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Mar. Drugs 2016, 14(1), 6;

Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 2 December 2015 / Revised: 13 December 2015 / Accepted: 21 December 2015 / Published: 29 December 2015
(This article belongs to the Collection Marine Polysaccharides)
Full-Text   |   PDF [1534 KB, uploaded 29 December 2015]   |  


Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through characterization and its immunological activity was investigated. MMPX-B2 consisted of d-glucose and d-galctose residues at a molar ratio of 3.51:1.00. The average molecular weight of MMPX-B2 was 510 kDa. This polysaccharide possessed a main chain of (1→4)-linked-α-d-glucopyranosyl residues, partially substituted at the C-6 position by a few terminal β-d-galactose residues or branched chains consisting of (1→3)-linked β-d-galactose residues. Preliminary immunological tests in vitro showed that MMPX-B2 could stimulate the murine macrophages to release various cytokines, and the structure-activity relationship was then established. The present study demonstrated the potential immunological activity of MMPX-B2, and provided references for studying the active ingredients in M. meretrix. View Full-Text
Keywords: Meretrix meretrix Linnaeus; polysaccharide; structure; immunological activity Meretrix meretrix Linnaeus; polysaccharide; structure; immunological activity

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Li, L.; Li, H.; Qian, J.; He, Y.; Zheng, J.; Lu, Z.; Xu, Z.; Shi, J. Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus. Mar. Drugs 2016, 14, 6.

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