Search Results (21,237)

This paper addresses the limitations of conventional single-stage direct-control maximum power point tracking (MPPT) methods, such as the Perturb and Observe (P&O) algorithm. Fixed-step-size duty-cycle perturbations cause a trade-off between slow tracking with small oscillations and fast tracking with large oscillations, along with poor responsiveness to rapid weather variations and output voltage fluctuations. Two main contributions are presented. First, a fractional-order DC–DC boost converter (FOBC) is introduced, incorporating fractional-order dynamics to enhance system performance beyond improvements in control algorithms alone. Second, a novel indirect-control MPPT strategy based on a two-stage architecture is developed, where the P&O algorithm generates the optimal voltage reference and a fractional-order linear-quadratic-integral (FOLQI) controller—designed using a fractional-order small-signal model—regulates the PV module voltage to generate the FOBC duty cycle. Hardware-in-the-loop simulations confirm substantial performance improvements. The proposed FOLQI-based indirect-control approach with FOBC achieves a maximum MPPT efficiency of 99.26%. An alternative indirect method using a classical linear-quadratic-integral (LQI) controller with an integer-order boost converter reaches 98.38%, while the conventional direct-control P&O method achieves only 94.21%, demonstrating the superiority of the proposed fractional-order framework. Full article

Background: In the era of rapid technological advancement, digital transformation has emerged as a pivotal strategy for enhancing operational efficiency and competitiveness in logistics enterprises, particularly amid globalization and post pandemic recovery; this study aims to evaluate its multifaceted impact on business performance using a multi-criteria framework focused on Vietnamese firms. Methods: Employing structural equation modeling on primary survey data from 346 middle and senior level managers, alongside the Malmquist productivity index derived from data envelopment analysis on secondary financial indicators spanning 2020 to 2024, the research integrates latent variables such as organizational capability, technological innovation capability, institutional pressure, digital transformation, and business performance. Results: Key findings reveal a strong positive correlation between technological innovation capability and organizational capability (path coefficient 0.522), with organizational capability directly influencing business performance (0.359), while institutional pressure positively affects digital transformation (0.321) but negatively impacts business performance (−0.152); overall, digital transformation exhibits limited optimization, contributing to modest productivity gains and a potential 23% cost reduction through technologies like Internet of Things and artificial intelligence. Conclusions: These results underscore the necessity for logistics enterprises to strengthen organizational integration and training to maximize digital transformation benefits, thereby fostering sustainable competitiveness in global supply chains. Full article

Chemotherapy remains a cornerstone of systemic cancer treatment, yet dose-limiting toxicities—cardiotoxicity, neurotoxicity, and nephrotoxicity—affect 40–80% of patients, interrupt 20–30% of treatment cycles, and double long-term mortality. We propose that these seemingly distinct organ toxicities converge on a single mechanism: selective disruption of the MQC network. MQC comprises five interdependent modules—biogenesis, dynamics, mitophagy, proteostasis, and the recently characterized migrasome-mediated mitocytosis—collectively maintaining ATP supply, redox balance, and Ca²⁺ homeostasis in high-demand tissues. Chemotherapeutics such as anthracyclines, platinum agents, and taxanes simultaneously repress PGC-1α-driven biogenesis, hyperactivate Drp1-mediated fission, impair autophagosome–lysosome fusion, and inhibit mitocytosis, triggering mitochondrial collapse, ROS overflow, and cell death. This first-in-field review delineates organ-specific MQC pathways and catalogs druggable interventions—including small molecules, natural products, and nano-delivery systems—that restore MQC checkpoints. We present an integrated “MQC disruption–multi-organ toxicity–targeted intervention” framework, identifying Drp1 hyperactivation, late-stage mitophagy arrest, and mitocytosis inhibition as core therapeutic nodes. Targeting these pathways offers a promising strategy to decouple anticancer efficacy from off-target toxicity, potentially enabling optimized dosing, reducing treatment discontinuation, and improving long-term prognosis. Most MQC-targeted agents, however, remain in preclinical or early-phase trials. Full article

Accurate segmentation of fruit tree leaf diseases is critical for yield protection and precision crop management, yet it is challenging due to complex field conditions, irregular leaf morphology, and diverse lesion patterns. To address these issues, Disease-Seg, a lightweight real-time segmentation framework, is proposed. It integrates CNN and Transformer with a parallel fusion architecture to capture local texture and global semantic context. The Extended Feature Module (EFM) enlarges the receptive field while retaining fine details. A Deep Multi-scale Attention mechanism (DM-Attention) allocates channel weights across scales to reduce redundancy, and a Feature-weighted Fusion Module (FWFM) optimizes integration of heterogeneous feature maps, enhancing multi-scale representation. Experiments show that Disease-Seg achieves 90.32% mIoU and 99.52% accuracy, outperforming representative CNN, Transformer, and hybrid-based methods. Compared with HRNetV2, it improves mIoU by 6.87% and FPS by 31, while using only 4.78 M parameters. It maintains 69 FPS on 512 × 512 crops and requires approximately 49 ms per image on edge devices, demonstrating strong deployment feasibility. On two grape leaf diseases from the PlantVillage dataset, it achieves 91.19% mIoU, confirming robust generalization. These results indicate that Disease-Seg provides an accurate, efficient, and practical solution for fruit leaf disease segmentation, enabling real-time monitoring and smart agriculture applications. Full article

The identification of non-circular critical slip surfaces in slopes using metaheuristic algorithms remains a frontier challenge in geotechnical engineering. Such approaches are particularly effective for assessing the stability of heterogeneous slopes, including earth dams. This study introduces ODACO, a comprehensive program developed to determine the optimum cross-section of earth dams with berms. The program employs the Max–Min Ant System (MMAS), one of the most robust variants of the ant colony optimization algorithm. For each candidate cross-section, the critical slip surface is first identified using MMAS. Among the stability-compliant alternatives, the configuration with the most efficient shell geometry is then selected. The optimization process is conducted automatically across all loading conditions, incorporating slope stability criteria and operational constraints. To ensure that the optimized cross-section satisfies seismic performance requirements, an artificial neural network (ANN) model is applied to rapidly and reliably predict seismic responses. These ANN-based predictions provide an efficient alternative to computationally intensive dynamic analyses. The proposed framework highlights the potential of optimization-driven approaches to replace conventional trial-and-error design methods, enabling more economical, reliable, and practical earth dam configurations. Full article

Conventional object detectors represent each object by a deterministic bounding box, regressing its center and size from RGB images. However, such discrete parameterization ignores the inherent uncertainty in object appearance and geometric projection, which can be more naturally modeled as a probabilistic density field. Recent works have introduced Gaussian-based formulations that treat objects as distributions rather than boxes, yet they remain limited to 2D images or require late fusion between image and depth modalities. In this paper, we propose a unified Gaussian-based framework for direct 3D object detection from RGB-D inputs. Our method is built upon a vision transformer backbone to effectively capture global context. Instead of separately embedding RGB and depth features or refining depth within region proposals, our method takes a full four-channel RGB-D tensor and predicts the mean and covariance of a 3D Gaussian distribution for each object in a single forward pass. We extend a pretrained vision transformer to accept four-channel inputs by augmenting the patch embedding layer while preserving ImageNet-learned representations. This formulation allows the detector to represent both object location and geometric uncertainty in 3D space. By optimizing divergence metrics such as the Kullback–Leibler or Bhattacharyya distances between predicted and target distributions, the network learns a physically consistent probabilistic representation of objects. Experimental results on the SUN RGB-D benchmark demonstrate that our approach achieves competitive performance compared to state-of-the-art point-cloud-based methods while offering uncertainty-aware and geometrically interpretable 3D detections. Full article

This study addresses the challenge of identifying heavy Building Information Modeling (BIM) library components that disproportionately degrade model performance. While BIM has become standard in the construction industry, heavy components characterized by excessive geometric complexity, numerous instances, or inefficient optimization—cause extended file loading times, interface lag, and coordination difficulties, particularly in large cross-industry projects. Current identification methods rely primarily on designer experience and manual inspection, lacking systematic evaluation frameworks. This research develops a multi-criteria evaluation method based on Multi-Criteria Decision Analysis (MCDA) that quantifies component performance impact through five weighted criteria: instance count (20%), geometry complexity (30%), face count (20%), edge count (10%), and estimated file size (20%). These metrics are aggregated into a composite Weight Score, with components exceeding a threshold of 200 classified as requiring optimization attention. The method was implemented as HeavyFamilies, a pyRevit plugin for Autodesk Revit featuring a graphical interface with tabular results, CSV export functionality, and direct model visualization. Validation on three real BIM projects of varying scales (133–680 families) demonstrated effective identification of heavy components within 8–165 s of analysis time. User validation with six BIM specialists achieved 100% task completion rate, with automatic color coding and direct model highlighting particularly valued. The proposed approach enables a shift from reactive troubleshooting to proactive quality control, supporting routine diagnostics and objective prioritization of optimization efforts in federated and multi-disciplinary construction projects. Full article

Background: Achieving deep decarbonization in global supply chains is essential for advancing net-zero objectives; however, the integrative role of artificial intelligence (AI) and robotics in this transition remains insufficiently explored. This study examines how these technologies support carbon-emission reduction across supply chain operations. Methods: A curated corpus of 83 Scopus-indexed peer-reviewed articles published between 2013 and 2025 is analyzed and organized into six domains covering supply chain and logistics, warehousing operations, AI methodologies, robotic systems, emission-mitigation strategies, and implementation barriers. Results: AI-driven optimization consistently reduces transport emissions by enhancing routing efficiency, load consolidation, and multimodal coordination. Robotic systems simultaneously improve energy efficiency and precision in warehousing, yielding substantial indirect emission reductions. Major barriers include the high energy consumption of certain AI models, limited data interoperability, and poor scalability of current applications. Conclusions: AI and robotics hold substantial transformative potential for advancing supply chain decarbonization; nevertheless, their net environmental impact depends on improving the energy efficiency of digital infrastructures and strengthening cross-organizational data governance mechanisms. The proposed framework delineates technological and organizational pathways that can guide future research and industrial implementation, providing novel insights and actionable guidance for researchers and practitioners aiming to accelerate the low-carbon transition. Full article

Parenteral nutrition (PN) is essential for patients who are unable to tolerate oral or enteral feeding, providing them with necessary nutrients intravenously, including dextrose, amino acids, electrolytes, vitamins, trace elements, and lipid emulsions. Clinical pharmacists (CPs) play a critical role in PN management by ensuring proper formulation, monitoring therapy, preventing complications, and optimizing patient outcomes. In Saudi Arabia, limited literature exists on CPs’ involvement in total parenteral nutrition (TPN) administration, health information management (HIM) systems, and pharmacist staffing ratios. This paper examines the evolving role of CPs in PN management, addressing key challenges such as the optimal patient-to-CP ratio, the impact of HIM systems on PN prescribing, and the advantages and limitations of centralized versus decentralized PN prescription models. It highlights the need for standardized staffing levels, structured pharmacist training, and improved HIM integration to enhance workflow efficiency and prescribing accuracy. Additionally, the study examines how the adoption of advanced HIM systems can streamline documentation, reduce prescribing errors, and enhance interdisciplinary collaboration. This paper provides a framework for optimizing PN delivery, enhancing healthcare quality, and strengthening CPs’ contributions to nutrition support by addressing these factors. Implementing these recommendations will improve patient outcomes and establish a more efficient PN management system in Saudi Arabia, reinforcing the vital role of CPs in multidisciplinary care. Full article

Power load forecasting is critical for ensuring grid security and stability and optimizing energy resource allocation. The high integration of renewable energy poses significant challenges to traditional methods in data-scarce scenarios. Recently, Large Language Models (LLMs) have shown considerable potential in processing time-series data, yet their effectiveness in very short-term power load forecasting lacks systematic evaluation. This paper proposes a targeted prompt engineering framework and conducts a systematic empirical study on various LLMs, including GPT-4, Claude-3, Gemini, the Llama series, DeepSeek, and Qwen, comparing them with traditional methods such as ARIMA, BiLSTM, MICN, TimesNet, and VMD-BiLSTM. Furthermore, Ele-LLM, a specialized model based on the Low-Rank Adaptation (LoRA) parameter-efficient fine-tuning strategy, is proposed. Experimental results show that Ele-LLM achieves the best forecasting performance (MAPE = 1.04%), significantly outperforming the best traditional baseline. LLMs also demonstrate notable advantages in few-shot learning, long-sequence dependency modeling, and generalization in complex scenarios. This study provides an evaluation benchmark and practical guidelines for applying LLMs in very short-term power load forecasting, proving their great potential and practical value as an emerging technological pathway. Full article

Cultural ecosystem services (CESs) are the non-material benefits people derive from ecosystems and are important for human well-being. Most research has focused on individual CES supply–demand relationships, with little systematic study of the overall CES structure, interactions, and mechanisms in metropolitan areas. This study takes the Nanjing Metropolitan Area as a case study, integrating multi-source geospatial data and employing the MaxEnt model, self-organizing maps (SOMs), Spearman correlation analysis, and the Optimal Parameters-based Geographical Detector (OPGD). It analyzes supply–demand matching, trade-offs, synergies, and drivers for four CES categories: aesthetic (AE), recreational entertainment (RE), knowledge education (KE), and cultural diversity (CD). The main findings are as follows: (1) CES supply and demand are spatially zoned: the core area has surplus supply, secondary centers are balanced, and the periphery has both weak supply and demand. (2) Three supply–demand bundles have distinct synergy and trade-off patterns: Bundle 1 primarily exhibits strong synergy between AE and CD; Bundle 2 shows a weak trade-off relationship; and Bundle 3 forms a synergy centered on AE. (3) The explanatory power of driving factors exhibits pronounced spatial heterogeneity: Bundle 1 is dominated by non-quantifiable social factors; Bundle 2 features dual synergistic drivers of population and transportation; and Bundle 3 demonstrates synergistic effects driven by facilities and economic factors. Overall, this study contributes an integrated metropolitan-scale framework that connects CES supply–demand mismatch patterns with bundle typologies, interaction structures, and bundle-specific drivers. The results provide an operational basis for targeted planning and coordinated ecological–cultural governance in the Nanjing Metropolitan Area and offer a transferable reference for other metropolitan regions. Full article

Oxalic acid serves as an environmentally benign leaching agent, exhibiting strong reducing and complexing capabilities. In the oxalic acid leachate derived from vanadium-bearing shale, aluminum ions are present as major impurities. Achieving efficient and deep separation of vanadium from aluminum remains a key technical challenge. This study investigates the selective separation of vanadium and aluminum from oxalic acid leaching solutions using solvent extraction with Aliquat 336, supported by density functional theory (DFT) calculations. Experimental results demonstrate that, under optimized conditions, Aliquat 336 enables effective separation of vanadium from aluminum. DFT analysis elucidates the molecular-level interaction mechanism, revealing that the binding affinity of Aliquat 336 for [VO(C₂O₄)₂]²⁻ (ΔG = −287.96 kJ/mol) is significantly stronger than for [Al(C₂O₄)₂]⁻ (ΔG = −186.68 kJ/mol). These results provide a solid thermodynamic basis for the observed selectivity and establish a robust theoretical framework for developing high-efficiency separation processes. This work thus clarifies, for the first time, the mechanistic foundation of vanadium–aluminum separation in oxalic acid systems. Full article

Background/Objectives: We aimed to establish and validate population-based reference intervals (RIs) for serum ferritin (SF) using an indirect, date-driven approach based on real-world laboratory data and to optimize partitioning strategies. Methods: SF results from 29,723 apparently healthy individuals who underwent health examinations at West China Hospital between 2020 and 2024 were retrospectively analyzed. SF was measured on a Roche Cobas e801 electrochemiluminescence immunoassay platform. After Box–Cox transformation, outliers were removed using an iterative Tukey method. Potential partitioning factors were evaluated, and data-driven age cut-points were explored using decision tree regression and verified with the Harris–Boyd criteria. RIs were estimated using nonparametric percentile methods and validated in an independent cohort of 2494 individuals. Results: SF concentrations were significantly higher in males than in females (p < 0.001). In females, SF showed a significant positive association with age (r = 0.466, p < 0.001), whereas no such association was observed in males. Decision tree analysis identified 50 years as the optimal age cut-off for females (R² = 0.2467). The final study-derived RIs were 98.02–997.78 µg/L for males, 10.30–299.55 µg/L for females ≤ 50 years, and 36.61–507.00 µg/L for females > 50 years. In the validation cohort, the study-derived RIs achieved pass rates of 93.83–94.72%, which were significantly higher than the manufacturer-provided RIs (37.12–73.97%, all p < 0.001). Conclusions: Using a large health examination database and a multi-step partitioning strategy, we established robust sex- and age-specific SF RIs on the Roche Cobas e801 platform for the local population. This work provides a reproducible, generalizable framework for indirect RI determination of other biomarkers. Full article

Deep reinforcement learning (DRL) has been widely adopted to solve decision-making problems in complex environments, demonstrating high performance across various domains. However, DRL-based FPS agents are typically trained with a traditional, monolithic policy that integrates heterogeneous functionalities into a single network. This design hinders policy interpretability and severely limits structural flexibility, since even minor design changes in the action space often necessitate complete retraining of the entire network. These constraints are particularly problematic in game development, where behavioral characteristics are distinct and design updates are frequent. To address these issues, this study proposes a Modular Reinforcement Learning (MRL) framework. Unlike monolithic approaches, this framework decomposes complex agent behaviors into semantically distinct action modules, such as movement and attack, which are optimized in parallel with specialized reward structures. Each module learns a policy specialized for its own behavioral characteristics, and the final agent behavior is obtained by combining the outputs of these modules. This modular design enhances structural flexibility by allowing selective modification and retraining of specific functions, thereby reducing the inefficiency associated with retraining a monolithic policy. Experimental results on the 1-vs-1 training map show that the proposed modular agent achieves a maximum win rate of 83.4% against a traditional monolithic policy agent, demonstrating superior in-game performance. In addition, the retraining time required for modifying specific behaviors is reduced by up to 30%, confirming improved efficiency for development environments that require iterative behavioral updates. Full article

With accelerating urbanization and climate change, outdoor thermal comfort (OTC) in high-intensity urban blocks presents a critical challenge. While existing studies have established the general correlation between morphology and microclimate, most remain descriptive and lack a systematic framework to quantitatively integrate the non-linear coupled effects between multi-dimensional morphological variables and green infrastructure. To address this, this study proposes an automated performance-based design (PBD) framework for urban morphology optimization in Shenzhen. Unlike traditional simulation-based analysis, this framework serves as a generative tool for urban renewal planning. It integrates a multi-dimensional design element system with a genetic algorithm (GA) workflow. Analysis across four urban typologies demonstrated that the Full Enclosure layout is the most effective strategy for mitigating thermal stress, achieving a final optimized UTCI of 37.15 °C. Crucially, this study reveals a non-linear synergistic mechanism: the high street aspect ratios (H/W) of enclosed forms act as a “radiation shelter”, which amplifies the cooling efficiency of green infrastructure (contributing an additional 1.79 °C reduction). This research establishes a significant, strong negative correlation between UTCI and the combined factors of building density and green shading coverage. The results provide quantifiable guidelines for retrofitting existing high-density districts, suggesting that maximizing structural shading is prioritized over ventilation in ultra-high-density, low-wind climates. Full article