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1,342 Results Found

  • Review
  • Open Access
42 Citations
7,054 Views
22 Pages

The Role of NK Cells in EBV Infection and EBV-Associated NPC

  • Yi Tian Png,
  • Audrey Zhi Yi Yang,
  • Mei Ying Lee,
  • Magdalene Jahn May Chua and
  • Chwee Ming Lim

15 February 2021

A vast majority of the population worldwide are asymptomatic carriers of Epstein-Barr Virus (EBV). However, some infected individuals eventually develop EBV-related cancers, including Nasopharyngeal Carcinoma (NPC). NPC is one of the most common EBV-...

  • Article
  • Open Access
1,670 Views
17 Pages

Quantitative Analysis of Balancing Range for Single-Phase 3L-NPC Converters

  • Ziying Wang,
  • Ning Jiao,
  • Shunliang Wang,
  • Junpeng Ma,
  • Rui Zhang and
  • Tianqi Liu

19 March 2024

Multiple techniques have been suggested to achieve control balance in single-phase three-level neutral-point clamped (3L-NPC) converters. Nevertheless, there is a deficiency of quantitative calculations related to the extent of balancing. Operating b...

  • Feature Paper
  • Article
  • Open Access
3 Citations
4,103 Views
15 Pages

Induction Motor Drives Fed by an NPC Inverter with Unbalanced DC-Link

  • Umberto Abronzini,
  • Ciro Attaianese,
  • Matilde D’Arpino,
  • Mauro Di Monaco and
  • Giuseppe Tomasso

21 November 2019

Neutral Point Clamped (NPC) converters with n levels are traditionally controlled in such a way that the DC-link capacitors operate at 1/(n − 1) of the total DC-link voltage level. The voltage level across the DC-link capacitors has to be prope...

  • Article
  • Open Access
8 Citations
1,846 Views
13 Pages

NPC Intracellular Cholesterol Transporter 1 Regulates Ovarian Maturation and Molting in Female Macrobrachium nipponense

  • Sufei Jiang,
  • Wenyi Zhang,
  • Yiwei Xiong,
  • Mengying Zhang,
  • Huwei Yuan,
  • Yunpeng Niu,
  • Hui Qiao and
  • Hongtuo Fu

NPC intracellular cholesterol transporter 1 (NPC1) plays an important role in sterol metabolism and transport processes and has been studied in many vertebrates and some insects, but rarely in crustaceans. In this study, we characterized NPC1 from Ma...

  • Article
  • Open Access
34 Citations
12,293 Views
14 Pages

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

  • Anuja Krishnan,
  • Emily Happy Miller,
  • Andrew S. Herbert,
  • Melinda Ng,
  • Esther Ndungo,
  • Sean P. Whelan,
  • John M. Dye and
  • Kartik Chandran

25 October 2012

We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick C1-like1 (NPC1L1), an NPC1...

  • Article
  • Open Access
2 Citations
2,700 Views
17 Pages

The battery is the only power source of full electric vehicles, and the converter plays a key role in power and signal conversion; therefore, the stability and reliability of the converter determine the performance of the whole vehicle system. In ord...

  • Article
  • Open Access
9 Citations
6,240 Views
14 Pages

4 September 2018

The Niemann Pick type C (NPC) proteins, NPC1 and NPC2, are involved in the lysosomal storage disease, NPC disease. The formation of a NPC1–NPC2 protein–protein complex is believed to be necessary for the transfer of cholesterol and lipids...

  • Article
  • Open Access
2 Citations
2,798 Views
12 Pages

The conventional three-level SVPWM (Space Vector Pulse Width Modulation) algorithm is a basic modulation algorithm, which can be performed easily due to clear modulation ideas. Considering different criteria for sectors, however, the basic vector act...

  • Article
  • Open Access
8 Citations
4,469 Views
22 Pages

A Study on Neutral-Point Potential in Three-Level NPC Converters

  • Maosong Zhang,
  • Ying Cui,
  • Qunjing Wang,
  • Jun Tao,
  • Xiuqin Wang,
  • Hongsheng Zhao and
  • Guoli Li

1 September 2019

This paper proposes an accurate mathematical model of three-level neutral-point-clamped (NPC) converters that can accurately represent the midpoint potential drift of the DC link with parameter perturbation. The mathematical relationships between the...

  • Article
  • Open Access
16 Citations
5,000 Views
15 Pages

Integrated Control and Modulation for Three-Level NPC Rectifiers

  • Antonio Ventosa-Cutillas,
  • Pablo Montero-Robina,
  • Francisco Umbría,
  • Federico Cuesta and
  • Francisco Gordillo

30 April 2019

This paper uses a novel approach for the control of three-level neutral-point-clamped (NPC) rectifiers in order to tackle the capacitor voltage balance problem. A distinctive feature of the new control approach is that it is based on a model which is...

  • Article
  • Open Access
2 Citations
1,689 Views
16 Pages

30 November 2023

Three-level NPC inverters have been widely used in grid-connected systems due to their superior performance compared with two-level inverters, but more switches lead to high fault probability. Meanwhile, the neutral point potential (NPP) fluctuation...

  • Article
  • Open Access
1 Citations
2,134 Views
20 Pages

30 May 2023

Three-level neutral-point clamped (NPC) inverters are widely used in the new energy power generation, motor drive, and many other occasions. However, the neutral-point voltage imbalance of an NPC inverter will affect the output of the inverter system...

  • Article
  • Open Access
3 Citations
2,427 Views
22 Pages

Assessment of a High-Order Stationary Frame Controller for Two-Level and Three-Level NPC Grid-Connected Inverters

  • Nawaf O. Almatani,
  • Abdullah Ali Alhussainy,
  • Sultan Alghamdi,
  • Hossam Kotb,
  • Kareem M. AboRas,
  • Mahendiran Vellingiri and
  • Muhyaddin Rawa

8 December 2022

Most grid-connected DC/AC inverters use traditional proportional–integral (PI) controllers in a synchronous frame. In addition to poor disturbance rejection capabilities, these PI controllers also exhibit steady-state errors for sinusoidal refe...

  • Article
  • Open Access
17 Citations
3,498 Views
17 Pages

28 June 2019

This paper proposes a fault diagnosis and tolerant control methods for an open-switch fault caused in a three-phase three-level neutral-point-clamped (NPC) pulse-width modulation (PWM) active rectifier. The open-switch fault in the three-level NPC ac...

  • Article
  • Open Access
4 Citations
4,903 Views
25 Pages

An Enhanced Control Scheme Based on New Adaptive Filters for Cascaded NPC/H-Bridge System

  • Jin-Wook Kang,
  • Hoon Lee,
  • Seung-Wook Hyun,
  • Jintae Kim and
  • Chung-Yuen Won

24 April 2018

This paper studies the voltage fluctuation of dc-link generated in a 13-level cascaded neutral point clamped (NPC)/h-bridge (CNHB) with single-phase active front end (AFE) at the input side of each cell. The voltage fluctuation may deteriorate the po...

  • Article
  • Open Access
1 Citations
2,361 Views
16 Pages

To meet the requirements of output harmonic distortion of neutral point clamped (NPC) three-level inverter under low switching frequency conditions, multi-mode synchronous space vector modulation is usually adopted. When switching between different p...

  • Article
  • Open Access
2 Citations
1,038 Views
25 Pages

Comparison of Induction Machine Drive Control Schemes on the Distribution of Power Losses in a Three-Level NPC Converter

  • Carlos A. Reusser,
  • Matías Parra,
  • Gerardo Mino-Aguilar and
  • Victor R. Gonzalez-Diaz

12 March 2025

Medium- and high-power drive applications have grown since the past decade as the most common solution for high demanding industrial processes. Multilevel converters, in particular the three-level neutral point clamped (3L-NPC) topology driving mediu...

  • Article
  • Open Access
2 Citations
1,808 Views
19 Pages

Small-Signal Model of the NPC + GCC Multilevel Transformerless Inverter in Single-Phase Photovoltaic Power Systems

  • Iván Patrao,
  • Marian Liberos,
  • Raúl González-Medina,
  • Enric Torán,
  • Emilio Figueres and
  • Gabriel Garcerá

22 August 2023

Photovoltaic transformerless inverters are very efficient and economical options for solar-power generation. The absence of the isolation transformer improves the converters’ efficiency, but high-frequency voltage to ground can appear in the ph...

  • Article
  • Open Access
15 Citations
7,646 Views
16 Pages

13 March 2015

In the research field of multilevel converters, three-level NPC (neutral-point-clamped) converters, which unfortunately may cause the deviation of the neutral-point voltage of DC-link capacitors, are widely discussed. Theoretically, virtual space vec...

  • Feature Paper
  • Article
  • Open Access
1 Citations
646 Views
17 Pages

6 November 2025

This paper presents a cascaded control strategy for neutral-point-clamped three-level (NPC-3L) inverter-fed permanent magnet synchronous motors (PMSMs), integrating continuous-control-set model-predictive control (CCS-MPC) with mid-point voltage regu...

  • Article
  • Open Access
10 Citations
3,209 Views
16 Pages

A High-Gain Observer-Based Adaptive Super-Twisting Algorithm for DC-Link Voltage Control of NPC Converters

  • Xiaoning Shen,
  • Jianxing Liu,
  • Abraham Marquez,
  • Wensheng Luo,
  • Jose I. Leon,
  • Sergio Vazquez and
  • Leopoldo G. Franquelo

2 March 2020

Acting as an interface between the grid and many energy systems, the active front-end (AFE) has been widely used in a large variety of industrial applications. In this paper, in order to ensure the fast dynamic performance and good disturbance reject...

  • Article
  • Open Access
7 Citations
4,832 Views
20 Pages

13 September 2021

In this paper, a model predictive control for an asymmetric T-type NPC 3-level inverter is presented. The mathematical model and characteristics of the reduced switching topology are described. An improvement for the predicted strategy with the pre-s...

  • Article
  • Open Access
7 Citations
7,894 Views
26 Pages

A Novel Zero Dead-Time PWM Method to Improve the Current Distortion of a Three-Level NPC Inverter

  • Jin-Wook Kang,
  • Seung-Wook Hyun,
  • Yong Kan,
  • Hoon Lee and
  • Jung-Hyo Lee

19 December 2020

This paper proposes a novel pulse width modulation (PWM) for a three-level neutral point clamped (NPC) voltage source inverter (VSI). When the conventional PWM method is used in three-level NPC VSI, dead time is required to prevent a short circuit ca...

  • Article
  • Open Access
516 Views
21 Pages

Design and Evaluation of a Generative AI-Enhanced Serious Game for Digital Literacy: An AI-Driven NPC Approach

  • Suepphong Chernbumroong,
  • Kannikar Intawong,
  • Udomchoke Asawimalkit,
  • Kitti Puritat and
  • Phichete Julrode

The rapid proliferation of misinformation on social media underscores the urgent need for scalable digital-literacy instruction. This study presents the design and evaluation of a Generative AI-enhanced serious game system that integrates Large Langu...

  • Article
  • Open Access
28 Citations
6,800 Views
16 Pages

Tetrandrine Induces Apoptosis of Human Nasopharyngeal Carcinoma NPC-TW 076 Cells through Reactive Oxygen Species Accompanied by an Endoplasmic Reticulum Stress Signaling Pathway

  • Ya-Jing Lin,
  • Shu-Fen Peng,
  • Meng-Liang Lin,
  • Chao-Lin Kuo,
  • Kung-Wen Lu,
  • Ching-Lung Liao,
  • Yi-Shih Ma,
  • Fu-Shin Chueh,
  • Kuo-Ching Liu and
  • Jing-Gung Chung
  • + 1 author

12 October 2016

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including acti...

  • Article
  • Open Access
558 Views
19 Pages

18 November 2025

This paper presents a high-performance sensorless control strategy for induction motors using an Adaptive Neuro-Fuzzy Inference System (ANFIS) for rotor speed estimation, eliminating the need for mechanical sensors. The ANFIS approach leverages stato...

  • Article
  • Open Access
4 Citations
2,240 Views
12 Pages

1 June 2022

The reduction or elimination of selected torque and current harmonics is widely used in multilevel inverter fed induction motor drives. A wide range of methods are employed to achieve this goal. Those modes of operation allow the avoidance of certain...

  • Article
  • Open Access
6 Citations
3,589 Views
16 Pages

2 October 2022

The three-level neutral-point clamped voltage source inverter (3L-NPC-VSI) is widely used in the maglev traction systems due to its high output voltage, large output capacity and low output current harmonics. In order to improve the utilization of th...

  • Article
  • Open Access
7 Citations
3,653 Views
22 Pages

5 May 2021

This paper presents a novel single-phase grid-tied neutral-point-clamped (NPC) five-level converter (SPFLC). Unlike the literature on five-level NPC topologies, the proposed one is capable of inherently balancing the voltage of the DC-link split capa...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,413 Views
16 Pages

This paper proposes a unidirectional finite control set-predictive toque control (UFCS-PTC) method for a three-level neutral-point-clamped (3L-NPC) inverter fed interior permanent magnet synchronous motor (IPMSM). The proposed algorithm can lower the...

