2,004 Results Found

Cholinesterases (ChEs) display a non-michaelian behavior with positively charged substrates. In the steady-state rate equation, the b factor describes this behavior: if b > 1 there is substrate activation, if b < 1 there is substrate inhibition...

We have reported excess B-cell activating factor (BAFF) in the blood of HIV-infected progressors, which was concomitant with increased frequencies of precursor-like marginal zone (MZp) B-cells, early on and despite antiretroviral therapy (ART). In co...

We have previously shown that blood levels of B-cell Activating Factor (BAFF) rise relatively to disease progression status in the context of HIV-1 infection. Excess BAFF was concomitant with hyperglobulinemia and the deregulation of blood B-cell pop...

(1) Background: Socioeconomic inequalities of survival in patients with lymphoma persist, which may be explained by patients’ comorbidities. We aimed to assess the association between comorbidities and the survival of patients diagnosed with diffuse...

Conceivable explanations of Belle-II measurements of a (surprising) excess of missing energy decays of the B meson to the K meson not covered by standard model neutrino–antineutrino pairs might be offered by additional contributions of dark mat...

Despite vitamin B12’s recognized importance for the nervous system, there is still a lack of research on the association between vitamin B12 and sleep, especially in primary care settings. We assessed vitamin B12 levels in adult primary healthc...

Prior research generally finds that the Pfizer-BioNTech (BNT162b2) and Moderna (mRNA1273) COVID-19 vaccines provide similar protection against mortality, sometimes with a Moderna advantage due to slower waning. However, most comparisons do not addres...

Astrocytes have critical roles in immune defense, homeostasis, metabolism, and synaptic remodeling and function in the central nervous system (CNS); however, excessive activation of astrocytes with increased intermediate filaments following neuronal...

Vitamin B12 (cobalamin) is a critical micronutrient involved in hematopoiesis and neurological function. Its deficiency, commonly presenting with anemia and neurological symptoms, is particularly relevant in oncology. While anemia affects up to 60% o...

The immunological findings from autopsies, biopsies, and various studies in COVID-19 patients show that the major cause of morbidity and mortality in COVID-19 is excess immune response resulting in hyper-inflammation. With the objective to review var...

Since the essentiality of boron (B) to plant growth was reported nearly one century ago, the implication of B in physiological performance, productivity and quality of agricultural products, and the morphogenesis of apical meristem in plants has wide...

Charged surfaces and particles of the same sign never attract, but oppositely oppositely charged ones do. If the surface potentials of two colloids, namely ψA and ψB, differ in sign, the difference among representative exponentials, i.e., (ex...

The formation of NbB2–MgAl2O4 composites from the MgO-added thermite-based reaction systems was investigated by self-propagating high-temperature synthesis (SHS). Two thermite mixtures, Nb2O5/B2O3/Al and Nb2O5/Al, were, respectively, adopted in React...

Characterized by social communication deficits and the presence of restricted and repetitive behaviors, autism spectrum disorder (ASD) is a significant neurodevelopmental condition. Genetic studies have revealed a strong association between ASD and n...

Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized we...

Boron (B) toxicity is a common limiting factor both in arid and semiarid regions, such as the Mediterranean Basin. Citrus trees are sensitive to B-toxicity, which generates a negative impact in citrus orchards. In this work, two promising citrus root...

Assessing for volume overload is a key component of both short and long-term management of heart failure patients. Physical examination findings are neither sensitive nor specific for detecting congestion, and subclinical congestion may not be eviden...

Boron (B) is an essential nutrient for plant growth and development, exhibiting extremely narrow margins between deficiency and toxicity. B toxicity is devastating for productivity and apparent for a continuously increasing part of agricultural land,...

Background/Objectives: Infective endocarditis (IE) remains a rare but increasingly complex condition, posing significant challenges for cardiologists and cardiac surgeons. Blood groups from the ABO/Rh system have been associated with susceptibility t...

Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy, and cell death, which have major impacts on the b...

Citrus is mainly cultivated in acid soil with low boron (B) and high copper (Cu). In this study, Citrus sinensis seedlings were submitted to 0.5 (control) or 350 μM Cu (Cu excess or Cu exposure) and 2.5, 10, or 25 μM B for 24 weeks. Thereafter,...

Excessive online behaviors refer to harmful or disproportionate use of digital network applications. Such behaviors are likely to be associated with escapist motives. Our aim was to analyze whether escapism predicts excessive gambling, excessive gami...

Boron (B) excess frequently impair plant performances and their productivity; in particular in arid and semi-arid environments. In the present experiment; hydroponically-grown ‘Granny Smith’ apple plants grafted on M9 rootstock were treat...

Boron (B) is a microelement required in vascular plants at a high concentration that produces excess boron and toxicity in many crops. B stress occurs widely and limits plant growth and crop productivity worldwide. Salicylic acid (SA) is an essential...

Inflammation in the context of Human Immunodeficiency Virus (HIV) establishes early and persists beyond antiretroviral therapy (ART). As such, we have shown excess B-cell activating factor (BAFF) in the blood of HIV-infected progressors, as soon as i...

Copper (Cu) is an essential element for most living plants, but it is toxic for plants when present in excess. To better understand the response mechanism under excess Cu in plants, especially in flowers, transcriptome sequencing on petunia buds and...

The prevalence of multidrug-resistant bacteria and their increased pathogenicity has led to a growing interest in metallic antimicrobial materials and bacteriophages as potential alternatives to conventional antibiotics. This study examines how resis...

Two types of single-photon avalanche diodes (SPADs) with different diameters are investigated regarding their avalanche behavior. SPAD type A was designed in standard 0.35-µm complementary metal-oxide-semiconductor (CMOS) including a 12-µ...

Excessive ultraviolet B (UV-B) irradiation is one of the most serious threats leading to severe crop production losses. It is known that secondary metabolite biosynthesis plays an important role in plant defense and forms a protective shield against...

Background/Objectives: The phyla Firmicutes and Bacteroidetes are the main constituents of the gut microbiota. An imbalance in the gut microbiota is a sign of dysbiosis, and the Firmicutes-to-Bacteroidetes ratio has been proposed to be a marker of it...

Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants o...

Background and Objectives: This study aimed to identify radiographic predictors and optimal cut-off values for determining the need for additional pedicle subtraction osteotomy (PSO) in patients with iatrogenic flatback syndrome following short-segme...

Long-term imbalance between fatigue and recovery may eventually lead to muscle weakness or even atrophy. We previously reported that excessive exercise induces pathological cardiac hypertrophy. However, the effect of excessive exercise on the skeleta...

Boron (B) is an essential trace nutrient element for citrus, but excessive B levels are frequently encountered in citrus production, potentially resulting in citrus toxicity. To better understand the tolerance and physiological responses of citrus ro...

MoAlB fine powders were prepared in molten NaCl from Al, B and Mo powders. The effects of key parameters affecting the synthesis process and phase morphology were examined and the underpinning mechanisms proposed. MoAlB product particles exhibited di...

The possibility of using Lecitase® Ultra as a novel alternative biocatalyst for the kinetic resolution of model racemic allyl esters of (E)-4-phenylbut-3-en-3-ol: Acetate (4a) and propionate (4b) through their enantioselective hydrolysis was inve...

Primary aldosteronism (PA) is considered the most common form of secondary hypertension, which is associated with excessive aldosterone secretion in the adrenal cortex. The cause of excessive aldosterone secretion is the induction of aldosterone synt...

Recently, many studies indicate that the GeV gamma ray excess signal from the central Milky Way can be best explained by ∼40–50 GeV dark matter annihilating via the b b ¯ channel. However, this model appears to be disfavored...

Glucocorticoid excess escalates osteoclastic resorption, accelerating bone mass loss and microarchitecture damage, which ramps up osteoporosis development. MicroRNA-29a (miR-29a) regulates osteoblast and chondrocyte function; however, the action of m...

Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed rea...

Excessive fat deposition in the hepatocytes, associated with excess dietary fat intake, was related to the occurrence of fatty livers in fish. miR-101b plays the important roles in controlling lipid metabolism, but the underlying mechanism at the pos...

Background: The psychological flexibility model states that activity patterns are not deemed to be intrinsically functional or dysfunctional; it is considered that underlying factors, such as personal goals and contextual factors, are what will deter...

Boron (B) toxicity is an important stressor that negatively affects maize yield and the quality of the produce. The excessive B content in agricultural lands is a growing problem due to the increase in arid and semi-arid areas because of climate chan...

A numerical solution for the broadband planar-lightwave-circuit (PLC) splitter with a variable splitting ratio based on asymmetric three waveguides weighted by the Blackman weighting function is designed for passive optical network applications with...

The H1069Q substitution is the most frequent mutation of the Cu transporter ATP7B that causes Wilson disease in the Caucasian population. ATP7B localizes to the Golgi complex in hepatocytes, but, in the presence of excessive Cu, it relocates to the e...

Flooding is an important factor, decreasing Allium cepa bulb yield and quality. A comparison, in terms of biometrical and biochemical parameters, of five Allium cepa cultivars, grown at two different locations, characterized by contrasting conditions...

The plant growth-promoting bacterium, B. subtilis subsp. Spizizizenii, has been proven to develop a biofilm under certain culture conditions, which can be applied as an efficient bioinoculant. Biofilm can be produced cost-effectively using biodiesel...

The aim of this study was to investigate the effects of imbalanced dietary BCAAs, especially Leu, on the growth and BCAA metabolism in turbot. A control diet was formulated by keeping optimum levels of Leu, Ile and Val. Four experimental diets were p...

Raw material is one of the most decisive factors for the quality of sintered boron carbide (B4C) products, in the past, there were relatively successful efforts for the synthesis of B4C powders via carbothermal reduction approaches. To prepare high-q...

The human airway surface is covered by a mucus layer composed primarily of the mucins MUC5AC and MUC5B. Excessive mucin production and secretion by airway epithelial cells in patients with asthma result in airway obstruction and worsened asthma sympt...