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336 Results Found

  • Article
  • Open Access
1 Citations
1,176 Views
14 Pages

4 March 2025

This study proposes an optimized approach to enhance the performance of the Weighted Geometric Center (WGC) method for stabilizing time-delay systems, which has applications in industrial process control, robotics, and high-order dynamic systems. The...

  • Article
  • Open Access
9 Citations
2,775 Views
18 Pages

24 August 2024

PI-PD controllers have superior performance compared to traditional PID controllers, especially for controlling unstable and integrating industrial processes with time delays. However, computing the four tuning parameters of this type of controller i...

  • Article
  • Open Access
1 Citations
1,943 Views
16 Pages

29 September 2023

For series cascade processes with a time delay, such as the first-order with time-delay (FOTD) process, the integral with time-delay (ITD) process, second-order integral with time-delay (SOITD) process, and unstable first-order with time-delay (UFOTD...

  • Article
  • Open Access
9 Citations
4,667 Views
25 Pages

Design and Development of Complex-Order PI-PD Controllers: Case Studies on Pressure and Flow Process Control

  • Muhammad Najmi Bin Roslan,
  • Kishore Bingi,
  • P. Arun Mozhi Devan and
  • Rosdiazli Ibrahim

This article examines the performance of the proposed complex-order, conventional and fractional-order controllers for process automation and control in process plants. The controllers are compared regarding disturbance rejection and set-point tracki...

  • Article
  • Open Access
23 Citations
3,311 Views
20 Pages

MPPT of PEM Fuel Cell Using PI-PD Controller Based on Golden Jackal Optimization Algorithm

  • Ahmed M. Agwa,
  • Tarek I. Alanazi,
  • Habib Kraiem,
  • Ezzeddine Touti,
  • Abdulaziz Alanazi and
  • Dhari K. Alanazi

14 September 2023

Subversive environmental impacts and limited amounts of conventional forms of energy necessitate the utilization of renewable energies (REs). Unfortunately, REs such as solar and wind energies are intermittent, so they should be stored in other forms...

  • Article
  • Open Access
10 Citations
2,215 Views
49 Pages

Efficient Frequency Management for Hybrid AC/DC Power Systems Based on an Optimized Fuzzy Cascaded PI−PD Controller

  • Awadh Ba Wazir,
  • Sultan Alghamdi,
  • Abdulraheem Alobaidi,
  • Abdullah Ali Alhussainy and
  • Ahmad H. Milyani

19 December 2024

A fuzzy cascaded PI−PD (FCPIPD) controller is proposed in this paper to optimize load frequency control (LFC) in the linked electrical network. The FCPIPD controller is composed of fuzzy logic, proportional integral, and proportional derivative...

  • Article
  • Open Access
51 Citations
3,774 Views
34 Pages

14 November 2022

Frequency, voltage, and power flow between different control zones in an interconnected power system are used to determine the standard quality of power. Therefore, the voltage and frequency control in an IPS is of vital importance to maintaining rea...

  • Article
  • Open Access
48 Citations
5,985 Views
30 Pages

26 September 2022

The stability control of nominal frequency and terminal voltage in an interconnected power system (IPS) is always a challenging task for researchers. The load variation or any disturbance affects the active and reactive power demands, which badly inf...

  • Article
  • Open Access
15 Citations
3,994 Views
16 Pages

25 December 2022

This paper presents a controller design technique for cascade control systems based on the grey wolf optimization (GWO) algorithm. In the proposed control scheme, the proportional-integral-proportional-derivative (PI-PD) controller structure is used...

  • Article
  • Open Access
34 Citations
3,146 Views
32 Pages

Development of Slime Mold Optimizer with Application for Tuning Cascaded PD-PI Controller to Enhance Frequency Stability in Power Systems

  • Slim Abid,
  • Ali M. El-Rifaie,
  • Mostafa Elshahed,
  • Ahmed R. Ginidi,
  • Abdullah M. Shaheen,
  • Ghareeb Moustafa and
  • Mohamed A. Tolba

10 April 2023

Multi-area power systems (MAPSs) are highly complex non-linear systems facing a fundamental issue in real-world engineering problems called frequency stability problems (FSP). This paper develops an enhanced slime mold optimization algorithm (ESMOA)...