  • Article
  • Open Access
5 Citations
2,938 Views
24 Pages

19 May 2022

This paper presents a novel concept of the DC-AC system with the input voltage boost ability, seven-level output voltage modulation, and the input AC current reduction at the double frequency of the output voltage. The system integrates the NPC full-...

  • Article
  • Open Access
4 Citations
3,543 Views
15 Pages

Robust Two-Layer Model Predictive Control for Full-Bridge NPC Inverter-Based Class-D Voltage Mode Amplifier

  • Xinwei Wei,
  • Hongliang Wang,
  • Kangliang Wang,
  • Kui Li,
  • Minying Li and
  • An Luo

14 November 2019

Finite control set model predictive control (FCS-MPC) is able to handle multiple control objectives and constraints simultaneously with good dynamic performance. However, its industrial application is limited by its high dependence on system model an...

  • Article
  • Open Access
1,791 Views
16 Pages

23 October 2024

Mining frequency converters are the primary means for achieving variable frequency speed regulation of electromechanical equipment in coal mines, offering energy-saving benefits for coal mining enterprises. The common power supply method involves con...

  • Article
  • Open Access
21 Citations
4,647 Views
16 Pages

Analytical and Simulation Fair Comparison of Three Level Si IGBT Based NPC Topologies and Two Level SiC MOSFET Based Topology for High Speed Drives

  • Jelena Loncarski,
  • Vito Giuseppe Monopoli,
  • Riccardo Leuzzi,
  • Leposava Ristic and
  • Francesco Cupertino

30 November 2019

Wide bandgap (WBG) power devices such as silicon carbide (SiC) can viably supply high speed electrical drives, due to their capability to increase efficiency and reduce the size of the power converters. On the other hand, high frequency operation of...

  • Article
  • Open Access
19 Citations
4,474 Views
20 Pages

Three-Level NPC Inverter Incipient Fault Detection and Classification using Output Current Statistical Analysis

  • Mehdi Baghli,
  • Claude Delpha,
  • Demba Diallo,
  • Abdelhamid Hallouche,
  • David Mba and
  • Tianzhen Wang

9 April 2019

This paper deals with open switch Fault Detection and Diagnosis (FDD) in three-level Neutral Point Clamped (NPC) inverter for electrical drives. The approach is based on the already available phase current time series measurements for different opera...

  • Article
  • Open Access
10 Citations
4,255 Views
19 Pages

18 October 2017

To meet the challenge of large-scale renewable energy penetration and take full advantage of existing AC infrastructure, the bipolar DC distribution system is of interest. In this article, the system structure and characteristics of the bipolar DC di...

  • Article
  • Open Access
2 Citations
961 Views
22 Pages

14 June 2025

Model Predictive Control (MPC) has become very attractive for the efficient control of power converters. This paper compares Classical MPC (C-MPC) and Sequential MPC (S-MPC) for a three-level NPC converter. Although C-MPC is simple to implement, it f...

  • Article
  • Open Access
11 Citations
5,928 Views
25 Pages

This paper investigates the fault-tolerance control of a multilevel cascaded NPC/H-bridge (CNHB) inverter. The fault-tolerance control method has been widely used for multilevel inverters, such as the neutral-point voltage-shifting control, which can...

  • Article
  • Open Access
5 Citations
1,802 Views
21 Pages

10 April 2024

This paper investigates the asynchronous motors driven by a Three-Level Neutral-Point-Clamped Voltage Source Inverter (3L-NPC-VSI) and aims to achieve control without weight factors and reduce torque ripple. It puts forward a non-weighted two-stage F...

  • Article
  • Open Access
30 Citations
7,622 Views
21 Pages

Molecular Genetics of Niemann–Pick Type C Disease in Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants

  • Andrea Dardis,
  • Stefania Zampieri,
  • Cinzia Gellera,
  • Rosalba Carrozzo,
  • Silvia Cattarossi,
  • Paolo Peruzzo,
  • Rosalia Dariol,
  • Annalisa Sechi,
  • Federica Deodato and
  • Bruno Bembi
  • + 15 authors

Niemann-Pick type C (NPC) disease is an autosomal recessive lysosomal storage disorder caused by mutations in NPC1 or NPC2 genes. In 2009, the molecular characterization of 44 NPC Italian patients has been published. Here, we present an update of the...

