282 Results Found

Background/Objectives: Triosephosphate Isomerase (TPI) is a glycolytic enzyme known to be associated with TPI deficiency, a severe form of childhood-onset glycolytic enzymopathy associated with hemolytic anemia, neuromuscular impairment and early dea...

The Transition Planning Inventory (TPI) is an important tool for planning the transition to life after school for students with disabilities. While interest in transition services has increased in the last decade in the Arab region, no transition ass...

Digital elevation models (DEMs), as the fundamental unit of terrain morphology, are crucial for understanding surface processes and for land use planning. However, automated classification faces challenges due to inefficient terrain feature extractio...

Background: Iron metabolism has emerged as a critical factor in cancer biology, with elevated intracellular iron levels contributing to increased oxidative stress and tumorigenesis. However, the molecular determinants governing ferroptosis sensitivit...

Leaf color mutants are key resources for uncovering the molecular mechanisms of chloroplast development and photosynthesis. Here, we identified a novel yellow-green melon mutant, ‘ygp2’, which displays yellow-green leaves and dwarfism thr...

Trans-l,4-polyisoprene (TPI) shape memory polymer composites with different chopped carbon fiber mass fractions were prepared to study the effects of different chopped carbon fiber mass fractions and temperatures on the TPI shape memory polymer compo...

Mycoplasma bovis is a global problem for the cattle industry due to its high infection rates and associated morbidity, although its pathophysiology is poorly understood. In this study, the M. bovis transcriptome and proteome were analyzed to further...

Trifluridine/tipiracil (FTD/TPI) (a.k.a. TAS-102) is a combination drug for metastatic colorectal cancer (CRC) and severely pretreated metastatic gastric/gastroesophageal junction (GEJ) cancers, comprising FTD, a thymidine-based antineoplastic nucleo...

T-cell acute lymphoblastic leukemia (T-ALL) is a challenging childhood cancer to treat, with limited therapeutic options and high relapse rates. This study explores deamidated triosephosphate isomerase (dTPI) as a novel therapeutic target. We hypothe...

The fall armyworm, Spodoptera frugiperda, is an important agricultural pest native to tropical and subtropical regions of the Western Hemisphere, and has invaded Africa and further spread into most countries of Asia within two years. Here, we analyze...

Roughness can be used to characterize the morphologies of a lava flow. It can be used to identify lava flow features, provide insight into eruption conditions, and link roughness pattern across a lava flow to emplacement conditions. In this study, we...

Metastatic gastric cancer (mGC) represents an economic and societal burden worldwide. The present study has two aims. Firstly, it evaluates the benefits and the added value of the introduction of trifluridine/tipiracil (FTD/TPI) in the Italian clinic...

Based on Himawari-8 Sea Surface Temperature (SST) data and the semi-automatic Topographic Position Index (TPI)-based mapping method, this study maps the significant coastal upwelling in the northern South China Sea (NSCS). The results show that the M...

Terahertz pulsed imaging (TPI) was introduced approximately fifteen years ago and has attracted a lot of interest in the pharmaceutical industry as a fast, non-destructive modality for quantifying film coatings on pharmaceutical dosage forms. In this...

Targeted protein inactivation (TPI) is an elegant approach to investigate protein function and its role in the cellular landscape, overcoming limitations of genetic perturbation strategies. These systems act in a reversible manner and reduce off-targ...

Background: Outcomes for patients with metastatic colorectal cancer (MCRC) are improving with the introduction of new treatments. Treatment for patients who are still fit after failure of all available therapies represents a significant unmet need. I...

In the past decade, Light Detection and Ranging (lidar) has fundamentally changed our ability to remotely detect archaeological features and deepen our understanding of past human-environment interactions, settlement systems, agricultural practices,...

The fall armyworm, Spodoptera frugiperda, an invasive, polyphagous pest, causes significant damage to corn. The majority of insects rely on a broad range of digestive enzymes and an intricate detoxifying mechanism to consume chemically diverse host p...

This study reports on heat transfer augmentation by knitted wire coil turbulators in a fully developed turbulent regime. Four knitted wire coil turbulators with different wire loop number densities (N = 6, 8, 10, and 12 loops per pitch, with 1.0 pitc...

With the development of cities, traffic congestion has become a common problem, which seriously affects the efficiency of motorway transport. This study proposed an improved ML-YOLO video data extraction model based on You Only Look Once (YOLOv8n) co...

Remote sensing plays an increasingly key role in the determination of soil organic carbon (SOC) stored in agriculturally managed topsoils at the regional and field scales. Contemporary Unmanned Aerial Systems (UAS) carrying low-cost and lightweight m...

The leaf is an important photosynthetic organ and plays an essential role in the growth and development of plants. Leaf color mutants are ideal materials for studying chlorophyll metabolism, chloroplast development, and photosynthesis. In this study,...

The characterization of prehistoric human behavior in terms of habitation practices using GIS cartography methods is an important aspect of any modern geoarchaeological approach. Furthermore, using unmanned aerial vehicle (UAV) surveys to identify ar...

Power electronics-based converters have been widely used in several applications, specifically electric propulsion systems. Ongoing advancements in converters have led to high-gain Quadratic Boost Converters (QBC) which control Permanent Magnet Synch...

This case study focuses on the area of El Plateado near the city of Loja, Ecuador, where landslides with a high impact on infrastructures require monitoring and control. The main objectives of this work are the characterization of the landslide and t...

Geological lineaments are linear or curvilinear surfaces that are considered a superficial expression of discontinuities on the earth’s surface. The extraction of lineaments from remotely sensed satellite data is one of the most frequently used...

The availability of portable water in sufficient quantity and standard quality is one of the basic requirements of a civilization. The study area of this present work is the University of Kashmir, where the existing WDS has served its function for mo...

Ravine forests are key to conserving biodiversity and maintaining ecosystem processes in fragmented landscapes. Here, we evaluated the phenology of plant species in the Los Nogales Nature Sanctuary (Lo Barnechea, Chile) using Sentinel-2 images (2019&...

The social burden of dementia is remarkable since it affects some 57.4 million people all over the world. Impairment of autophagy in age-related diseases, such as dementia, deserves deep investigation for the detection of novel disease-modifying appr...

The landforms of the Earth’s surface ranging from large-scale features to local topography are factors that influence human behavior in terms of habitation practices. The ability to extract geomorphological settings using geoinformatic techniqu...

Cryptosporidium spp. and Giardia duodenalis are the main non-viral causes of diarrhoea in humans and domestic animals globally. Comparatively, much less information is currently available in free-ranging carnivore species in general and in the endang...

In this article, we survey various non-contact, non-destructive testing methods by way of terahertz (THz) spectroscopy and imaging designed for use in various industrial sectors. A brief overview of the working principles of THz spectroscopy and imag...

Analyses of thermokarst hazard risk are becoming increasingly crucial in the context of global warming. A significant aspect of thermokarst research is the mapping of landscapes based on their vulnerability to thermokarst processes. The exponential g...

Energy poverty remains a pressing social and policy challenge across Europe, particularly in countries like Greece, where economic disparities and climatic conditions vary significantly between regions. This paper presents a scalable and transparent...

Background/Objectives: Patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy face limited treatment options. While trifluridine–tipiracil (FTD–TPI) and regorafenib have shown modest efficacy in prio...

Two-photon imaging (TPI) microscopy, namely, two-photon excited fluorescence (TPEF), fluorescence lifetime imaging (FLIM), and second-harmonic generation (SHG) modalities, has emerged in the past years as a powerful tool for the examination of biolog...

In 2016, the fall armyworm (FAW), Spodoptera frugiperda, invaded western Africa and rapidly spread in sub-Saharan Africa, causing significant losses in yields of corn, a major food crop in Africa. Although the Democratic Republic of the Congo (DRC) i...

Triosephosphate isomerase (TPI) is a glycolysis enzyme, which catalyzes the reversible isomerization between dihydroxyactetone-3-phosphate (DHAP) and glyceraldehyde-3-phosphate (GAP). In pathogenic organisms, TPI is essential to obtain the energy use...

In this study, a triangular polynomial interpolation (TPI) scheme was developed to estimate the vertical eddy viscosity coefficient (VEVC) on the basis of the Ekman model with adjoint assimilation. In the twin experiments, the advantages and disadvan...

Triosephosphate isomerase (TPI) dysfunction is a critical factor in diverse pathological conditions. Deficiencies in TPI lead to the accumulation of toxic methylglyoxal (MGO), which induces non-enzymatic post-translational modifications, thus comprom...

Thermoplastic polyimides (TPIs) are promising lightweight materials for replacing metal components in aerospace, rocketry, and automotive industries. Key TPI attributes include low density, thermal stability, mechanical strength, inherent flame retar...

Shape memory composites of trans-1,4-polyisoprene (TPI) and low-density polyethylene (LDPE) with easily achievable transition temperatures were prepared by a simple physical blending method. Carbon black (CB) was introduced to improve the mechanical...

The main causative agent of pneumonia, Streptococcus pneumoniae, is also responsible for invasive diseases. S. pneumoniae recruits human plasminogen for the invasion and colonization of host tissues. We previously discovered that S. pneumoniae triose...

Thermoplastic polyimide (TPI) was synthesized via a traditional one-step method using 2,3,3′,4′-biphenyltetracarboxylic dianhydride (3,4′-BPDA), 4,4′-oxydianiline (4,4′-ODA), and 2,2′-bis(trifluoromethyl)benzidine...

Background: Gastric cancer mortality remains among the highest of all cancers. Trifluridine/tipiracil (FTD/TPI) represents Canada’s first standard-of-care, third-line, systemic therapy for metastatic gastric/gastroesophageal cancer. We characte...

Calves are born agammaglobulinemic and they rely on transfer of passive immunity (TPI) through ingestion of colostrum from the dam. Ensuring the effectiveness of TPI through blood serum immunoglobulins (IgG) quantification is of critical importance f...

Teacher’s professional identity (TPI) is an essential and decisive element in the way future EY and primary teachers approach their labour. This study aims to analyse how and when student teachers build TPI and to study its relationship with pe...

Background: Our objective was to identify and validate proteins that predict which patients with ovarian cancer will respond to SHetA2, an investigational drug in a phase 1 trial for patients with advanced or recurrent solid tumors (clinicaltrials.go...

The performance and programming conditions of the triple shape memory of crosslinked trans-polyisoprene/poly (ethylene-co-vinyl acetate) (TPI/EVA) composites with different contents of dicumyl peroxide (DCP) were investigated. The effect of triple sh...

In this study, which was inspired by mussel-biomimetic bonding research, carbon nanotubes (CNTs) were interfacially modified with polydopamine (PDA) to prepare a novel nano-filler (CNTs@PDA). The structure and properties of the CNTs@PDA were studied...