  • Article
  • Open Access
4 Citations
2,665 Views
16 Pages

1 July 2024

This research aims to apply Artificial Intelligence (AI) methods, specifically Artificial Immune Systems (AIS), to design an optimal control strategy for a multivariable control plant. Two specific industrial control approaches are investigated: I-PD...

  • Article
  • Open Access
3 Citations
1,792 Views
20 Pages

2 November 2023

In a smart grid (SG) system with load uncertainties and the integration of variable solar and wind energies, an effective frequency control strategy is necessary for generation and load balancing. Cyberattacks are emerging threats, and SG systems are...

  • Article
  • Open Access
25 Citations
5,433 Views
18 Pages

NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer

  • Tung-Yung Huang,
  • Tung-Cheng Chang,
  • Yu-Tang Chin,
  • Yi-Shin Pan,
  • Wong-Jin Chang,
  • Feng-Cheng Liu,
  • Ema Dwi Hastuti,
  • Shih-Jiuan Chiu,
  • Shwu-Huey Wang and
  • Paul J. Davis
  • + 11 authors

3 August 2020

The property of drug-resistance may attenuate clinical therapy in cancer cells, such as chemoresistance to gefitinib in colon cancer cells. In previous studies, overexpression of PD-L1 causes proliferation and metastasis in cancer cells; therefore, t...

  • Article
  • Open Access
1 Citations
1,620 Views
22 Pages

In Vivo PK-PD and Drug–Drug Interaction Study of Dorzagliatin for the Management of PI3Kα Inhibitor-Induced Hyperglycemia

  • Guanqin Jin,
  • Kewei Zheng,
  • Shihuang Liu,
  • Huan Yi,
  • Wei Wei,
  • Congjian Xu,
  • Xiaoqiang Xiang and
  • Yu Kang

Objectives: The anticancer effects of PI3Kα inhibitors (PI3Ki) are constrained by their hyperglycemic side effects, while the efficacy of conventional hypoglycemic agents, such as insulin, metformin, and SGLT-2 inhibitors, in mitigating PI3Ki-i...

  • Article
  • Open Access
4 Citations
2,625 Views
17 Pages

Robust Fractional-Order PI/PD Controllers for a Cascade Control Structure of Servo Systems

  • Vo Lam Chuong,
  • Ngo Hong Nam,
  • Le Hieu Giang and
  • Truong Nguyen Luan Vu

In this paper, a cascade control structure is suggested to control servo systems that normally include a servo motor in coupling with two kinds of mechanism elements, a translational or rotational movement. These kinds of systems have high demands fo...

  • Review
  • Open Access
115 Citations
14,390 Views
16 Pages

Postural Instability in Parkinson’s Disease: A Review

  • Bhavana Palakurthi and
  • Sindhu Preetham Burugupally

18 September 2019

Parkinson’s disease (PD) is a heterogeneous progressive neurodegenerative disorder, which typically affects older adults; it is predicted that by 2030 about 3% of the world population above 65 years of age is likely to be affected. At present,...

  • Article
  • Open Access
15 Citations
2,521 Views
24 Pages

Applications of Novel Combined Controllers for Optimizing Grid-Connected Hybrid Renewable Energy Systems

  • Fatima Menzri,
  • Tarek Boutabba,
  • Idriss Benlaloui,
  • Larbi Chrifi-Alaoui,
  • Abdulaziz Alkuhayli,
  • Usama Khaled and
  • Mohamed Metwally Mahmoud

9 August 2024

Hybrid renewable energy systems (HRES) integrating solar, wind, and storage technologies offer enhanced efficiency and reliability for grid-connected applications. However, existing control methods often struggle with maintaining DC voltage stability...

  • Article
  • Open Access
4 Citations
2,705 Views
18 Pages

29 August 2024

This research delves into the primary issue of polyimide (PI) insulation failures in high-frequency power transformers (HFPTs) by scrutinizing partial discharge development under high-frequency electrical stress. This study employs an experimental ap...

  • Review
  • Open Access
12 Citations
7,393 Views
26 Pages

11 June 2024

The introduction of anti-programmed cell death protein-1 (anti-PD-1) to the clinical management of triple-negative breast cancer (TNBC) represents a breakthrough for a disease whose treatment has long relied on the standards of chemotherapy and surge...

  • Article
  • Open Access
15 Citations
4,201 Views
16 Pages

25 February 2021

HNSCC is the sixth most common cancer, with around 650,000 new cases yearly. Gain of function mutations in the PI3K pathway are common in HNSCC, and inhibition of the PI3K p110γ subunit has shown promise in HNSCC treatment. However, given that PI3K p...

  • Article
  • Open Access
3 Citations
6,142 Views
21 Pages

AMPK Is the Crucial Target for the CDK4/6 Inhibitors Mediated Therapeutic Responses in PANC-1 and MIA PaCa-2 Pancreatic Cancer Cell Lines

  • Bortecine Sevgin,
  • Merve Nur Coban,
  • Özge Rencuzogullari,
  • Ajda Coker-Gurkan,
  • Pinar Obakan-Yerlikaya,
  • Pinar Uysal Onganer and
  • Elif Damla Arisan

18 March 2021

The survival rate of pancreatic ductal adenocarcinoma (PDAC) patients is short, and PDAC is a cancer type that ranks fourth in the statistics regarding death due to cancer. Mutation in the KRAS gene, which plays a role in pancreatic cancer developmen...

  • Article
  • Open Access
3,213 Views
16 Pages

21 December 2023

Internet of Things (IoT) applications based on the single-board computer Raspberry Pi depend on reliable and sufficiently powerful energy systems to allow system diversity, flexibility, and available computing power. On this account, we developed an...

  • Article
  • Open Access
14 Citations
3,751 Views
22 Pages

Optimal Cascade Non-Integer Controller for Shunt Active Power Filter: Real-Time Implementation

  • Hoda Nikkhah Kashani,
  • Reza Rouhi Ardeshiri,
  • Meysam Gheisarnejad and
  • Mohammad-Hassan Khooban

1 April 2022

Active power filters (APFs) are used to mitigate the harmonics generated by nonlinear loads in distribution networks. Therefore, due to the increase of nonlinear loads in power systems, it is necessary to reduce current harmonics. One typical method...

  • Article
  • Open Access
53 Citations
5,560 Views
16 Pages

Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells

  • Alexis Rugamba,
  • Dong Young Kang,
  • Nipin Sp,
  • Eun Seong Jo,
  • Jin-Moo Lee,
  • Se Won Bae and
  • Kyoung-Jin Jang

29 June 2021

Recently, natural compounds have been used globally for cancer treatment studies. Silibinin is a natural compound extracted from Silybum marianum (milk thistle), which has been suggested as an anticancer drug through various studies. Studies on its a...

  • Article
  • Open Access
10 Citations
2,293 Views
21 Pages

An Optimized Fuzzy Based Control Solution for Frequency Oscillation Reduction in Electric Grids

  • Hina Maqbool,
  • Adnan Yousaf,
  • Rao Muhammad Asif,
  • Ateeq Ur Rehman,
  • Elsayed Tag Eldin,
  • Muhammad Shafiq and
  • Habib Hamam

23 September 2022

The demand for uninterruptible electricity supply is increasing, and the power engineering sector has started researching alternative solutions. Distributed generation (DG) dissemination into the electric grid to cope with the accelerating demand for...

  • Article
  • Open Access
7 Citations
3,958 Views
36 Pages

27 November 2024

This study presents the design, simulation, and comparative analysis of three advanced control strategies applied to a 3-Degree-of-Freedom (DoF) robot manipulator. The controllers investigated are a variant from the Computed Torque Control family, a...