  • Article
  • Open Access
5 Citations
2,058 Views
17 Pages

9 January 2023

A three-level neutral point clamped inverter with three phase legs is often used to power three-phase electrical motors. This type of multilevel inverter has its advantages over two-level inverters. The main advantages are lower harmonic distortion a...

  • Article
  • Open Access
1 Citations
1,496 Views
26 Pages

17 November 2024

This work presents an islanded microgrid energy system that uses backstepping control applied to neutral point clamped (NPC) multilevel converters coupled with batteries to behave as virtual generators, able to absorb surplus renewable energy, theref...

  • Article
  • Open Access
5 Citations
3,582 Views
14 Pages

26 February 2019

To suppress the direct current (DC) capacitor voltage fluctuations and the common-mode voltage (CMV) in a three-phase, five-level, neutral-point-clamped (NPC)/H-bridge inverter, this paper analyzes the influence of all voltage vectors on the neutral...

  • Proceeding Paper
  • Open Access
2 Citations
3,436 Views
9 Pages

28 September 2023

In this paper, the model predictive control technique is proposed to control the voltage balancing for the subway train 1500 V DC system for variable loads. This paper compares the conventional neutral point clamped converter (NPC) using the control...

  • Article
  • Open Access
3 Citations
2,604 Views
11 Pages

Targeting NPC1 in Renal Cell Carcinoma

  • Rushaniya Fazliyeva,
  • Peter Makhov,
  • Robert G. Uzzo and
  • Vladimir M. Kolenko

25 January 2024

Rapidly proliferating cancer cells have a greater requirement for cholesterol than normal cells. Tumor cells are largely dependent on exogenous lipids given that their growth requirements are not fully met by endogenous pathways. Our current study sh...

  • Article
  • Open Access
2,535 Views
13 Pages

11 June 2023

This article presents the concept of switching and conduction loss reduction in a T-NPC inverter based on IGBT transistors. The method of limiting switching losses involves the connection of an LC circuit designed to cause transistors in vertical bra...

  • Article
  • Open Access
18 Citations
5,435 Views
20 Pages

NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer

  • Kathleen I. O’Neill,
  • Li-Wei Kuo,
  • Michelle M. Williams,
  • Hanne Lind,
  • Lyndsey S. Crump,
  • Nia G. Hammond,
  • Nicole S. Spoelstra,
  • M. Cecilia Caino and
  • Jennifer K. Richer

21 July 2022

Triple-negative breast cancer (TNBC) often undergoes at least partial epithelial-to-mesenchymal transition (EMT) to facilitate metastasis. Identifying EMT-associated characteristics can reveal novel dependencies that may serve as therapeutic vulnerab...

  • Article
  • Open Access
1,594 Views
15 Pages

30 October 2024

This study proposes a receiving-end voltage compensation method employing a phase-specific reactive power control strategy with a neutral-point-clamped (NPC) inverter in a three-phase four-wire distribution system. The principle of the proposed recei...

  • Article
  • Open Access
5 Citations
6,605 Views
41 Pages

Organ Weights in NPC1 Mutant Mice Partly Normalized by Various Pharmacological Treatment Approaches

  • Veronica Antipova,
  • Lisa-Marie Steinhoff,
  • Carsten Holzmann,
  • Arndt Rolfs,
  • Carlos Junior Hempel,
  • Martin Witt and
  • Andreas Wree

29 December 2022

Niemann-Pick Type C1 (NPC1, MIM 257220) is a rare, progressive, lethal, inherited autosomal-recessive endolysosomal storage disease caused by mutations in the NPC1 leading to intracellular lipid storage. We analyzed mostly not jet known alterations o...

  • Article
  • Open Access
2 Citations
3,188 Views
10 Pages

Novel Mutation in the Feline NPC2 Gene in Cats with Niemann–Pick Disease

  • Tofazzal Md Rakib,
  • Md Shafiqul Islam,
  • Mohammad Mejbah Uddin,
  • Mohammad Mahbubur Rahman,
  • Akira Yabuki,
  • Tetsushi Yamagami,
  • Motoji Morozumi,
  • Kazuyuki Uchida,
  • Shinichiro Maki and
  • Osamu Yamato
  • + 1 author

24 May 2023

Niemann–Pick disease (NP) type C is an autosomal, recessive, and inherited neurovisceral genetic disorder characterized by the accumulation of unesterified cholesterol and glycolipids in cellular lysosomes and late endosomes, with a wide spectr...

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