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Clinical Advances in Diagnosis and Personalized Treatments of Chronic Kidney...
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Clinical Advances in Diagnosis and Personalized Treatments of Chronic Kidney Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 2767

Special Issue Editors

Dr. Claudia Torino

E-Mail Website
Guest Editor
National Research Council—Institute of Clinical Physiology, Via Vallone Petrara SNC, 89124 Reggio Calabria, Italy
Interests: epidemiology; CKD; ESKD; dialysis; outcomes; clinical trials; clinical studies
Special Issues, Collections and Topics in MDPI journals
Dr. Vincenzo Antonio Panuccio

E-Mail Website
Guest Editor
GOM “Bianchi-Melacrino-Morelli”, Via Vallone Petrara SNC, 89124 Reggio Calabria, Italy
Interests: hemodialysis; peritoneal dialysis; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure; acute kidney injury; kidney transplantation; renal biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, there have been significant advances in the diagnosis and personalized treatment of chronic kidney diseases (CKD). Researchers have identified several biomarkers of kidney damage or kidney function that are useful in the early detection and diagnosis of CKD.

In addition, genetic testing has become increasingly important in understanding the underlying causes of CKD. Genetic mutations can predispose individuals to certain types of CKD, and identifying these mutations can help in personalized treatment planning and prognosis assessment.

Advances in genomic medicine and precision medicine have led to personalized treatment approaches for CKD. By analyzing individual genetic profiles and other clinical data, healthcare providers can tailor the treatment plans to the specific needs of each patient, potentially improving the outcomes and inhibiting adverse effects.

Several new pharmacological agents have been developed for the treatment of CKD, targeting various pathways involved in pathogenesis. These therapies offer new options for patients with CKD, especially those who are resistant to the traditional treatments.

Telemedicine and remote monitoring technologies have become increasingly important in the management of CKD, especially in remote or underserved areas. These technologies allow healthcare providers to monitor patients' kidney function, blood pressure, and other relevant parameters remotely, enabling timely intervention and reducing the need for frequent hospital visits.

Nutritional interventions play a crucial role in the management of CKD, and there have been advancements in understanding the role of diet in CKD progression. Personalized dietary plans can help slow disease progression and improve outcomes for patients with CKD.

Finally, regenerative medicine approaches, including stem cell therapy and tissue engineering, hold promise for the treatment of CKD. These therapies aim to repair or replace damaged kidney tissue and restore kidney function. While it is still in the early stages of development, regenerative medicine offers potential long-term solutions for patients with CKD.

Overall, these advancements in diagnosis and personalized treatment have the potential to improve the outcomes and quality of life of patients with CKD. However, further research and clinical trials are needed to fully understand the efficacy and safety of these interventions and to optimize their implementation in clinical practice.

We invite researchers to contribute original articles and review articles that offer insight into clinical advances in diagnosis and personalized treatments of CKD. The potential topics include, but are not limited to the following:

  • Biomarkers for early diagnosis;
  • Genetic testing;
  • Precision medicine approaches;
  • Novel therapies;
  • Telemedicine and remote monitoring;
  • Nutritional interventions;
  • Regenerative medicine.

Dr. Claudia Torino
Dr. Vincenzo Antonio Panuccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers for early diagnosis
  • genetic testing
  • precision medicine approaches
  • novel therapies
  • telemedicine and remote monitoring
  • nutritional interventions
  • regenerative medicine

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Published Papers (2 papers)

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13 pages, 476 KiB  
Article
High Ocular Disease Burden and Increased Referral Needs in Patients with Chronic Kidney Disease: A Step Toward Personalized Care
by Yulia Liem, Pavitra Thyagarajan, Miao Li Chee, Cynthia Ciwei Lim, Boon Wee Teo and Charumathi Sabanayagam
J. Pers. Med. 2025, 15(5), 204; https://doi.org/10.3390/jpm15050204 - 19 May 2025
Viewed by 154
Abstract
Background/Objectives: To evaluate the prevalence of eye diseases in patients with confirmed chronic kidney disease (CKD) and their referral patterns to ophthalmologists, with the aim of informing personalized screening and referral strategies. Methods: This study involved 528 CKD patients from a tertiary hospital’s [...] Read more.
Background/Objectives: To evaluate the prevalence of eye diseases in patients with confirmed chronic kidney disease (CKD) and their referral patterns to ophthalmologists, with the aim of informing personalized screening and referral strategies. Methods: This study involved 528 CKD patients from a tertiary hospital’s outpatient renal clinics in Singapore, with CKD defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Retinal photographs from each dilated eye were graded for the presence of diabetic retinopathy (DR) and other eye diseases by professional graders. Patients with significant eye conditions were referred to ophthalmologists based on severity and urgency, categorized as urgent (same day or within 24 h), semi-urgent (within 1–2 weeks), fast-track (within 1–3 months), or annual referrals. Results: More than half of the CKD patients (53.7%) had some form of eye disease; 20% were diagnosed with DR, and 29% required fast-track referrals. Of the 251 patients with diabetes, 67% adhered to annual follow-ups; however, despite this regular monitoring, over half required fast-track referrals for severe eye conditions. Among the 167 non-diabetic CKD patients, nearly a third (31%) were on follow-up, with 7.8% requiring fast-track referrals. Notably, 11% of those not on follow-up also needed fast-track referrals. Seven non-diabetic and ten diabetic patients required urgent referral due to critical conditions such as pseudo-holes, impending occlusions, and disc swelling. Conclusions: These findings underscore the high prevalence and severe nature of eye diseases in CKD patients, even those who are under regular annual follow-up. Integrating systematic eye screening into CKD care supports personalized medicine by enabling early detection and tailored interventions, ultimately improving both visual and overall patient outcomes. Full article
(This article belongs to the Special Issue Clinical Advances in Diagnosis and Personalized Treatments of Chronic Kidney Diseases)
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Other

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11 pages, 957 KiB  
Perspective
Precision Medicine in Peritoneal Dialysis: An Expert Opinion on the Application of the Sharesource Platform for the Remote Management of Patients
by Loris Neri, Lorenzo Di Liberato, Gaetano Alfano, Valeria Allegrucci, Nicoletta Appio, Carla Bussi, Daniela Cecilia Cannarile, Ilaria De Palma, Silvio Di Stante, Rosa Pacifico, Vincenzo Panuccio, Silvia Porreca, Vincenzo Terlizzi, Silvia D’Alonzo and Giusto Viglino
J. Pers. Med. 2024, 14(8), 807; https://doi.org/10.3390/jpm14080807 - 30 Jul 2024
Cited by 2 | Viewed by 1594
Abstract
The management of end-stage kidney disease (ESKD) has been constantly evolving over the last decade with the development of targeted approaches. In this field, telemedicine and remote monitoring are based on the availability of new cyclers that allow for bidirectional communication (between patient [...] Read more.
The management of end-stage kidney disease (ESKD) has been constantly evolving over the last decade with the development of targeted approaches. In this field, telemedicine and remote monitoring are based on the availability of new cyclers that allow for bidirectional communication (between patient and physician) and for the application of the Sharesource cloud-based platform. These technologies allow patients with ESKD to undergo automated peritoneal dialysis (APD) at home. However, these approaches are not well standardized and largely applied yet. Therefore, this study aimed to elaborate a protocol for the utilization of the Sharesource platform to facilitate the practical management of patients treated with APD. A series of expert meetings were held between September 2022 and January 2023 in Italy. The participants (ten nephrologists and five nurses) from nine Italian public dialysis centers shared their opinions, examined the current scientific literature in the field, and reviewed the key characteristics of the Sharesource system to achieve a common position on this topic. A detailed and practical document containing experts’ opinions and suggestions on the use of the Sharesource platform for the management of patients treated with APD was produced. This expert opinion might represent a new useful instrument in clinical practice for managing patients undergoing home-based peritoneal dialysis (PD) through the Sharesource platform, which is valid not only for Italy. These recommendations pave the way to novel patient-centered and personalized therapeutic approaches for ESKD and highlight the advantages of telemedicine and remote monitoring in the management of patients with ESKD undergoing PD and its positive impact on their quality of life. Full article
(This article belongs to the Special Issue Clinical Advances in Diagnosis and Personalized Treatments of Chronic Kidney Diseases)
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