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Non-Coding RNA 2016, 2(4), 14;

Current perspectives in Set7 mediated stem cell differentiation

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3004, Australia
Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia
Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR
Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Received: 26 October 2016 / Revised: 18 November 2016 / Accepted: 23 November 2016 / Published: 4 December 2016
(This article belongs to the Special Issue The Biology of Non-Coding RNAs and Metabolic Diseases)
Full-Text   |   PDF [624 KB, uploaded 8 December 2016]   |  


Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity. View Full-Text
Keywords: Set7; stem cell differentiation; non-coding RNA; histone; non-histone protein Set7; stem cell differentiation; non-coding RNA; histone; non-histone protein

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Karimnia, N.; Rafehi, H.; Tuano, N.K.; Ziemann, M.; K.N, H.; Okabe, J.; El-Osta, A. Current perspectives in Set7 mediated stem cell differentiation. Non-Coding RNA 2016, 2, 14.

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