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Research Advances in Antibiotic Resistance
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Research Advances in Antibiotic Resistance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 1185

Special Issue Editors

Prof. Dr. José Pascual Abad

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Guest Editor
Department of Molecular Biology, Faculty of Sciences, Biology Building, Autonomous University of Madrid, Cantoblanco, 28049 Madrid, Spain
Interests: antibiotic resistance; prevalence of antibiotic resistance in the environment; antimicrobial substances; silver nanoparticles; antimicrobial-producing microorganisms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Irma Marín

E-Mail Website
Guest Editor
Department of Molecular Biology, Faculty of Sciences, Biology Building, Autonomous University of Madrid, Cantoblanco, 28049 Madrid, Spain
Interests: applied microbiology; biogenic silver nanoparticles; extremophilic microorganisms; microbial biodiversity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antibiotic resistance is one of the major threads that humanity is dealing with, and the problem could worsen soon. The outcome of this issue has much to do with the research advances that the scientific community could achieve in the next few years. The One Health approach is expected to generate good results in preventing a further rise in antibiotic resistance, allowing us to gain better knowledge of the current situation and expectations for the future, as well as helping us to develop approaches for downplaying the consequences of antibiotic resistance.

In this Special Issue, we would like to report new advances in any aspects of antibiotic resistance research, including its prevalence in the various elements that are involved, encompassing the environment, farming, clinics, etc.; the rise of new antibiotic-resistant pathogens; research on new genes and mechanisms producing resistance; proposals for new strategies against infection; new compounds or substances that, alone or in combinations, could be useful against antibiotic-resistant microorganisms; and studies on the use of antibiotics in different countries concerning the rise in antibiotic resistance.

We invite members of the scientific community that are investigating this field to contribute their results to this Special Issue of the International Journal of Molecular Sciences.

Prof. Dr. José Pascual Abad
Prof. Dr. Irma Marín
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance
  • resistant pathogenic microorganisms
  • One Health
  • prevalence of antibiotic-resistant microorganisms
  • multidrug resistance
  • antibiotic resistance levels
  • alternative anti-infectious strategies and compounds
  • antibiotic-resistant genes
  • mechanisms of antimicrobial resistance

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Published Papers (2 papers)

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Research

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15 pages, 2813 KB  
Article
Uropathogenic Escherichia coli Biofilms: Antibiotic Pressure and Interaction with Human Neutrophils
by Irina L. Maslennikova, Irina V. Nekrasova, Marjanca Starčič Erjavec, Nina V. Karimova and Marina V. Kuznetsova
Int. J. Mol. Sci. 2025, 26(19), 9484; https://doi.org/10.3390/ijms26199484 - 28 Sep 2025
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Abstract
Uropathogenic Escherichia coli (UPEC) is a primary cause of urinary tract infections (UTIs), with recurrent cases often linked to its ability to form biofilms. This study investigated the effects of various antibiotics on UPEC biofilm formation and the subsequent interaction of these biofilms/their [...] Read more.
Uropathogenic Escherichia coli (UPEC) is a primary cause of urinary tract infections (UTIs), with recurrent cases often linked to its ability to form biofilms. This study investigated the effects of various antibiotics on UPEC biofilm formation and the subsequent interaction of these biofilms/their supernatants with human neutrophils. We determined the minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC), and biofilm eradication concentrations (MBEC) for ampicillin, gentamicin, chloramphenicol, ciprofloxacin, and levofloxacin. Our results showed an increase in MBEC compared to MBC for all tested antibiotics, confirming the enhanced antibiotic resistance of bacteria in biofilm. We found that sub-MICs of ciprofloxacin, which moderately inhibited planktonic growth, actually stimulated an increase in biofilm biomass. This antibiotic-induced biofilm growth was accompanied by changes in bacterial morphology, including the formation of elongated, filamentous cells, an adaptive stress response. Biofilm-embedded bacteria, but not their supernatants, significantly reduced neutrophil viability, primarily by inducing neutrophil necrosis. The presence of ciprofloxacin during biofilm formation did not fundamentally alter interactions with neutrophils. These findings highlight the importance of studying effects of antibiotic pressure on biofilm formation, underscoring the challenges in antibiotic treatment of UTIs. Full article
(This article belongs to the Special Issue Research Advances in Antibiotic Resistance)
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Review

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31 pages, 2290 KB  
Review
Predicting Antibiotic Resistance in Listeria monocytogenes from Food and Food-Processing Environments Using Next-Generation Sequencing: A Systematic Review
by Patryk Wiśniewski, Patryk Adamski, Miłosz Trymers, Wioleta Chajęcka-Wierzchowska and Anna Zadernowska
Int. J. Mol. Sci. 2025, 26(20), 10112; https://doi.org/10.3390/ijms262010112 - 17 Oct 2025
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Abstract
Listeria monocytogenes is a ubiquitous foodborne pathogen whose occurrence in food and food-processing environments raises public-health concerns, particularly when isolates carry antimicrobial-resistance determinants. Next-generation sequencing (NGS) is increasingly used to detect resistance genes and to predict phenotypic resistance. Following the Preferred Reporting Items [...] Read more.
Listeria monocytogenes is a ubiquitous foodborne pathogen whose occurrence in food and food-processing environments raises public-health concerns, particularly when isolates carry antimicrobial-resistance determinants. Next-generation sequencing (NGS) is increasingly used to detect resistance genes and to predict phenotypic resistance. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines, PubMed, Web of Science, and Scopus were searched for original articles (2015–2024) that used second- and/or third-generation sequencing to characterize antibiotic resistance in L. monocytogenes from food and food-processing environments. After deduplication and screening, 58 studies were included from an initial 418 records. NGS reliably detected a set of recurrent resistance determinants across diverse sample types and geographies. The fosX locus (intrinsic fosfomycin-related marker) was effectively ubiquitous across studies, while acquired determinants were variably distributed: lin (35/58 studies, 60.34%), norB (33/58, 56.90%), and tetracycline genes overall in 20/58 (34.48%) with tetM as the most common (11/58, 18.97%). Reported concordance between the genotypes and phenotypes for acquired resistance was very high (>99% for most agents), with notable exceptions (e.g., ciprofloxacin and some fosfomycin cases). Common analysis pipelines and databases included ResFinder, CARD, BIGSdb-Lm, ABRicate, and ARIBA; most sequencing used Illumina short reads, with an increasing use of long-read or hybrid approaches. NGS is a powerful surveillance tool for detecting resistance determinants and for source-tracking, but its predictive value depends on integration with phenotypic testing, standardized reporting, and comprehensive, curated databases. Key gaps include inconsistent phenotype reporting, variable database coverage, and limited assessment of gene expression/regulatory effects. Full article
(This article belongs to the Special Issue Research Advances in Antibiotic Resistance)
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