4,673 Results Found

Although green process technology is vital to sustainable development, few articles focus on how to implement it from the perspective of firms. This article tries to answer this question. Being set as an antecedent of green process innovation, the in...

The “excess salt replication process” is a new simple method of fabrication of open-cell metal foam based on the commonly known salt replication method. Porous materials with porosity between 46% and 66% result when the employed alloy is...

Background: Upregulation of H3K27me3 induced by EZH2 overexpression or somatic heterozygous mutations were implicated in lymphomagenesis. It has been demonstrated that several EZH2-target agents have notable therapeutic effects in EZH2-mutant B-cell...

The protein encoded by the vaccinia virus D4R gene has base excision repair uracil–DNA N-glycosylase (vvUNG) activity and also acts as a processivity factor in the viral replication complex. The use of a protein unlike PolN/PCNA sliding clamps...

Controlling the activity of the heterohexameric Mcm2–7 replicative helicase is crucial for regulation of replication origin activity in eukaryotes. Because bidirectional replication forks are generated from every replication origin, when origin...

Replication-competent virus particles hold significant therapeutic potential in application as oncolytic viruses or cancer vaccines. Ensuring the viral integrity of these particles is crucial for their infectivity, safety, and efficacy. Enveloped vir...

In a previous study in young adults, we showed that hemodynamic changes as measured by functional near-infrared spectroscopy (fNIRS) were sensitive for identifying visuospatial working memory (WM)-related functional brain activation in the prefrontal...

The study of co-fusion was one of the essential topics in the history of metallurgy in China. Simulation experiments were an essential concept in the study of the co-fusion steelmaking process. This paper mainly studied the simulation experiments of...

African swine fever virus (ASFV) is the etiological agent of an economically important disease of swine currently affecting large areas of Africa, Eurasia and the Caribbean. ASFV has a complex structure harboring a large dsDNA genome which encodes fo...

The possibility of tailoring key surface properties through the injection molding process makes it intriguing from the perspective of sustainability enhancement. The surface properties depend on the replication accuracy of micro and nanostructures on...

Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. Prion particles are assemblies formed from a misfolded, β-sheet rich, aggregation-prone isoform (PrP^Sc) of the host-encoded c...

Acquiring reliable thermal data during the high-pressure die-casting (HPDC) process remains a significant challenge due to its complexity and rapidly evolving thermal environment. In industrial settings, the influence of process parameters is typical...

Open-cell-type aluminum foam demonstrates excellent heat dissipation owing to interconnected pores. In this study, open-cell-type aluminum foams with various pore sizes and porosities were fabricated using the replication-casting process, which is a...

The conserved nuclease-helicase DNA2 has been linked to mitochondrial myopathy, Seckel syndrome, and cancer. Across species, the protein is indispensable for cell proliferation. On the molecular level, DNA2 has been implicated in DNA double-strand br...

The DNA of all living organisms is a common matrix for both replication and transcription processes. This sometimes leads to inevitable collisions between DNA replication and transcription machinery. There is plethora of evidence demonstrating that s...

Injection compression molding (ICM) provides enhanced optical performances of molded polymer optics in terms of birefringence and transmission of light compared to Injection molding (IM). Nevertheless, ICM requires case-dedicated process optimization...

This paper presents an integrated high temperature ultrasonic transducer (HTUT) on a sensor insert and its application for real-time diagnostics of the conventional hot embossing process to fabricate V-cut patterns. The sensor was directly deposited...

Coxsackieviruses possess two proteases that are engaged in cleaving viral polyprotein and hijacking host cell processes such as RNA biosynthesis. Integrator subunit 10 (INTS10), a subunit of the integrator complex, facilitates the processing of small...

The increasing demand for micro-injection molding process technology and the corresponding micro-molded products have materialized in the need for models and simulation capabilities for the establishment of a digital twin of the manufacturing process...

The rapid growth in cloud service demand has led to the establishment of large-scale virtualized data centers in which virtual machines (VMs) are used to handle user requests for service. A user’s request cannot be completed if the VM fails. Replicat...

This investigation of morphology-wetting links was performed using a biomimetic approach. Three natural leaves’ surfaces were studied: two bamboo varieties and Ginkgo Biloba. Multiscale surface topographies were analyzed by SEM observations, FFT, and...

The wide availability and small size of different types of sensors have allowed for the acquisition of a huge amount of data about a person’s life in real time. With these data, usually denoted as lifelog data, we can analyze and understand per...

Prune dwarf virus (PDV) is one of the members of Bromoviridae family, genus Ilarvirus. Host components that participate in the regulation of viral replication or cell-to-cell movement via plasmodesmata are still unknown. In contrast, viral infections...

The capsid precursor P1 constitutes the N-terminal part of the enterovirus polyprotein. It is processed into VP0, VP3, and VP1 by the viral proteases, and VP0 is cleaved autocatalytically into VP4 and VP2. We observed that poliovirus VP0 is recognize...

The replication casting process is used for manufacturing open-pore aluminum foams with advanced performances, such as stability and repeatability of foam structure with porosity over 60%. A simple foam structure model based on the interaction betwee...

This article presents an analytical procedure developed to replicate, document, and analyse the formation and evolution of use-wear traces on task-specific ground stone tools. The purpose of this study is to build a reference collection for wear patt...

Under the ‘PPP + EPC + whole-process engineering consultation’ mode, this article constructs a replication dynamic evolutionary game model of the main participants, namely, the government, social capital, and the whole-process engineering...

The time on task (ToT) effect describes the relationship of the time spent on a cognitive task and the probability of successful task completion. The effect has been shown to vary in size and direction across tests and even within tests, depending on...

The paper debates the results achieved in the Sanità district of Naples within the funded research project Play_ACT by the Department of Architecture, University of Naples Federico II. The research investigates community engagement processes i...

Ecuador has a high prevalence of malnutrition. In this scenario, Ecuador promotes education on healthy eating through informative materials and talks. However, their content is usually extensive and does not consider the age, economic status, and edu...

Particles of many paramyxoviruses include small amounts of proteins with a molecular weight of about 20 kDa. These proteins, termed “C”, are basic, have low amino acid homology and some secondary structure conservation. C proteins are enc...

In the dynamic realm of sustainable energy storage technologies, the global research landscape presents myriad scientific and economic challenges. The erratic growth of renewable energies alongside the phasing out of conventional power plants poses a...

The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication. Replisome progression and establishme...

The initiation reactions of DNA synthesis are central processes during human chromosomal DNA replication. They are separated into two main processes: the initiation events at replication origins, the start of the leading strand synthesis for each rep...

Ultrasonic molding is a new technology for processing small and micro polymeric components with reasonable cost and energy savings when small and medium batch sizes are required. However, when microcomponents are manufactured, the replicability of di...

Vacuum-pressure casting technology allows small batches of components to be manufactured from polymer materials, mainly from thermosetting plastics such as polyurethane and epoxy resins. Apart from being very simple, the process is also advantageous...

Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 a...

Human intestinal enteroids (HIEs) culture is an emerging model for assessing the infectivity of human noroviruses (HuNoVs). The model is based on detecting an increase in HuNoV RNA post-infection of HIEs. HuNoV fecal samples used for HIE infection ar...

African swine fever virus (ASFV) causes a devastating disease of swine that has caused outbreaks in Central Europe since 2007, spreading into Asia in 2018. ASFV is a large, structurally complex virus with a large dsDNA genome encoding for more than 1...

Ebola virus (EBOV) glycoprotein (GP) is a class I fusion protein whose maturation is dependent on furin-mediated processing. EBOV-GP is heavily glycosylated, with glycans constituting ~50% of its molecular mass. Compared with 15 N-linked glycosylatio...

The coronavirus transforms the cytoplasm of susceptible cells to support virus replication. It also activates autophagy-like processes, the role of which is not well understood. Here, we studied SARS-CoV-2-infected Vero E6 cells using transmission el...

The relative structural simplicity of chaotic oscillators and the possibility of obtaining signals with a large dimension is of great interest for wireless data transmission and processing. The diversity of signal waveforms from the same source of ch...

A novel time-domain algorithm is proposed in this paper for the iterative estimation of drive files. A drive file is a synchronized batch of dynamic time series commands that are simultaneously sent to one or more actuators in a test rig that is desi...

This review discusses a set of experimental results that support the existence of extended strand displacement events during budding yeast lagging strand DNA synthesis. Starting from introducing the mechanisms and factors involved in leading and lagg...

The manufacturing of aluminium foams with a total porosity of 87% using the sponge replication method and a combination of the sponge replication and freezing technique is presented. Foams with different cell counts were prepared from polyurethane (P...

Type I interferons (IFN-Is) are pivotal in innate immunity against human immunodeficiency virus I (HIV-1) by eliciting the expression of IFN-stimulated genes (ISGs), which encompass potent host restriction factors. While ISGs restrict the viral repli...

Open cell foams consisting of Fe and Fe-Mn oxides are prepared from metallic Fe and Mn powder precursors by the replication method using porous polyurethane (PU) templates. First, reticulated PU templates are coated by slurry impregnation. The templa...

Liquid–liquid phase separation (LLPS) represents a major physiochemical principle to organize intracellular membrane-less structures. Studies with non-segmented negative-sense (NNS) RNA viruses have uncovered a key role of LLPS in the formation of vi...

The process of “self-organization” takes place in open and complex systems that acquire spatio-temporal or functional structures without specific ordering instructions from the outside. [...]

Transcription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzym...