Depression and Anxiety: Recent Advances in Personalized Treatment and Management

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 600

Special Issue Editor


E-Mail Website
Guest Editor
Department of Human and Social Sciences, Mercatorum University, 00186 Rome, Italy
Interests: psychology; depression; psychogeriatrics; sexual addiction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The link between depression and anxiety represents a major global health challenge, characterised by a complex aetiology, diverse clinical manifestations, and varied therapeutic responses. Recent advances in understanding the neurobiological basis of depression and/or anxiety, the development of innovative pharmacological and psychotherapeutic interventions, and the integration of digital health technologies offer new opportunities for improved diagnosis, treatment, and long-term management. Emerging precision medicine approaches, new biomarkers, and personalised treatment strategies have the potential to optimise therapeutic outcomes, improve resilience, and prevent relapse. In addition, the incorporation of patient-centred care models, remote therapy and digital interventions are transforming the mental healthcare landscape, offering accessibility and personalised support.

This Special Issue aims to comprehensively explore the current landscape of the link between depression and anxiety to provide a comprehensive overview of recent advances in the diagnosis, management, and treatment of these diagnoses, with a focus on personalised medicine, new therapies, and the psychosocial dimensions of the disorders. By addressing these critical aspects, this Special Issue seeks to promote interdisciplinary dialogue, fill existing knowledge gaps and highlight future directions for research and clinical practice.

Dr. Stefano Eleuteri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized treatment
  • mood disorders and anxiety
  • treatment
  • therapy
  • depression and anxiety

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

17 pages, 1756 KB  
Review
Neuroanatomical and Functional Correlates in Depressive Spectrum: A Narrative Review
by Giulio Perrotta, Anna Sara Liberati and Stefano Eleuteri
J. Pers. Med. 2025, 15(10), 478; https://doi.org/10.3390/jpm15100478 - 2 Oct 2025
Viewed by 420
Abstract
Depressive spectrum disorders are considered among the most common in the general population. Major depressive disorder and persistent depressive disorder (or dysthymia) are the most recognized, but other depressive disorders exist with varying or no specificity. The main difference between major depressive disorder [...] Read more.
Depressive spectrum disorders are considered among the most common in the general population. Major depressive disorder and persistent depressive disorder (or dysthymia) are the most recognized, but other depressive disorders exist with varying or no specificity. The main difference between major depressive disorder and dysthymia lies in the duration and intensity of symptoms. Improving our understanding of its etiology and pathogenesis must be a priority for health and safety. Given the complexity of the evidence in the literature, it was deemed useful to provide a comprehensive summary of the neuroanatomical dysfunctions currently identified, with particular attention to the anterior and medial cingulate cortex, dorsolateral and ventromedial prefrontal cortex, posterior parietal cortex, insula, amygdala, and hippocampus. Significant neural network alterations include hyperconnectivity of the default mode network (DMN), impairment of the executive control network (ECN), and dysfunction of the salience network (Salience Network). Neurophysiological markers reveal frontal alpha asymmetries and front-striatal metabolic alterations. Studying neural correlates is essential to deepen our understanding of the depressive spectrum and the development of personalized therapeutic interventions, including noninvasive neurostimulation techniques and target-specific pharmacological therapies, opening new avenues for translational research in neuropsychiatric settings. Full article
Show Figures

Graphical abstract

Back to TopTop