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  • Article
  • Open Access
7 Citations
4,502 Views
14 Pages

Clinical Predictors of Monkeypox Diagnosis: A Case-Control Study in a Nonendemic Region during the 2022 Outbreak

  • Alberto Kousuke De la Herrán-Arita,
  • Cuitláhuac González-Galindo,
  • Gerardo Kenny Inzunza-Leyva,
  • Marco Antonio Valdez-Flores,
  • Claudia Desiree Norzagaray-Valenzuela,
  • Alejandro Camacho-Zamora,
  • José Candelario Batiz-Beltrán,
  • Francisco Javier Urrea-Ramírez,
  • Alejandra Romero-Utrilla and
  • Juan Fidel Osuna-Ramos
  • + 5 authors

Monkeypox (Mpox) is an emerging zoonotic disease with the potential for severe complications. Early identification and diagnosis are essential to prompt treatment, control its spread, and reduce the risk of human-to-human transmission. This study aim...

(This article belongs to the Special Issue Monkeypox—Current Knowledge and Future Perspectives)
  • Article
  • Open Access
10 Citations
4,285 Views
10 Pages

Molecular Diagnosis of Human Monkeypox Virus during 2022–23 Outbreak: Preliminary Evaluation of Novel Real-Time Qualitative PCR Assays

  • Vanessa De Pace,
  • Bianca Bruzzone,
  • Valentina Ricucci,
  • Alexander Domnich,
  • Giulia Guarona,
  • Giada Garzillo,
  • Rexhina Qosja,
  • Giulia Ciccarese,
  • Antonio Di Biagio and
  • Giancarlo Icardi
  • + 1 author

In 2022–23, the human monkeypox virus (MPXV) caused a global outbreak in several non-endemic countries. Here, we evaluated the diagnostic performance of four real-time qualitative PCR assays for the laboratory diagnosis of mpox (monkeypox) monk...

(This article belongs to the Section Virology)
  • Abstract
  • Open Access
594 Views
2 Pages

Introduction: Monkeypox (mpox) is an emerging public health concern, with more than 134,000 confirmed cases worldwide by 2025 [...]

(This article belongs to the Proceedings of The 6th International Congress on Health Innovation—INOVATEC 2025)
  • Communication
  • Open Access
22 Citations
4,626 Views
6 Pages

Monkeypox Diagnosis by Cutaneous and Mucosal Findings

  • Diogo de Sousa,
  • João Patrocínio,
  • Joana Frade,
  • Claúdia Brazão,
  • Dora Mancha,
  • Catarina Correia,
  • João Borges-Costa and
  • Paulo Filipe

27 September 2022

A monkeypox outbreak has been reported in several countries since early May 2022. Human monkeypox (MPX) diagnosis is based on a clinical suspicion supported by typical skin and mucosal lesions, confirmed with molecular testing. We present the results...

(This article belongs to the Section Viral Infections)
  • Brief Report
  • Open Access
7 Citations
2,195 Views
7 Pages

Usefulness of Non-Skin Samples in the PCR Diagnosis of Mpox (Monkeypox)

  • Sonia Algarate,
  • Jessica Bueno,
  • María J. Crusells,
  • Mariano Ara,
  • Henar Alonso,
  • Elena Alvarado,
  • María Ducons,
  • Sara Arnal and
  • Rafael Benito

30 April 2023

Cases of mpox have been reported in several European countries, including Spain. Our objective was to evaluate the usefulness of serum and nasopharyngeal samples for diagnosis of mpox. The presence of MPXV DNA was studied using real-time PCR (CerTest...

(This article belongs to the Section Human Virology and Viral Diseases)
  • Case Report
  • Open Access
7 Citations
5,854 Views
9 Pages

Monkeypox Clinical Features and Differential Diagnosis: First Case in Campania Region

  • Novella Carannante,
  • Claudia Tiberio,
  • Raffaele Bellopede,
  • Michela Liguori,
  • Filomena Di Martino,
  • Nicola Maturo,
  • Raffaele Di Sarno,
  • Sabrina Scarica,
  • Giovanna Fusco and
  • Alessandro Perrella
  • + 3 authors

As of 15 June, there have been, globally, a total of 2103 laboratory-confirmed cases and one probable case of Monkeypox, including one death. We report two cases of vesicular infectious diseases, one of those is the first case of Monkeypox in the Cam...

(This article belongs to the Section Emerging Pathogens)
  • Review
  • Open Access
64 Citations
11,814 Views
23 Pages

Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies

  • Diana Emilia Martínez-Fernández,
  • David Fernández-Quezada,
  • Fidel Antonio Guadalupe Casillas-Muñoz,
  • Francisco Josué Carrillo-Ballesteros,
  • Ana Maria Ortega-Prieto,
  • Jose M. Jimenez-Guardeño and
  • Jose Angel Regla-Nava

Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular–pustular skin lesions. However, the differential diagnosis bet...

(This article belongs to the Special Issue Host-Virus Interactions in Viral Infectious Diseases)
  • Case Report
  • Open Access
5 Citations
6,192 Views
7 Pages

A Case Report of Monkeypox in an Adult Patient from Italy: Clinical and Dermoscopic Manifestations, Diagnosis and Management

  • Ilaria Proietti,
  • Paolo Emilio Santoro,
  • Nevena Skroza,
  • Tiziana Tieghi,
  • Nicoletta Bernardini,
  • Ersilia Tolino,
  • Agnieszka Ewa Dybala,
  • Antonio Di Guardo,
  • Alessandra Rallo and
  • Concetta Potenza
  • + 6 authors

10 November 2022

Monkeypox infection is an emerging problem and a new challenge for modern medicine. With an increasing number of new cases worldwide, new data regarding the clinical manifestations, characteristics of the patients, risk factors and treatment options...

(This article belongs to the Special Issue Monkeypox Virus Infection: Analysis and Detection)
  • Article
  • Open Access
5 Citations
1,545 Views
26 Pages

16 September 2025

Background/Objectives: Monkeypox is a zoonotic virus that presents with smallpox-like symptoms, making visual diagnosis challenging due to overlap with other dermatological conditions. Existing AI-based studies on monkeypox classification have largel...

(This article belongs to the Special Issue Explainable Machine Learning in Clinical Diagnostics)
  • Article
  • Open Access
26 Citations
4,191 Views
17 Pages

An Enhanced Diagnosis of Monkeypox Disease Using Deep Learning and a Novel Attention Model Senet on Diversified Dataset

  • Shivangi Surati,
  • Himani Trivedi,
  • Bela Shrimali,
  • Chintan Bhatt and
  • Carlos M. Travieso-González

With the widespread of Monkeypox and increase in the weekly reported number of cases, it is observed that this outbreak continues to put the human beings in risk. The early detection and reporting of this disease will help monitoring and controlling...

  • Article
  • Open Access
68 Citations
6,857 Views
16 Pages

A Transfer Learning Approach for Clinical Detection Support of Monkeypox Skin Lesions

  • Maram Fahaad Almufareh,
  • Samabia Tehsin,
  • Mamoona Humayun and
  • Sumaira Kausar

Monkeypox (MPX) is a disease caused by monkeypox virus (MPXV). It is a contagious disease and has associated symptoms of skin lesions, rashes, fever, and respiratory distress lymph swelling along with numerous neurological distresses. This can be a d...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
86 Citations
9,825 Views
14 Pages

Computer-Aided Detection and Classification of Monkeypox and Chickenpox Lesion in Human Subjects Using Deep Learning Framework

  • Dilber Uzun Ozsahin,
  • Mubarak Taiwo Mustapha,
  • Berna Uzun,
  • Basil Duwa and
  • Ilker Ozsahin

Monkeypox is a zoonotic viral disease caused by the monkeypox virus. After its recent outbreak, it has become clear that a rapid, accurate, and reliable diagnosis may help reduce the risk of a future outbreak. The presence of skin lesions is one of t...

(This article belongs to the Special Issue Artificial Intelligence and Machine Learning for Infectious Diseases)
  • Article
  • Open Access
65 Citations
7,011 Views
19 Pages

31 August 2022

As the 2022 human monkeypox (HMPX) multi-country outbreak is spreading, the response of healthcare workers (HCWs) is central to mitigation efforts. The current study aimed to evaluate HMPX knowledge and confidence in diagnosis and management among HC...

(This article belongs to the Special Issue Human Monkeypox: An Emerging Sexually Transmitted Infection?)
  • Review
  • Open Access
27 Citations
4,702 Views
15 Pages

Clinical Strategies and Therapeutics for Human Monkeypox Virus: A Revised Perspective on Recent Outbreaks

  • Nilanjan Ghosh,
  • Leena Chacko,
  • Jayalakshmi Vallamkondu,
  • Tanmoy Banerjee,
  • Chandrima Sarkar,
  • Birbal Singh,
  • Rajkumar Singh Kalra,
  • Jasvinder Singh Bhatti,
  • Ramesh Kandimalla and
  • Saikat Dewanjee

12 July 2023

An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus Orthopoxviridae, a family of notorious smallpox viruses, and so it shares similar clinical p...

(This article belongs to the Special Issue Controlling Zoonotic Viral Diseases from One Health Perspective 2026)
  • Review
  • Open Access
8 Citations
8,360 Views
13 Pages

Monkeypox: Re-Emerging Zoonotic Threat

  • Rajeev Ranjan and
  • Jitendra Kumar Biswal

18 October 2022

Monkeypox (MPX) is a relatively unknown and minor resurgent viral zoonotic disease caused by the monkeypox virus (MPXV). The disease can spread from person to person or from animal to person. The disease is most prevalent in the tropical rainforests...

(This article belongs to the Special Issue Feature Papers of Zoonotic Diseases 2021–2022)
  • Article
  • Open Access
76 Citations
8,960 Views
16 Pages

Assessing Healthcare Workers’ Knowledge and Their Confidence in the Diagnosis and Management of Human Monkeypox: A Cross-Sectional Study in a Middle Eastern Country

  • Malik Sallam,
  • Kholoud Al-Mahzoum,
  • Ala’a B. Al-Tammemi,
  • Mohammed Alkurtas,
  • Fatemeh Mirzaei,
  • Nariman Kareem,
  • Hala Al-Naimat,
  • Laila Jardaneh,
  • Laith Al-Majali and
  • Azmi Mahafzah
  • + 6 authors

8 September 2022

The ongoing multi-country human monkeypox (HMPX) outbreak was declared as a public health emergency of international concern. Considering the key role of healthcare workers (HCWs) in mitigating the HMPX outbreak, we aimed to assess their level of kno...

(This article belongs to the Special Issue Infectious Disease Prevention and Public Health Promotion)
  • Article
  • Open Access
133 Citations
6,997 Views
29 Pages

Classification of Monkeypox Images Based on Transfer Learning and the Al-Biruni Earth Radius Optimization Algorithm

  • Abdelaziz A. Abdelhamid,
  • El-Sayed M. El-Kenawy,
  • Nima Khodadadi,
  • Seyedali Mirjalili,
  • Doaa Sami Khafaga,
  • Amal H. Alharbi,
  • Abdelhameed Ibrahim,
  • Marwa M. Eid and
  • Mohamed Saber

2 October 2022

The world is still trying to recover from the devastation caused by the wide spread of COVID-19, and now the monkeypox virus threatens becoming a worldwide pandemic. Although the monkeypox virus is not as lethal or infectious as COVID-19, numerous co...

(This article belongs to the Special Issue Data-Driven Methods and Artificial Intelligence in Reliability and Maintenance)
  • Review
  • Open Access
1 Citations
3,324 Views
37 Pages

Monkeypox (Mpox), a Resurging Global Public Health Concern: An Updated Outlook Through 2025

  • Dewan Zubaer Islam,
  • Fahmida Sultana Tamanna,
  • Mohtasim Fuad,
  • Mst. Sanzida Akter Shanta,
  • Akhi Khanom,
  • Md. Mehedi Hasan,
  • Md. Shiful Islam Sujan,
  • Shahad Saif Khandker,
  • Md Shahin Reza and
  • Abu Ali Ibn Sina
  • + 4 authors

Monkeypox (Mpox) disease, caused by the Monkeypox virus (Mpox virus), emerged as a significant global health threat during the 2022 outbreak, prompting the World Health Organisation (WHO) to declare it a Public Health Emergency of International Conce...

