Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary arter...
A modified micromechanics failure criterion (MMF3) based multi-scale analysis strategy was proposed in this article to analyze the failure behaviors of the plain-woven fabric composites. The finite-element (FE) representative unit cell (RUC) models o...
The absence of sufficient knowledge of the heterogeneous damage behaviour of textile reinforced composites, especially under combined in-plane and out-of-plane loadings, requires the development of multi-scale experimental and numerical methods. In t...
This paper focuses on presenting an intelligent model that can generate the desired geometry of a unit cell metasurface for a given resonant frequency at which we expect the metasurface structure to work. The model consists of the use of a multilayer...
Representative volume elements (RVEs) are commonly used to compute the effective elastic properties of solid media having repeating microstructure, such as fiber reinforced composites. However, for softening materials, an RVE could be problematic due...
Top-down tissue engineering aims to produce functional tissues using biomaterials as scaffolds, thus providing cues for cell proliferation and differentiation. Conversely, the bottom-up approach aims to precondition cells to form modular tissues unit...
The impact of weak particle-matrix interfaces in aluminum matrix composites (AMCs) on effective elastic properties was studied using micromechanical finite-element analysis. Both simplified unit cell representations (i.e., representative area or volu...
Fuel cell-powered Autonomous Underwater Vehicles (AUVs) represent a growing area of research as fuel cells can increase their endurance. Fuel cells consume hydrogen and oxygen to generate electricity. Typically, the fuel cell generates as much heat a...
The main characteristic of materials with a functional gradient is the progressive composition or the structure variation across its geometry. This results in the properties variation in one or more specific directions, according to the functional ap...
This study presents a new efficient method for determining the 2D unit cell size from HAADF STEM images using angle-resolved lattice population density (ALPD) plots. The approach uses the maxima in these plots, which represent the lines with the high...
The design of a scaffold of bone tissue engineering plays an important role in ensuring cell viability and cell growth. Therefore, it is a necessity to produce an ideal scaffold by predicting and simulating the properties of the scaffold. Hence, the...
Cutaneous squamous cell carcinoma (cSCC) represents the second most frequent skin cancer, recently showing a rapid increase in incidence worldwide, with around >1 million cases/year in the United States and 2500 deaths [...]
Ferrocenyl amides (FB1-FB13) and their organic analogues (BZ1-BZ13) were prepared by a low-temperature condensation method. Ferrocenyl amides were synthesised using 4-ferrocenylbenzoyl chloride and ether-based amines and diamines. Benzoyl chloride wa...
The term diabetic cardiomyopathy (DCM) labels an abnormal cardiac structure and performance due to intrinsic heart muscle malfunction, independently of other vascular co-morbidity. DCM, accounting for 50%–80% of deaths in diabetic patients, represent...
Auxetic materials and structures exhibit negative values of Poisson’s ratio, which is the source of their unusual deformation pattern. Auxetic materials can be utilized in the development of multiphase materials with increased Young’s mod...
A homogenization-based five-step multi-scale finite element (FsMsFE) simulation framework is developed to describe the time-temperature-dependent viscoelastic behavior of 3D braided four-directional composites. The current analysis was performed via...
The realization of physiologically-relevant advanced in vitro models is not just related to the reproduction of a three-dimensional multicellular architecture, but also to the maintenance of a cell culture environment in which parameters, such as tem...
Auxetic materials represent a relatively new class of materials that are characterized by a cellular structure and a negative Poisson coefficient. Auxetics are extremely useful for morphing applications thanks to their synclastic deformation capabili...
Background: Malignant epithelial nail unit tumors pose significant diagnostic and therapeutic challenges due to their clinical presentation often mimicking benign conditions and due to the need to preserve as much nail unit function as possible durin...
Most existing research on periodic beams concerns bending waves in mono-coupled and bi-coupled periodic mono-component beams with the unit cell containing only one beam segment, and very few works on bi-coupled periodic multi-component beams with the...
Sickle cell disease (SCD) encompasses a group of inherited red cell disorders characterized by an abnormal hemoglobin, Hb S. The most common forms of SCD in the United States and Canada are identified through universal newborn screening (NBS) program...
The aim of this paper was to investigate the compression properties of several trabecular structures produced by additive laser manufacturing of a Ti6Al4V, having different densities and unit cells. Filling space structures were investigated, with di...
Automotive manufacturing is energy-intensive. The consumed energy contributes to the generation of significant amounts of greenhouse gas (GHG) emissions by the automotive manufacturing industry. In this paper, a study is conducted on assessing the ap...
The creation of a liver tissue that recapitulates the micro-architecture and functional complexity of a human organ is still one of the main challenges of liver tissue engineering. Here we report on the development of a 3D vascularized hepatic tissue...
Stroke remains a major cause of death and disability in the United States and around the world. Solid safety and efficacy profiles of novel stroke therapeutics have been generated in the laboratory, but most failed in clinical trials. Investigations...
Gangliosides are glycolipids occurring in higher animals, with a sphingoid core in the form of ceramide, bound to a glycan moiety including several units of sialic acid. Gangliosides are involved in important (patho)-physiological processes as compon...
Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing,...
Chemical examination of a marine sponge-associated Penicillium copticola fungus resulted in the isolation of ten undescribed eremophilanes, namely copteremophilanes A–J (1–10), along with two new glycosides, 5-glycopenostatin F (11) and 5...
Tetra-auricupride, ideally AuCu, represents the only species showing the coexistence of Au with an elevated level of Pt, as in the case of a detrital grain studied structurally for the first time, from an ophiolite-associated placer at Bolshoy Khaily...
Background: Today, in Western countries, patients with allo-antibodies to high-frequency antigens or with complex antibody mixtures represent one of the most significant challenges in transfusion medicine. Another important aspect is the prevention o...
Recent years have shown that additive manufacturing is able to significantly increase the potential for enhancing lightweight structural design. In particular, strut-based lattices have attracted considerable research interest due to their promising...
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the developmen...
The recovery of metagenome-assembled genomes is biased towards the most abundant species in a given community. To improve the identification of species, even if only dominant species are recovered, we investigated the integration of flow cytometry ce...
Prostate cancer (PCa) is the most common noncutaneous cancer diagnosis and the second leading cause of cancer-related deaths among men in the United States. Effective treatment modalities for advanced metastatic PCa are limited. Immunotherapeutic str...
Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has the poten...
Colorectal cancer (CRC) represents one of the most deadly cancers worldwide. Colorectal cancer stem cells (cCSCs) are the driving units of CRC initiation and development. After the concept of cCSC was first formulated in 2007, a huge bulk of research...
Non-Hodgkin lymphomas (NHLs) represent a diverse group of hematologic malignancies derived from various cells. B-cell NHLs represent the largest fraction of lymphomas diagnosed and treated in the United States. Standard chemo-immunotherapies with rit...
In this paper, a novel auxetic structure with rotating squares with holes is investigated. The unit cell of the structure consists of four units in the shape of a square with cut corners and holes. Finally, the structure represents a kind of modified...
An exergy analysis of a novel integrated power system is represented in this study. A Solid Oxide Fuel Cell (SOFC), which has been assisted with a Gas Turbine (GT) and Organic Rankine Cycle (ORC) by employing liquefied natural gas (LNG) as a heat sin...
Lattice structures have demonstrated the ability to provide secondary stability in orthopedic implants by promoting internal bone growth. In response to the growing prevalence of lattices in orthopedic design, we investigated the effects of porosity...
The technological advancement of optical approaches, and the growth of their applications in neuroscience, has allowed investigations of the physio-pathology of neural networks at a single cell level. Therefore, better understanding the role of singl...
Bacterial surface layers (S-layers) have been observed as the outermost cell envelope component in a wide range of bacteria and most archaea. S-layers are monomolecular lattices composed of a single protein or glycoprotein species and have either obl...
The blood–brain barrier and blood–spinal cord barrier (BBB/BSCB) are essential protective components for the healthy functioning of the central nervous system (CNS). While these barriers protect the CNS from peripheral factors, such as im...
We herein investigate the scattering of orthogonal counterpropagating waves and one-way propagating bulk waves in discrete acoustic superlattices subjected to a scattering potential applied to one of the superlattice unit cells. We demonstrate theore...
This article deals with stress wave decay performance, analysing the stress wave propagation generated by an impulsive unit load in a 2D representative unit cell (RUC) of a polymer composite with circular particles representing spherical particles, e...
Even in adult brains, restorative mechanisms are still retained to maintain the microenvironment. Under the pathological conditions of central nervous system (CNS) diseases, several immature cells in the brain would be activated as a compensative res...
Optimally sizing grid cells is a relevant research issue in landslide susceptibility evaluation. In fact, the size of the adopted mapping units influences several aspects spanning from statistical (the number of positive/negative cases and prevalence...
9 October 2023
The spatial organization of euchromatin (EC) and heterochromatin (HC) appears as a cell-type specific network, which seems to have an impact on gene regulation and cell fate. The spatial organization of cohesin should thus also be characteristic for...
The volume-of-fluid (VOF) method is widely used for multiphase flow simulations, where the VOF function implicitly represents the interface through the volume fraction field. The height function (HF) method on a Cartesian grid integrates the volume f...
Introns represent almost half of the human genome, yet their vast majority is eliminated from eukaryotic transcripts through RNA splicing. Nevertheless, they feature key elements and functions that deserve further interest. At the level of DNA, intro...
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