Next Article in Journal / Special Issue
Neonatal Screening for Sickle Cell Disease in Belgium for More than 20 Years: An Experience for Comprehensive Care Improvement
Previous Article in Journal / Special Issue
Newborn Sickle Cell Disease Screening Using Electrospray Tandem Mass Spectrometry
Article Menu

Export Article

Open AccessReview
Int. J. Neonatal Screen. 2018, 4(4), 36; https://doi.org/10.3390/ijns4040036

Newborn Screening for SCD in the USA and Canada

Department of Hematology-Oncology, UCSF Benioff Children’s Hospital Oakland, Oakland, CA 94609, USA
*
Author to whom correspondence should be addressed.
Received: 3 October 2018 / Revised: 19 November 2018 / Accepted: 20 November 2018 / Published: 26 November 2018
  |  
PDF [630 KB, uploaded 26 November 2018]
  |  

Abstract

Sickle cell disease (SCD) encompasses a group of inherited red cell disorders characterized by an abnormal hemoglobin, Hb S. The most common forms of SCD in the United States and Canada are identified through universal newborn screening (NBS) programs. Now carried out in all fifty U.S. states and 8 Canadian provinces, NBS for SCD represents one of the major public health advances in North America. The current status of NBS programs for hemoglobinopathies and the screening techniques employed in many regions worldwide reflect in large part the U.S. and Canadian experiences. Although the structure, screening algorithms and laboratory procedures, as well as reporting and follow up, vary between NBS programs, the overall workflow is similar. The current review summarized the historical background, current approaches, and methods used to screen newborns for SCD in the United States and Canada. View Full-Text
Keywords: hemoglobinopathies; newborn screening; methods; review hemoglobinopathies; newborn screening; methods; review
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

El-Haj, N.; Hoppe, C.C. Newborn Screening for SCD in the USA and Canada. Int. J. Neonatal Screen. 2018, 4, 36.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Neonatal Screen. EISSN 2409-515X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top