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Open AccessArticle

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

1
Department of Materials Science Engineering, Seoul National University, Seoul 08826, Korea
2
Department of Materials Science and Engineering, Chosun University, Gwangju 61452, Korea
3
Department of Biomedical-Chemical Engineering, Catholic University of Korea, Bucheon-si 03083, Korea
4
Department of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(10), 2390; https://doi.org/10.3390/polym12102390
Received: 13 September 2020 / Revised: 12 October 2020 / Accepted: 15 October 2020 / Published: 17 October 2020
(This article belongs to the Special Issue Polymers in Biomedical Engineering)
Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic materials. A bioresorbable composite made of PLLA and hydroxyapatite (HA) may improve biocompatibility but typically causes deterioration in mechanical properties, and bioactive coatings inevitably carry a risk of coating delamination. Therefore, in this study, we embedded micropatterned HA on the surface of PLLA to improve bioactivity while eliminating the risk of HA delamination. An HA pattern was successfully embedded in a PLLA matrix without degeneration of the matrix’s mechanical properties, thanks to a transfer technique involving conversion of Mg to HA. Furthermore, patterned HA/PLLA’s biological response outperformed that of pure PLLA. These results confirm patterned HA/PLLA as a candidate for wide acceptance in biodegradable load-bearing implant applications. View Full-Text
Keywords: poly(L-Lactic) acid; hydroxyapatite; patterning; load-bearing implant; biocompatibility poly(L-Lactic) acid; hydroxyapatite; patterning; load-bearing implant; biocompatibility
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MDPI and ACS Style

Kim, S.-M.; Kang, I.-G.; Cheon, K.-H.; Jang, T.-S.; Kim, H.-E.; Jung, H.-D.; Kang, M.-H. Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant. Polymers 2020, 12, 2390.

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