(This article belongs to the Section Molecular Microbiology)
  • Review
  • Open Access
39 Citations
7,609 Views
17 Pages

Current Insights into Diagnosis, Prevention Strategies, Treatment, Therapeutic Targets, and Challenges of Monkeypox (Mpox) Infections in Human Populations

  • Mitesh Patel,
  • Mohd Adnan,
  • Abdu Aldarhami,
  • Abdulrahman S. Bazaid,
  • Nizar H. Saeedi,
  • Almohanad A. Alkayyal,
  • Fayez M. Saleh,
  • Ibrahim B. Awadh,
  • Amir Saeed and
  • Khalid Alshaghdali

16 January 2023

In the wake of the emergence and worldwide respread of a viral infection called Monkeypox (Mpox), there is a serious threat to the health and safety of the global population. This viral infection was endemic to the western and central parts of Africa...

(This article belongs to the Section Epidemiology)
  • Review
  • Open Access
60 Citations
7,311 Views
17 Pages

Current and Perspective Sensing Methods for Monkeypox Virus

  • Ijaz Gul,
  • Changyue Liu,
  • Xi Yuan,
  • Zhicheng Du,
  • Shiyao Zhai,
  • Zhengyang Lei,
  • Qun Chen,
  • Muhammad Akmal Raheem,
  • Qian He and
  • Peiwu Qin
  • + 8 authors

The outbreak of the monkeypox virus (MPXV) in non-endemic countries is an emerging global health threat and may have an economic impact if proactive actions are not taken. As shown by the COVID-19 pandemic, rapid, accurate, and cost-effective virus d...

(This article belongs to the Section Biochemical Engineering)
  • Communication
  • Open Access
21 Citations
5,635 Views
10 Pages

Rapid Amplicon Nanopore Sequencing (RANS) for the Differential Diagnosis of Monkeypox Virus and Other Vesicle-Forming Pathogens

  • Ofir Israeli,
  • Yehoudit Guedj-Dana,
  • Ohad Shifman,
  • Shirley Lazar,
  • Inbar Cohen-Gihon,
  • Sharon Amit,
  • Ronen Ben-Ami,
  • Nir Paran,
  • Ofir Schuster and
  • Adi Beth-Din
  • + 2 authors

18 August 2022

As of July 2022, more than 16,000 laboratory-confirmed monkeypox (MPX) cases have been reported worldwide. Until recently, MPX was a rare viral disease seldom detected outside Africa. MPX virus (MPXV) belongs to the Orthopoxvirus (OPV) genus and is a...

(This article belongs to the Special Issue Monkeypox Virus (Mpox))
  • Perspective
  • Open Access
83 Citations
9,170 Views
14 Pages

15 May 2024

Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022–2023, due to Clade IIb mpox virus (MPXV), disproportionately affected gay, bisexual, and other men who have sex with men. More than 35% a...

(This article belongs to the Section Human Virology and Viral Diseases)
  • Review
  • Open Access
3 Citations
1,445 Views
17 Pages

Maternal–Fetal Implications of Mpox Infection: Current Evidence

  • Stefany Silva Pereira,
  • Antonio Braga,
  • Beatriz Bussi Rosolen,
  • Talita Almeida Durães,
  • Marcela Fermoselle de Vita Silva,
  • Giovanna Alves de Britto,
  • Giuliana Augustinelli Sales,
  • Gustavo Yano Callado,
  • Camilla Martins dos Santos Maia and
  • Roberta Granese
  • + 3 authors

5 January 2026

Mpox is an emerging zoonotic infection caused by the Monkeypox virus, an Orthopoxvirus with increasing global relevance following the 2022 multinational outbreak. Historically endemic to Central and West Africa, the disease has evolved from sporadic...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
36 Citations
5,344 Views
12 Pages

Development of a Novel Loop-Mediated Isothermal Amplification Method for the Rapid Detection of Monkeypox Virus Infections

  • Chao Yu,
  • Lulu Zuo,
  • Jing Miao,
  • Lingjing Mao,
  • Benjamin Selekon,
  • Ella Gonofio,
  • Emmanuel Nakoune,
  • Nicolas Berthet and
  • Gary Wong

28 December 2022

A recent outbreak of monkeypox virus (mpox) has prompted researchers to explore diagnostics as a means of impeding transmission and further spread. Rapid, sensitive, and specific methods are crucial for accurately diagnosing mpox infections. Here, we...

(This article belongs to the Special Issue Monkeypox Virus (Mpox))
  • Review
  • Open Access
39 Citations
8,941 Views
22 Pages

Omicron Variant of SARS-CoV-2: An Indian Perspective of Vaccination and Management

  • Vivek P. Chavda,
  • Pankti Balar,
  • Dixa Vaghela,
  • Hetvi K. Solanki,
  • Akta Vaishnav,
  • Vivek Hala and
  • Lalitkumar Vora

11 January 2023

Omicron variants have highly influenced the entire globe. It has a high rate of transmissibility, which makes its management tedious. There are various subtypes of omicron, namely BA.1, BA.2, BA.3, BA.4, and BA.5. Currently, one omicron subvariant BF...

(This article belongs to the Section Vaccines, Clinical Advancement, and Associated Immunology)
  • Review
  • Open Access
51 Citations
23,758 Views
24 Pages

Mpox 2022 to 2025 Update: A Comprehensive Review on Its Complications, Transmission, Diagnosis, and Treatment

  • Rajesh Yadav,
  • Anis Ahmad Chaudhary,
  • Ujjwal Srivastava,
  • Saurabh Gupta,
  • Sarvesh Rustagi,
  • Hassan Ahmed Rudayni,
  • Vivek Kumar Kashyap and
  • Sanjay Kumar

25 May 2025

Monkeypox virus (Mpox virus) is a zoonotic orthopoxvirus that has gained increased global attention due to recent outbreaks. The current review reports the latest update of Mpox cases from 25 February 2022 to 29 April 2025. It also evaluates the poss...

(This article belongs to the Special Issue Advanced Strategies against SARS-CoV-2 Variants and Future Emerging Virus Outbreaks)
  • Review
  • Open Access
28 Citations
6,729 Views
10 Pages

Mpox (Monkeypox) and the Eye: Ocular Manifestation, Diagnosis, Treatment and Vaccination

  • Yuan Zong,
  • Koju Kamoi,
  • Jing Zhang,
  • Mingming Yang and
  • Kyoko Ohno-Matsui

23 February 2023

At present, the world is at the tipping point of the outbreak of mpox. The World Health Organization has declared the current mpox outbreak a ‘public health emergency of international concern’. Mpox has been shown to be associated with se...

(This article belongs to the Section Human Virology and Viral Diseases)
  • Review
  • Open Access
50 Citations
17,547 Views
14 Pages

Clinical Manifestation, Transmission, Pathogenesis, and Diagnosis of Monkeypox Virus: A Comprehensive Review

  • Faheem Anwar,
  • Fatima Haider,
  • Sarmir Khan,
  • Ibrar Ahmad,
  • Naveed Ahmed,
  • Muhammad Imran,
  • Summya Rashid,
  • Zhi-Guang Ren,
  • Saadullah Khattak and
  • Xin-Ying Ji

14 February 2023

Monkeypox virus is a double-stranded DNA virus species that causes disease in humans and mammals. It is a zoonotic virus belongs the genus Orthopoxviral, the family of Poxviridae, associated with the smallpox virus in many aspects. The first human ca...

(This article belongs to the Section Epidemiology)
  • Article
  • Open Access
48 Citations
4,913 Views
21 Pages

Diagnosis of Monkeypox Disease Using Transfer Learning and Binary Advanced Dipper Throated Optimization Algorithm

  • Amal H. Alharbi,
  • S. K. Towfek,
  • Abdelaziz A. Abdelhamid,
  • Abdelhameed Ibrahim,
  • Marwa M. Eid,
  • Doaa Sami Khafaga,
  • Nima Khodadadi,
  • Laith Abualigah and
  • Mohamed Saber

The virus that causes monkeypox has been observed in Africa for several years, and it has been linked to the development of skin lesions. Public panic and anxiety have resulted from the deadly repercussions of virus infections following the COVID-19...

(This article belongs to the Special Issue Nature-Inspired Computer Algorithms)
  • Review
  • Open Access
8 Citations
3,969 Views
12 Pages

Monkeypox: An Unfamiliar Virus—Clinical and Epidemiological Characteristics, Diagnosis, and Treatment with Special Emphasis on Oral Health

  • Visha Shailesh Pandya,
  • Vini Mehta,
  • Mohammas Miraj,
  • Sharifa M. Alasiry,
  • Wdad Alanazy,
  • Tintu Thomas Uthup,
  • Riyaz Ahamed Shaik,
  • Cesare D’Amico,
  • Maura Mancini and
  • Aida Meto
  • + 2 authors

10 November 2022

With the recent increased prevalence of human outbreaks, monkeypox has been recognized for decades as an infectious disease with substantial pandemic potential. The majority of cases of this virus have been observed in the European region (11,865), w...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
9 Citations
2,897 Views
14 Pages

Resident Physicians’ Knowledge and Preparedness Regarding Human Monkeypox: A Cross-Sectional Study from Saudi Arabia

  • Ali Mohammad Shafei,
  • Khalid M. Al-Mosaa,
  • Najm Z. Alshahrani,
  • Mohammed Hassan Mohammed ALAmmari,
  • Mashael Obaid Othman Almuhlafi,
  • Nasser Hassan Awdah Al Draim,
  • Afnan Misfer Alwadie and
  • Abdullah Ibrahim Alghrab

This study aimed to evaluate knowledge about monkeypox and confidence in dealing with monkeypox diagnosis and management among resident physicians in the Asir region of Saudi Arabia. The data of this cross-sectional study were collected online throug...

(This article belongs to the Section Epidemiology of Infectious Diseases)
  • Review
  • Open Access
45 Citations
11,300 Views
12 Pages

24 January 2023

Monkeypox is a zoonotic infectious disease caused by the monkeypox virus (MPXV) infection, which is mainly manifested as characteristic rashes. It spreads mainly through direct skin-to-skin contact. In some cases, respiratory transmission occurs thro...

(This article belongs to the Section Infectious Diseases)
  • Review
  • Open Access
40 Citations
6,322 Views
19 Pages

25 August 2022

In 1958, several monkeys in a Copenhagen laboratory developed a skin rash from which an orthopoxvirus could be isolated, which was named monkeypox virus (MPXV). However, the natural animal reservoir for MPXV is thought to be a rodent. The first human...

  • Review
  • Open Access
8 Citations
4,146 Views
14 Pages

Monkeypox 2022 Outbreak: How Alarming Is the Situation? Epidemiological and Clinical Review

  • Farah Marraha,
  • Ibtissam Al Faker,
  • Hanane Chahoub,
  • Youness Benyamna,
  • Najlae Rahmani and
  • Salim Gallouj

13 January 2023

Monkeypox is a disease caused by Orthopoxvirus, which also includes the smallpox virus. Several endemics have been reported on the African continent, typically in the western and central regions. However, since 13 May 2022, there have been several ca...

  • Review
  • Open Access
3 Citations
3,076 Views
34 Pages

Insights into Monkeypox Virus: Host Immunity, Viral Immune Evasion, Recent Advances in Vaccines, Therapeutic Development, and Future Perspectives

  • Mingzhuo Chen,
  • Weigang Ren,
  • Xin Wu,
  • Jamal Muhammad Khan,
  • Humera Nazir,
  • Shafeeq Ur Rehman,
  • Faizan Ali and
  • Junwei Li

Monkeypox (Mpox), a zoonotic viral disease caused by the Monkeypox Virus (MPXV), has gained significant attention in recent years due to its increasing incidence and the grave threat it poses to global health. MPXV has spread at a rapid pace during t...

(This article belongs to the Section Virology)
  • Case Report
  • Open Access
22 Citations
2,904 Views
3 Pages

An Adult Patient with Suspected of Monkeypox Infection Differential Diagnosed to Chickenpox

  • Junis Tumewu,
  • Maya Wardiana,
  • Evy Ervianty,
  • Sawitri,
  • Rahmadewi,
  • Astindari,
  • Sylvia Anggraeni,
  • Yuri Widia,
  • Mochamad Amin and
  • Maria Inge Lusida
  • + 3 authors

Background: Monkeypox is a zoonosis. The disease has a similar appearance to chickenpox caused by the varicella-zoster virus (VZV). On May 9th 2019, there was one laboratory-confirmed case of monkeypox reported in Singapore. A man was also suspected...

  • Article
  • Open Access
100 Citations
5,620 Views
22 Pages

An Al-Biruni Earth Radius Optimization-Based Deep Convolutional Neural Network for Classifying Monkeypox Disease

  • Doaa Sami Khafaga,
  • Abdelhameed Ibrahim,
  • El-Sayed M. El-Kenawy,
  • Abdelaziz A. Abdelhamid,
  • Faten Khalid Karim,
  • Seyedali Mirjalili,
  • Nima Khodadadi,
  • Wei Hong Lim,
  • Marwa M. Eid and
  • Mohamed E. Ghoneim

21 November 2022

Human skin diseases have become increasingly prevalent in recent decades, with millions of individuals in developed countries experiencing monkeypox. Such conditions often carry less obvious but no less devastating risks, including increased vulnerab...

(This article belongs to the Special Issue Machine Learning in Signal and Image Analysis for Biomedical Application)
  • Article
  • Open Access
53 Citations
4,401 Views
11 Pages

11 October 2022

After the COVID-19 disease, monkeypox disease has emerged today and has started to be seen almost everywhere in the world in a short time. Monkeypox causes symptoms such as fever, chills, and headache in people. In addition, rashes are seen on the sk...

(This article belongs to the Special Issue Applications of Deep Learning and Artificial Intelligence Methods)
  • Review
  • Open Access
73 Citations
10,553 Views
19 Pages

Disease History, Pathogenesis, Diagnostics, and Therapeutics for Human Monkeypox Disease: A Comprehensive Review

  • AbdulRahman A. Saied,
  • Manish Dhawan,
  • Asmaa A. Metwally,
  • Mathumalar Loganathan Fahrni,
  • Priyanka Choudhary and
  • Om Prakash Choudhary

7 December 2022

The monkeypox disease is a zoonotic-infectious disease that transmits between animals and humans. It is caused by a double-stranded DNA virus belonging to the Orthopoxvirus genus that is closely related to the variola virus –the causative agent...

  • Article
  • Open Access
42 Citations
4,446 Views
26 Pages

In this research, we demonstrate a Deep Convolutional Neural Network-based classification model for the detection of monkeypox. Monkeypox can be difficult to diagnose clinically in its early stages since it resembles both chickenpox and measles in sy...

(This article belongs to the Special Issue Medical Image Processing and Analysis)
  • Article
  • Open Access
7 Citations
3,905 Views
10 Pages

Evaluation of Five Buffers for Inactivation of Monkeypox Virus and Feasibility of Virus Detection Using the Panther Fusion® Open Access System

  • Robert J. Fischer,
  • Shane Gallogly,
  • Jonathan E. Schulz,
  • Neeltje van Doremalen,
  • Vincent Munster and
  • Sanchita Das

10 October 2022

Rapid diagnosis is key to containing viral outbreaks. However, for the current monkeypox outbreak the major deterrent to rapid testing is the requirement for higher biocontainment of potentially infectious monkeypox virus specimens. The current CDC g...

(This article belongs to the Topic Human Monkeypox Research)
  • Article
  • Open Access
17 Citations
6,432 Views
11 Pages

A Comparative Evaluation of Three Diagnostic Assays for the Detection of Human Monkeypox

  • Jing Qu,
  • Xiaomin Zhang,
  • Kun Liu,
  • You Li,
  • Ting Wang,
  • Zhonggang Fang,
  • Cheng Chen,
  • Xiao Tan,
  • Ying Lin and
  • Bo Peng
  • + 8 authors

12 August 2024

Accurate and early diagnosis of monkeypox virus (MPXV) is crucial for controlling epidemics and treating affected individuals promptly. This study aimed to assess the analytical and clinical performance of the MolecisionTM Monkeypox Virus qPCR Assay,...

(This article belongs to the Topic Human Monkeypox Research)
  • Systematic Review
  • Open Access
22 Citations
7,442 Views
18 Pages

Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review

  • Darwin A. León-Figueroa,
  • Joshuan J. Barboza,
  • Hortencia M. Saldaña-Cumpa,
  • Emilly Moreno-Ramos,
  • D. Katterine Bonilla-Aldana,
  • Mario J. Valladares-Garrido,
  • Ranjit Sah and
  • Alfonso J. Rodriguez-Morales

Due to the rapid evolution of the monkeypox virus, the means by which the monkeypox virus is spread is subject to change. Therefore, the present study aims to analyze the detection of the monkeypox virus according to the collection site of samples fr...

(This article belongs to the Topic Human Monkeypox Research)
  • Review
  • Open Access
14 Citations
9,101 Views
13 Pages

A Review of Monkeypox: The New Global Health Emergency

  • Kritika Srinivasan Rajsri and
  • Mana Rao

5 September 2022

Monkeypox, once a rare zoonotic disease, has been endemic to some African countries since its original identification among humans in 1970. Since then, cases in non-endemic regions have been linked to returning travelers or those who had contact with...

(This article belongs to the Special Issue New Advances in Management and Treatment of Sexually Transmitted Infections)
  • Review
  • Open Access
8 Citations
3,125 Views
7 Pages

Monkeypox: A Mini-Review on the Globally Emerging Orthopoxvirus

  • Amy Evans,
  • Bara’ Abdallah AlShurman,
  • Hibah Sehar and
  • Zahid Ahmad Butt

Monkeypox is a zoonotic infectious disease belonging to the orthopoxvirus family that has predominantly occurred in West and Central Africa since it was initially discovered in 1958. In May 2022, a global outbreak of monkeypox began to occur on an in...

(This article belongs to the Section Infectious Disease Epidemiology)
  • Review
  • Open Access
62 Citations
8,767 Views
10 Pages

Human Monkeypox: A Comprehensive Narrative Review and Analysis of the Public Health Implications

  • Francesco Di Gennaro,
  • Nicola Veronese,
  • Claudia Marotta,
  • Jae Il Shin,
  • Ai Koyanagi,
  • Andrea Silenzi,
  • Mario Antunes,
  • Annalisa Saracino,
  • Davide Fiore Bavaro and
  • Lee Smith
  • + 9 authors

Recently, numerous cases of monkeypox were reported from several non-endemic countries in Europe, North America, and Oceania, suggesting an unusual and alarming public health issue, particularly considering that the disease is not directly related to...

(This article belongs to the Special Issue Monkeypox—Current Knowledge and Future Perspectives)
  • Systematic Review
  • Open Access
45 Citations
8,416 Views
12 Pages

Antiviral Treatment against Monkeypox: A Scoping Review

  • Brando Ortiz-Saavedra,
  • Darwin A. León-Figueroa,
  • Elizbet S. Montes-Madariaga,
  • Alex Ricardo-Martínez,
  • Niza Alva,
  • Cielo Cabanillas-Ramirez,
  • Joshuan J. Barboza,
  • Abdelmonem Siddiq,
  • Luis A. Coaguila Cusicanqui and
  • Alfonso J. Rodriguez-Morales
  • + 1 author

During the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy a...

(This article belongs to the Topic Human Monkeypox Research)
  • Systematic Review
  • Open Access
39 Citations
6,644 Views
18 Pages

Epidemiological Situation of Monkeypox Transmission by Possible Sexual Contact: A Systematic Review

  • Darwin A. León-Figueroa,
  • Joshuan J. Barboza,
  • Edwin A. Garcia-Vasquez,
  • D. Katterine Bonilla-Aldana,
  • Milagros Diaz-Torres,
  • Hortencia M. Saldaña-Cumpa,
  • Melissa T. Diaz-Murillo,
  • Olga Campos-Santa Cruz and
  • Alfonso J. Rodriguez-Morales

Monkeypox (MPX), a zoonotic infection caused by the monkeypox virus (MPXV), has re-emerged worldwide with numerous confirmed cases with person-to-person transmission through close contacts, including in sexual networks. Therefore, this study aimed to...

(This article belongs to the Special Issue Rising Stars in Mpox Research)
  • Article
  • Open Access
7 Citations
4,559 Views
13 Pages

Rapid Detection of the Varicella-Zoster Virus Using a Recombinase-Aided Amplification-Lateral Flow System

  • Kathrina Mae Bienes,
  • Lingjing Mao,
  • Benjamin Selekon,
  • Ella Gonofio,
  • Emmanuel Nakoune,
  • Gary Wong and
  • Nicolas Berthet

25 November 2022

Varicella-zoster virus (VZV) is the etiological agent of varicella (chickenpox) and herpes zoster (shingles). VZV infections are ubiquitous and highly contagious, and diagnosis is mostly based on the assessment of signs and symptoms. However, monkeyp...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
22 Citations
4,927 Views
16 Pages

A Deep Learning-Based Mobile Application for Monkeypox Detection

  • Haifa F. Alhasson,
  • Elaf Almozainy,
  • Manar Alharbi,
  • Naseem Almansour,
  • Shuaa S. Alharbi and
  • Rehan Ullah Khan

22 November 2023

The recent outbreak of monkeypox has raised significant concerns in the field of public health, primarily because it has quickly spread to over 40 countries outside of Africa. Detecting monkeypox in its early stages can be quite challenging because i...

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