Skip to Content
You are currently on the new version of our website. Access the old version .

4,879 Results Found

  • Article
  • Open Access
19 Citations
5,958 Views
18 Pages

16 February 2021

Brewer’s spent grain (BSG) is the main by-product of the beer brewing process. It has a huge potential as a feedstock for bio-based manufacturing processes to produce high-value bio-products, biofuels, and platform chemicals. For the valorisation of...

(This article belongs to the Special Issue Bioethanol Production Processes)
  • Article
  • Open Access
3 Citations
1,410 Views
12 Pages

Loss Function Optimization Method and Unsupervised Extraction Approach D-DBSCAN for Improving the Moving Target Perception of 3D Imaging Sonar

  • Jingfeng Yu,
  • Aigen Huang,
  • Zhongju Sun,
  • Rui Huang and ,
  • Gao Huang and
  • Qianchuan Zhao
  • + 1 author+ 0 author

Imaging sonar is a crucial tool for underwater visual perception. Compared to 2D sonar images, 3D sonar images offer superior spatial positioning capabilities, although the data acquisition cost is higher and lacks open source references for data ann...

(This article belongs to the Section Ocean Engineering)
  • Article
  • Open Access
3 Citations
2,489 Views
17 Pages

Functionally graded materials (FGMs) are revolutionizing various industries with their customizable properties, a key advantage over traditional composites. The rise of voxel-based 3D printing has furthered the development of FGMs with complex micros...

(This article belongs to the Special Issue Multifunctional Composites, Volume III)
  • Article
  • Open Access
11 Citations
3,640 Views
38 Pages

5 January 2022

This paper presents the steady-state stress analysis of single-layered and multilayered plates and shells embedding Functionally Graded Material (FGM) layers under moisture conditions. This solution relies on an exact layer-wise approach; the formula...

(This article belongs to the Special Issue Recent Advances in Theoretical and Computational Modeling of Composite Materials and Structures)
  • Editorial
  • Open Access
27 Citations
3,841 Views
5 Pages

Microbial biofilms are found everywhere and can be either beneficial or detrimental, as they are involved in crucial ecological processes and in severe chronic infections. The functional properties of biofilms are closely related to their three-dimen...

(This article belongs to the Special Issue Microbial Biofilms: Structural Plasticity and Emerging Properties)
  • Article
  • Open Access
1,772 Views
10 Pages

Computation of the Multi-Spheres Scattering Coefficient Using the Prime Index Method

  • Fangcheng Huang,
  • Carlo Santini,
  • Fabio Mangini and
  • Fabrizio Frezza

8 December 2024

The analytical-numerical evaluation of the scattering of electromagnetic waves by multiple spheres requires the computation of numerous coefficients. For this purpose, many contributions, available in the literature, have traditionally employed the r...

(This article belongs to the Special Issue Optical Imaging and Measurements: 2nd Edition)
  • Review
  • Open Access
4 Citations
5,192 Views
12 Pages

Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models

  • P. Jonathan Li,
  • Jeroen P. Roose,
  • David M. Jablons and
  • Johannes R. Kratz

9 February 2021

3D models of cancer have the potential to improve basic, translational, and clinical studies. Patient-derived xenografts, spheroids, and organoids are broad categories of 3D models of cancer, and to date, these 3D models of cancer have been establish...

(This article belongs to the Collection Application of Bioinformatics in Cancers)
  • Article
  • Open Access
16 Citations
5,079 Views
27 Pages

Exploration of Free Energy Surface and Thermal Effects on Relative Population and Infrared Spectrum of the Be6B11− Fluxional Cluster

  • Carlos Emiliano Buelna-Garcia,
  • José Luis Cabellos,
  • Jesus Manuel Quiroz-Castillo,
  • Gerardo Martinez-Guajardo and ,
  • Cesar Castillo-Quevedo,
  • Aned de-Leon-Flores,
  • Gilberto Anzueto-Sanchez and
  • Martha Fabiola Martin-del-Campo-Solis
  • + 3 authors+ 0 author

29 December 2020

The starting point to understanding cluster properties is the putative global minimum and all the nearby local energy minima; however, locating them is computationally expensive and difficult. The relative populations and spectroscopic properties tha...

(This article belongs to the Section Materials Chemistry)
  • Feature Paper
  • Article
  • Open Access
12 Citations
4,676 Views
17 Pages

14 January 2018

This work deals with the study of the convergence ratio of the exponential matrix method used in the 3D static analysis of functionally graded structures subjected to harmonic loads. The equilibrium equations are written in mixed orthogonal curviline...

