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Open AccessArticle

Modulation of Food Intake by Differential TAS2R Stimulation in Rat

1
MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
2
Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
3
CIBER Obesity and Nutrition, Institute of Health Carlos III, Av. Diagonal 643, 08028 Barcelona, Spain
4
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3784; https://doi.org/10.3390/nu12123784
Received: 31 October 2020 / Revised: 3 December 2020 / Accepted: 4 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Appetite and Satiety Control-Gut Mechanisms)
Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats. View Full-Text
Keywords: TAS2R5; TAS2R39; TAS2R14; agonist; food intake; GLP1; CCK; PYY TAS2R5; TAS2R39; TAS2R14; agonist; food intake; GLP1; CCK; PYY
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MDPI and ACS Style

Grau-Bové, C.; Miguéns-Gómez, A.; González-Quilen, C.; Fernández-López, J.-A.; Remesar, X.; Torres-Fuentes, C.; Ávila-Román, J.; Rodríguez-Gallego, E.; Beltrán-Debón, R.; Blay, MT.; Terra, X.; Ardévol, A.; Pinent, M. Modulation of Food Intake by Differential TAS2R Stimulation in Rat. Nutrients 2020, 12, 3784. https://doi.org/10.3390/nu12123784

AMA Style

Grau-Bové C, Miguéns-Gómez A, González-Quilen C, Fernández-López J-A, Remesar X, Torres-Fuentes C, Ávila-Román J, Rodríguez-Gallego E, Beltrán-Debón R, Blay MT, Terra X, Ardévol A, Pinent M. Modulation of Food Intake by Differential TAS2R Stimulation in Rat. Nutrients. 2020; 12(12):3784. https://doi.org/10.3390/nu12123784

Chicago/Turabian Style

Grau-Bové, Carme; Miguéns-Gómez, Alba; González-Quilen, Carlos; Fernández-López, José-Antonio; Remesar, Xavier; Torres-Fuentes, Cristina; Ávila-Román, Javier; Rodríguez-Gallego, Esther; Beltrán-Debón, Raúl; Blay, M T.; Terra, Ximena; Ardévol, Anna; Pinent, Montserrat. 2020. "Modulation of Food Intake by Differential TAS2R Stimulation in Rat" Nutrients 12, no. 12: 3784. https://doi.org/10.3390/nu12123784

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