  • Article
  • Open Access
6 Citations
3,694 Views
17 Pages

The Novel IGF-1R Inhibitor PB-020 Acts Synergistically with Anti-PD-1 and Mebendazole against Colorectal Cancer

  • Bo Kang,
  • Xiaobing Zhang,
  • Weibing Wang,
  • Shiqi She,
  • Wenjie Chen,
  • Cheng Chen,
  • Yisha Wang,
  • Xiaoyun Pan,
  • Ouyuan Xu and
  • Yingjie Wang

23 November 2022

CRC is one of the leading causes of cancer mortality worldwide. Chemotherapy is widely used for the treatment of CRC, but its efficacy remains unsatisfactory, mainly due to drug resistance. Therefore, it is urgent to develop new strategies to overcom...

  • Article
  • Open Access
13 Citations
3,288 Views
18 Pages

CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways

  • Xiyang Tang,
  • Jie Yang,
  • Anping Shi,
  • Yanlu Xiong,
  • Miaomiao Wen,
  • Zhonglin Luo,
  • Huanhuan Tian,
  • Kaifu Zheng,
  • Yujian Liu and
  • Jinbo Zhao
  • + 3 authors

15 November 2022

Background: Esophageal cancer is still a leading cause of death among all tumors in males, with unsatisfactory responses to novel immunotherapies such as anti-PD-1 agents. Herein, we explored the role of CD155 in esophageal squamous cell cancer (ESCA...

  • Article
  • Open Access
2 Citations
889 Views
49 Pages

30 September 2025

The increasing integration of renewable energy sources (RES) and rising energy demand have created challenges in maintaining stability in interconnected power systems, particularly in terms of frequency, voltage, and tie-line power. While traditional...

  • Feature Paper
  • Article
  • Open Access
14 Citations
3,130 Views
18 Pages

An Experimental Tuning Approach of Fractional Order Controllers in the Frequency Domain

  • Isabela Birs,
  • Silviu Folea,
  • Ovidiu Prodan,
  • Eva Dulf and
  • Cristina Muresan

31 March 2020

Fractional calculus has been used intensely in recent years in control engineering to extend the capabilities of the classical proportional–integral–derivative (PID) controller, but most tuning techniques are based on the model of the pro...

  • Article
  • Open Access
10 Citations
3,311 Views
24 Pages

1 June 2023

This paper presents a new fractional-order proportional-integral, (PI)λ (FO[PI]) type structure to investigate the load frequency control (LFC) problem. In the literature, some controllers’ extensive tuning options may slow or complicate...

  • Article
  • Open Access
6 Citations
3,364 Views
25 Pages

30 June 2022

Sliding pressure control is a well-known method of controlling supercritical power plants that improves energy efficiency and reduces pressure dynamic stresses. This paper presents a novel approach for developing a supercritical cleaner coal power pl...

  • Article
  • Open Access
1 Citations
1,627 Views
19 Pages

Simplified Model Characterization and Control of an Unmanned Surface Vehicle

  • Aldo Lovo-Ayala,
  • Roosvel Soto-Diaz,
  • Carlos Andres Gutierrez-Martinez,
  • Jose Fernando Jimenez-Vargas,
  • Javier Jiménez-Cabas and
  • Jose Escorcía-Gutierrez

This study presents the modeling and control of the unmanned surface vehicle (USV) SABALO. Two models were built, one based on a transfer function matrix and another based on state variables, and from these models, two control strategies were develop...

  • Article
  • Open Access
5 Citations
2,421 Views
29 Pages

Metaheuristic Optimization Algorithm Based Cascaded Control Schemes for Nonlinear Ball and Balancer System

  • Farhan Zafar,
  • Suheel Abdullah Malik,
  • Tayyab Ali,
  • Amil Daraz,
  • Atif M. Alamri,
  • Salman A. AlQahtani and
  • Farkhunda Bhatti

29 January 2024

The ball and balancer system is a popular research platform for studying underactuated mechanical systems and developing control algorithms. It is a well-known two-dimensional balancing problem that has been addressed by a variety of controllers. Thi...

  • Article
  • Open Access
6 Citations
7,526 Views
12 Pages

An Investigation of the High Performance of a Novel Type of Benzobisoxazole Fiber Based on 3,3-Diaminobenzidine

  • Yang Wang,
  • Yuanjun Song,
  • Lei Zhao,
  • Nahla Rahoui,
  • Bo Jiang and
  • Yudong Huang

13 December 2016

The mechanical and thermal properties of poly{2,6-diimidazo[4,5-b:4′5′-e] pyridinylene-1,4(2,5-dihydroxy) phenylene} (PIPD)-3,3-diaminobenzidine (DAB) fibers were analyzed. Compared to other types of benzimidazole fiber structures and properties, PIP...

  • Article
  • Open Access
36 Citations
3,405 Views
12 Pages

26 February 2022

This study proposes a virgin structure of Fuzzy Logic Control (FLC) for Load Frequency Control (LFC) in a dual-area interconnected electrical power system. This configuration benefits from the advantages of fuzzy control and the merits of Fractional...

  • Article
  • Open Access
10 Citations
5,281 Views
19 Pages

Energy-Efficient Control of a Gas Turbine Power Generation System

  • Marwan Al-Shami,
  • Omar Mohamed and
  • Wejdan Abu Elhaija

Gas turbines are used in the energy sectors as propulsion and power generation technologies. Despite technological advances in power generation and the emergence of numerous energy resources, gas turbine technology remains important due to its flexib...

  • Article
  • Open Access
17 Citations
4,459 Views
13 Pages

Pediatric Invasive Pneumococcal Disease Three Years after PCV13 Introduction in the National Immunization Plan—The Continued Importance of Serotype 3

  • Catarina Silva-Costa,
  • Joana Gomes-Silva,
  • Lúcia Prados,
  • Mário Ramirez,
  • José Melo-Cristino,
  • on behalf of the Portuguese Group for the Study of Streptococcal Infections and
  • the Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society

The introduction of pneumococcal conjugate vaccines PCV7 and PCV13 led to decreases in incidence of pediatric invasive pneumococcal disease (pIPD) and changes in serotype distribution. We evaluated the consequences of higher vaccine uptake after the...

  • Article
  • Open Access
1 Citations
1,056 Views
39 Pages

An Optimal Two-Stage Tuned PIDF + Fuzzy Controller for Enhanced LFC in Hybrid Power Systems

  • Saleh Almutairi,
  • Fatih Anayi,
  • Michael Packianather and
  • Mokhtar Shouran

14 October 2025

Ensuring reliable power system control demands innovative architectural solutions. This research introduces a fault-tolerant hybrid parallel compensator architecture for load frequency control (LFC), combining a Proportional–Integral–Deri...

  • Article
  • Open Access
2,023 Views
59 Pages

Manufacture of a 4-Degree-of-Freedom Robot to Support an IRB 120 Robot

  • Ricardo Balcazar,
  • José de Jesús Rubio,
  • Mario Alberto Hernandez,
  • Jaime Pacheco,
  • Adrian-Josue Guel-Cortez,
  • Genaro Ochoa,
  • Enrique Garcia,
  • Alejandro Zacarías and
  • Gabriela Saavedra González

28 November 2024

In this work, we present the construction and control of a four-degrees-of-freedom (DOF) manipulator aimed at addressing one of the key challenges faced by the Academy-Industry Cooperation Center (CCAI): the need for mechatronic equipment to support...

  • Review
  • Open Access
6 Citations
3,175 Views
10 Pages

Idiopathic multicentric Castleman disease (iMCD) and TAFRO syndrome present a variety of symptoms thought to be caused by excessive inflammatory cytokines and chemokines, but the underlying mechanisms are unknown. iMCD is broadly classified into two...

  • Article
  • Open Access
4 Citations
1,157 Views
27 Pages

13 September 2024

An active stabiliser bar significantly enhances the anti-roll capabilities of vehicles. The control strategy is a crucial factor in enabling the active stabiliser bar to function effectively. This paper investigates an active disturbance rejection co...

  • Article
  • Open Access
3 Citations
3,340 Views
18 Pages

21 December 2023

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the first committed step of the oxidative pentose phosphate pathway (OPPP). Our recent phosphoproteomics study revealed that the cytosolic G6PD6 isozyme became hyperphosphorylated at Ser12, Thr13 and...

