Next Article in Journal
Iodine: Its Role in Thyroid Hormone Biosynthesis and Beyond
Next Article in Special Issue
Amino Acids and Lipids Associated with Long-Term and Short-Term Red Meat Consumption in the Chinese Population: An Untargeted Metabolomics Study
Previous Article in Journal
Breakfast Habits and Associations with Fruit and Vegetable Intake, Physical Activity, Sedentary Time, and Screen Time among Swedish 13–14-Year-Old Girls and Boys
Previous Article in Special Issue
Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
 
 
Article

Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients

1
Duga Resa Special Hospital for Extended Treatment, 47250 Duga Resa, Croatia
2
Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health (IMROH), Ksaverska Cesta 2, 10001 Zagreb, Croatia
3
Radiation Dosimetry and Radiobiology Unit, Institute for Medical Research and Occupational Health (IMROH), Ksaverska Cesta 2, 10001 Zagreb, Croatia
4
Department of Pharmaceutical Botany, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
5
Mutagenesis Unit, Institute for Medical Research and Occupational Health (IMROH), Ksaverska Cesta 2, 10001 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Emily Sonestedt
Nutrients 2021, 13(12), 4468; https://doi.org/10.3390/nu13124468
Received: 8 November 2021 / Revised: 10 December 2021 / Accepted: 11 December 2021 / Published: 14 December 2021
(This article belongs to the Special Issue Biomarkers of Nutritional Exposure and Nutritional Status)
Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized weight loss program developed at the Duga Resa Special Hospital for Extended Treatment, Croatia, we evaluated anthropometric, biochemical, and permanent DNA damage parameters (assessed with the cytochalasin B-blocked micronucleus cytome assay—CBMN) in severely obese patients (BMI ≥ 35 kg m−2) after 3-weeks on a 567 kcal, hospital-controlled VLCD. This is the first study on the permanent genomic (in)stability in such VLCD patients. VLCDs caused significant decreases in weight (loss), parameters of the lipid profile, urea, insulin resistance, and reduced glutathione (GSH). Genomic instability parameters were lowered by half, reaching reference values usually found in the healthy population. A correlation was found between GSH decrease and reduced DNA damage. VLCDs revealed susceptible individuals with remaining higher DNA damage for further monitoring. In a highly heterogeneous group (class II and III in obesity, differences in weight, BMI, and other categories) consisting of 26 obese patients, the approach demonstrated its usefulness and benefits in health improvement, enabling an individual approach to further monitoring, diagnosis, treatment, and risk assessment based on changing anthropometric/biochemical VLCD parameters, and CBMN results. View Full-Text
Keywords: cytochalasin B-blocked micronucleus cytome assay; DNA repair; DNA stability; excessive weight loss; low-calorie restriction diet cytochalasin B-blocked micronucleus cytome assay; DNA repair; DNA stability; excessive weight loss; low-calorie restriction diet
Show Figures

Figure 1

MDPI and ACS Style

Ožvald, I.; Božičević, D.; Duh, L.; Vinković Vrček, I.; Pavičić, I.; Domijan, A.-M.; Milić, M. Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients. Nutrients 2021, 13, 4468. https://doi.org/10.3390/nu13124468

AMA Style

Ožvald I, Božičević D, Duh L, Vinković Vrček I, Pavičić I, Domijan A-M, Milić M. Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients. Nutrients. 2021; 13(12):4468. https://doi.org/10.3390/nu13124468

Chicago/Turabian Style

Ožvald, Ivan, Dragan Božičević, Lidija Duh, Ivana Vinković Vrček, Ivan Pavičić, Ana-Marija Domijan, and Mirta Milić. 2021. "Effects of a 3-Week Hospital-Controlled Very-Low-Calorie Diet in Severely Obese Patients" Nutrients 13, no. 12: 4468. https://doi.org/10.3390/nu13124468

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop