Personalized Diagnosis and Treatment for Neurological Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 1542

Special Issue Editor


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Guest Editor
1. Department of Neurology, Medical University of Warsaw, Banacha 1a Str., 02-097 Warsaw, Poland
2. Department of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Interests: tourette syndrome; tics; movement disorders; functional neurological disorders; neuropsychiatry
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Special Issue Information

Dear Colleagues,

Neurological diseases, including Alzheimer's, Parkinson's, epilepsy, and stroke, pose a significant burden on global health. Their complex and heterogeneous nature calls for tailored diagnostic and therapeutic strategies.

Traditional approaches often apply generalized treatment protocols, leading to variable outcomes. Recent advances in biomarkers, neuroimaging, and genomics have paved the way for more individualized care.

This Special Issue aims to highlight progress in personalized medicine for neurological disorders, focusing on precision diagnostics, targeted therapies, and patient-specific management plans.

Original articles in addition to reviews that advance personalized approaches to the diagnosis and treatment of neurological diseases are welcome.

Dr. Natalia Szejko
Guest Editor

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Keywords

  • movement disorders
  • Alzheimer’s disease
  • Parkinson’s disease
  • multiple sclerosis
  • personalized diagnosis

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Published Papers (1 paper)

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Research

31 pages, 1379 KB  
Article
Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions
by Electra Chatzidimitriou, Georgios Ntritsos, Roza Lagoudaki, Eleni Poptsi, Emmanouil Tsardoulias, Andreas L. Symeonidis, Magda Tsolaki, Eleni Konstantinopoulou, Kyriaki Papadopoulou, Panos Charalambous, Katherine P. Rankin, Eleni Aretouli, Chrissa Sioka, Ioannis Iakovou, Theodora Afrantou, Panagiotis Ioannidis and Despina Moraitou
J. Pers. Med. 2025, 15(10), 466; https://doi.org/10.3390/jpm15100466 - 1 Oct 2025
Viewed by 1412
Abstract
Background/Objectives: Behavioral variant frontotemporal dementia (bvFTD), the most prevalent clinical subtype within the frontotemporal lobar degeneration spectrum disorders, is characterized by early and prominent changes that significantly disrupt everyday functioning. This study aims to identify the key correlates of functional status in bvFTD [...] Read more.
Background/Objectives: Behavioral variant frontotemporal dementia (bvFTD), the most prevalent clinical subtype within the frontotemporal lobar degeneration spectrum disorders, is characterized by early and prominent changes that significantly disrupt everyday functioning. This study aims to identify the key correlates of functional status in bvFTD by investigating the relative contributions of cognitive deficits, behavioral disturbances, personality changes, and brain perfusion abnormalities. Additionally, it seeks to develop a theoretical framework to elucidate how these factors may interconnect and shape unique functional profiles. Methods: A total of 26 individuals diagnosed with bvFTD were recruited from the 2nd Neurology Clinic of “AHEPA” University Hospital in Thessaloniki, Greece, and underwent a comprehensive neuropsychological assessment to evaluate their cognitive functions. Behavioral disturbances, personality traits, and functional status were rated using informant-based measures. Regional cerebral blood flow was assessed using Single Photon Emission Computed Tomography (SPECT) imaging to evaluate brain perfusion patterns. Penalized Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was performed to identify the most robust correlates of functional impairment, followed by path analyses using structural equation modeling to explore how these factors may interrelate and contribute to functional disability. Results: The severity of negative behavioral symptoms (e.g., apathy), conscientiousness levels, and performance on neuropsychological measures of semantic verbal fluency, visual attention, visuomotor speed, and global cognition were identified as the strongest correlates of performance in activities of daily living. Neuroimaging analysis revealed hypoperfusion in the right prefrontal (Brodmann area 8) and inferior parietal (Brodmann area 40) cortices as statistically significant neural correlates of functional impairment in bvFTD. Path analyses indicated that reduced brain perfusion was associated with attentional and processing speed deficits, which were further linked to more severe negative behavioral symptoms. These behavioral disturbances were subsequently correlated with declines in global cognition and conscientiousness, which were ultimately associated with poorer daily functioning. Conclusions: Hypoperfusion in key prefrontal and parietal regions, along with the subsequent cognitive and neuropsychiatric manifestations, appears to be associated with the pronounced functional limitations observed in individuals with bvFTD, even in early stages. Understanding the key determinants of the disease can inform the development of more targeted, personalized treatment strategies aimed at mitigating functional deterioration and enhancing the quality of life for affected individuals. Full article
(This article belongs to the Special Issue Personalized Diagnosis and Treatment for Neurological Diseases)
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