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Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019)

Sustainable Momentum, SL. Av. Ansite 3, 4–6, E-35011 Las Palmas Gran Canaria, Spain
Organic Chemistry Departament, University of Sevilla, c/ Profesor García González 2, 41012 Sevilla, Spain
Department of Chemistry in Pharmaceutical Sciences, Section of Organic Chemistry (Pharmaceutical Chemistry), Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal, s/n., E-28040 Madrid, Spain
Authors to whom correspondence should be addressed.
Catalysts 2019, 9(10), 802;
Received: 6 September 2019 / Revised: 18 September 2019 / Accepted: 22 September 2019 / Published: 25 September 2019
(This article belongs to the Special Issue Biocatalysis: Chemical Biosynthesis)
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This paper analyses the intellectual property activities of the last five years (2014–2019) with a specific focus on biocatalysis applied to asymmetric synthesis. Furthermore, to reflect the inventive and innovative steps, only patents that were granted during that period are considered. Patent searches using several keywords (e.g., enzyme names) have been conducted by using several patent engine servers (e.g., Espacenet, SciFinder, Google Patents), with focus on granted patents during the period 2014–2019. Around 200 granted patents have been identified, covering all enzyme types. The inventive pattern focuses on the protection of novel protein sequences, as well as on new substrates. In some other cases, combined processes, multi-step enzymatic reactions, as well as process conditions are the innovative basis. Both industries and academic groups are active in patenting. As a conclusion of this survey, we can assert that biocatalysis is increasingly recognized as a useful tool for asymmetric synthesis and being considered as an innovative option to build IP and protect synthetic routes. View Full-Text
Keywords: biocatalysis; asymmetric synthesis; patents; lipases; oxidoreductases; lyases; transaminases biocatalysis; asymmetric synthesis; patents; lipases; oxidoreductases; lyases; transaminases
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MDPI and ACS Style

de María, P.D.; de Gonzalo, G.; Alcántara, A.R. Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019). Catalysts 2019, 9, 802.

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