(This article belongs to the Special Issue Functionally Graded Material (FGM) and Functionally Graded Carbon Nanotube (FG-CNT) Reinforced Composites)
  • Article
  • Open Access
2 Citations
2,618 Views
21 Pages

Geometric–Statistical Model for Middle-Ear Anatomy and Ventilation

  • Marian Rădulescu,
  • Adela-Ioana Mocanu,
  • Ionela Teodora Dascălu,
  • Mihai-Adrian Schipor and
  • Horia Mocanu

7 November 2022

The ventilation of the middle-ear (ME) is achieved by the mucosa covering the bony cavities of this segment, which we have previously defined as consisting of two distinct epithelial areas, each representing an independent organ with characteristic f...

(This article belongs to the Section Biomedical Engineering)
  • Review
  • Open Access
837 Views
27 Pages

The temporomandibular joint (TMJ) is a highly specialized synovial joint responsible for essential functions such as mastication, speech, and swallowing. Owing to its unique anatomical organization, complex biomechanics, and heterogeneous tissue comp...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Article
  • Open Access
10 Citations
5,240 Views
16 Pages

Evaluation of Physicochemical Properties of a Hydrocolloid-Based Functional Food Fortified with Caulerpa lentillifera: A D-Optimal Design Approach

  • Nor Atikah Husna Ahmad Nasir,
  • Mohd Hafis Yuswan,
  • Nor Nadiah Abd Karim Shah,
  • Aswir Abd Rashed and ,
  • Kazunori Kadota and
  • Yus Aniza Yusof
  • + 1 author+ 0 author

29 June 2023

This study introduced a D-optimal design mixture to assess the physicochemical properties of a hydrocolloid-based functional food fortified with C. lentillifera. The combination incorporated vital jelly constituents, including extract (10–15%),...

(This article belongs to the Special Issue Recent Advances in Food Gels)
  • Perspective
  • Open Access
1 Citations
728 Views
30 Pages

19 April 2026

3D bioprinting of hydrogel–cell composites requires simultaneous consideration of the biomechanical properties of the printed structures, the construct’s geometric stability, and conditions conducive to cell survival and function. Hydroge...

(This article belongs to the Special Issue Design and Process Strategies for Mechanical Reinforcement in Polymer Additive Manufacturing)
  • Article
  • Open Access
13 Citations
4,616 Views
25 Pages

Spongin as a Unique 3D Template for the Development of Functional Iron-Based Composites Using Biomimetic Approach In Vitro

  • Anita Kubiak,
  • Martyna Pajewska-Szmyt,
  • Martyna Kotula,
  • Bartosz Leśniewski and ,
  • Alona Voronkina,
  • Parvaneh Rahimi,
  • Sedigheh Falahi,
  • Korbinian Heimler,
  • Anika Rogoll and
  • Hermann Ehrlich
  • + 14 authors+ 9 authors

22 August 2023

Marine sponges of the subclass Keratosa originated on our planet about 900 million years ago and represent evolutionarily ancient and hierarchically structured biological materials. One of them, proteinaceous spongin, is responsible for the formation...

(This article belongs to the Special Issue Collagen and Chitin from Marine Resources and Their Interdisciplinary Applications)
  • Article
  • Open Access
12 Citations
2,215 Views
34 Pages

A Refined Fuzzy MARCOS Approach with Quasi-D-Overlap Functions for Intuitive, Consistent, and Flexible Sensor Selection in IoT-Based Healthcare Systems

  • Mahmut Baydaş,
  • Safiye Turgay,
  • Mert Kadem Ömeroğlu,
  • Abdulkadir Aydin and ,
  • Gıyasettin Baydaş,
  • Željko Stević,
  • Enes Emre Başar,
  • Murat İnci and
  • Mehmet Selçuk
  • + 4 authors+ 0 author

6 August 2025

Sensor selection in IoT-based smart healthcare systems is a complex fuzzy decision-making problem due to the presence of numerous uncertain and interdependent evaluation criteria. Traditional fuzzy multi-criteria decision-making (MCDM) approaches oft...

(This article belongs to the Special Issue Advances in Multiple-Criteria Decision Making: New Trends and Applications)
  • Review
  • Open Access
1 Citations
7,083 Views
22 Pages

17 April 2014

We summarize recent progress on the symmetric subtraction of the Non-Linear Sigma Model in D dimensions, based on the validity of a certain Local Functional Equation (LFE) encoding the invariance of the SU(2) Haar measure under local left transformat...

(This article belongs to the Special Issue Physics based on Two-by-two Matrices)
  • Article
  • Open Access
81 Citations
12,058 Views
18 Pages

The Direct 3D Printing of Functional PEEK/Hydroxyapatite Composites via a Fused Filament Fabrication Approach

  • Krzysztof Rodzeń,
  • Preetam K. Sharma,
  • Alistair McIlhagger,
  • Mozaffar Mokhtari and ,
  • Foram Dave,
  • David Tormey,
  • Richard Sherlock,
  • Brian J. Meenan and
  • Adrian Boyd
  • + 4 authors+ 0 author

12 February 2021

The manufacture of polyetheretherketone/hydroxyapatite (PEEK/HA) composites is seen as a viable approach to help enhance direct bone apposition in orthopaedic implants. A range of methods have been used to produce composites, including Selective Lase...

(This article belongs to the Section Polymer Composites and Nanocomposites)
  • Article
  • Open Access
40 Citations
3,857 Views
14 Pages

Strength Evaluation of Functionalized MWCNT-Reinforced Polymer Nanocomposites Synthesized Using a 3D Mixing Approach

  • Vijay Patel,
  • Unnati Joshi,
  • Anand Joshi,
  • Ankit D. Oza and ,
  • Chander Prakash,
  • Emanoil Linul,
  • Raul Duarte Salgueiral Gomes Campilho,
  • Sandeep Kumar and
  • Kuldeep Kumar Saxena
  • + 4 authors+ 0 author

18 October 2022

The incorporation of carboxyl functionalized multi-walled carbon nanotube (MWCNT- COOH) into a polymethyl methacrylate (PMMA) has been investigated. The resultant tensile and flexural mechanical properties have been determined. In this paper, a novel...

  • Article
  • Open Access
1 Citations
4,137 Views
16 Pages

Sheet Metal Design Approach for 3D Shaped Facade Elements with Integrated Solar Thermal Functionality

  • Peter Scholz,
  • Dieter Weise,
  • Linda Schmidt,
  • Martin Dembski and ,
  • Alexander Stahr,
  • Martin Dix,
  • Florin Duminica,
  • Sebastien Le Craz and
  • Jiri Koziorek
  • + 4 authors+ 0 author

13 April 2023

This paper provides an overview of the development of a 3D formed and metal-based facade element that combines a custom design and solar thermal functionality. To achieve this, a novel simplified solar thermal collector structure was developed using...

(This article belongs to the Topic Advances in Renewable Energy and Energy Storage)
  • Article
  • Open Access
6 Citations
1,761 Views
16 Pages

7 July 2023

We consider the coefficient inverse problem for the 2D acoustic equation. The problem is recovering the speed of sound in the medium (which depends only on the depth) and the density (function of both variables). We describe the method, based on the...

(This article belongs to the Special Issue Direct and Inverse Spectral Problems for Ordinary Differential and Functional-Differential Operators)
  • Article
  • Open Access
8 Citations
4,006 Views
24 Pages

21 August 2021

Guiding an aircraft to 4D waypoints at a certain heading is a multi-dimensional goal aircraft guidance problem. [d=Zu]In order to improve the performance and solve this problem, this paper proposes a multi-layer RL approach.To enhance the performance...

(This article belongs to the Topic Intelligent Transportation Systems)
  • Article
  • Open Access
1 Citations
5,441 Views
10 Pages

We consider a gas of interacting electrons in the limit of nearly uniform density and treat the one dimensional (1D), two dimensional (2D) and three dimensional (3D) cases. We focus on the determination of the correlation part of the kinetic function...

(This article belongs to the Special Issue Advances in Electronic Structure Theory: Method Development and Application)
  • Review
  • Open Access
61 Citations
15,268 Views
18 Pages

6D Pose Estimation of Objects: Recent Technologies and Challenges

  • Zaixing He,
  • Wuxi Feng,
  • Xinyue Zhao and
  • Yongfeng Lv

29 December 2020

6D pose estimation is a common and important task in industry. Obtaining the 6D pose of objects is the basis for many other functions such as bin picking, autopilot, etc. Therefore, many corresponding studies have been made in order to improve the ac...

(This article belongs to the Special Issue Trends and Challenges in Robotic Applications)
  • Article
  • Open Access
3 Citations
2,707 Views
16 Pages

Understanding the Structure–Function Relationship through 3D Imaging and Biomechanical Analysis: A Novel Methodological Approach Applied to Anterior Cruciate Ligaments

  • Marco Bontempi,
  • Nicola Sancisi,
  • Gregorio Marchiori,
  • Michele Conconi and ,
  • Matteo Berni,
  • Giorgio Cassiolas,
  • Gianluca Giavaresi,
  • Annapaola Parrilli and
  • Nicola Francesco Lopomo
  • + 4 authors+ 0 author

Understanding the microstructure of fibrous tissues, like ligaments, is crucial due to their nonlinear stress-strain behavior from unique fiber arrangements. This study introduces a new method to analyze the relationship between the microstructure an...

  • Article
  • Open Access
68 Citations
13,093 Views
29 Pages

3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors

  • Mahreen Arooj,
  • Sundarapandian Thangapandian,
  • Shalini John,
  • Swan Hwang and ,
  • Jong Keun Park and
  • Keun Woo Lee
  • + 1 author+ 0 author

12 December 2011

Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like pharmacophore modeling, database screening, molecular docking and Density Functional Theory (DFT) calculations, an inves...

(This article belongs to the Section Biochemistry)
  • Article
  • Open Access
7 Citations
7,970 Views
20 Pages

11 May 2023

3D shape generation is widely applied in various industries to create, visualize, and analyse complex data, designs, and simulations. Typically, 3D shape generation uses a large dataset of 3D shapes as the input. This paper proposes a variational aut...

  • Article
  • Open Access
5 Citations
3,844 Views
21 Pages

A New Approach to Decoupled Non-Resonant Polishing

  • Yucheng Li,
  • Xiaoqin Zhou,
  • Guilian Wang,
  • Peiqun Ma and
  • Rongqi Wang

18 July 2019

Two-dimensional vibration-assisted polishing (2D-VAP) is a new polishing approach proposed in recent years, which is considered to be very suitable for the polishing of micro-optical parts and micro-structured surfaces. The advantages of the 2D-VAP a...

  • Article
  • Open Access
2 Citations
2,976 Views
18 Pages

Learning to Prioritize Test Cases for Computer Aided Design Software via Quantifying Functional Units

  • Fenfang Zeng,
  • Shaoting Liu,
  • Feng Yang,
  • Yisen Xu and ,
  • Guofu Zhou and
  • Jifeng Xuan
  • + 1 author+ 0 author

15 October 2022

Computer Aided Design (CAD) is a family of techniques that support the automation of designing and drafting 2D and 3D models with computer programs. CAD software is a software platform that provides the process from designing to modeling, such as Aut...

(This article belongs to the Special Issue Reliability and Safety of Software Systems)
  • Article
  • Open Access
1 Citations
688 Views
17 Pages

Design and Implementation of 3D Geological Suitability Evaluation System for Underground Space Development

  • Fanfan Dou,
  • Meijun Xu,
  • Yong Guan,
  • Hui Zhang and ,
  • Lan Liu,
  • Yanming Li and
  • Baokai Yang
  • + 2 authors+ 0 author

19 February 2026

Traditional underground space evaluation systems often employ 2D GIS methods to represent 3D information, leading to issues such as the loss of 3D spatial data and insufficient resolution in depth. To address the practical needs and methodological st...

(This article belongs to the Topic Development of Underground Space for Engineering Application, 2nd Edition)
  • Review
  • Open Access
7 Citations
6,579 Views
14 Pages

2 February 2024

Context: Type 1 diabetes (T1D) results from the autoimmune T-cell mediated destruction of pancreatic beta cells leading to insufficient insulin secretion. At the time of diagnosis of T1D, there is residual beta cell function that declines over the su...

(This article belongs to the Special Issue Advances in Childhood Diabetes)
  • Article
  • Open Access
4 Citations
1,982 Views
11 Pages

A Matrix Approach to Vertex-Degree-Based Topological Indices

  • Roberto Cruz,
  • Carlos Espinal and
  • Juan Rada

30 June 2024

A VDB (vertex-degree-based) topological index over a set of digraphs H is a function φ:H→R, defined for each H∈H as φH=12∑uv∈Eφdu+dv−, where E is the arc set of H, du+ and dv− denote the out-degree and in-de...

(This article belongs to the Special Issue Graph Theory and Applications, 2nd Edition)
  • Article
  • Open Access
8 Citations
3,248 Views
18 Pages

16 September 2021

Functional annotation of unknown function genes reveals unidentified functions that can enhance our understanding of complex genome communications. A common approach for inferring gene function involves the ortholog-based method. However, genetic dat...

(This article belongs to the Special Issue Complex Networks, Bio-Molecular Systems, and Machine Learning)
  • Article
  • Open Access
245 Citations
16,399 Views
9 Pages

18 October 2019

This article concerns the expressive power of depth in neural nets with ReLU activations and a bounded width. We are particularly interested in the following questions: What is the minimal width w min ( d ) so that ReLU nets of width ...

(This article belongs to the Special Issue Computational Mathematics, Algorithms, and Data Processing)
  • Article
  • Open Access
6 Citations
2,675 Views
15 Pages

12 July 2021

Recently, for calculating the effective pair interactions in liquid transition metals, we have developed an approach which includes the Wills-Harrison and Bretonnet-Silbert models as limit cases. Here, we apply this approach to noble liquid metals. T...

(This article belongs to the Special Issue Liquid Metals, Alloys, Salts, Oxides, and Their Coexistence and Interaction with Solid Phases)
  • Article
  • Open Access
6 Citations
8,811 Views
16 Pages

12 January 2023

Recent studies have shown that deep learning achieves excellent performance in reconstructing 3D scenes from multiview images or videos. However, these reconstructions do not provide the identities of objects, and object identification is necessary f...

(This article belongs to the Section E1: Mathematics and Computer Science)
  • Article
  • Open Access
17 Citations
4,648 Views
25 Pages

Estimating Permeability of Porous Media from 2D Digital Images

  • Gang Lei,
  • Tianle Liu,
  • Qinzhuo Liao and
  • Xupeng He

Digital rock physics (DRP) has been widely used as an effective approach for estimating the permeability of porous media. However, conventional implementation of DRP requires the reconstruction of three-dimensional (3D) pore networks, which suffer fr...

(This article belongs to the Special Issue High-Efficient Exploration and Development of Oil & Gas from Ocean)
  • Article
  • Open Access
11 Citations
8,508 Views
13 Pages

Self-Assembly of 1D/2D Hybrid Nanostructures Consisting of a Cd(II) Coordination Polymer and NiAl-Layered Double Hydroxides

  • Gonzalo Abellán,
  • Pilar Amo-Ochoa,
  • José Luis G. Fierro,
  • Antonio Ribera and ,
  • Eugenio Coronado and
  • Félix Zamora
  • + 1 author+ 0 author

29 December 2015

The preparation and characterization of a novel hybrid material based on the combination of a 2D-layered double hydroxide (LDH) nanosheets and a 1D-coordination polymer (1D-CP) has been achieved through a simple mixture of suspensions of both buildin...

(This article belongs to the Special Issue Coordination Polymers: New Materials for Multiple Applications)
  • Article
  • Open Access
29 Citations
2,597 Views
10 Pages

Modified Exp-Function Method to Find Exact Solutions of Ionic Currents along Microtubules

  • Attaullah,
  • Muhammad Shakeel,
  • Nehad Ali Shah and
  • Jae Dong Chung

8 March 2022

A number of solitary wave solutions for microtubules (MTs) are observed in this article by using the modified exp-function approach. We tackle the problem by treating the results as nonlinear RLC transmission lines, and then finding exact solutions t...

(This article belongs to the Special Issue Mathematics and Engineering II)
  • Review
  • Open Access
11 Citations
8,160 Views
19 Pages

Preventive Epigenetic Mechanisms of Functional Foods for Type 2 Diabetes

  • Bilyaminu Abubakar,
  • Dawoud Usman,
  • Kamaldeen Olalekan Sanusi,
  • Nur Hanisah Azmi and
  • Mustapha Umar Imam

Type 2 diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential...

(This article belongs to the Special Issue Lifestyle Behavior Intervention for Diabetes Prevention and Management)
  • Feature Paper
  • Review
  • Open Access
3 Citations
3,709 Views
27 Pages

The Saccharomyces cerevisiae α-factor mating pheromone receptor (Ste2p) has been studied as a model for the large medically important family of G protein-coupled receptors. Diverse yeast genetic screens and high-throughput mutagenesis of STE2 i...

(This article belongs to the Special Issue Transmembrane and Intracellular Signal Transduction Mechanisms: A Themed Issue in Honor of Professor Jeremy Thorner)
  • Article
  • Open Access
2,220 Views
18 Pages

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess the potential for chondrogenic differentiation, offering a promising alternative source for cartilage regeneration. To address the limited availability and expansion capacity of a...

