Skip Content
You are currently on the new version of our website. Access the old version .

48 Results Found

  • Review
  • Open Access
11 Citations
11,913 Views
16 Pages

Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023

  • Patrick Unterbrink,
  • Erik Schulze zur Wiesche,
  • Frederic Meyer,
  • Pascal Fandrich,
  • Bennett T. Amaechi and
  • Joachim Enax

4 March 2024

Modern toothpastes are complex formulations with various ingredients. The aim of this study was to analyze the improvement of toothpaste formulations from 1900 to 2023 focusing on active ingredients with remineralizing, antibacterial, or plaque-remov...

  • Proceeding Paper
  • Open Access
2,927 Views
7 Pages

Carbon allotropes, including graphene, graphene oxide (GO) and reduced graphene oxide (r-GO), have the potential as coating nanomaterials to improve the performance of dental implants. Furthermore, graphene has demonstrated strong antibacterial activ...

  • Review
  • Open Access
11 Citations
3,937 Views
10 Pages

Thiocoumarins: From the Synthesis to the Biological Applications

  • Maria J. Matos,
  • Lourdes Santana,
  • Eugenio Uriarte and
  • Fernanda Borges

31 July 2022

Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins are a particular class of cou...

  • Feature Paper
  • Review
  • Open Access
35 Citations
6,813 Views
24 Pages

After generating much interest in the past as an aid in solving structural problems for complex molecules such as polysaccharides, carbohydrate-hydrolyzing enzymes of marine origin still appear as interesting biocatalysts for a range of useful applic...

  • Proceeding Paper
  • Open Access

7 November 2025

In the era of smart garments, textile electrodes for electromyography (EMG) or functional electric stimulation (FES) represent a very interesting and promising area of development and exploitation. In this frame, we conducted a patent landscape analy...

  • Review
  • Open Access
4 Citations
3,593 Views
34 Pages

Polysaccharide-Based Drug Carriers—A Patent Analysis

  • Snežana Ilić-Stojanović,
  • Fouad Damiri,
  • Adina Magdalena Musuc and
  • Mohammed Berrada

6 December 2024

Polysaccharide-based carriers as biomaterials for drug delivery have been inspiring scientists for years due to their exceptional characteristics, such as nontoxicity, biocompatibility, and degradability, as they are able to protect pharmaceutically...

  • Proceeding Paper
  • Open Access
1 Citations
2,610 Views
8 Pages

The aim of this study is to present an overview of patented industrial hydrogen peroxide production processes. Searches were conducted using two databases, namely, Espacenet and Orbit, using mainly IPC and CPC classification symbols, sometimes combin...

  • Systematic Review
  • Open Access
2,106 Views
29 Pages

Cardiac Simulator Technologies and Design for Medical Education and Auscultation Training: A Systematic Review

  • Christian Romero-Martínez,
  • Luis Adrián Zúñiga-Avilés,
  • Giorgio M. Cruz-Martínez,
  • José Javier Reyes-Lagos,
  • Joel Zagoya-López and
  • Ángel Eduardo Bárcenas-García

Medical simulators have revolutionized clinical training, particularly in teaching skills such as cardiac auscultation. This review synthesizes recent advances in the technological design and implementation of cardiac simulators for medical education...

  • Review
  • Open Access
21 Citations
15,462 Views
17 Pages

Bioactive Lignans from Flaxseed: Biological Properties and Patented Recovery Technologies

  • Paola Sangiorgio,
  • Simona Errico,
  • Alessandra Verardi,
  • Stefania Moliterni,
  • Gabriella Tamasi,
  • Claudio Rossi and
  • Roberto Balducchi

Flaxseed lignans frequently feature in the literature. However, much remains to be discovered about the mechanisms underlying their functional and therapeutic properties. Furthermore, it is necessary to identify systems for lignan production and deto...

  • Review
  • Open Access
66 Citations
11,003 Views
40 Pages

Application of Social Robots in Healthcare: Review on Characteristics, Requirements, Technical Solutions

  • Luca Ragno,
  • Alberto Borboni,
  • Federica Vannetti,
  • Cinzia Amici and
  • Nicoletta Cusano

31 July 2023

Cyber-physical or virtual systems or devices that are capable of autonomously interacting with human or non-human agents in real environments are referred to as social robots. The primary areas of application for biomedical technology are nursing hom...

  • Review
  • Open Access
31 Citations
5,756 Views
22 Pages

Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present rece...

  • Review
  • Open Access
2 Citations
1,926 Views
23 Pages

Sustainable Valorization of Tequila Industry Vinasse: A Patent Review on Bioeconomy-Driven Technologies

  • Mauricio Suárez-Sánchez,
  • Humberto Merritt,
  • Guadalupe Oyoque-Salcedo,
  • Diana Priscila Estrella-Santiago,
  • Ernesto Oregel-Zamudio and
  • Sergio Arias-Martínez

27 June 2025

The tequila industry generates significant quantities of vinasse, a highly polluting byproduct that poses serious environmental challenges. Addressing this issue requires innovative solutions that align with the principles of bioeconomy, transforming...

  • Review
  • Open Access
6 Citations
5,701 Views
21 Pages

Toward Sourdough Microbiome Data: A Review of Science and Patents

  • Gabriel Albagli,
  • Priscilla V. Finotelli,
  • Tatiana Felix Ferreira and
  • Priscilla F. F. Amaral

16 January 2023

Technological prospecting was performed on documents related to sourdough microbiota using SCOPUS, Web of Science, Google Scholar, Espacenet and Patent Inspiration databases. Scientific articles and patents were analyzed based on three different pers...

  • Review
  • Open Access
27 Citations
6,100 Views
11 Pages

Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome

  • Tamara Rubilar,
  • Elena S. Barbieri,
  • Ayelén Gazquez and
  • Marisa Avaro

11 May 2021

Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA is a polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. EchA is the most studied mole...

  • Review
  • Open Access
3,247 Views
18 Pages

Trends in Viral Vector-Based Vaccines for Tuberculosis: A Patent Review (2010–2023)

  • Lana C. Santos,
  • Antônio Márcio Santana Fernandes,
  • Izabel Almeida Alves,
  • Mairim Russo Serafini,
  • Leandra da Silva e Silva,
  • Humberto Fonseca de Freitas,
  • Luciana C. C. Leite and
  • Carina C. Santos

2 August 2024

Tuberculosis (TB) is an ancient global public health problem. Several strategies have been applied to develop new and more effective vaccines against TB, from attenuated or inactivated mycobacteria to recombinant subunit or genetic vaccines, includin...

  • Review
  • Open Access
9 Citations
6,957 Views
23 Pages

Knee Exoskeletons Design Approaches to Boost Strength Capability: A Review

  • Juan R. Meda-Gutiérrez,
  • Luis Adrián Zúñiga-Avilés,
  • Adriana H. Vilchis-González and
  • Juan Carlos Ávila-Vilchis

26 October 2021

There are different devices to increase the strength capacity of people with walking problems. These devices can be classified into exoskeletons, orthotics, and braces. This review aims to identify the state of the art in the design of these medical...

  • Systematic Review
  • Open Access
20 Citations
17,374 Views
24 Pages

Upper Limb Prostheses by the Level of Amputation: A Systematic Review

  • Diego Segura,
  • Enzo Romero,
  • Victoria E. Abarca and
  • Dante A. Elias

19 March 2024

This review article aims to provide an updated and comprehensive overview of the latest trends in adult upper limb prostheses, specifically targeting various amputation levels such as transradial, transmetacarpal, transcarpal, and transhumeral. A sys...

  • Review
  • Open Access
12 Citations
6,389 Views
53 Pages

Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects

  • Gustavo Souza dos Santos,
  • Thais Luz de Souza,
  • Thaiz Rodrigues Teixeira,
  • João Pedro Cezário Brandão,
  • Keila Almeida Santana,
  • Luan Henrique Santos Barreto,
  • Samantha de Souza Cunha,
  • Daniele Cristina Muniz Batista dos Santos,
  • Conor R. Caffrey and
  • Aníbal de Freitas Santos Júnior
  • + 1 author

Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applic...

  • Review
  • Open Access
12 Citations
5,298 Views
22 Pages

Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review

  • Ingrid Andrea Rodríguez,
  • Mairim Serafini,
  • Izabel Almeida Alves,
  • Karen Luise Lang,
  • Fátima Regina Mena Barreto Silva and
  • Diana Marcela Aragón

Diabetes mellitus (DM) is a metabolic syndrome that can be considered a growing health problem in the world. High blood glucose levels are one of the most notable clinical signs. Currently, new therapeutic alternatives have been tackled from clinicia...

  • Review
  • Open Access
80 Citations
16,322 Views
42 Pages

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019)

  • Pablo Domínguez de María,
  • Gonzalo de Gonzalo and
  • Andrés R. Alcántara

25 September 2019

The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This paper analyses the intellectu...

  • Review
  • Open Access
24 Citations
7,291 Views
29 Pages

Innovation in Alternative Food Sources: A Review of a Technological State-of-the-Art of Insects in Food Products

  • Pedro Paulo Lordelo Guimarães Tavares,
  • Matheus dos Santos Lima,
  • Luiggi Cavalcanti Pessôa,
  • Roberta Barreto de Andrade Bulos,
  • Thâmilla Thalline Batista de Oliveira,
  • Larissa Farias da Silva Cruz,
  • Denilson de Jesus Assis,
  • Elba Santos da Boa Morte,
  • Cláudio Vaz Di Mambro Ribeiro and
  • Carolina Oliveira de Souza

24 November 2022

Insects present great potential for the food industry due to their easier rearing conditions and high nutritional value, in comparison with traditional livestock. However, there is a lack of evaluation of the technological status of food products dev...

  • Article
  • Open Access
1,055 Views
23 Pages

31 October 2025

The use of insects for feed has a significant impact on aquaculture, contributing to the achievement of the Sustainable Development Goal of Zero Hunger and Sustainable Agriculture (SDG 2), among others. This study mapped the intermediate Technology R...

  • Systematic Review
  • Open Access
7 Citations
10,057 Views
31 Pages

14 March 2025

Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that sho...

  • Review
  • Open Access
6 Citations
4,338 Views
17 Pages

Analysis and Modeling of Innovations in the Global Microalgae Lipids Market

  • Natália Santana Carvalho,
  • Luiggi Cavalcanti Pessôa,
  • Kricelle Mosquera Deamici,
  • Jania Betânia Alves da Silva,
  • Fernanda Aleluia de Souza Parga,
  • Carolina Oliveira de Souza,
  • Pedro Paulo Lordelo Guimarães Tavares and
  • Denilson de Jesus Assis

24 August 2022

Microalgae lipids offer numerous advantages over those of plants and animals, enabling the sustainable commercialization of high value-added products in different markets. Although these markets are in a vertiginous annual expansion, technological li...

  • Review
  • Open Access
6 Citations
6,114 Views
21 Pages

Melatonin’s cytoprotective properties may have therapeutic implications in treating ocular diseases like glaucoma and age-related macular degeneration. Literature data suggest that melatonin could potentially protect ocular tissues by decreasin...

  • Review
  • Open Access
731 Views
21 Pages

Patent Landscape Analysis of Bivalve Mollusc Decontamination Technologies: A Review

  • Marcel Afonso Provenzi,
  • Gislaine Fongaro,
  • Juliano De Dea Lindner,
  • Itaciara Larroza Nunes,
  • Beatriz Pereira Savi,
  • Lucas Zanchetta,
  • Svetoslav Dimitrov Todorov,
  • Michael Leonidas Chikindas and
  • Marilia Miotto

4 November 2025

Bivalve molluscs represent an important food source and have a significant economic impact through their commercialization in many countries. As high-capacity filter feeders, they can bioaccumulate contaminants and pathogens, creating tangible consum...

  • Review
  • Open Access
926 Views
24 Pages

Frugal Innovation and Patent Analysis in Sericulture: Lessons for Sustainable Rural Bioeconomy Systems

  • Mónica Fernanda Suárez-Sánchez,
  • Humberto Merritt,
  • Carlos Victor Muñoz-Ruiz,
  • Mauricio Suárez-Sánchez,
  • Ernesto Oregel-Zamudio and
  • Sergio Arias-Martínez

10 November 2025

Sericulture sustains rural livelihoods in Asia, Africa, and Latin America, where it provides income for women, elderly workers, and smallholder households. Yet this sector faces a critical technological divide: traditional reeling methods remain labo...

  • Review
  • Open Access
19 Citations
4,699 Views
18 Pages

The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents

  • Roohi Mohi-ud-din,
  • Reyaz Hassan Mir,
  • Taha Umair Wani,
  • Khalaf F. Alsharif,
  • Waqas Alam,
  • Ashraf Albrakati,
  • Luciano Saso and
  • Haroon Khan

12 April 2022

Cancer is a major health problem across the globe, and is expeditiously growing at a faster rate worldwide. The endoplasmic reticulum (ER) is a membranous cell organelle having inextricable links in cellular homeostasis. Altering ER homeostasis initi...

  • Review
  • Open Access
21 Citations
5,426 Views
15 Pages

29 June 2023

Fresh fruits and vegetables are important sources of minerals, vitamins, fibers, and antioxidants, essential for human well-being. However, some fruits and vegetables are highly perishable with a very short shelf life during storage. Serious consumer...

  • Review
  • Open Access
2 Citations
6,370 Views
39 Pages

Innovative and Patented Liposome-Based Drug Carriers

  • Snežana Ilić-Stojanović,
  • Suzana Cakić,
  • Nada Nikolić and
  • Slobodan Petrović

13 September 2024

Liposome-based drug carriers are multipurpose colloidal drug delivery systems developed mainly for targeted therapy. Researchers have expanded their research on liposomes due to their unique characteristics (e.g., non-toxicity, biodegradability, bioc...

  • Review
  • Open Access
25 Citations
7,359 Views
15 Pages

Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

  • Mohd Imran,
  • Shah Alam Khan,
  • Abida,
  • Mohammed Kanan Alshammari,
  • Saif M. Alkhaldi,
  • Fayez Nafea Alshammari,
  • Mehnaz Kamal,
  • Ozair Alam,
  • Syed Mohammed Basheeruddin Asdaq and
  • Shahamah Jomah
  • + 1 author

25 April 2022

COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islam...

  • Review
  • Open Access
14 Citations
5,058 Views
22 Pages

Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review

  • Keth Ribeiro Garcia,
  • Ruy Carlos Ruver Beck,
  • Rosmary Nichele Brandalise,
  • Venina dos Santos and
  • Letícia Scherer Koester

The use of nanocellulose in pharmaceutics is a trend that has emerged in recent years. Its inherently good mechanical properties, compared to different materials, such as its high tensile strength, high elastic modulus and high porosity, as well as i...

  • Review
  • Open Access
58 Citations
15,625 Views
19 Pages

The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature

  • Mohd Imran,
  • Hamdy Khamees Thabet,
  • Saleh I. Alaqel,
  • Abdullah R. Alzahrani,
  • Abida Abida,
  • Mohammed Kanan Alshammari,
  • Mehnaz Kamal,
  • Anupama Diwan,
  • Syed Mohammed Basheeruddin Asdaq and
  • Sultan Alshehri

Quercetin is a phenolic flavonol compound with established antioxidant, anti-inflammatory, and immuno-stimulant properties. Recent studies demonstrate the potential of quercetin against COVID-19. This article highlighted the prophylactic/therapeutic...

