Next Article in Journal
Hybrid Plasma/Molecular-Dynamics Approach for Efficient XFEL Radiation Damage Simulations
Next Article in Special Issue
Coordination Compounds Featuring Non-Toxic Chiral 1,4-Dicarboxylic Acids and Copper(II)
Previous Article in Journal
Ion Charge Influence on the Molecular Structure of Polyethylene Terephthalate Films after Irradiation with Swift Heavy Ions
Previous Article in Special Issue
Quantum Crystallography in the Last Decade: Developments and Outlooks
Open AccessArticle

Synthesis, Characterization and Biological Studies of Ether–Based Ferrocenyl Amides and their Organic Analogues

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
National Centre for Physics, Quaid-i-Azam University, Islamabad 44000, Pakistan
Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany
Department of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84604, USA
Department of Biochemistry & Molecular Biology, University of Gujrat, Gujrat 50700, Pakistan
Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Authors to whom correspondence should be addressed.
Crystals 2020, 10(6), 480;
Received: 22 April 2020 / Revised: 28 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
Ferrocenyl amides (FB1-FB13) and their organic analogues (BZ1-BZ13) were prepared by a low-temperature condensation method. Ferrocenyl amides were synthesised using 4-ferrocenylbenzoyl chloride and ether-based amines and diamines. Benzoyl chloride was used to synthesise organic analogues by reacting with various amines. The synthesised compounds were characterised by elemental, spectroscopic (FT-IR and NMR) and single crystal X-ray diffraction methods. Crystal structures of the representative organic analogues (BZ2 and BZ6) were solved by single crystal X-ray diffraction. BZ2 crystallises in the triclinic space group P 1 ¯ with a unit cell volume of V = 1056.6(3) Å3 and with two formula units per unit cell. Whereas BZ6 assembles in the orthorhombic space group Pbca with four formula units per unit cell and a unit cell volume of V = 1354.7(2) Å3. Spectral studies confirmed the presence of amide linkages in the synthesised compound with a strong N—H·····O=C hydrogen bonding network established between amide groups of neighbouring molecular scaffolds further stabilising the molecular stacking in accordance with the archetypal crystal structures. The bioactive nature of each compound was assessed by DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity, hydrogen peroxide scavenging activity and total antioxidant activity. Antidiabetic, anticholinesterase enzyme inhibition tests, as well as antibacterial activities, were performed showing significant biological activity for ferrocenyl amides as compared to their organic analogues. View Full-Text
Keywords: ferrocenyl amides; organic amides; biological activities ferrocenyl amides; organic amides; biological activities
Show Figures

Figure 1

MDPI and ACS Style

Waseem Abbasi, S.; Ali, N.Z.; Etter, M.; Shabbir, M.; Akhter, Z.; Smith, S.J.; Ismail, H.; Mirza, B. Synthesis, Characterization and Biological Studies of Ether–Based Ferrocenyl Amides and their Organic Analogues. Crystals 2020, 10, 480.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop