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Advances in Prenatal Diagnosis and Maternal Fetal Medicine
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Advances in Prenatal Diagnosis and Maternal Fetal Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1201

Special Issue Editor

Dr. Themistoklis I. Dagklis

E-Mail Website
Guest Editor
Third Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Agiou Dimitriou, 54124 Thessaloniki, Greece
Interests: maternal fetal medicine; prenatal diagnosis; gestational diabetes; congenital defects; fetal growth restriction; placental abnormalities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advancements in prenatal diagnosis and maternal–fetal medicine have significantly transformed obstetric care, enabling earlier detection of fetal anomalies, improving maternal health outcomes, and fostering personalized approaches to pregnancy management. The integration of cutting-edge technologies and interdisciplinary research has paved the way for innovative diagnostic tools and therapeutic interventions, enhancing the ability to tailor medical care to the unique needs of each mother and fetus. This rapidly evolving field is crucial for optimizing perinatal outcomes and ensuring the health and well-being of both mothers and their babies.

We are pleased to invite you to contribute to the Special Issue titled “Advances in Prenatal Diagnosis and Maternal Fetal Medicine” in the Journal of Personalized Medicine. This Special Issue aims to compile a comprehensive collection of the latest research and developments in prenatal diagnosis and maternal–fetal medicine, aligning with the journal’s commitment to personalized healthcare. By focusing on this specialized area, we seek to highlight innovative approaches and foster the dissemination of knowledge that can drive personalized interventions and improve clinical practices in maternal and fetal health.

In this Special Issue, original research articles and review papers are welcome. Potential topics include, but are not limited to, the following:

  • Genetic and genomic screening techniques;
  • Fetal imaging and diagnostic technologies;
  • Personalized therapeutic interventions in fetal therapy;
  • Maternal health monitoring and management strategies;
  • Innovations in obstetric care and perinatal medicine;
  • Ethical considerations in prenatal diagnostics;
  • Biomarkers for pregnancy complications;
  • Advances in non-invasive prenatal testing (NIPT);
  • Integration of artificial intelligence in maternal–fetal medicine;
  • Long-term outcomes of personalized prenatal care.

We look forward to receiving your valuable contributions and collaborating to advance the field of prenatal diagnosis and maternal–fetal medicine through this Special Issue.

Dr. Themistoklis I. Dagklis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal diagnosis
  • maternal–fetal medicine
  • fetal anomalies
  • genetic screening
  • fetal imaging
  • non-invasive prenatal testing (NIPT)
  • obstetric care
  • perinatal outcomes
  • diagnostic technologies
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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13 pages, 601 KiB  
Article
The Association of Assisted Reproductive Technology with Placental and Umbilical Abnormalities
by Antonios Siargkas, Ioannis Tsakiridis, Sonia Giouleka, Petya Chaveeva, Maria Mar Gil, Walter Plasencia, Catalina De Paco Matallana, Efstratios M. Kolibianakis and Themistoklis Dagklis
J. Pers. Med. 2025, 15(5), 176; https://doi.org/10.3390/jpm15050176 - 27 Apr 2025
Cited by 1 | Viewed by 649
Abstract
Objective: Global utilization of assisted reproductive technology (ART) is increasing; however, it is associated with adverse perinatal outcomes. Placental and umbilical cord abnormalities contribute significantly to these negative outcomes. However, it remains unclear whether ART independently increases the risk of such abnormalities. This [...] Read more.
Objective: Global utilization of assisted reproductive technology (ART) is increasing; however, it is associated with adverse perinatal outcomes. Placental and umbilical cord abnormalities contribute significantly to these negative outcomes. However, it remains unclear whether ART independently increases the risk of such abnormalities. This study aimed to investigate the association between ART and key umbilico-placental abnormalities, after adjustment for confounders. Methods: In this retrospective cohort study, singleton pregnancies receiving routine antenatal care (January 2015 to June 2024) at the 3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece, were analyzed. Pregnancies conceived via ART were compared to those conceived spontaneously. To investigate placental and cord anomalies, this study employed multiple logistic regression. This approach adjusted for various confounders, including maternal age, BMI, parity, smoking status, history of previous cesarean section, diabetes mellitus, and thyroid disease. Results: This study included a total of 13,854 singleton pregnancies, of which 647 were conceived via ART. ART was significantly associated with an increased risk of placenta previa (aOR 1.99, 95% CI 1.10–3.61), low-lying placenta (aOR 1.71, 95% CI 1.38–2.11), bilobate placenta (aOR 2.81, 95% CI 1.92–4.11), single umbilical artery (aOR 2.62, 95% CI 1.022–6.715), marginal (aOR 1.63, 95% CI 1.32–2.01) and velamentous cord insertion (aOR 3.13, 95% CI 1.98–4.95), and vasa previa (aOR 5.51, 95% CI 1.28–23.76). Conclusions: ART-conceived pregnancies appear to carry a higher risk for certain placental and umbilical cord abnormalities, potentially contributing to adverse perinatal outcomes. Further studies are required to investigate the pathophysiology underlying these associations. Full article
(This article belongs to the Special Issue Advances in Prenatal Diagnosis and Maternal Fetal Medicine)
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Review

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18 pages, 385 KiB  
Review
Fetal Supraventricular Tachycardia: What Do We Know up to This Day?
by Sophia Tsokkou, Ioannis Konstantinidis, Vasileios Anastasiou, Alkis Matsas, Eleni Stamoula, Emmanuela Peteinidou, Antonia Sioga, Theodora Papamitsou, Antonios Ziakas and Vasileios Kamperidis
J. Pers. Med. 2025, 15(8), 341; https://doi.org/10.3390/jpm15080341 - 1 Aug 2025
Cited by 1 | Viewed by 244
Abstract
Fetal tachyarrhythmias, particularly supraventricular tachycardia (SVT) and atrial flutter (AFL), pose significant clinical challenges, especially when complicated by hydrops fetalis. This article provides a comprehensive review of the tachyarrhythmia types, the diagnostic modalities applied, and the therapeutic strategies followed in fetal tachyarrhythmias. Diagnostic [...] Read more.
Fetal tachyarrhythmias, particularly supraventricular tachycardia (SVT) and atrial flutter (AFL), pose significant clinical challenges, especially when complicated by hydrops fetalis. This article provides a comprehensive review of the tachyarrhythmia types, the diagnostic modalities applied, and the therapeutic strategies followed in fetal tachyarrhythmias. Diagnostic techniques such as M-mode echocardiography and fetal magnetocardiography (fMCG) are highlighted for their capacity to provide real-time, high-quality assessments of fetal cardiac rhythms. The review, also, focuses on pharmacologic management via transplacental therapy, discussing the safety and efficacy of the key agents including digoxin, flecainide, and sotalol, under different clinical scenarios, such as hydropic fetus and renal impairment. In addition to transplacental administration, alternative approaches such as direct fetal intramuscular or intravascular injections are examined. These direct methods, while potentially more effective in refractory cases, carry risks that necessitate specialized expertise and careful consideration of maternal and fetal safety. The limitations of current evidence, largely based on small case studies and retrospective analyses, underscore the need for larger, prospective multicenter observational studies and randomized control trials to establish standardized protocols for fetal tachyarrhythmia management. Overall, this review advocates for a personalized, multidisciplinary approach, emphasizing early fetal tachyarrhythmias diagnosis, tailored treatment regimens that balances efficacy with safety, and rigorous monitoring to optimize outcomes for both the fetus and the mother. Full article
(This article belongs to the Special Issue Advances in Prenatal Diagnosis and Maternal Fetal Medicine)
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