J. Funct. Biomater. 2018, 9(2), 32; https://doi.org/10.3390/jfb9020032
Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application
Iffa A. Fiqrianti 1, Prihartini Widiyanti 1,2,*
, Muhammad A. Manaf 1, Claudia Y. Savira 1, Nadia R. Cahyani 1 and Fitria R. Bella 1
, Muhammad A. Manaf 1, Claudia Y. Savira 1, Nadia R. Cahyani 1 and Fitria R. Bella 11
Biomedical Engineering, Faculty of Science and Technology, Universitas Airlangga, Jawa Timur 60115, Indonesia
2
Institute of Tropical Disease, Universitas Airlangga, Jawa Timur 60115, Indonesia
*
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 3 March 2018 / Accepted: 8 March 2018 / Published: 30 April 2018
Abstract
Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on the morphology, chemical bond, tensile strength, burst pressure, hemocompatibility, and cell viability (cytotoxicity) of the tube.In vitro assessments indicated that addition of chitosan-collagen could improve cell viability and hemocompatibility. Best results were demonstrated by the conduit with 10% PLLA, 0.5% chitosan, and 1% collagen. Tensile strength reached 2.13 MPa and burst pressure reached 2593 mmHg, both values that are within the range value of native blood vessel. A hemolysis percentage of 1.04% and a cell viability of 86.2% were obtained, meeting the standards of high hemocompatibility and low cytotoxicity for vascular graft material. The results are promising for further development toward vascular graft application. View Full-TextKeywords:
poly L-lactic acid; collagen; chitosan; electrospinning; tube; vascular graft
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Fiqrianti, I.A.; Widiyanti, P.; Manaf, M.A.; Savira, C.Y.; Cahyani, N.R.; Bella, F.R. Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application. J. Funct. Biomater. 2018, 9, 32.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
J. Funct. Biomater.
EISSN 2079-4983
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert