- Article
The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain
- Nuzhat Parveen,
- Wei-Jung Chiu,
- Li-Ching Shen,
- Ruey-Hwang Chou,
- Chung-Ming Sun and
- Chin Yu
The S100A1 protein in humans is a calcium-binding protein. Upon Ca2+ binding to S100A1 EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target proteins. RAGE consists of three domains: the cytoplasmic, transmembrane,...