  • Review
  • Open Access
14 Citations
5,668 Views
26 Pages

Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review

  • Sarmin Jamaddar,
  • António Raposo,
  • Chandan Sarkar,
  • Uttam Kumar Roy,
  • Isaac Moura Araújo,
  • Henrique Douglas Melo Coutinho,
  • Ali Saleh Alkhoshaiban,
  • Hmidan A. Alturki,
  • Ariana Saraiva and
  • Muhammad Torequl Islam
  • + 1 author

20 December 2022

Litsea glutinosa (Lour.) C. B. Robinson, belonging to the family Lauraceae, is a multipurpose and fast-growing evergreen or deciduous tree that has been traditionally used for numerous purposes such as treatment for diarrhea, dysentery, abdominal pai...

  • Review
  • Open Access
12 Citations
8,218 Views
18 Pages

Innovation in Cocoa Fermentation: Evidence from Patent Documents and Scientific Articles

  • Luciana Lordelo Nascimento,
  • Marizania Sena Pereira,
  • Lorena Santos de Almeida,
  • Larissa da Silveira Ferreira,
  • Bruna Louise de Moura Pita,
  • Carolina Oliveira de Souza,
  • Camila Duarte Ferreira Ribeiro and
  • Alini Tinoco Fricks

This review aims to analyze the technological and scientific applications regarding cocoa fermentation through a prospective study of patent documents and research articles. The Espacenet database was used as a patent research tool by searching both...

  • Review
  • Open Access
5 Citations
3,706 Views
23 Pages

31 October 2023

The third-largest land plant family, Fabaceae (Papilionaceae), includes trees, shrubs, and perennial or annual herbaceous plants containing both numerous beneficial constituents (e.g., proteins, carbohydrates, dietary fibre) and antinutrients (e.g.,...

  • Review
  • Open Access
41 Citations
7,607 Views
22 Pages

Shape-Memory Polymers in Dentistry: Systematic Review and Patent Landscape Report

  • Alessandro Bruni,
  • Francesca Giulia Serra,
  • Andrea Deregibus and
  • Tommaso Castroflorio

10 July 2019

Objective: To perform a systematic review (SR) of existing literature and a patent landscape report (PLR) regarding the potential applications of shape-memory polymers (SMPs) in dentistry. Search strategy: Clinical and Biomedical online databases (Pu...

  • Review
  • Open Access
1 Citations
3,573 Views
77 Pages

26 November 2024

Background/Objectives: The environmental problems associated with meat production, the pain and distress of animals, and health problems have contributed to the increased appreciation of meat alternatives. Methods: The review of patented inventions p...

  • Review
  • Open Access
696 Views
31 Pages

17 December 2025

Background/Objectives. Edible oils derived from herbaceous and woody plants are an important nutritional resource, assuring the health and performance of sportspeople. The aim of this study was to review the inventions and experimental articles refer...

  • Article
  • Open Access
2 Citations
3,335 Views
16 Pages

Single-Cell Transcriptomic Analysis of Different Liver Fibrosis Models: Elucidating Molecular Distinctions and Commonalities

  • Guofei Deng,
  • Xiaomei Liang,
  • Yuxi Pan,
  • Yusheng Luo,
  • Zizhen Luo,
  • Shaoxuan He,
  • Shuai Huang,
  • Zhaopeng Chen,
  • Jiancheng Wang and
  • Shuo Fang

Background: Liver fibrosis, a consequence of various chronic liver diseases, is characterized by excessive accumulation of extracellular matrix (ECM), leading to impaired liver function and potentially progressing to cirrhosis or hepatocellular carci...

  • Review
  • Open Access
25 Citations
14,930 Views
30 Pages

This review focuses on the promising technology of solid-state batteries (SSBs) that utilize lithium metal and solid electrolytes. SSBs offer significant advantages in terms of high energy density and enhanced safety. This review categorizes solid el...

  • Systematic Review
  • Open Access
749 Views
27 Pages

Agricultural Biomass as a Resource for Biomaterials, Biofertilizers, and Bioproducts: A Systematic Review

  • Bruna Pereira Almeida,
  • Luiz Felipe Silveira Pavão,
  • Marcelo Silveira de Farias,
  • Nidgia Maria Nicolodi,
  • Mirta Teresinha Petry,
  • Marisa Menezes Leal,
  • Paulo Carteri Coradi,
  • Victória Lumertz de Souza,
  • Mayara de Souza Queirós and
  • Giovani Leone Zabot
  • + 2 authors

This systematic review aimed to examine recent advances (2021–2025) in the conversion of agricultural biomass into biomaterials, biofertilizers, and bioproducts. Studies were included when addressing biomass types, pretreatment methods, convers...