  • Article
  • Open Access
19 Citations
4,634 Views
23 Pages

23 February 2022

Piwi interacting RNAs (piRNAs) are small non-coding single-stranded RNA species 20–31 nucleotides in size generated from distinct loci. In germline tissues, piRNAs are amplified via a “ping-pong cycle” to produce secondary piRNAs, w...

  • Article
  • Open Access
22 Citations
4,272 Views
16 Pages

Concordance of Radiological, Laparoscopic and Laparotomic Scoring to Predict Complete Cytoreduction in Women with Advanced Ovarian Cancer

  • Mariano Catello Di Donna,
  • Giuseppe Cucinella,
  • Giulia Zaccaria,
  • Giuseppe Lo Re,
  • Agata Crapanzano,
  • Sergio Salerno,
  • Vincenzo Giallombardo,
  • Giulio Sozzi,
  • Anna Fagotti and
  • Vito Chiantera
  • + 2 authors

13 January 2023

Objective: To identify the best method among the radiologic, laparoscopic and laparotomic scoring assessment to predict the outcomes of cytoreductive surgery in patients with advanced ovarian cancer (AOC). Methods: Patients with AOC who underwent pre...

  • Article
  • Open Access
3 Citations
3,067 Views
12 Pages

Quantitative Evaluation of Inflammatory Markers in Peri-Implantitis and Periodontitis Tissues: Digital vs. Manual Analysis—A Proof of Concept Study

  • Dolaji Henin,
  • Luiz Guilherme Fiorin,
  • Daniela Carmagnola,
  • Gaia Pellegrini,
  • Marilisa Toma,
  • Aurora Cristofalo and
  • Claudia Dellavia

29 June 2022

Background and Objectives: In dentistry, the assessment of the histomorphometric features of periodontal (PD) and peri-implant (PI) lesions is important to evaluate their underlying pathogenic mechanism. The present study aimed to compare manual and...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,915 Views
10 Pages

Postural Instability and Risk of Falls in Patients with Parkinson’s Disease Treated with Deep Brain Stimulation: A Stabilometric Platform Study

  • Giorgio Leodori,
  • Marco Santilli,
  • Nicola Modugno,
  • Michele D’Avino,
  • Maria Ilenia De Bartolo,
  • Andrea Fabbrini,
  • Lorenzo Rocchi,
  • Antonella Conte,
  • Giovanni Fabbrini and
  • Daniele Belvisi

25 August 2023

Postural instability (PI) in Parkinson’s disease (PD) exposes patients to an increased risk of falls (RF). While dopaminergic therapy and deep brain stimulation (DBS) improve motor performance in advanced PD patients, their effects on PI and RF...

  • Article
  • Open Access
4 Citations
6,546 Views
22 Pages

Development of an Impairment Point in Time Probability of Default Model for Revolving Retail Credit Products: South African Case Study

  • Douw Gerbrand Breed,
  • Niel van Jaarsveld,
  • Carsten Gerken,
  • Tanja Verster and
  • Helgard Raubenheimer

15 November 2021

A new methodology to derive IFRS 9 PiT PDs is proposed. The methodology first derives a PiT term structure with accompanying segmented term structures. Secondly, the calibration of credit scores using the Lorenz curve approach is used to create accou...

  • Article
  • Open Access
11 Citations
4,476 Views
11 Pages

23 November 2020

Background: There have been several pathologic data that support an association between postural instability (PI) and autonomic dysfunction in Parkinson’s disease (PD). The purpose of this study was to investigate the correlation of PI and auto...

  • Article
  • Open Access
36 Citations
6,552 Views
16 Pages

Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway

  • Jing Wang,
  • Huaide Liu,
  • Xuan Zhang,
  • Xinpeng Li,
  • Lihua Geng,
  • Hong Zhang and
  • Quanbin Zhang

6 April 2017

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Recent studies suggest that sulfated hetero-polysaccharides (UF) protect against developing PD. However, the detailed mechanisms of how UF suppress neuronal death have not...

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