Cancer Biomarker and Molecular Oncology

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Disease Biomarkers".

Deadline for manuscript submissions: 27 February 2026 | Viewed by 358

Special Issue Editor


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Guest Editor
Department of Health Management, Economics and Policy, The Graduate School, Augusta University, Augusta, GA, USA
Interests: biomarkers; obesity; nutrition; cancer; genomics

Special Issue Information

Dear Colleagues,

Advances in cancer biomarker research and molecular oncology are driving precision medicine by enabling tailored therapies through tumor molecular profiling. These fields focus on identifying biological indicators and molecular pathways that inform diagnosis, prognosis, and treatment strategies, addressing challenges such as tumor heterogeneity and therapeutic resistance.

This Special Issue highlights cutting-edge research at the intersection of biomarker discovery, molecular mechanisms, and clinical translation. It explores topics such as liquid biopsies, multi-omics integration, and computational approaches to characterize tumor profiles and predict treatment responses. By synthesizing basic science and clinical insights, this Special Issue will foster innovations that enhance patient stratification and optimize targeted interventions.

We welcome submissions of original research and reviews that advance our understanding of cancer biomarkers and molecular pathways, particularly those with the potential to improve diagnostic accuracy and treatment efficacy. Together, these contributions will shape the future of personalized oncology, guiding the development of more precise and effective therapeutic strategies.

Dr. Jeane Silva
Guest Editor

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Keywords

  • cancer biomarkers
  • molecular oncology
  • precision medicine
  • liquid biopsies
  • therapeutic resistance

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Published Papers (1 paper)

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Research

14 pages, 2426 KB  
Article
Molecular Profiling of SYT-SSX Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas
by Sara Louati, Kaoutar Bentayebi, Ibtissam Saad, Yvonne Gloor, Nadia Senhaji, Abdelmajid Elmrini, Lahcen Belyamani, Rachid Eljaoudi, Marc Ansari, Sanae Bennis and Youssef Daali
J. Pers. Med. 2025, 15(10), 455; https://doi.org/10.3390/jpm15100455 - 29 Sep 2025
Viewed by 214
Abstract
Background/Objectives: Synovial sarcoma (SS) is an aggressive soft-tissue tumor characterized by the chromosomal translocation t(X;18) (p11.2;q11.2), most commonly involving the fusion of the SYT gene on chromosome 18 with the SSX1 or SSX2 genes on chromosome X. This study aims to explore [...] Read more.
Background/Objectives: Synovial sarcoma (SS) is an aggressive soft-tissue tumor characterized by the chromosomal translocation t(X;18) (p11.2;q11.2), most commonly involving the fusion of the SYT gene on chromosome 18 with the SSX1 or SSX2 genes on chromosome X. This study aims to explore the clinicopathological and molecular characteristics of synovial sarcoma in a cohort of Moroccan patients. Methods: We analyzed 48 cases of synovial sarcoma using formalin-fixed, paraffin-embedded (FFPE) tissue samples. Histological grading was performed according to the FNCLCC system. Immunohistochemical staining was employed to detect cytokeratin (CK) and epithelial membrane antigen (EMA). Molecular analysis included fluorescence in situ hybridization (FISH) to identify SS18 gene rearrangements and reverse transcription–polymerase chain reaction (RT-PCR) to detect SYT-SSX fusion transcripts. Results: Among the cohort, 56% of cases showed SS18 gene rearrangements via FISH, while RT-PCR confirmed the presence of SS18-SSX1 and SS18-SSX2 transcripts in 60% and 32% of cases, respectively. The remainder was classified as undifferentiated sarcoma. Notably, no significant associations were observed between SYT-SSX fusion type and clinicopathological features. Conclusions: These findings underscore the importance of integrating molecular techniques for precise diagnosis in synovial sarcoma. The results align with global patterns, emphasizing the necessity for molecular testing to enhance diagnostic accuracy and informing potential therapeutic advancements. Full article
(This article belongs to the Special Issue Cancer Biomarker and Molecular Oncology)
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