We present synthetic experiments of lactic acid (LA) polycondensation to produce poly(lactic acid) (PLA) as well as kinetic modeling calculations that capture the polymer molecular weight increase with time, given the initial concentrations. Tin-octo...
In this study, a facile, eco-friendly route, in two steps, for obtaining of poly-L-lactic acid/chitosan-silver nanoparticles scaffolds under quiescent conditions was presented. The method consists of plasma treatment and then wet chemical treatment o...
Regenerative medicine aims to restore the structure and function for improved tissue health; reduced tissue health can arise from causes such as aging, which results in the ongoing degradation of the extracellular matrix (ECM) of the skin. Replacemen...
Poly(l-lactic acid) with high molecular weight was used to prepare PLLA films by means of the solvent casting technique. Poly(d-lactic acid) (PDLA) and poly(d-lactic acid-co-glucose) copolymer (PDLAG) with a low molecular weight were synthesized from...
Poly-L-lactic acid (PLLA) implants have been used for bone fixation for decades. However, upon insertion, they can cause a foreign body reaction (FBR) that may lead to complications. On 15 December 2023, a systematic review was conducted to search fo...
Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. Despite these beneficial characteristics, its poor bioactivity ofte...
Poly(L-lactic acid) (PLLA) and PLLA/gelatin polymers were prepared via electrospinning to evaluate the effect of PLLA and gelatin content on the mechanical properties, water uptake capacity (WUC), water contact angle (WCA), degradation rate, cytotoxi...
Rejuvenation of the perioral region using minimally invasive aesthetic techniques is frequently used to address age-related changes. While hyaluronic acid-based dermal fillers are a frequently used treatment, limited data are available on the injecta...
Poly-L-lactic acid (PLLA) filler, which increases volume and collagen synthesis, is used for skin rejuvenation. Subcutaneous adipose tissue (SAT) contains precursors that differentiate into mature adipocytes that secrete adiponectin, which modulates...
Poly(L–lactic acid) (PLLA), as a biodegradable polymer, has attracted attention for use as a biomaterial. In order to apply PLLA as a cardiovascular stent, stronger mechanical properties and anti–inflammatory effects against acidic by&nda...
Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to its high biocompatibility. However, its inherent brittleness and inflammatory responses by acidic b...
Pathological hypoxia following cutaneous injury is a critical driver of wound chronicity and fibrotic remodeling. The nuclear receptor binding SET domain protein 2 (NSD2)/lysine demethylase 2A (KDM2A)–histone H3 lysine 36 dimethylation (H3K36me...
Macroscopic and microscopic aggregation patterns of reconstituted poly-L-lactic acid (PLLA) products may vary with product formulation, diluent, preparation protocol, and time. This descriptive in vitro pilot study compared two commercial formulation...
The nucleating effect of silk fibroin nano-disc (SFN) on the crystallization behavior of poly(L-lactic acid) (PLLA) was investigated by simultaneous synchrotron small- and wide-angle X-ray scattering measurements. For the isothermal crystallization a...
Poly(L-lactic acid) (PLLA) was blended with an ethylene-vinyl acetate (EVA) copolymer, which is generally recognized as a phase-separated system. The interactions between these polymer species were examined via spherulite observation. The PLLA/EVA bl...
Osteochondral repair remains challenging due to cartilage’s limited self-healing capacity and the structural complexity of the osteochondral interface, particularly the hypertrophic layer anchoring cartilage to bone. We fabricated melt electrow...
For many years, we have been developing flexible sensors made of braided piezoelectric poly-l-lactic acid (PLLA) fibers that can be tied and untied for practical applications in society. To ensure good quality of sleep, the occurrence of bruxism has...
This study evaluated the thermal properties, crystallinity, particle size, morphology, and in vivo local inflammation and persistence of two poly-L-lactic acid (PLLA) injectable implants, Sculptra® (PLLA-SCA) and GANA V® (PLLA-GA). PLLA-SCA a...
Bio-based composites made of poly(l-lactic acid) (PLLA) and pine wood were prepared by melt extrusion. The composites were compatibilized by impregnation of wood with γ-aminopropyltriethoxysilane (APE). Comparison with non-compatibilized formul...
Poly-L-lactic acid (PLLA) fillers correct cutaneous volume loss by stimulating fibroblasts to synthesize collagen and by augmenting the volume. PLLA triggers the macrophage-induced activation of fibroblasts that secrete transforming growth factor-&be...
Poly-l-Lactic acid (PLLA) is a synthetic, absorbable injectable implant widely used in both facial and body cosmetic applications. Originally approved by the Food and Drug Administration (FDA) for treating facial lipoatrophy in Human Immunodeficiency...
Poly(l-lactic acid)-based films which include 60 wt % of vaterite (V) or siloxane-containing vaterite (SiV) were coated on a pure magnesium substrate, denoted by PLLA/V or PLLA/SiV, respectively, to suppress early corrosion and improve its cytocompat...
The bio-based biodegradable material poly(L-lactic acid) (PLLA) has received extensive attention due to its inherent sustainability. Ultra-high molecular weight (UHMW) PLLA possesses superior physical, chemical, and mechanical properties, but its dif...
Poly-L-lactic acid (PLLA) has gained great popularity with researchers in regenerative medicine owing to its superior biocompatibility and biodegradability, although its inadequate bioactivity inhibits the further use of PLLA in the field of bone reg...
