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Article

Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties

1
Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Korea
2
Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Korea
3
Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Korea
4
School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Francesco Branda and Aurelio Bifulco
Materials 2021, 14(19), 5869; https://doi.org/10.3390/ma14195869
Received: 6 August 2021 / Revised: 29 September 2021 / Accepted: 5 October 2021 / Published: 7 October 2021
(This article belongs to the Special Issue Surface Modifications for Advanced Polymer Composites)
Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to its high biocompatibility. However, its inherent brittleness and inflammatory responses by acidic by-products of PLLA limit its application in biomedical materials. Magnesium hydroxide (MH) has drawn attention as a potential additive since it has a neutralizing effect. Despite the advantages of MH, the MH can be easily agglomerated, resulting in poor dispersion in the polymer matrix. To overcome this problem, oligo-L-lactide-ε-caprolactone (OLCL) as a flexible character was grafted onto the surface of MH nanoparticles due to its acid-neutralizing effect and was added to the PLLA to obtain PLLA/MH composites. The pH neutralization effect of MH was maintained after surface modification. In an in vitro cell experiment, the PLLA/MH composites including OLCL-grafted MH exhibited lower platelet adhesion, cytotoxicity, and inflammatory responses better than those of the control group. Taken together, these results prove that PLLA/MH composites including OLCL-grafted MH show excellent augmented mechanical and biological properties. This technology can be applied to biomedical materials for vascular devices such as biodegradable vascular scaffolds. View Full-Text
Keywords: poly(L-lactic acid); magnesium hydroxide; oligo(D,L-lactic acid); oligo(lactide-co-caprolactone); biodegradable vascular scaffold poly(L-lactic acid); magnesium hydroxide; oligo(D,L-lactic acid); oligo(lactide-co-caprolactone); biodegradable vascular scaffold
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MDPI and ACS Style

Baek, S.-W.; Song, D.H.; Lee, H.I.; Kim, D.-S.; Heo, Y.; Kim, J.H.; Park, C.G.; Han, D.K. Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties. Materials 2021, 14, 5869. https://doi.org/10.3390/ma14195869

AMA Style

Baek S-W, Song DH, Lee HI, Kim D-S, Heo Y, Kim JH, Park CG, Han DK. Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties. Materials. 2021; 14(19):5869. https://doi.org/10.3390/ma14195869

Chicago/Turabian Style

Baek, Seung-Woon, Duck Hyun Song, Ho In Lee, Da-Seul Kim, Yun Heo, Jun Hyuk Kim, Chun Gwon Park, and Dong Keun Han. 2021. "Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties" Materials 14, no. 19: 5869. https://doi.org/10.3390/ma14195869

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