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Nanomaterials 2019, 9(3), 428;

Eco-Friendly Method for Tailoring Biocompatible and Antimicrobial Surfaces of Poly-L-Lactic Acid

Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania
Sanimed International IMPEX SRL, Sos. Bucuresti—Magurele, nr. 70F, Sector 5, Bucharest 051434, Romania
Author to whom correspondence should be addressed.
Received: 16 February 2019 / Revised: 6 March 2019 / Accepted: 7 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Green Synthesis of Nanomaterials)
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In this study, a facile, eco-friendly route, in two steps, for obtaining of poly-L-lactic acid/chitosan-silver nanoparticles scaffolds under quiescent conditions was presented. The method consists of plasma treatment and then wet chemical treatment of poly-L-lactic acid (PLLA) films in a chitosan based-silver nanoparticles solution (Cs/AgNp). The changes of the physical and chemical surface proprieties were studied using scanning electron microscopy (SEM), small angle X-Ray scattering (SAXS), Fourier transform infrared spectroscopy (FTIR) and profilometry methods. A certain combination of plasma treatment and chitosan-based silver nanoparticles solution increased the biocompatibility of PLLA films in combination with cell line seeding as well as the antimicrobial activity for gram-positive and gram-negative bacteria. The sample that demonstrated from Energy Dispersive Spectroscopy (EDAX) to have the highest amount of nitrogen and the smallest amount of Ag, proved to have the highest value for cell viability, demonstrating better biocompatibility and very good antimicrobial proprieties. View Full-Text
Keywords: chitosan; poly-L-lactic acid; plasma; silver nanoparticles; antimicrobial chitosan; poly-L-lactic acid; plasma; silver nanoparticles; antimicrobial

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Aflori, M.; Butnaru, M.; Tihauan, B.-M.; Doroftei, F. Eco-Friendly Method for Tailoring Biocompatible and Antimicrobial Surfaces of Poly-L-Lactic Acid. Nanomaterials 2019, 9, 428.

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