Abstract: Major biophysical, economic, and political changes in the Arctic regions during the past two decades has grown business opportunities in the Arctic countries, such as tourism. More specifically, with a focus on sustainability of resources,...
In dogs, symmetrical lupoid onychodystrophy (SLO) results in nail loss and an abnormal regrowth of the claws. In Bearded Collies, an autoimmune nature has been suggested because certain dog leukocyte antigen (DLA) class II haplotypes are associated w...
The aim of this study was to compare measurements of macular thickness, obtained from patients with diabetic macular edema, using two spectral-domain optical coherence tomography (SD-OCT) devices. These were the Spectralis Heidelberg Retina Angiograp...
Sperm cells must undergo a complex maturation process after ejaculation to be able to fertilize an egg. One component of this maturation is hyperpolarization of the membrane potential to a more negative value. The ion channel responsible for this hyp...
Sperm ion channels are associated with the quality and type of flagellar movement, and their differential regulation is crucial for sperm function during specific phases. The principal potassium ion channel is responsible for the majority of K+ ion f...
Background/Objectives: Smith–Lemli–Opitz syndrome (SLOS) is a genetic metabolic disorder characterized by impaired cholesterol synthesis and a wide range of developmental anomalies. This article presents a case of a girl with SLOS, diagno...
This study sought to identify and localize SLO1 channels in boar spermatozoa by immunoblotting and immunofluorescence, and to determine their physiological role during in vitro sperm capacitation. Sperm samples from 14 boars were incubated in a capac...
Propose an enhanced LoRA (Low-Rank Adaptation) MoE (mixed expert) architecture, SLoRA (Enhanced LoRA MoE Architecture), aimed at addressing the key problem of efficient parameter fine-tuning in multitasking scenarios. Given the high cost of tradition...
BKCa channels, originally discovered in Drosophila melanogaster as slowpoke (slo), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BKCa channels in cellular and organ protection possibly for thei...
Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome,...
The Covid-19 crisis lockdown caused rapid transformation to remote working/learning modes and the need for e-commerce-, web-education-related projects development, and maintenance. However, an increase in internet traffic has a direct impact on infra...
Failure prediction is an important aspect of self-aware computing systems. Therefore, a multitude of different approaches has been proposed in the literature over the past few years. In this work, we propose a taxonomy for organizing works focusing o...
Lithium, that is now exclusively produced outside the European Union (EU), is needed urgently for the green energy transition. The EU has promising lithium projects; however, the social license to operate (SLO) is important for their long-term viabil...
Multiple sclerosis (MS), a chronic disease of the central nervous system, is known to cause structural and vascular changes in the retina. Although optical coherence tomography (OCT) and fundus photography can detect retinal thinning and circulatory...
Scanning laser ophthalmoscopes (SLOs) have been available since the early 1990s, but they were not commonly used because their advantages were not enough to replace conventional color fundus photography. In recent years, color SLOs have improved sign...
Background: Smith–Lemli–Opitz syndrome (SLOS) is an inborn error of cholesterol biosynthesis, caused by biallelic mutations in the DHCR7 gene. Genotype–phenotype correlations regarding DHCR7 variants could explain the variation in s...
Symmetrical lupoid onychodystrophy (SLO) is characterized by inflammation of the nail bed and nail sloughing that causes affected dogs considerable pain. Disease etiology remains unclear, although an autoimmune component is suspected. A genome-wide a...
Research investigating the mechanisms that contribute to romantic love is in its infancy. The behavioral activation system is one biopsychological system that has been demonstrated to play a role in several motivational outcomes. This study was the f...
Geothermal energy is a resource that has the potential for development in many countries around the world. Despite its versatility and economic viability, this resource faces numerous obstacles that hinder its deployment and capacity for achieving a...
The Social License to Operate (SLO) has become a key component of mining sustainability. However, the literature continues to address its main dimensions through fragmented approaches, limiting the understanding of social legitimacy as a dynamic and...
Multi-anthelmintic resistance in hookworms poses a significant challenge to both human and veterinary health, underscoring the need for novel treatment strategies. In this study, we evaluated the in vitro efficacy of three anthelmintics—pyrante...
Large language model (LLM) serving has emerged as a major source of energy consumption in modern AI infrastructure. In current deployments, graphics processing units (GPUs) are typically operated at default high-frequency settings to maximize perform...
Inference now dominates the lifecycle footprint of large language models, yet published estimates often use inconsistent boundaries and optimize carbon while ignoring water. We present a provider-agnostic framework that unifies scope-transparent meas...
No commercial vaccine is yet available against Group A Streptococcus (GAS), major cause of pharyngitis and impetigo, with a high frequency of serious sequelae in low- and middle-income countries. Group A Carbohydrate (GAC), conjugated to an appropria...
Smith–Lemli–Opitz syndrome (SLOS) is a rare, autosomal recessive genetic disorder caused by mutations in the DHCR7 gene, which encodes the enzyme responsible for the final step in cholesterol biosynthesis. Impaired enzyme function leads t...
Little data exist about the physiological role of ion channels during the freeze–thaw process in mammalian sperm. Herein, we determined the relevance of potassium channels, including SLO1, and of voltage-gated proton channels (HVCN1) during mammalian...
Smith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC). 7-DHC spontaneously oxid...
The measurement of antibodies to vaccine antigens is crucial for research towards a safe and effective vaccine for Streptococcus pyogenes (Strep A). We describe the establishment and detailed characterisation of a four-plex assay to measure IgG to th...
Retinal imaging has undergone a revolution in the past 50 years to allow for better understanding of the eye in health and disease. Significant improvements have occurred both in hardware such as lasers and optics in addition to software image analys...
Brn3b (Pou4f2) is a class-4 POU domain transcription factor known to play central roles in the development of different neuronal populations of the Central Nervous System, including retinal ganglion cells (RGCs), the neurons that connect the retina w...
The Social License to Operate (SLO), understood as the consent of a wide group of stakeholders to mining activities, has become an important element in the process of obtaining a mining license in recent years. Such a pattern of increasing importance...
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the KCNT1 gene. KCNT1 encodes the sodium-activated potassium channel known as SLACK,...
The aim of our study was to investigate the clinical features of central serous chorioretinopathy (CSC) with autofluorescence (AF), retromode (RM), and enface imaging. This retrospective study was conducted at Fondazione Policlinico Universitario A....
The aim of the present study was to assess the effects exerted in vitro by three asymmetrical porphyrins (5-(2-hydroxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrin, 5-(2-hydroxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrinat...
GAL-021 has recently been developed as a novel breathing control modulator. However, modifications of ionic currents produced by this agent remain uncertain, although its efficacy in suppressing the activity of big-conductance Ca2+-activated K+ (BKCa...
The emerging serverless computing has become a captivating paradigm for deploying cloud applications, alleviating developers’ concerns about infrastructure resource management by configuring necessary parameters such as latency and memory const...
Internet of Things (IoT) covers scenarios of cyber–physical interaction of smart devices with humans and the environment and, such as applications in smart city, smart manufacturing, predictive maintenance, and smart home. Traditional scenarios...
Calcium- and voltage-gated potassium channels of large conductance (BK channels) in smooth muscle (SM) act as part of a negative feedback mechanism on SM contraction and associated decrease in cerebral artery diameter. Functional BK channels result f...
This article articulates the outcomes of the spatial survey of an EU Interreg-funded project titled “Development of Innovation Eco-Systems and Value Chains: Supporting Cross-Border Innovation through Creative Industries” (DIVA). The study...
Age-related macular degeneration (ARMD), a major cause of sight impairment for elderly people, is still not well understood despite intensive research. Measuring the size of the lesions in the fundus is the main biomarker of the severity of the disea...
Using Starting Strong as a case study, this article examines how four successful Student Learning Outcomes (SLO’s) emerged and one was eliminated during the Quality Enhancement Plan’s (QEP’s) development process. In comparison to th...
(1) Background: The fundus examination is one of the best and popular methods in the assessment of vascular status in the human body. Direct viewing of retinal vessels by ophthalmoscopy has been utilized in judging hypertensive change or arterioscler...
To address the limitations of traditional optimization methods in achieving high accuracy in high-dimensional problems, this paper introduces the snow leopard optimization (SLO) algorithm. SLO is a novel meta-heuristic approach inspired by the territ...
As the two types of major impurities in FCC slurry oil (SLO), olefins and sulfur seriously deteriorate the preparation and quality of mesophase pitch or needle coke. The development of a hydrotreatment for SLO to remove olefins and sulfur selectively...
Research has firmly established that infection by human immunodeficiency virus (HIV) leads to structural disruption in secondary lymph organs (SLOs) and that IL-7 expression by SLOs is downregulated in simian immunodeficiency virus (SIV)-infected rhe...
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an unlimited source of human CMs that could be a standard tool in drug research. However, there is concern whether hiPSC-CMs express all cardiac ion channels at physiolo...
Carbon farming has expanded in Australia’s rangelands over recent years, incentivised under the Australian Government’s Emissions Reduction Fund. While this has largely been driven by economic benefits for landholders, the long-term viabi...
A reliable, sustainable, and transparent supply of critical raw materials is vital for developing future technologies and transitioning to a carbon emission-free world. However, mining can generate social, economic, and environmental impacts, comprom...
Large-conductance, voltage- and calcium-activated potassium (BK) channels are crucial regulators of cellular excitability, influenced by various signaling molecules, including heme. The BK channel contains a heme-sensitive motif located at the sequen...
Gain-of-function mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel known as SLACK, are associated with the rare but devastating developmental and epileptic encephalopathy known as epilepsy of infancy with migrating foc...
of 4