Special Issue "Canine Genetics"
Deadline for manuscript submissions: closed (1 July 2019) | Viewed by 59832
Interests: dog breeds; canine genetics; prostate cancer; domestic dog
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The domestic dog is unique among mammals, as it divided into an extraordinary number of breeds (over 400), with each characterized by specific attributes of behavior and morphology. However, the recent timeframe for the development of most breeds and their associated breeding programs means that dogs develop most of the same diseases as humans, often with the same symptoms, pathology, and response to treatment. Since the 1990s, we as a community have worked to develop the dog as a genetic system on par with other commonly used mammalian model systems (e.g., mice). This was facilitated first by the creation of maps which permitted navigation of the dog genome, followed by whole-genome sequencing of the boxer in 2005. Since then, we have developed a plethora of tools and resources for advancing dog genomics, as evidenced by the enormous strides in mapping genes and identifying variants responsible for diseases and breed traits important to both human and animal health. Key to fully exploiting the dog system is a need to understand critical issues in dog history, such as domestication, timing, and mechanisms of individual breed formation, and to perform additional whole-genome sequencing. Equally important are the needed advances in bioinformatics that will allow us to accurately identify actionable genetic variants among the many candidates presented from association and sequencing studies. For this Special Issue, we will present state-of-the-art work in canine genetics and genomics, assembling the most recent advances in our field in one place.
Dr. Elaine Ostrander
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