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Personalized Medicine for Otolaryngology (ENT)
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Personalized Medicine for Otolaryngology (ENT)

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 6589

Special Issue Editor

Dr. Mehdi Abouzari

E-Mail Website
Guest Editor
Division of Neurotology and Skull Base Surgery, Department of Otolaryngology, Head, and Neck Surgery, University of California, Irvine, CA, USA
Interests: hearing loss; tinnitus; dizziness; Meniere’s disease; artificial intelligence in clinical decision-making processes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision medicine endeavors to combine health sciences, engineering, artificial intelligence, clinical genomics, data science, and public health in order to provide personalized and effective health and wellness strategies. In the last decade, personalized medicine has shifted the traditional “one size/drug fits all” approach into a more stratified therapeutic strategy, which includes prevention, diagnostics, therapy/treatment, and rehabilitation. Personalized medicine aims to change the healthcare landscape, focusing on the individual patient to empirically identify the most effective health and wellness strategies at a personal level. This approach will also assess if the cost of treatments are validated by their utility, as well as opening doors for innovations regarding diseases where no current treatments change the course of the disease, such as head and neck squamous cell carcinoma, tinnitus, or hearing loss.

This Special Issue aims to provide a broad overview of personalized medicine across all subspecialties of otolaryngology, different clinical or basic science methodology, as well as cutting edge therapeutic options, such as gene/stem cell therapy. Moreover, this Special Issue will cover all aspects of personalized treatment or rehabilitation options in the field of otolaryngology and their positive impact on the patient’s survival or quality of life.

Dr. Mehdi Abouzari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • otology
  • head and neck cancer
  • rhinology
  • laryngology
  • facial plastic surgery
  • sleep medicine
  • biomarker
  • clinical genomics
  • artificial intelligence

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Published Papers (5 papers)

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11 pages, 405 KiB  
Article
Pain after Licorice or Sugar-Water Gargling in Patients Recovering from Oropharyngeal Surgery—A Randomized, Double-Blind Trial
by Marita Windpassinger, Michal Prusak, Jana Gemeiner, Olga Plattner, Stefan Janik, Gerold Besser, Wolfgang Gstoettner, Pu Xuan, Daniel I. Sessler and Kurt Ruetzler
J. Pers. Med. 2024, 14(10), 1056; https://doi.org/10.3390/jpm14101056 - 12 Oct 2024
Viewed by 1202
Abstract
Background: Glycyrrhiza glabrata (licorice) is used in traditional medicine and herbal remedies and reduces sore throats consequent to intubation, but whether it is protective for more intense pain after oropharyngeal surgery remains unclear. We thus tested the joint hypothesis that gargling with licorice, [...] Read more.
Background: Glycyrrhiza glabrata (licorice) is used in traditional medicine and herbal remedies and reduces sore throats consequent to intubation, but whether it is protective for more intense pain after oropharyngeal surgery remains unclear. We thus tested the joint hypothesis that gargling with licorice, which has anti-inflammatory and antioxidant properties, reduces postoperative pain and morphine consumption. Methods: We enrolled patients having elective oropharyngeal surgery. Participants were randomly allocated to gargle with either 1 g licorice or a sugar placebo before and for up to three days after surgery. A numerical rating scale (NRS) for pain along with morphine consumption was evaluated every 30 min during the post-anesthesia care unit (PACU) stay and then three times daily for three days. We pre-specified that licorice gargling would be deemed better than sugar gargling only if found non-inferior on both morphine consumption and pain score and superior on at least one of the two. Results: 65 patients were randomized to the licorice group and 61 to placebo. We found noninferiority (NI) in pain scores with an estimated mean difference of −0.09 (95.2% CI: −0.88, 0.70; p = 0.001; NI delta = 1) between licorice and placebo gargling. There were no adverse events reported in either group that required treatment discontinuation. Conclusions: Gargling with licorice did not significantly or meaningfully reduce postoperative pain or morphine consumption in patients recovering from oropharyngeal surgery. While higher doses might prove more effective, our results suggest that other topical analgesics should be considered. Full article
(This article belongs to the Special Issue Personalized Medicine for Otolaryngology (ENT))
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11 pages, 958 KiB  
Article
The Characterization of Normal Male and Female Voice from Surface Electromyographic Parameters
by Clara Puig-Herreros, José Luis Sanz, Luz Barona-Lleó, Leopoldo Forner and Vicent Rosell-Clari
J. Pers. Med. 2024, 14(6), 592; https://doi.org/10.3390/jpm14060592 - 1 Jun 2024
Viewed by 1019
Abstract
Currently, there is no consensus on the characterization of the human voice. The objective of the present study is to describe the myoelectric behavior of the extrinsic musculature of the larynx in 146 people with normal voice (Spanish speakers), aged between 20 and [...] Read more.
Currently, there is no consensus on the characterization of the human voice. The objective of the present study is to describe the myoelectric behavior of the extrinsic musculature of the larynx in 146 people with normal voice (Spanish speakers), aged between 20 and 50 years old. Different vocal tasks were recorded using a surface electromyograph (SEMG). In all vocal tasks, it was observed that women had higher activation (µV) in the suprahyoid and sternocleidomastoid muscles than men, while men had higher activation in the infrahyoid muscles. SEMG is a valid procedure to help define normal vocal characteristics in the studied population, providing reference values during clinical examination. However, it is necessary to adopt a universal system of assessment tasks and standardized measurement techniques to allow for comparisons with future studies. Full article
(This article belongs to the Special Issue Personalized Medicine for Otolaryngology (ENT))
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11 pages, 509 KiB  
Article
Association between Hearing Aid Use and Cognitive Function in Persons with Hearing Impairment Stratified by Cardiovascular Risk
by Kouki Tomida, Sangyoon Lee, Keitaro Makino, Osamu Katayama, Kenji Harada, Masanori Morikawa, Ryo Yamaguchi, Chiharu Nishijima, Kazuya Fujii, Yuka Misu and Hiroyuki Shimada
J. Pers. Med. 2024, 14(5), 479; https://doi.org/10.3390/jpm14050479 - 29 Apr 2024
Viewed by 1470
Abstract
The purpose of this study was to conduct a cross-sectional analysis of the association between hearing aid use and cognitive decline in community-dwelling older adults with hearing impairment, stratified by cardiovascular risk level. This cross-sectional study covers 1857 hearing-impaired individuals selected among 10,674 [...] Read more.
