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54 Results Found

  • Article
  • Open Access
13 Citations
4,345 Views
13 Pages

Vibrios can degrade chitin surfaces to soluble N-acetyl glucosamine oligosaccharides (GlcNAcn) that can be utilized as a carbon source and also induce a state of natural genetic competence. In this study, we characterized chitin-dependent growth and...

  • Review
  • Open Access
871 Views
40 Pages

Antisense Versus Antigene in the Computer-Aided Design of Triplex-Forming Oligonucleotides (TFO): Insights from a Dual-Method Review, Combining Bibliometric and Systematic Review

  • Martha Hincapié-López,
  • Jeison Marín-Alfonso,
  • Efrén Romero-Riaño,
  • Rafael Augusto Núñez-Rodríguez and
  • Yarley Vladimir Pabón-Martínez

12 November 2025

This study offers a comprehensive overview of the scientific landscape surrounding computer-aided drug design (CADD) for triplex-forming oligonucleotides (TFOs) within antisense and antigene therapeutic strategies. A dual-method approach was used, co...

  • Article
  • Open Access
990 Views
13 Pages

Development of a Novel Algorithm for Tip Fold-Over Detection in Cochlear Implants and Evaluation on Bench and Multiple Clinical Data Bases

  • Mehrangiz Ashiri,
  • Tony Spahr,
  • Azret Botash,
  • Ashish Mehta,
  • Jordan J. Varghese,
  • Craig A. Buchman,
  • Andrea J. DeFreese,
  • Patrick Boyle,
  • Matthew Miller and
  • Kanthaiah Koka
  • + 4 authors

18 September 2025

Objectives: Tip fold-over (TFO) is a rare but critical occurrence in cochlear implant procedures where the electrode array folds back on itself within the cochlea, compromising programming and device performance. Timely intraoperative detection is es...

  • Article
  • Open Access
2,967 Views
24 Pages

Individualized Target Fortification of Breast Milk with Protein, Carbohydrates, and Fat for Preterm Infants: Effect on Neurodevelopment

  • Niels Rochow,
  • Nicolas Gabriel Leier,
  • Gisela Adrienne Weiss,
  • Gerhard Fusch,
  • Anaam Ali,
  • Akshdeep Bhatia,
  • Salhab el Helou,
  • Jan Däbritz and
  • Christoph Fusch

23 May 2025

Background/Objectives: Preterm infants are at high risk of extrauterine growth restriction and suboptimal neurological development due to cumulative nutrient deficits. Standard fortification (SF) of human milk does not account for individual macronut...

  • Article
  • Open Access
1 Citations
2,684 Views
11 Pages

17 May 2024

Loop-mediated isothermal amplification (LAMP) technology is extensively utilized for the detection of infectious diseases owing to its rapid processing and high sensitivity. Nevertheless, conventional LAMP signaling methods frequently suffer from a l...

  • Article
  • Open Access
11 Citations
8,861 Views
13 Pages

Exercise Fat Oxidation Is Positively Associated with Body Fatness in Men with Obesity: Defying the Metabolic Flexibility Paradigm

  • Isaac A. Chávez-Guevara,
  • Rosa P. Hernández-Torres,
  • Marina Trejo-Trejo,
  • Everardo González-Rodríguez,
  • Verónica Moreno-Brito,
  • Abraham Wall-Medrano,
  • Jorge A. Pérez-León and
  • Arnulfo Ramos-Jiménez

Obesity is thought to be associated with a reduced capacity to increase fat oxidation in response to physical exercise; however, scientific evidence supporting this paradigm remains scarce. This study aimed to determine the interrelationship of diffe...

  • Article
  • Open Access
4 Citations
8,104 Views
13 Pages

Triplex stability is studied in crowding conditions using small cosolutes (ethanol, acetonitrile and dimethylsulfoxide) by ultraviolet (UV), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopies. The results indicate that the tr...

  • Article
  • Open Access
2 Citations
603 Views
17 Pages

This study presents a comprehensive Lyapunov-based framework for analyzing partial practical stability in nonlinear tempered fractional-order systems (TFOS). We develop novel stability concepts including β*-practical uniform generalized Mittag&n...

  • Article
  • Open Access
20 Citations
2,614 Views
12 Pages

Categorization of the Aqueous Deficient Dry Eye by a Cut-Off Criterion of TMH Measured with Tearscope

  • Belen Sabucedo-Villamarin,
  • Hugo Pena-Verdeal,
  • Jacobo Garcia-Queiruga,
  • Maria Jesus Giraldez,
  • Carlos Garcia-Resua and
  • Eva Yebra-Pimentel

2 December 2022

A decrease of the Tear Meniscus Height (TMH) has been proposed as a useful indicator for Aqueous Deficient Dry Eye (ADDE) categorization. The present study aimed to calculate a TMH cut-off criterion for the categorization or severity assessment of AD...

  • Article
  • Open Access
9 Citations
4,061 Views
12 Pages

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

  • Hugo Pena-Verdeal,
  • Jacobo Garcia-Queiruga,
  • Belen Sabucedo-Villamarin,
  • Carlos Garcia-Resua,
  • Maria J. Giraldez and
  • Eva Yebra-Pimentel

23 January 2024

(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height...

  • Article
  • Open Access
4 Citations
5,217 Views
11 Pages

Oligonucleotide Binding to Non-B-DNA in MYC

  • Tea Umek,
  • Karin Sollander,
  • Helen Bergquist,
  • Jesper Wengel,
  • Karin E. Lundin,
  • C.I. Edvard Smith and
  • Rula Zain

12 March 2019

MYC, originally named c-myc, is an oncogene deregulated in many different forms of cancer. Translocation of the MYC gene to an immunoglobulin gene leads to an overexpression and the development of Burkitt’s lymphoma (BL). Sporadic BL constitute...

  • Article
  • Open Access
24 Citations
4,395 Views
18 Pages

Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH—Novel Heme Acquisition Strategy in the Oral Microbiome

  • Paulina Ślęzak,
  • Michał Śmiga,
  • John W. Smalley,
  • Klaudia Siemińska and
  • Teresa Olczak

The oral cavity of healthy individuals is inhabited by commensals, with species of Streptococcus being the most abundant and prevalent in sites not affected by periodontal diseases. The development of chronic periodontitis is linked with the environm...

  • Article
  • Open Access
227 Views
25 Pages

10 January 2026

This work investigates the mechanisms of information transfer underlying causal relationships between brain regions during resting-state conditions in patients with schizophrenia (SCZ). A large fMRI dataset including healthy controls and SCZ patients...

  • Article
  • Open Access
12 Citations
2,209 Views
8 Pages

Inter-Eye Comparison of the Ocular Surface of Glaucoma Patients Receiving Surgical and Medical Treatments

  • Dario Romano,
  • Valentino De Ruvo,
  • Paolo Fogagnolo,
  • Roberta Farci and
  • Luca Mario Rossetti

24 February 2022

Background: Ocular surface frequently affects glaucoma patients. In this paper we aimed at evaluating the impact of glaucoma surgery on the ocular surface of patients who received unilateral trabeculectomy. Methods: 26 consecutive patients successful...

  • Brief Report
  • Open Access
3 Citations
3,814 Views
13 Pages

Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates

  • Hanah F. Huber,
  • Majid Jaberi-Douraki,
  • Sarah DeVader,
  • Cesar Aparicio-Lopez,
  • Juliet Nava-Chavez,
  • Xuan Xu,
  • Nuwan Indika Millagaha Gedara,
  • Natasha N. Gaudreault and
  • Robert K. Delong

1 October 2021

The emergence of SARS-CoV-2 variants is cause for concern, because these may become resistant to current vaccines and antiviral drugs in development. Current drugs target viral proteins, resulting in a critical need for RNA-targeted nanomedicines. To...

  • Article
  • Open Access
1 Citations
1,238 Views
27 Pages

Traffic congestion has increased significantly in today’s rapidly urbanizing world, influencing people’s daily lives. Traffic signal control systems (TSCSs) play an important role in alleviating congestion by optimizing traffic light timi...

  • Review
  • Open Access
3 Citations
3,410 Views
11 Pages

Cataracts are characterized by the crystalline lens of the eye becoming cloudy, and dry eye disease (DED) is a multifactorial disease in which the homeostasis of the tear film is lost. As the prevalence of both diseases increases with age, there is a...

  • Article
  • Open Access
12 Citations
7,535 Views
23 Pages

11 February 2021

This study focuses on true and fair view (TFV) and fair presentation (FP) in financial statements. It questions if attitudes towards the true and fair override (TFO) condition, included in European Union (EU) legislation and International Financial R...

  • Article
  • Open Access
50 Citations
8,117 Views
14 Pages

Target Fortification of Breast Milk: How Often Should Milk Analysis Be Done?

  • Niels Rochow,
  • Gerhard Fusch,
  • Bianca Zapanta,
  • Anaam Ali,
  • Sandip Barui and
  • Christoph Fusch

1 April 2015

Target fortification (TFO) reduces natural macronutrient variation in breast milk (BM). Daily BM analysis for TFO increases neonatal intensive care unit work load by 10–15 min/patient/day and may not be feasible in all nurseries. The variation of ma...

  • Article
  • Open Access
863 Views
18 Pages

Carbon dioxide, the primary greenhouse gas responsible for global warming, represents today a critical environmental challenge for humans. Mitigating CO2 emissions and other greenhouse gases is a pressing global concern. The primary goal of this stud...

  • Article
  • Open Access
1 Citations
2,101 Views
14 Pages

Vapor Pressure of Ionic Liquids with a Common Tetrabutylammonium Cation and Three Different Anions

  • Ivan Fabrizi,
  • Simone Di Muzio,
  • Fabio Ramondo,
  • Francesco Trequattrini,
  • Oriele Palumbo and
  • Annalisa Paolone

27 May 2025

The vapor pressures, pv, of three ionic compounds used as starting materials of deep eutectic systems, namely, tetrabutylammonium bromide (TBA-Br), tetrabutylammonium trifluoromethanesulfonate (TBA-TFO), and tetrabutylammonium bis(trifluoromethanesul...

  • Article
  • Open Access
1,618 Views
12 Pages

Crown–Root Ratio as a Predictive Morphometric Indicator in Mandibular First Molars with Occlusal Trauma and Periodontitis: A Radiographic and Clinical Modeling Study

  • Lidya Irani Nainggolan,
  • Bramma Kiswanjaya,
  • Menik Priaminiarti,
  • Sri Lelyati Chaidar Masulili,
  • Hanna H. Bachtiar-Iskandar,
  • Yuniarti Soeroso,
  • Pitu Wulandari,
  • Eha Renwi Astuti and
  • Akihiro Yoshihara

12 September 2025

Background/Objectives: Trauma from occlusion (TFO) is a modifying factor in periodontal disease progression, yet its morphometric impact on mandibular molars remains underexplored. The crown–root ratio (CRR), traditionally used in prosthodontic...

  • Article
  • Open Access
9 Citations
2,342 Views
14 Pages

14 September 2022

Soil surface electrochemical properties, such as specific surface area and surface charge number, are important indexes to evaluate the agricultural soil quality change. However, there is not enough focus on the effect of different improved materials...

  • Review
  • Open Access
13 Citations
5,071 Views
21 Pages

Recent developments in artificial nucleic acid and drug delivery systems present possibilities for the symbiotic engineering of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering ribonucleic acids (siRNAs)....

  • Article
  • Open Access
21 Citations
5,163 Views
18 Pages

Waste Apple Pomace Conversion to Acrylic Acid: Economic and Potential Environmental Impact Assessments

  • Oseweuba Valentine Okoro,
  • Lei Nie,
  • Houman Alimoradi and
  • Amin Shavandi

The global demand for acrylic acid (AA) is increasing due to its wide range of applications. Due to this growing demand, alternative AA production strategies must be explored to avoid the exacerbation of prevailing climate and global warming issues s...

  • Article
  • Open Access
3 Citations
2,350 Views
13 Pages

Diagnostic Performance of the Tear Meniscus Osmolarity Measurement for Dry Eye Disease in Rheumatoid Arthritis Patients

  • Paola De La Parra-Colin,
  • Karen Palacios-Aguirre,
  • Andrea Perez-Pria-Kasusky,
  • Rolando Espinosa-Morales and
  • Alberto Hidalgo-Bravo

19 September 2023

Background: The aim of our study was to evaluate the diagnostic capacity of the tear meniscus osmolarity measurement for dry eye disease (DED) in patients with rheumatoid arthritis (RA), using a portable osmometer based on electrical impedance and an...

  • Article
  • Open Access
7 Citations
2,306 Views
19 Pages

14 July 2023

Aggregate stability is a key factor in the evaluation of soil structure and erosion resistance, which is largely influenced by soil electric field and particle interaction. However, there are few studies on how different organic and inorganic soil co...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,801 Views
18 Pages

11 May 2023

We present an ARXPS study on the surface composition and interfacial behavior of commercial [Rh(COD)2][TfO] in [C2C1Im][TfO], [C4C1Im][TfO], [C8C1Im][TfO], and [C2C1Im][EtOSO3]. The complex was found to be non-intact in a solution of these ILs throug...

  • Communication
  • Open Access
11 Citations
9,284 Views
10 Pages

Alcohol Dehydrogenation with a Dual Site Ruthenium, Boron Catalyst Occurs at Ruthenium

  • Zhiyao Lu,
  • Brock Malinoski,
  • Ana V. Flores,
  • Brian L. Conley,
  • Denver Guess and
  • Travis J. Williams

11 October 2012

The complex [(κ3-(N,N,O-py2B(Me)OH)Ru(NCMe)3]+ TfO− (1) is a catalyst for transfer dehydrogenation of alcohols, which was designed to function through a cooperative transition state in which reactivity was split between boron and ruthenium. We show h...

  • Article
  • Open Access
8 Citations
7,306 Views
10 Pages

The Valid Diagnostic Parameters in Bilateral CT Scan to Predict Unstable Syndesmotic Injury with Ankle Fracture

  • Si-Wook Lee,
  • Kyung-Jae Lee,
  • Chul Hyun Park,
  • Hyuk-Jun Kwon and
  • Beom-Soo Kim

13 October 2020

The purpose of this study is to evaluate the reasonable parameters to predict unstable syndesmotic injuries in ankle fractures. Seventy consecutive patients who underwent preoperative bilateral computed tomography (CT) scans were enrolled. Group A co...

  • Review
  • Open Access
1,800 Views
59 Pages

Turn-Taking Modelling in Conversational Systems: A Review of Recent Advances

  • Rutherford Agbeshi Patamia,
  • Ha Pham Thien Dinh,
  • Ming Liu and
  • Akansel Cosgun

Effective turn-taking is fundamental to conversational interactions, shaping the fluidity of communication across human dialogues and interactions with spoken dialogue systems (SDS). Despite its apparent simplicity, conversational turn-taking involve...

  • Communication
  • Open Access
12 Citations
3,066 Views
12 Pages

To acquire heme, Porphyromonas gingivalis uses a hemophore-like protein (HmuY). HmuY sequesters heme from host hemoproteins or heme-binding proteins produced by cohabiting bacteria, and delivers it to the TonB-dependent outer-membrane receptor (HmuR)...

  • Article
  • Open Access
7 Citations
11,738 Views
8 Pages

13 February 2009

To synthesize 4-chloro-5-methoxy-2-(b-trifluoroethyl)-3(2H)-pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH2CF3 (R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration...

  • Short Note
  • Open Access
1 Citations
1,833 Views
5 Pages

31 March 2023

This short note describes the synthesis of a novel compound, 6,6′-di-(8″-quinoline)-2,2′-bypyridine (2), that bears a bipyridyl backbone and quinoline donors. Compound 2 coordinates with a cobalt(II) ion in a tetradentate manner and...

  • Article
  • Open Access
9 Citations
3,881 Views
15 Pages

Effect of Co-Encapsulated Natural Antioxidants with Modified Starch on the Oxidative Stability of β-Carotene Loaded within Nanoemulsions

  • Ahmad Ali,
  • Abdur Rehman,
  • Seid Mahdi Jafari,
  • Muhammad Modassar Ali Nawaz Ranjha,
  • Qayyum Shehzad,
  • Hafiz Muhammad Shahbaz,
  • Sohail Khan,
  • Muhammad Usman,
  • Przemysław Łukasz Kowalczewski and
  • Wenshui Xia
  • + 1 author

20 January 2022

β-Carotene (vitamin A precursor) and α-tocopherol, the utmost energetic form of vitamin E (VE), are known to be fat-soluble vitamins (FSVs) and essential nutrients needed to enhance the growth and metabolic functions of the human body. The...

  • Article
  • Open Access
2 Citations
4,023 Views
11 Pages

Temperature and Pressure Dependence of the Infrared Spectrum of 1-Ethyl-3-Methylimidazolium Trifluoromethanesulfonate Ionic Liquid

  • Francesco Trequattrini,
  • Anna Celeste,
  • Francesco Capitani,
  • Oriele Palumbo,
  • Adriano Cimini and
  • Annalisa Paolone

26 June 2020

The infrared absorption spectrum of 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EMI–TfO) was investigated at ambient pressure and variable temperatures between 120 and 330 K, or at room temperature and variable pressures up to 10 GPa...

  • Article
  • Open Access
8 Citations
1,483 Views
10 Pages

SOS Approach for Practical Stabilization of Tempered Fractional-Order Power System

  • Hamdi Gassara,
  • Dhouha Kharrat,
  • Abdellatif Ben Makhlouf,
  • Lassaad Mchiri and
  • Mohamed Rhaima

7 July 2023

Fractional systems have been widely utilized in various fields, such as mathematics, physics and finance, providing a versatile framework for precise measurements and calculations involving partial quantities. This paper aims to develop a novel polyn...

  • Review
  • Open Access
9 Citations
4,964 Views
17 Pages

Recent Development in Biomedical Applications of Oligonucleotides with Triplex-Forming Ability

  • Incherah Bekkouche,
  • Alexander Y. Shishonin and
  • Alexandre A. Vetcher

9 February 2023

A DNA structure, known as triple-stranded DNA, is made up of three oligonucleotide chains that wind around one another to form a triple helix (TFO). Hoogsteen base pairing describes how triple-stranded DNA may be built at certain conditions by the at...

  • Communication
  • Open Access
5 Citations
2,982 Views
12 Pages

14 January 2023

The objective of this work was to study the electrochemical behavior of AB5 alloy and its composite with Pd nanoparticles in selected ionic liquids. The protic ionic liquid (diethylmethylammonium triflate) and the mixture of aprotic ionic liquid (1-e...

  • Review
  • Open Access
14 Citations
5,976 Views
12 Pages

Promising High-Tech Devices in Dry Eye Disease Diagnosis

  • Andrea De Luca,
  • Alessandro Ferraro,
  • Chiara De Gregorio,
  • Mariateresa Laborante,
  • Marco Coassin,
  • Roberto Sgrulletta and
  • Antonio Di Zazzo

21 June 2023

Background: Dry eye disease (DED) is a common and debilitating condition that affects millions of people worldwide. Despite its prevalence, the diagnosis and management of DED can be challenging, as the condition is multifactorial and symptoms can be...

  • Article
  • Open Access
2 Citations
3,026 Views
13 Pages

Metal-Free Phosphination and Continued Functionalization of Pyridine: A Theoretical Study

  • Pan Du,
  • Yuhao Yin,
  • Dai Shi,
  • Kexin Mao,
  • Qianyuan Yu and
  • Jiyang Zhao

3 September 2022

This study investigates the mechanism of metal-free pyridine phosphination with P(OEt)3, PPh3, and PAr2CF3 using density functional theory calculations. The results show that the reaction mechanism and rate-determining step vary depending on the phos...

  • Article
  • Open Access
1 Citations
2,374 Views
19 Pages

14 October 2022

For the asymmetric six-phase motor fed by a two-level six-phase voltage source inverter (VSI), when the modulation index is less than 0.5774, the motor operates in the linear region, and the harmonics in the Z1 − Z2 subspace can be suppressed t...

  • Article
  • Open Access
6 Citations
5,662 Views
21 Pages

19 August 2020

Background: The frequency of visits to restaurants has been suggested to contribute to the pandemic of obesity. However, few studies have examined how individual use of these restaurants is related to Body Mass Index (BMI). Aim: To investigate the as...

  • Article
  • Open Access
7 Citations
2,729 Views
17 Pages

13 April 2022

Density functional theory (DFT) calculations have been performed to investigate the interfacial interactions of ionic liquids (ILs) on the α- and β-phases of phosphorene (P) and arsenene (As). Nine representative ILs based on the combinati...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,788 Views
20 Pages

23 February 2023

Currently, freshwater scarcity is one of the main issues that the world population has to face. To address this issue, new wastewater treatment technologies have been developed such as membrane processes. Among them, due to the energy disadvantages o...

  • Article
  • Open Access
1 Citations
1,653 Views
19 Pages

Conformational Geometry Matters: The Case of the Low-Melting-Point Systems of Tetrabutylammonium Triflate with Fumaric or Maleic Acid

  • Simone Di Muzio,
  • Fabio Ramondo,
  • Oriele Palumbo,
  • Francesco Trequattrini,
  • Pascale Roy,
  • Jean-Blaise Brubach and
  • Annalisa Paolone

28 October 2024

For this article, the interaction of tetrabutylammonium trifluoromethanesulfonate (TBATFO) with either fumaric (FUM) or maleic (MAL) acid has been investigated. These acids are isomers and can be considered the trans and cis configurations of the sam...

  • Article
  • Open Access
6 Citations
3,036 Views
15 Pages

30 June 2023

The dynamical properties of four protic ionic liquids, based on the ethyltriazolium ([C2HTr124]) and the ethylimidazolium ([C2HIm]) cation, were investigated. The associated anions were the triflate ([TfO]) and the bistriflimide ([TFSI]). Ionic condu...

  • Review
  • Open Access
2,073 Views
17 Pages

Pregnancy and Dry Eye Syndrome: A Review for Clinical Practice

  • Marta Jaruchowska,
  • Joanna Przybek-Skrzypecka and
  • Janusz Skrzypecki

14 October 2025

Pregnancy is a unique physiological state associated with profound hormonal, metabolic, and immunological changes that may affect ocular surface homeostasis. Among these changes, fluctuations in estrogen and progesterone are the most consistent facto...

  • Article
  • Open Access
7 Citations
2,664 Views
21 Pages

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes

  • Mónica Martínez-Estévez,
  • Soledad García-Fontán,
  • Saray Argibay-Otero,
  • Inmaculada Prieto and
  • Ezequiel M. Vázquez-López

17 November 2022

The reaction of [Ru2Cl2(μ-Cl)2(η6-p-cymene)2] with two thiosemicarbazones obtained by the condensation of N-(4-methoxybenzyl) thiosemicarbazide and 1,4-hydroxy-3-methoxyphenyl)ethan-1-one (HL1) or 2-fluoro-4-hydroxybenzaldehyde (HL2) was studi...

  • Article
  • Open Access
783 Views
12 Pages

Advancing Diagnostics with Semi-Automatic Tear Meniscus Central Area Measurement for Aqueous Deficient Dry Eye Discrimination

  • Hugo Pena-Verdeal,
  • Jacobo Garcia-Queiruga,
  • Belen Sabucedo-Villamarin,
  • Carlos Garcia-Resua,
  • Maria J. Giraldez and
  • Eva Yebra-Pimentel

22 July 2025

Background and Objectives: To clinically validate a semi-automatic measurement of Tear Meniscus Central Area (TMCA) to differentiate between Non-Aqueous Deficient Dry Eye (Non-ADDE) and Aqueous Deficient Dry Eye (ADDE) patients. Materials and Methods...

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