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Article

Biodegradable 3D Printed Scaffolds of Modified Poly (Trimethylene Carbonate) Composite Materials with Poly (L-Lactic Acid) and Hydroxyapatite for Bone Regeneration

by 1,2,†, 1,†, 1, 1,*, 1,* and 2
1
School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China
2
Department of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: David Jenkins and Fabiana Quaglia
Nanomaterials 2021, 11(12), 3215; https://doi.org/10.3390/nano11123215
Received: 12 October 2021 / Revised: 21 November 2021 / Accepted: 23 November 2021 / Published: 26 November 2021
(This article belongs to the Special Issue Advance in Nanostructured Polymers)
Biodegradable scaffolds based on biomedical polymeric materials have attracted wide interest in bone transplantation for clinical treatment for bone defects without a second operation. The composite materials of poly(trimethylene carbonate), poly(L-lactic acid), and hydroxyapatite (PTMC/PLA/HA and PTMC/HA) were prepared by the modification and blending of PTMC with PLA and HA, respectively. The PTMC/PLA/HA and PTMC/HA scaffolds were further prepared by additive manufacturing using the biological 3D printing method using the PTMC/PLA/HA and PTMC/HA composite materials, respectively. These scaffolds were also characterized by Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), automatic contact-angle, scanning electronic micrographs (SEM), diffraction of X-rays (XRD), differential scanning calorimetry (DSC), and thermogravimetry (TG). Subsequently, their properties, such as mechanical, biodegradation, cell cytotoxicity, cell compatibility in vitro, and proliferation/differentiation assay in vivo, were also investigated. Experiment results indicated that PTMC/PLA/HA and PTMC/HA scaffolds possessed low toxicity, good biodegradability, and good biocompatibility and then enhanced the cell multiplication ability of osteoblast cells (MC3T3-E1). Moreover, PTMC/PLA/HA and PTMC/HA scaffolds enhanced the adhesion and proliferation of MC3T3-E1 cells and enabled the bone cell proliferation and induction of bone tissue formation. Therefore, these composite materials can be used as potential biomaterials for bone repatriation and tissue engineering. View Full-Text
Keywords: poly (trimethylene carbonate); poly (L-lactic acid); hydroxyapatite; biodegradability; cell proliferation poly (trimethylene carbonate); poly (L-lactic acid); hydroxyapatite; biodegradability; cell proliferation
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MDPI and ACS Style

Kang, H.; Jiang, X.; Liu, Z.; Liu, F.; Yan, G.; Li, F. Biodegradable 3D Printed Scaffolds of Modified Poly (Trimethylene Carbonate) Composite Materials with Poly (L-Lactic Acid) and Hydroxyapatite for Bone Regeneration. Nanomaterials 2021, 11, 3215. https://doi.org/10.3390/nano11123215

AMA Style

Kang H, Jiang X, Liu Z, Liu F, Yan G, Li F. Biodegradable 3D Printed Scaffolds of Modified Poly (Trimethylene Carbonate) Composite Materials with Poly (L-Lactic Acid) and Hydroxyapatite for Bone Regeneration. Nanomaterials. 2021; 11(12):3215. https://doi.org/10.3390/nano11123215

Chicago/Turabian Style

Kang, Honglei, Xudong Jiang, Zhiwei Liu, Fan Liu, Guoping Yan, and Feng Li. 2021. "Biodegradable 3D Printed Scaffolds of Modified Poly (Trimethylene Carbonate) Composite Materials with Poly (L-Lactic Acid) and Hydroxyapatite for Bone Regeneration" Nanomaterials 11, no. 12: 3215. https://doi.org/10.3390/nano11123215

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