The orientation of poly(l-lactic acid) (PLLA) crystals was controlled through crystal growth from a magnetically oriented nucleating agent, phenylphosphonic acid zinc (PPAZn). The one-dimensional magnetically oriented microcrystal array of PPAZn micr...
Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on th...
Poly-l-lactic acid (PLLA) is one of the most common bioabsorbable materials in the medical device field. However, its use in load-bearing applications is limited due to its inferior mechanical properties when compared to many of the competing metal-b...
Bilayer scaffolds could provide a suitable topology for osteochondral defect repair mimicking cartilage and subchondral bone architecture. Hence, they could facilitate the chondro- and osteogenic lineage commitment of multipotent mesenchymal stromal...
Lamellar assembly with fractal-patterned growth into dendritic and ringed spherulites of crystallized poly(l-lactic acid) (PLLA), of two molecular weight (MW) grades and crystallized at (temperature of crystallization) Tc = 120 and 130 °C, respec...
Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical pr...
In terms of drug delivery, the attractive properties of poly(L-lactic acid) (PLA) and its aliphatic polyesters, poly(ethylene adipate) (PEAd) and poly(butylene adipate) (PBAd), render them ideal co-formulants for the preparation of modified-release p...
Poly(l-lactic acid) (PLLA) crystal possesses a complex polymorphism, and the formation mechanism of various crystal forms has been a hot research topic in the field of polymer condensate matter. In this research, five kinds of PLLA with different mol...
Today, the use of natural biodegradable materials in the production processes is more and more adopted by industry to achieve cyclic economy targets and to improve environmental and human health indexes. Active packaging is the latest trend for food...
This study aims to demonstrate the possibility of incorporating a natural antioxidant biomolecule into polymeric porous scaffolds. To this end, Poly-l-Lactic Acid (PLLA) scaffolds were produced using the Thermally Induced Phase Separation (TIPS) tech...
The present study evaluates the use of newly synthesized poly(l-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of aripiprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect...
In some traumatic nerve injuries, autologous nerve grafting is the first choice for bridging the gap between the severed nerve ends. However, this therapeutic strategy has some disadvantages, including permanent loss of donor function and requirement...
Poly-l-lactic acid (PLLA), a synthetic, biocompatible, biodegradable polymer, has been safely used in several clinical applications in recent decades. Typically, SculptraTM, the commercially injectable PLLA in the form of microparticles, has been use...
One of the most effective strategies for modifying the surface properties of nano-fillers and enhancing their composite characteristics is through polymer grafting. In this study, a coprecipitation method was employed to modify hydroxyapatite (HAP) w...
Poly(l-lactic acid) or poly(l-lactide) (PLLA) is an optically active polymer derived from renewable sources and fully biodegradable. It is known that PLLA assumes a left-handed helix in the solid state and also in solution it still keeps a certain de...
Biodegradable polymers play a crucial role in the medical device field, with a broad range of applications such as suturing, drug delivery, tissue engineering, scaffolding, orthopaedics, and fixation devices. Poly-l-lactic acid (PLLA) is one of the m...
In the present study the development of novel polymer-supported nanocomposite graphene oxide (GO)–TiO2 films, based on poly(L-lactic acid), one of the most exploited bioplastics worldwide, was explored for photocatalytic applications. The nanoc...
Optical rotatory dispersion (ORD) is a beautiful analytical technique for the study of chiral molecules and polymers. In this study, ORD was applied successfully to follow the degree of polycondensation of l-(+)-lactic acid toward the formation of po...
A poly(l-lactic acid)/nanohydroxyapatite (PLLA/nHA) scaffold works as a bioactive, osteoconductive scaffold for bone-tissue engineering, but its low degradation rate limits embedded HA in PLLA to efficiently interact with body fluids. In this work, n...
Poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLLA) particles have been applied as dermal fillers for soft-tissue augmentation because they can induce foreign-body reactions, resulting in fibroblast proliferation and collagen formation. Alth...
Electrospun nanofiber mats have attracted intense attention as advanced wound dressing materials. The objective of this study was to fabricate methacrylated gelatin (MeGel)/poly(L-lactic acid) (PLLA) hybrid nanofiber mats with an extracellular matrix...
Biobased packaging solutions with active functions for different food categories are a very attractive topic nowadays. This packaging provides suitable preservation of the food quality and extends the shelf life of packed items. In addition, this is...
Poly(l-lactic acid)/ethylene propylene diene monomer/organic montmorillonite (PLLA/EPDM/OMMT) samples were melt-compounded and then processed into sheets via two routes, namely, compression-molding and calendering. Tensile performance, morphology, an...
Biodegradable scaffolds based on biomedical polymeric materials have attracted wide interest in bone transplantation for clinical treatment for bone defects without a second operation. The composite materials of poly(trimethylene carbonate), poly(L-l...
Objective: This study aimed to evaluate the reconstitution and solubility characteristics of two injectable poly L-lactic acid (PLLA) formulations, the next-generation injectable PLLA-LASYNPRO™ and a previous-generation PLLA (PLLA-SCA), through...
The physical properties and non-isothermal melt- and cold-crystallisation kinetics of poly (l-lactic acid) (PLLA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) biobased polymers reprocessed by mechanical milling of moulded specimens and fol...
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