  • Article
  • Open Access
28 Citations
11,809 Views
32 Pages

28 December 2010

This paper presents a model-based approach for reconstructing 3D polyhedral building models from aerial images. The proposed approach exploits some geometric and photometric properties resulting from the perspective projection of planar structures. D...

(This article belongs to the Special Issue 10 Years Sensors - A Decade of Publishing)
  • Article
  • Open Access
6 Citations
3,297 Views
17 Pages

25 February 2023

Focused electron-beam-induced deposition (FEBID) is a highly versatile direct-write approach with particular strengths in the 3D nanofabrication of functional materials. Despite its apparent similarity to other 3D printing approaches, non-local effec...

(This article belongs to the Special Issue Nanomaterials Fabricated by Electron-Beam-Induced Deposition and Related Processes)
  • Article
  • Open Access
13 Citations
7,091 Views
17 Pages

11 July 2017

The Gottesman–Knill theorem established that stabilizer states and Clifford operations can be efficiently simulated classically. For qudits with odd dimension three and greater, stabilizer states and Clifford operations have been found to correspond...

(This article belongs to the Special Issue Quantum Information and Foundations)
  • Article
  • Open Access
1 Citations
857 Views
24 Pages

Multi-State Structural Genomics Enables Large-Scale, Mechanistic, and Context-Specific Classification of ABCC6 Genetic Variants Implicated in Calcification Diseases

  • Jessica B. Wagenknecht,
  • Neshatul Haque,
  • Salomao D. Jorge,
  • Brian D. Ratnasinghe and ,
  • Raul Urrutia,
  • William A. Gahl,
  • Shira G. Ziegler and
  • Michael T. Zimmermann
  • + 3 authors+ 0 author

14 February 2026

Genetic variation in ATP Binding Cassette Subfamily C Member 6 (ABCC6) can cause both pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI). There are 930 distinct missense variants in ABCC6 reported, 87% of which ar...

(This article belongs to the Special Issue Genomic Research of Rare Diseases)
  • Article
  • Open Access
3 Citations
2,559 Views
8 Pages

The Fifth Coefficient of Bazilevič Functions

  • Oh Sang Kwon,
  • Derek Keith Thomas and
  • Young Jae Sim

26 July 2020

Let f∈A, the class of normalized analytic functions defined in the unit disk D, and be given by f(z)=z+∑n=2∞anzn for z∈D. This paper presents a new approach to finding bounds for |an|. As an application, we find the sharp bound fo...

(This article belongs to the Special Issue Symmetry in Geometric Functions and Mathematical Analysis)
  • Review
  • Open Access
311 Citations
37,276 Views
22 Pages

A Review of the Important Role of CYP2D6 in Pharmacogenomics

  • Christopher Taylor,
  • Ian Crosby,
  • Vincent Yip,
  • Peter Maguire and ,
  • Munir Pirmohamed and
  • Richard M. Turner
  • + 1 author+ 0 author

30 October 2020

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology. Nevertheless, CYP2D6 is h...

(This article belongs to the Special Issue Pharmacogenomic Determinants of Interindividual Drug Response Variability: From Discovery to Implementation)
  • Review
  • Open Access
31 Citations
7,889 Views
12 Pages

We review the first successes and failures of a “new wave” of quantum chemistry-based approaches to the treatment of protein/ligand interactions. These approaches share the use of “enhanced”, dispersion (D), and/or hydrogen-bond (H) corrected density...

(This article belongs to the Special Issue Proteins and Protein-Ligand Interactions)
  • Article
  • Open Access
11 Citations
6,223 Views
18 Pages

Fluorene-Based Donor-Acceptor Copolymers Containing Functionalized Benzotriazole Units: Tunable Emission and their Electrical Properties

  • Iván Torres-Moya,
  • Rebeca Vázquez-Guilló,
  • Sara Fernández-Palacios,
  • José Ramón Carrillo and ,
  • Ángel Díaz-Ortiz,
  • Juan Teodomiro López Navarrete,
  • Rocío Ponce Ortiz,
  • Mari Carmen Ruiz Delgado,
  • Ricardo Mallavia and
  • Pilar Prieto
  • + 5 authors+ 0 author

22 January 2020

Monomers 4,7-dibromo-2H-benzo[d]1,2,3-triazole (m1) and 4,7-(bis(4-bromophenyl)ethynyl)-2H-benzo[d]1,2,3-triazole (m2) have been synthesized in good yields using different procedures. Monomers m1 and m2 have been employed for building new copolymers...

of 98