  • Article
  • Open Access
16 Citations
2,748 Views
17 Pages

25 August 2022

The development of biomaterials that exhibit profound bioactivity and stimulate stem cell differentiation is imperative for the success and prognosis of vital pulp therapies. The objectives were to (1) synthesize calcium strontium silicate (CSR) cera...

(This article belongs to the Section Biomaterials)
  • Article
  • Open Access
6 Citations
4,268 Views
15 Pages

Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes

  • Andrea Fracchia,
  • Drirh Khare,
  • Samar Da’na,
  • Reuven Or,
  • Amnon Buxboim,
  • Boaz Nachmias,
  • Claudine Barkatz,
  • Regina Golan-Gerstl,
  • Swasti Tiwari and
  • Batia Avni
  • + 5 authors

5 September 2023

Recent studies have highlighted the therapeutic potential of small extracellular bodies derived from mesenchymal stem cells (MSC-sEVs) for various diseases, notably through their ability to alter T-cell differentiation and function. The current study...

(This article belongs to the Special Issue Mesenchymal Stem Cells and Their Therapeutic Application)
  • Review
  • Open Access
4 Citations
3,971 Views
18 Pages

17 February 2023

Lung cancer is the second most common cancer in the world, being the first cause of cancer-related mortality. Surgery remains the only potentially curative treatment for Non-Small Cell Lung Cancer (NSCLC), but the recurrence risk remains high (30&nda...

(This article belongs to the Special Issue Precision Medicine in Oncology)
  • Article
  • Open Access
10 Citations
3,710 Views
18 Pages

Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma

  • Yuuki Sandhu,
  • Norihiro Harada,
  • Hitoshi Sasano,
  • Sonoko Harada,
  • Shoko Ueda,
  • Tomohito Takeshige,
  • Yuki Tanabe,
  • Ayako Ishimori,
  • Kei Matsuno and
  • Kazuhisa Takahashi
  • + 8 authors

15 March 2023

Benralizumab treatment reduces exacerbations and improves symptom control and quality of life in patients with severe eosinophilic asthma. However, the determination of biomarkers that predict therapeutic effectiveness is required for precision medic...

(This article belongs to the Special Issue Eosinophils in Allergy and Related Diseases—Selected Papers from “The Workshop on Eosinophils in Allergy and Related Diseases 2022 and 2023”)
  • Article
  • Open Access
481 Views
31 Pages

Sporadic Creutzfeldt–Jakob disease (sCJD) is a rapidly progressive fatal neurodegenerative disease whose basis of pathogenesis remains incompletely defined. Public datasets allow molecular changes to be compared across transcriptomic, post-tran...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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  • Open Access
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22 April 2021

A modified one-step process was used to prepare tetracalcium phosphate/monetite/calcium sulfate hemihydrate powder cement mixtures (CAS). The procedure allowed the formation of monetite and calcium sulfate hemihydrate (CSH) in the form of nanoparticl...

(This article belongs to the Special Issue Bioceramics and Bioactive Glass-Based Composites)

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