- Article
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
- Sofia Ranta-aho,
- Niina Piippo,
- Eveliina Korhonen,
- Kai Kaarniranta,
- Maria Hytti and
- Anu Kauppinen
Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation leading to the maturation...