  • Review
  • Open Access
26 Citations
5,617 Views
14 Pages

Oral Brincidofovir Therapy for Monkeypox Outbreak: A Focused Review on the Therapeutic Potential, Clinical Studies, Patent Literature, and Prospects

  • Mohd. Imran,
  • Mohammed Kanan Alshammari,
  • Mandeep Kumar Arora,
  • Amit Kumar Dubey,
  • Sabya Sachi Das,
  • Mehnaz Kamal,
  • Abdulaziz Saad Abdulrahman Alqahtani,
  • Mohammed Ahmed Yahya Sahloly,
  • Ahmed Hammad Alshammari and
  • Tafadzwa Dzinamarira
  • + 4 authors

The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one hundred countries and is becoming a global concern. Unfortunately, only a few treatments, such as tecovirimat (TCV), are available against MPX. Brincidofovir (BCV) is a U...

  • Article
  • Open Access
23 Citations
6,340 Views
28 Pages

Proposal to Reuse Rubber Waste from End-Of-Life Tires Using Thermosetting Resin

  • Andre Hekermann Buss,
  • João Luiz Kovaleski,
  • Regina Negri Pagani,
  • Vander Luiz da Silva and
  • Jaqueline de Matos Silva

7 December 2019

Due to the increasing production of motor vehicles, a large amount of waste with different characteristics and compositions is generated, notably end-of-life tires, which are harmful to the environment when not properly disposed. Their composition co...

  • Proceeding Paper
  • Open Access
4 Citations
1,730 Views
11 Pages

15 November 2023

This report aims to provide a patent landscape analysis on carbon allotrope-based textile electrodes and biosensors to measure biosignals and detect several parameters. Espacenet, a free-of-charge patent database provided by the EPO (European Patent...

  • Proceeding Paper
  • Open Access
1,665 Views
4 Pages

2 December 2020

Over the last 20 years, the dairy industry has implemented new technologies related to automatic milking systems (AMS). AMSs have the potential to maximize milk production and animals’ welfare thanks to voluntary milking access, as well as to increas...

  • Review
  • Open Access
9 Citations
12,531 Views
16 Pages

Highlights on the Development, Related Patents, and Prospects of Lenacapavir: The First-in-Class HIV-1 Capsid Inhibitor for the Treatment of Multi-Drug-Resistant HIV-1 Infection

  • Tafadzwa Dzinamarira,
  • Mazen Almehmadi,
  • Ahad Amer Alsaiari,
  • Mamdouh Allahyani,
  • Abdulelah Aljuaid,
  • Abdulaziz Alsharif,
  • Abida Khan,
  • Mehnaz Kamal,
  • Ali A. Rabaan and
  • Mohd Imran
  • + 4 authors

28 May 2023

The multidrug-resistant (MDR) human immunodeficiency virus 1 (HIV-1) infection is an unmet medical need. HIV-1 capsid plays an important role at different stages of the HIV-1 replication cycle and is an attractive drug target for developing therapies...

  • Review
  • Open Access
25 Citations
5,210 Views
15 Pages

MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature

  • Mohd. Imran,
  • Mandeep Kumar Arora,
  • Anurag Chaudhary,
  • Shah Alam Khan,
  • Mehnaz Kamal,
  • Manal Mutlaq Alshammari,
  • Raghad Mohammad Alharbi,
  • Nuha Abdullah Althomali,
  • Ibrahim Mohammed Alzimam and
  • Ali A. Rabaan
  • + 5 authors

Tuberculosis (TB) is accountable for considerable global morbidity and mortality. Effective TB therapy with multiple drugs completes in about six months. The longer duration of TB therapy challenges patient compliance and contributes to treatment col...