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J. Funct. Biomater. 2018, 9(2), 32; https://doi.org/10.3390/jfb9020032

Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application

1
Biomedical Engineering, Faculty of Science and Technology, Universitas Airlangga, Jawa Timur 60115, Indonesia
2
Institute of Tropical Disease, Universitas Airlangga, Jawa Timur 60115, Indonesia
*
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 3 March 2018 / Accepted: 8 March 2018 / Published: 30 April 2018
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Abstract

Poly-L-Lactic acid (PLLA) blended with chitosan and collagen was used to fabricate a conduit for blood vessel engineering through an electrospinning process. Various concentrations of chitosan were used in the blend in order to study its effect on the morphology, chemical bond, tensile strength, burst pressure, hemocompatibility, and cell viability (cytotoxicity) of the tube.In vitro assessments indicated that addition of chitosan-collagen could improve cell viability and hemocompatibility. Best results were demonstrated by the conduit with 10% PLLA, 0.5% chitosan, and 1% collagen. Tensile strength reached 2.13 MPa and burst pressure reached 2593 mmHg, both values that are within the range value of native blood vessel. A hemolysis percentage of 1.04% and a cell viability of 86.2% were obtained, meeting the standards of high hemocompatibility and low cytotoxicity for vascular graft material. The results are promising for further development toward vascular graft application. View Full-Text
Keywords: poly L-lactic acid; collagen; chitosan; electrospinning; tube; vascular graft poly L-lactic acid; collagen; chitosan; electrospinning; tube; vascular graft
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Fiqrianti, I.A.; Widiyanti, P.; Manaf, M.A.; Savira, C.Y.; Cahyani, N.R.; Bella, F.R. Poly-L-lactic Acid (PLLA)-Chitosan-Collagen Electrospun Tube for Vascular Graft Application. J. Funct. Biomater. 2018, 9, 32.

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