The purpose of this study was to conduct a cross-sectional analysis of the association between hearing aid use and cognitive decline in community-dwelling older adults with hearing impairment, stratified by cardiovascular risk level. This cross-sectional study covers 1857 hearing-impaired individuals selected among 10,674 community-dwelling older adults (≥65 years of age) in Japan. We investigate the association between hearing aid use and cognitive decline stratified by cardiovascular risk level, by assessing self-reported hearing impairment and hearing aid use, absolute cardiovascular risk, cognitive function, and potential confounding factors. The association between hearing impairment severity and increased cardiovascular risk, and the benefit of hearing aid use in preventing cognitive decline, were examined in a binomial logistic regression analysis, with the presence of cognitive decline as the objective variable. In the low cardiovascular risk group, hearing aid users had a lower odds ratio for decline in executive function than non-users (odds ratio = 0.61, 95% confidence interval: 0.39–0.98). However, there was no significant association between hearing aid use and cognitive decline in the high cardiovascular risk group (p > 0.05). Among older adults with hearing impairment, hearing aid use was associated with the maintenance of executive function in individuals of low cardiovascular risk. Full article
(This article belongs to the Special Issue Personalized Medicine for Otolaryngology (ENT))
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11 pages, 627 KiB  
Systematic Review
Endoscopic Sinus Surgery in Frontal Sinus Inverted Papilloma: A Systematic Review
by Maxime Fieux, Valentin Favier, Andre Sousa Machado, Mikail Nourredine, Caroline Giroudon, Florent Carsuzaa, Paresh P. Naik and the yo-IFOS Group
J. Pers. Med. 2025, 15(5), 183; https://doi.org/10.3390/jpm15050183 (registering DOI) - 2 May 2025
Abstract
Background: Frontal sinus inverted papilloma (IP) is a particularly rare form of IP and its management is challenging, with a high rate of recurrence. Objectives: Our aim was to evaluate the recurrence rate of frontal sinus IP after surgery and compare [...] Read more.
Background: Frontal sinus inverted papilloma (IP) is a particularly rare form of IP and its management is challenging, with a high rate of recurrence. Objectives: Our aim was to evaluate the recurrence rate of frontal sinus IP after surgery and compare this rate according to the surgical modality (purely endoscopic sinus surgery vs. a combined/open approach). Design: A systematic review without meta-analysis conducted by a working group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (yo-IFOS). Data Sources and Methods: A systematic analysis of the literature was performed and reported following the criteria laid down in the SWiM guidelines. The review was registered on Prospero, a dedicated software was used for screening (Covidence), and R (v.4.2.2) was used for statistical analysis. Eligible articles were studies reporting at least five cases of frontal sinus IP surgically treated. Results: A total of 2925 studies were identified based on the MeSH equation, and 39 studies were included (n = 642 patients). Among the studies included, the recurrence rate was 18.4% (118/642) with a mean time to recurrence of 25.6 (±11.7) months. The difference between surgical modalities was not statistically significant in terms of recurrence rate (14.7% vs. 16.5%; p = 0.675). Conclusions: The recurrence rate of frontal sinus IP is not different between surgical modalities. However, it does not reduce the need for a tailored therapeutic strategy, as other factors also need to be considered (time to recurrence, complications, quality of life) when choosing the most appropriate approach. Full article
(This article belongs to the Special Issue Personalized Medicine for Otolaryngology (ENT))
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13 pages, 2890 KiB  
Systematic Review
Efficacy of Internet-Based Therapies for Tinnitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Egidio Sia, Giancarlo Tirelli, Annalisa Gatto, Chiara Angela Mineo, Kaveri Curlin and Mehdi Abouzari
J. Pers. Med. 2024, 14(8), 813; https://doi.org/10.3390/jpm14080813 - 31 Jul 2024
Viewed by 2235
Abstract
Background: Tinnitus presents a major public health challenge, impacting quality of life. With conventional therapies being often time-consuming and costly, interest in Internet-based treatments, such as auditory treatments and Internet-based cognitive behavioral therapy, has grown due to their improved patient adherence. This meta-analysis [...] Read more.
Background: Tinnitus presents a major public health challenge, impacting quality of life. With conventional therapies being often time-consuming and costly, interest in Internet-based treatments, such as auditory treatments and Internet-based cognitive behavioral therapy, has grown due to their improved patient adherence. This meta-analysis aims to review existing scientific literature to assess the effectiveness of Internet-based therapies (IBTs) in treating tinnitus. Methods: Studies up to February 2024 using the Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), or Tinnitus Reactions Questionnaire (TRQ) to monitor tinnitus before and after IBTs were searched in PubMed, Google Scholar, Web of Science, and the Cochrane Central Register of Controlled Trials. Variation of the score with time was analyzed and a comparison was made with non-IBT studies. Treatment effects were analyzed using Cohen’s d model. Results: A total of 14 articles were considered, with a total of 1574 patients. Significant improvements in questionnaire scores were noted post-treatment. In the IBT group, THI and TFI decreased by 17.97 and 24.56 points, respectively (Cohen’s d THI: 0.85; TFI: 0.80). In the control group, THI and TFI decreased by 13.7 and 4.25 points, respectively (Cohen’s d THI: 0.55; TFI: 0.10). Conclusions: Internet-based therapies showed reliable effectiveness, possibly due to improved patient compliance, accessibility, cost-effectiveness, and customization. Full article
(This article belongs to the Special Issue Personalized Medicine for Otolaryngology (ENT))
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