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Journal of Personalized Medicine, Volume 15, Issue 10

October 2025 - 56 articles

Cover Story: Psychedelics are gaining attention across disciplines for their profound psychological and neurobiological effects. Research highlights their efficacy in treating mood disorders, PTSD, and addiction by enhancing neuroplasticity and disrupting maladaptive cognitive patterns. From a psychological standpoint, psychedelics facilitate introspection, emotional processing, and therapeutic breakthroughs. Neuroscientific findings reveal altered brain network dynamics, while anthropological and philosophical perspectives contextualize their cultural and existential significance. In medicine, they offer interventions for chronic pain and palliative care. This review underscores the need for rigorous, ethically grounded research to explore psychedelics’ potential from a multidisciplinary perspective. View this paper
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Articles (56)

  • Article
  • Open Access
691 Views
10 Pages

17 October 2025

Background: Sentinel lymph node biopsy (SLNB) is the standard procedure for axillary staging in early-stage breast cancer. However, its necessity for some patient groups is being reevaluated. This change mainly arises from the procedure’s impac...

  • Article
  • Open Access
598 Views
11 Pages

Innovative Approach to Embolization of Pelvic Varices Using Endovaginal Guidance: Methodology and Early Outcomes

  • Eva Fourage-Jambon,
  • Rayann Soueidan,
  • Hamza Sawalha,
  • Yassine Lamfichekh,
  • Benjamin Linares,
  • Hugo Hans,
  • Mathieu David,
  • Isabelle Molina-Andreo,
  • Charlotte Douchez and
  • Nicolas Pangon
  • + 3 authors

17 October 2025

Objective: To retrospectively assess the safety and efficacy of endovaginal guidance for embolizing perivaginal varices associated with persistent localized symptoms, including dyspareunia and postcoital pain. Methods: From February 2024 to January 2...

  • Review
  • Open Access
1,094 Views
20 Pages

Inflammatory Phenotypes of Bronchiectasis

  • Evangelia Koukaki,
  • Georgia Papaiakovou,
  • Argyri Klironomou,
  • Efthymia Theofani,
  • Andreas M. Matthaiou,
  • Adamantia Liapikou,
  • Nektarios Anagnostopoulos,
  • Grigorios Stratakos,
  • Petros Bakakos and
  • Nikoletta Rovina

17 October 2025

Bronchiectasis is a heterogeneous chronic airway disease traditionally viewed as neutrophil-driven. Emerging evidence demonstrates distinct complex inflammatory phenotypes influencing clinical outcomes, prognosis and therapeutic options. A narrative...

  • Article
  • Open Access
514 Views
11 Pages

Pulmonary Embolism Detection in Unenhanced CT Exams: A Radiomic-Based Classifier as a Promising Screening-Diagnostic Tool

  • Diletta Cozzi,
  • Alessio Gnerucci,
  • Giulia Zantonelli,
  • Matteo Benelli and
  • Maurizio Bartolucci

17 October 2025

Background: Pulmonary embolism (PE) is a life-threatening condition in which early diagnosis and prompt treatment are essential to reduce morbidity and mortality. Recent advances in radiomics have introduced software tools for PE detection on CT pulm...

  • Article
  • Open Access
648 Views
18 Pages

Differentially Expressed Genes Identify FIGO Stage II Cervical Cancer Patients with a Higher Risk of Relapse in a Small Cohort

  • Carolina P. S. Melo,
  • Angelo B. Melo,
  • Fábio R. Queiroz,
  • Álvaro P. Costa,
  • Laurence R. Amaral,
  • Ramon A. Pereira,
  • Izabela F. G. Amorim,
  • Jorge G. G. Ferreira,
  • Wander J. Jeremias and
  • Pedro L. L. Bertarini
  • + 3 authors

16 October 2025

Background/Objectives: Most studies investigating prognostic biomarkers in cervical cancer (CC) analyze patients irrespective of FIGO stage, potentially masking molecular features that underlie the aggressiveness of some FIGO II tumors. To address th...

  • Article
  • Open Access
685 Views
10 Pages

Laterocervical Lymph Node Metastases in Papillary Thyroid Carcinoma: Predictive Factors for Recurrence and Oncological Outcome

  • Andrea Migliorelli,
  • Marianna Manuelli,
  • Agnese Maria Tringali,
  • Claudio Moretti,
  • Virginia Corazzi,
  • Matteo Geminiani,
  • Andrea Ciorba,
  • Francesco Stomeo,
  • Stefano Pelucchi and
  • Chiara Bianchini

16 October 2025

Background/Objectives: Papillary cancer is the most common thyroid cancer. The development of lateral cervical lymph node metastases (I–V levels) is considered a major cause of recurrence. The aim of this study is to investigate the potential p...

  • Review
  • Open Access
606 Views
10 Pages

The Neuro-Ophthalmologic Manifestations of SPG7-Associated Disease

  • Ruben Jauregui,
  • Christian Diaz Curbelo,
  • Steven L. Galetta and
  • Scott N. Grossman

16 October 2025

The gene SPG7 codes for the protein paraplegin, a subunit of the m-AAA protease in the inner mitochondrial membrane involved in protein quality control. SPG7 was initially identified as causing autosomal recessive hereditary spastic paraplegia (HSP),...

  • Review
  • Open Access
1,881 Views
41 Pages

14 October 2025

Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication by transporting functionally active molecules, including proteins, lipids, and nucleic acids. While extensive research has focused on EVs generated from traditional two-di...

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J. Pers. Med. - ISSN 2075-4426