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Int. J. Neonatal Screen. 2018, 4(4), 36;

Newborn Screening for SCD in the USA and Canada

Department of Hematology-Oncology, UCSF Benioff Children’s Hospital Oakland, Oakland, CA 94609, USA
Author to whom correspondence should be addressed.
Received: 3 October 2018 / Revised: 19 November 2018 / Accepted: 20 November 2018 / Published: 26 November 2018
PDF [630 KB, uploaded 26 November 2018]


Sickle cell disease (SCD) encompasses a group of inherited red cell disorders characterized by an abnormal hemoglobin, Hb S. The most common forms of SCD in the United States and Canada are identified through universal newborn screening (NBS) programs. Now carried out in all fifty U.S. states and 8 Canadian provinces, NBS for SCD represents one of the major public health advances in North America. The current status of NBS programs for hemoglobinopathies and the screening techniques employed in many regions worldwide reflect in large part the U.S. and Canadian experiences. Although the structure, screening algorithms and laboratory procedures, as well as reporting and follow up, vary between NBS programs, the overall workflow is similar. The current review summarized the historical background, current approaches, and methods used to screen newborns for SCD in the United States and Canada. View Full-Text
Keywords: hemoglobinopathies; newborn screening; methods; review hemoglobinopathies; newborn screening; methods; review

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El-Haj, N.; Hoppe, C.C. Newborn Screening for SCD in the USA and Canada. Int. J. Neonatal Screen. 2018, 4, 36.

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Int. J. Neonatal Screen. EISSN 2409-515X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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