Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports o...
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2’-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition...
Antimicrobial resistance has significantly compromised the therapeutic efficacy of many antibiotics, highlighting the need for new agents capable of overcoming bacterial resistance. The discovery of antibiotics in the early 20th century contributed s...
Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hyp...
The emergence of pathogenic bacteria-resistant strains is a major public health issue. In this regard, natural product scaffolds offer a promising source of new antimicrobial drugs. In the present study, we report the antimicrobial activity against G...
Glycoproteins are special proteins and important nutrients for hypoglycemic activity. However, the structure of Auricularia Auricula glycoprotein (AAG) and the stability of its hypoglycemic activity during simulated digestion (including saliva, gastr...
The paper discusses a comprehensive analysis of contemporary approaches to the structural modification of phenolic acids from the benzoic (C6–C1) and cinnamic (C6–C3) series, which have a wide range of biological activity. The main direct...
A previous study found that a crude Perilla seed polysaccharide (PFSP) fraction exhibited obviously antitumor activity; however, the structural characterization and antitumor properties of this polysaccharide remain unclear. In this study, the PFSP w...
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review en...
In this study, water-soluble natural polysaccharides were extracted from the stems of Houttuynia cordata Thunb (HCPS). The optimization of the hot water extraction process using response surface methodology (RSM), and the extraction factors, were ana...
Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through...
Quicklime (CaO) is extensively used in metallurgy, chemical engineering, materials science, and greenhouse gas reduction due to its high reactivity, low energy consumption, and environmental benefits. It is considered as one of the most promising raw...
Sanghuang as a medicinal fungus in China has a history of more than 2000 years, and is known as the “forest gold”. Most notably, the polysaccharides of Sanghuangporus sp. have attracted widespread attention due to their significant bioact...
Diabetes ranks first among non-communicable chronic diseases worldwide, with its incidence rising year on year; this makes the search for safer and more effective drugs an effective strategy. Ophiopogon japonicus (OJ) is a traditional Chinese medicin...
Antioxidants are molecules that can prevent the harmful effects of oxygen, help capture and neutralize free radicals, and thus eliminate the damage of free radicals to the human body. Persimmon tannin (PT) has excellent antioxidant activity, which is...
An alkali-soluble β-glucan (AHEP-A-b, 20 kDa) purified from Hericium erinaceus fruiting bodies, was structurally characterized and examined for antioxidant activity. Methylation analysis and NMR spectroscopy show that the backbone of AHEP-A-b is...
Activity recognition using data collected with smart devices such as mobile and wearable sensors has become a critical component of many emerging applications ranging from behavioral medicine to gaming. However, an unprecedented increase in the diver...
Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably depression), presenting it as a significant therapeutic target for treating such conditions. Inhibitors of serotoninergic signaling (especially selective ser...
Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in hi...
In our ongoing quest to design effective antimicrobial peptides (AMPs), this study aimed to elucidate the mechanisms governing cyclic amphiphilic AMPs and their interactions with membranes. The objective was to discern the nature of these interaction...
Tricholoma matsutake, as a rare wild edible mushroom, is popular due to its unique flavor and taste, as well as high nutritional and economic value. Investigating the relationship between the complex structure and in vitro immunological activity of T...
This study aimed to investigate the effects of ultrasound-assisted extraction (UAE) on the physicochemical properties, biological activities, and intestinal flora regulatory capacity of jackfruit polysaccharides (JPs). Under optimized UAE conditions...
Scorpion venom is a rich source of biologically active components and various peptides with high-potential therapeutic use that have been characterized for their antimicrobial and antiproliferative activities. Stigmurin is a peptide identified from t...
A novel polysaccharide from Cynanchum auriculatum Royle ex Wight was isolated, structurally characterized, and its antioxidant activity was evaluated. The crude extract was purified by ion exchange and size exclusion chromatography to obtain a homoge...
Phlebopus portentosus is an edible and medicinal mushroom with a delicious taste and high nutritional value. The oligosaccharides derived from P. portentosus may be the material basis for its biological activity. The degradation of polysaccharide and...
Ethnopharmacological relevance: Sophora flavescens Ait. (S. flavescens) is a classical traditional Chinese medicine (TCM) with a long history of clinical use for clearing heat, drying dampness, killing parasites, and promoting diuresis. In recent yea...
Dendrobium officinale (DO) is a traditional medicinal and edible plant whose polysaccharides help modulate gastrointestinal and metabolic functions. Fresh DO is commonly processed into “Fengdou” to prolong shelf life, but the effects of t...
Previous research has shown that structural barriers negatively influence the physical activity (PA) behavior of cancer patients, but underlying mechanisms are unclear. The aim of the current study was to explore the potential mediating role of socia...
The panax genus is a widely used medicinal plant with good biological activity. As one of the main active components of the Panax genus, polysaccharides have various pharmacological effects. This review summarizes the latest research reports on ginse...
This study focuses on polysaccharides from Cistanche deserticola and Cistanche tubulosa, medicinal plants renowned for their health benefits. The “water extraction and alcohol precipitation” method was used to obtain the crude polysacchar...
The constantly growing resistance of bacteria to antibiotics and other antibacterial substances has led us to an era in which alternative antimicrobial therapies are urgently required. One promising approach is to target bacterial pathogens using met...
Background/Objectives: Human glioblastoma (GBM) is the most aggressive brain cancer in adults and a highly treatment-refractory malignancy. The overall prognosis for the GBM is extremely poor, with a median survival of 12–14 months after initia...
Lotus flower polysaccharide (LFP) and lotus seedpod polysaccharide (LSP) were separated by water extract–alcohol precipitation, and their structures and biological activities were investigated. The results of monosaccharide composition showed t...
Limonin is a natural compound which is rich in the fruit of various plants of the Rutaceae family and demonstrated to have a wide range of biological activities. In this work, seven limonin derivatives were successfully synthesized by hydrogenation o...
The effects of limited hydrolysis following glycosylation with dextran on the structural properties and antioxidant activity of the soybean protein isolate (SPI) were investigated. Three SPI hydrolysate (SPIH) fractions, F30 (>30 kDa), F30-10 (10&...
This study aims to identify the causal relationship between travel and activity times using the dataset collected from the 2019 Time Use Survey in Korea. As a statistical solution, a structural equation model (SEM) was developed. A total number of 31...
This study optimized the extraction process of crude polysaccharides from Panax notoginseng leaves (PNLP) using the ultrasonic-assisted dual-enzyme method through a single-factor combined with response surface experiment. The crude polysaccharides we...
Water-quenched copper slag (WCS) modified with alumina (Al2O3) has been proven as a cement substitute; however, the effect of Al2O3 on structural properties of WCS related to pozzolanic activity has not been well investigated. The structural properti...
Rare ginsenosides are the major components of red ginseng. However, there has been little research into the relationship between the structure of ginsenosides and their anti-inflammatory activity. In this work, BV-2 cells induced by lipopolysaccharid...
The global rise of antimicrobial resistance represents a major challenge to public health and highlights the urgent need for the discovery of new antibacterial agents. Xanthones, characterized by a rigid dibenzo-γ-pyrone scaffold, have emerged...
Elaeagnus angustifolia Linnaeus is a medicinal plant and its fruit has pharmacological activity such as antiinflammatory, antiedema, antinociceptive, and muscle relaxant functions, etc. Two acidic homogeneous polysaccharides (EAP-H-a1 and EAP-H-a2) w...
In the present study, a novel water-soluble polysaccharide (DNP−1) was isolated and purified from the root of Duhaldea nervosa via column chromatography. Structural analyses indicated that DNP−1 had a linear backbone consisting of (2&rarr...
Soybean whey is a high-yield but low-utilization agricultural by-product in China. In this study, soybean whey was used as a substrate of fermentation by Lacticaseibacillus plantarum 70810 strains. An exopolysaccharide (LPEPS-1) was isolated from soy...
In this study, a novel polysaccharide (PSH) with potent anti-gout activity was extracted and separated from Sanghuangporus vaninii (S. vaninii). The structural characteristics of PSH were elucidated using analytical techniques. HPLC analysis revealed...
Two structurally different copper(II) complexes of the compositions [{Cu(9dhx)(H2O)3}2(µ-SO4)2] (1) and [Cu(9dhx)2(H2O)2(NO3)2]·H2O (2), involving 9-deazahypoxanthine (9dhx; 6-oxo-9-deazapurine; 9-deazahypoxanthine), have been prepared and character...
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along wi...
Chondroitin sulfate (CS), commonly derived from animal cartilages, is a glycosaminoglycan with various bioactivities. This study employed an alkaline-enzyme method to prepare CS derived from Channa argus (referred to as CCS), using the heads and spin...
This study was designed to investigate the structure of synthesized hesperidin glycosides (HGs) and evaluate their antibacterial and α-glucosidase inhibitory activities. The preliminary structure of HGs was confirmed by glucoamylase treatment and ana...
This study aims to identify the chemical structure and immunomodulatory activity of exopolysaccharides (EPSs) from Acetilactobacillus jinshanensis BJ01 and suggest its potential applications in the pharmaceutical field and as functional food additive...
In order to efficiently extract β-glucan from highland barley (HBG) and study its structural characterization and antioxidant activity, ultrasonic–microwave-assisted extraction (UME) was optimized by the response surface method (RSM). Unde...
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